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Protein

Ran GTPase-activating protein 1

Gene

rangap1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for RAN, converting it to the GDP-bound state (PubMed:9108047). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is required for RAN-mediated nuclear import and export (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ran GTPase-activating protein 1
Short name:
RanGAP1
Gene namesi
Name:rangap1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567391 – 580Ran GTPase-activating protein 1Add BLAST580

Post-translational modificationi

May be sumoylated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiO13066

Interactioni

Subunit structurei

Homodimer (By similarity). Identified in a complex with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBE2I) (PubMed:9108047).By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliO13066
SMRiO13066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 71LRR 1Add BLAST24
Repeati111 – 134LRR 2Add BLAST24
Repeati141 – 168LRR 3Add BLAST28
Repeati207 – 230LRR 4Add BLAST24
Repeati235 – 258LRR 5Add BLAST24
Repeati292 – 315LRR 6Add BLAST24
Repeati320 – 343LRR 7Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi359 – 396Asp/Glu-rich (highly acidic)Add BLAST38

Sequence similaritiesi

Belongs to the RNA1 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOVERGENiHBG017720

Family and domain databases

Gene3Di1.25.40.200, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR009109 Ran_GTPase_activating_1_C
IPR027038 RanGap
IPR036720 RanGAP1_C_sf
PANTHERiPTHR24113 PTHR24113, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF07834 RanGAP1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF69099 SSF69099, 1 hit

Sequencei

Sequence statusi: Complete.

O13066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEDIAQLA DCLAKANVGD GELSFKGKTL KLNTAQDAEE VIREIEEYEG
60 70 80 90 100
LQALRLEGNT VGVEAAKAIA EVLQRKPDLK RCHWSDMFTG RLRPEIPTAL
110 120 130 140 150
RSLGDALITA GAQLTELDLS DNAFGPDGVR GFEALLKSPT CFTLQELKLN
160 170 180 190 200
NCGMGIGGGK ILAAALTECH KKSSAHGKPL ALKVFIAGRN RLENDGATAL
210 220 230 240 250
SEAFRLIGTL EEVHMPQNGI NHAGITALAE SFKANSLLKV INLNDNTFTE
260 270 280 290 300
KGGVAMAEAL KTLRQVEVIN FGDCLVRSKG AQAIASALKE GLHKLKDLNL
310 320 330 340 350
SYCEIKADAA VSLAESVEDK SDLEKLDLNG NCLGEEGCEQ VQEILESINM
360 370 380 390 400
ANILGSLSDD EDEDDDDDDE DDDDDEDDEN DDEEVEEEEE EVEEEEGGDN
410 420 430 440 450
ENKEKSKEIP CLSGSAPASP PKLPVDASTF LSFPSPEKLV RMGPRRSAMI
460 470 480 490 500
AQQVNVADTE KVVQAFIQVS SVYREDGEIK AAVEETIDGL MKEAFENRGF
510 520 530 540 550
QANVFITSLL VQMGLLKSED KMKTIPHLNG PLLTLNHMVQ QNYFPKSLAS
560 570 580
TLLAFISKPN GVLENNASAR HTLLCNLHNL
Length:580
Mass (Da):62,908
Last modified:July 1, 1997 - v1
Checksum:iBE1ED7693E8FFE3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88155 mRNA Translation: AAB62321.1
UniGeneiXl.57165

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88155 mRNA Translation: AAB62321.1
UniGeneiXl.57165

3D structure databases

ProteinModelPortaliO13066
SMRiO13066
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO13066

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017720

Family and domain databases

Gene3Di1.25.40.200, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR009109 Ran_GTPase_activating_1_C
IPR027038 RanGap
IPR036720 RanGAP1_C_sf
PANTHERiPTHR24113 PTHR24113, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF07834 RanGAP1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF69099 SSF69099, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAGP1_XENLA
AccessioniPrimary (citable) accession number: O13066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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