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Protein

Tyrosine-protein phosphatase non-receptor type 1

Gene

PTPN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei181SubstrateBy similarity1
Active sitei215Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei262SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-GGA-354192 Integrin alphaIIb beta3 signaling
R-GGA-6807004 Negative regulation of MET activity
R-GGA-912694 Regulation of IFNA signaling
R-GGA-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 1 (EC:3.1.3.48)
Alternative name(s):
CPTP1
Protein-tyrosine phosphatase 1B
Short name:
PTP-1B
Gene namesi
Name:PTPN1
Synonyms:PTP1B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947511 – 434Tyrosine-protein phosphatase non-receptor type 1Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO13016
PRIDEiO13016

PTM databases

iPTMnetiO13016

Expressioni

Gene expression databases

BgeeiENSGALG00000008010

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDH2P1028810EBI-6938259,EBI-985728

Protein-protein interaction databases

BioGridi675966, 3 interactors
IntActiO13016, 7 interactors
MINTiO13016
STRINGi9031.ENSGALP00000012986

Structurei

3D structure databases

ProteinModelPortaliO13016
SMRiO13016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 277Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 221Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
HOGENOMiHOG000273908
HOVERGENiHBG008321
InParanoidiO13016
KOiK05696
PhylomeDBiO13016
TreeFamiTF315897

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012265 Ptpn1/Ptpn2
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

O13016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIEKEFHRL DQAASWAAIY QDIRHEASDF PCKVAKHPRN KNRNRYRDVS
60 70 80 90 100
PFDHSRIKLN QGDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW
110 120 130 140 150
EQKSRGVVML NRVMEKGSIK CAQYWPRKEE KEMFFEDTNL KLTLISEDIK
160 170 180 190 200
SYYTVRQLEL ENLTTQETRE ILHFHYTTWP DFGVPESPAS FLNFLFKVRE
210 220 230 240 250
SGSLNPEYGP VVVHCSAGIG RSGTFCLVDT CLLLMDKRKD PSSVDVKQVL
260 270 280 290 300
LEMRKYRMGL IQTADQLRFS YLAVIEGAKF IMGDASVQEQ WKELSNEDLD
310 320 330 340 350
PPPEHTPPPP RPPKRTSEMH NGRMHEHAEF FPKHQVVEEE IRCSVSTAEE
360 370 380 390 400
TVSDGRVFSS VPLITDSTSQ DTEIRRRTVG ENLHVTAHKE ESKSESVEED
410 420 430
DENMMTTWKP FLVNICMFTF LTAGAYLCYR VCFH
Length:434
Mass (Da):50,334
Last modified:July 1, 1997 - v1
Checksum:i0FF340B2333CC311
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14A → R in AAA91186 (Ref. 3) Curated1
Sequence conflicti62 – 63GD → RC in AAA91186 (Ref. 3) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86410 mRNA Translation: AAB53270.1
U46662 mRNA Translation: AAA91186.1
PIRiJW0049
RefSeqiNP_990206.1, NM_204875.1
UniGeneiGga.4404

Genome annotation databases

GeneIDi395688
KEGGigga:395688

Similar proteinsi

Entry informationi

Entry nameiPTN1_CHICK
AccessioniPrimary (citable) accession number: O13016
Secondary accession number(s): Q90704
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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