UniProtKB - O11436 (POLG_RGMVD)
Genome polyprotein
Functioni
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
By similarityAn RNA-dependent RNA polymerase that plays an essential role in the virus replication.
By similarityRequired for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).
By similarityHas helicase activity. It may be involved in replication (By similarity).
By similarityBoth 6K peptides are indispensable for virus replication.
By similarityHas RNA-binding and proteolytic activities.
By similarityCatalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
- Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved. EC:3.4.22.44
- Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein. EC:3.4.22.45
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 173 | For P1 proteinase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 182 | For P1 proteinase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 215 | For P1 proteinase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 598 | For helper component proteinase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 670 | For helper component proteinase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 2045 | For nuclear inclusion protein A activityPROSITE-ProRule annotation | 1 | |
Active sitei | 2080 | For nuclear inclusion protein A activityPROSITE-ProRule annotation | 1 | |
Active sitei | 2149 | For nuclear inclusion protein A activityPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1202 – 1209 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- helicase activity Source: UniProtKB-KW
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- serine-type peptidase activity Source: UniProtKB-KW
- structural molecule activity Source: InterPro
GO - Biological processi
- RNA-protein covalent cross-linking Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Helicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Serine protease, Suppressor of RNA silencing, Thiol protease, Transferase |
Biological process | Viral RNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
MEROPSi | C04.012 |
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinCleaved into the following 10 chains: P1 proteinase (EC:3.4.-.-) Alternative name(s): N-terminal protein Alternative name(s): VPg Alternative name(s): 49 kDa proteinase Short name: 49 kDa-Pro NIa-pro Alternative name(s): RNA-directed RNA polymerase Alternative name(s): Coat protein |
Organismi | Ryegrass mosaic virus (isolate Denmark/Danish) (RGMV) |
Taxonomic identifieri | 652106 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Stelpaviricetes › Patatavirales › Potyviridae › Rymovirus › |
Virus hosti | Dactylis glomerata (Orchard grass) (Cock's-foot grass) [TaxID: 4509] Lolium [TaxID: 4520] |
Proteomesi |
|
Subcellular locationi
- Virion Curated
Keywords - Cellular componenti
Capsid protein, Helical capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420021 | 1 – 3086 | Genome polyproteinAdd BLAST | 3086 | |
ChainiPRO_5000146992 | 1 – 256 | P1 proteinaseSequence analysisAdd BLAST | 256 | |
ChainiPRO_5000146993 | 257 – 711 | Helper component proteinaseSequence analysisAdd BLAST | 455 | |
ChainiPRO_5000146994 | 712 – 1063 | Protein P3Sequence analysisAdd BLAST | 352 | |
ChainiPRO_5000146995 | 1064 – 1116 | 6 kDa protein 1Sequence analysisAdd BLAST | 53 | |
ChainiPRO_5000146996 | 1117 – 1753 | Cytoplasmic inclusion proteinSequence analysisAdd BLAST | 637 | |
ChainiPRO_5000146997 | 1754 – 1806 | 6 kDa protein 2Sequence analysisAdd BLAST | 53 | |
ChainiPRO_5000146998 | 1807 – 1999 | Viral genome-linked proteinSequence analysisAdd BLAST | 193 | |
ChainiPRO_5000146999 | 2000 – 2240 | Nuclear inclusion protein ASequence analysisAdd BLAST | 241 | |
ChainiPRO_5000147000 | 2241 – 2758 | Nuclear inclusion protein BSequence analysisAdd BLAST | 518 | |
ChainiPRO_5000147001 | 2759 – 3086 | Capsid proteinSequence analysisAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1870 | O-(5'-phospho-RNA)-tyrosineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 256 – 257 | Cleavage; by P1 proteinasePROSITE-ProRule annotation | 2 | |
Sitei | 711 – 712 | Cleavage; by autolysisPROSITE-ProRule annotation | 2 | |
Sitei | 1063 – 1064 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 1116 – 1117 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 1753 – 1754 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 1806 – 1807 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 1999 – 2000 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 2240 – 2241 | Cleavage; by NIa-proBy similarity | 2 | |
Sitei | 2758 – 2759 | Cleavage; by NIa-proBy similarity | 2 |
Keywords - PTMi
Covalent protein-RNA linkage, PhosphoproteinStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 122 – 256 | Peptidase S30PROSITE-ProRule annotationAdd BLAST | 135 | |
Domaini | 590 – 711 | Peptidase C6PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 1189 – 1341 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 153 | |
Domaini | 2000 – 2217 | Peptidase C4PROSITE-ProRule annotationAdd BLAST | 218 | |
Domaini | 2482 – 2606 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1970 – 1990 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 2762 – 2822 | DisorderedSequence analysisAdd BLAST | 61 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1291 – 1294 | DEAH box | 4 |
Domaini
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits 3.30.70.270, 1 hit 3.40.50.300, 2 hits 3.90.70.150, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001456, HC-pro IPR031159, HC_PRO_CPD_dom IPR042308, HC_PRO_CPD_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR002540, Pept_S30_P1_potyvir IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001592, Poty_coat IPR001730, Potyv_NIa-pro_dom IPR039560, Potyvirid-P3 IPR013648, PP_Potyviridae IPR043128, Rev_trsase/Diguanyl_cyclase IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00863, Peptidase_C4, 1 hit PF00851, Peptidase_C6, 1 hit PF01577, Peptidase_S30, 1 hit PF00767, Poty_coat, 1 hit PF08440, Poty_PP, 1 hit PF13608, Potyvirid-P3, 1 hit PF00680, RdRP_1, 1 hit |
PRINTSi | PR00966, NIAPOTYPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 2 hits SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51744, HC_PRO_CPD, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51436, POTYVIRUS_NIA_PRO, 1 hit PS51871, PV_P1_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MMNFGSLNVG LKQVDGTWVP RVFEEKEMAR LLAEKQHARV MRATQEMMKA
60 70 80 90 100
PNPFAEFDEM HQRGNPFAGR VRKCETREPK SAQKPIVTVD TVPVAIYTDV
110 120 130 140 150
IWPENGKVHA LSRRRAPRKH ARRSKILACD LLTQVLNISR RAGKSVEVIG
160 170 180 190 200
KRRCCLKPRR RDGKSCFGVI TKHHKGVLSS RDMVKDLFVD SIIEHIAYTG
210 220 230 240 250
HTPLIDAADI KPGDSGLIYR EKKDGYVTRV VRGRHDGDII DARDYVRAGI
260 270 280 290 300
HTIKHYSDDG KSLVKYAPYC QPSHHTFGHM CRVTWSDTEI LQFREMLSQA
310 320 330 340 350
IMPQRDPRCD ICAEVAGQRT KDEILQHART SQMMQMLEFG KEDERWKAPR
360 370 380 390 400
RVMETLLEES NWPSMDYSTS SEITTICCGN NDEPFRRIYS IMKVLAEPNL
410 420 430 440 450
ADVSAWQEAN SSLLQLARYM KNREMSVQAG NSATFTNPFP PTVHTFGPTN
460 470 480 490 500
NGADILQGPW DNWGDKQPIA LAFFEKHFNK WQINEFSIDR RVRKHIRGTR
510 520 530 540 550
KLALMDLNQS RSIKDLEDHV QEEEIPYERK TESCITMYKD QYLYSCSCVT
560 570 580 590 600
ARDGKPYLSM RYLQATGLIP IARGADVQHM PNSDSWQGFY YVAPEGYCYI
610 620 630 640 650
NIFLPMLALA PYYKVGKLSE LIGKLIKVLG KWPKLKDVAL ACLYITEYHT
660 670 680 690 700
YAQNALLPPI LVHHSTRTMH VVDTLGSLSV GYHVLKAGTV KHLVNLASRL
710 720 730 740 750
ATGEMLDYNV GGSLGGIHAY DLLIRSTFDH VLLERALETD PYYILYSALS
760 770 780 790 800
PTVLKQMYTS KSYANALRVF VRSNQSLFQV VCTLENLARR MTRAQSIEQQ
810 820 830 840 850
IMQLQSLYPQ LLDMLADNIP DSPLSWLSHH VTTDSMQRAI ELNNCDIELA
860 870 880 890 900
RGGYASINTS WRKKKEQYYA DLIKEYYNAL SPQAKIFVSR AYIGYLHATT
910 920 930 940 950
PLFANARKIS SEIASNICTQ AYSRTIGRGI SIVSSGGRKG KTWLTARGDS
960 970 980 990 1000
FYKTMISRAI KLYTPEVSAV IGVATVVGIL LSTMTTLHTY LVKNKQTAQK
1010 1020 1030 1040 1050
TNEKFEELMY DKVALYIPKY DAEHSHLQGK DLDFEHFARW LMARDKKLSS
1060 1070 1080 1090 1100
FVQSHLVDTV THQAKDDTNV WIEKCIATIV LMMMAIDSNK SDKLYQILCK
1110 1120 1130 1140 1150
LRTVFSTMGQ TVVTHQSIDE ILDIDESKRT TIDFERVEVM QPTQPILKTT
1160 1170 1180 1190 1200
FEGFWDMQIQ MGRTVAHYRT TGRLVELTRE NIAEVVATIS SDTANAEFIV
1210 1220 1230 1240 1250
RGGVGTGKST SLPTALCERG RVLMLEPTRP LTENVAQQLR GEPHFKSPSV
1260 1270 1280 1290 1300
HMRGLNTFGS SRITIMTSGY ALHYYANNRQ LLRDFEFIMF DECHVMDSSA
1310 1320 1330 1340 1350
MAFYSLCNDA KVAAKLLKVS ATPAGRECEF KPMFPVRVSE AAQLSFESFV
1360 1370 1380 1390 1400
TAQGSKSTYD IIQYGNNILV YVASYNEVDK LAAMLLEKRF RVTKVDGRTM
1410 1420 1430 1440 1450
KLNTHGIELH GTAQVKHFIV ATNIIENGVT LEIDCLVDFG TKVVAQLDTE
1460 1470 1480 1490 1500
GRRIMYMKVP ISYGERIQRL GRVGRTKPGA RLKVGHTMRG IVEIPEVIAT
1510 1520 1530 1540 1550
EAAFQCFMYD LPVMTGQVSV SLLSKCTREQ ARTMAAFELS PFTMSNLVAF
1560 1570 1580 1590 1600
DGTMHPAIHD LLKKFKLRDS TVVLRRTALP LRASASWYTV REYETIIGDL
1610 1620 1630 1640 1650
HIENKDVRIP FVANDLSNSL LEGLWDAIQC NRSDVSTTKL TTVSANKIAY
1660 1670 1680 1690 1700
TLKTDTSSIQ RTISIIDDLL AEERKKQEMF THHLSTTSGG YTFGLNAIAM
1710 1720 1730 1740 1750
CIKSRYAKGY CIENIATLTN VRNQLTEFSG MSEDQYTSEI IQNYPDLTLV
1760 1770 1780 1790 1800
HHQSKQEIIR NLKLKAKYDQ TLIASDLLLG TAVLIGGGAM LYKTFMTETN
1810 1820 1830 1840 1850
TRVHLEGDGK RQREKLQYRA ARDSKQDYEV YADEREIQEN YGEAYTKHGR
1860 1870 1880 1890 1900
KGPAHEKGTG SKTREFTNFY GFDPAEYDTV RLVDPITGKT CDKAVRDLLR
1910 1920 1930 1940 1950
MRDVADTFAE IRESMDEDMI LQPGVNFAPA LIEAYFMNSR TNAARRVDLV
1960 1970 1980 1990 2000
PHNPMQVGRL SNNIAGFPTH DGELRQSRPS RPIQKDQVPA ANEYSVQHES
2010 2020 2030 2040 2050
KSIAKGLRDY HPVSSNLCAL EYYCGDMRTS IYGVCYGPYI LTTAHLIKEK
2060 2070 2080 2090 2100
GGWLKIRTKH GLFKLEAMDR VQIRELCGSD IIVIKGPKDM PPAPMRLKFR
2110 2120 2130 2140 2150
APKSGERAVL VGFVDDNLDR QLVSDSSAVY RRENTGFWKH WITTKYGNCG
2160 2170 2180 2190 2200
LPMVSVDTMD IIGLHSLGAQ NSNENYFAAL TDDFSKQFFE PETDVPWQRK
2210 2220 2230 2240 2250
WSYNADKVNY GTMDLTSNQP SGAFKTTKLL EDLLEAVSHQ SQEYTWLTKY
2260 2270 2280 2290 2300
CGANLLVIGK CPGNLITKHV IKGKSPTFDL FLSVDAQASD FFKPLMGDYA
2310 2320 2330 2340 2350
PSRLNREAFV KDITKYDTEI PIGNLSITDF ENAVEDTYYI LKDSGIEQCN
2360 2370 2380 2390 2400
YITDAIPIFD SMNMKAATGA LYGGKKKDYF ENYTDDMKQN ILKESYIRLR
2410 2420 2430 2440 2450
EGKMGIWNGS LKAELRSKEK VEANKTRVFT AAPLDTLLAG KGCVDDFNNQ
2460 2470 2480 2490 2500
FYAAHLKGPW TVGITKFFGR WNDFLSELPP GWDYFDADGS RFDSSLTPFL
2510 2520 2530 2540 2550
LNAVLNIRKK FMINWAFGQR CLGNLYTEII YTPIATPDGS VVKKMRGNNS
2560 2570 2580 2590 2600
GQPSTVVDNT IMVIIAMQYA ISKAEFPAGR LRDQIRYFAN GDDLVVAVEP
2610 2620 2630 2640 2650
SLSDKISSFS ASFAELGLSY DFSNKVNDRS ELQFMSHTGK LIDGMYIPML
2660 2670 2680 2690 2700
ERERICAILE WSRSDEPQFQ LDAISAAMIE AWGDDELLYQ IRRYYSWLLE
2710 2720 2730 2740 2750
QEPYKSIAEL GHAPYLAEAA LKALYTGKDP DAELIAIYER AMLNTPPTED
2760 2770 2780 2790 2800
RPTKVVHEAN VTAASSAATQ TSTTSPTVTS TSGASTSTSS GTTSAPLAST
2810 2820 2830 2840 2850
TPPVSATTTP STGTTAPTTP TVRAANLPDI AGHRKAKANG ESQLNVRGEN
2860 2870 2880 2890 2900
DDEDVPAASE FALPRLPTLG AKIRVPKFKG AIVLNKDHLI KYTPDQRDLS
2910 2920 2930 2940 2950
NTRATQEQFE KWYSGVRNEV EKTDEEMALL LNGSMVWCME NGTSPDLSGS
2960 2970 2980 2990 3000
WTMMEGEEQI AYPLEPFCRH AQPTLRSIMA HFSDAATAYV VLRNQKSRYM
3010 3020 3030 3040 3050
PRYGLKRGLN DYSLAPYAFD FYEITSTSPL RARERHAQMK AAAIRGKASR
3060 3070 3080
MFGLDGNVSA QSENTERHTV EDVNTRVHSL SGANML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09854 Genomic RNA Translation: CAA70983.1 |
RefSeqi | NP_044727.1, NC_001814.1 |
Genome annotation databases
GeneIDi | 1403650 |
KEGGi | vg:1403650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09854 Genomic RNA Translation: CAA70983.1 |
RefSeqi | NP_044727.1, NC_001814.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C04.012 |
Genome annotation databases
GeneIDi | 1403650 |
KEGGi | vg:1403650 |
Family and domain databases
Gene3Di | 2.40.10.10, 2 hits 3.30.70.270, 1 hit 3.40.50.300, 2 hits 3.90.70.150, 1 hit |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001456, HC-pro IPR031159, HC_PRO_CPD_dom IPR042308, HC_PRO_CPD_sf IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR002540, Pept_S30_P1_potyvir IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001592, Poty_coat IPR001730, Potyv_NIa-pro_dom IPR039560, Potyvirid-P3 IPR013648, PP_Potyviridae IPR043128, Rev_trsase/Diguanyl_cyclase IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00863, Peptidase_C4, 1 hit PF00851, Peptidase_C6, 1 hit PF01577, Peptidase_S30, 1 hit PF00767, Poty_coat, 1 hit PF08440, Poty_PP, 1 hit PF13608, Potyvirid-P3, 1 hit PF00680, RdRP_1, 1 hit |
PRINTSi | PR00966, NIAPOTYPTASE |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 2 hits SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51744, HC_PRO_CPD, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51436, POTYVIRUS_NIA_PRO, 1 hit PS51871, PV_P1_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | POLG_RGMVD | |
Accessioni | O11436Primary (citable) accession number: O11436 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | July 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families