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Protein

Myelin and lymphocyte protein

Gene

Mal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Plays a role in the maintenance of the myelin sheath and in axon-glia and glia-glia interactions.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene namesi
Name:Mal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:892970 Mal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 46HelicalSequence analysisAdd BLAST22
Topological domaini47 – 53ExtracellularSequence analysis7
Transmembranei54 – 75HelicalSequence analysisAdd BLAST22
Topological domaini76 – 92CytoplasmicSequence analysisAdd BLAST17
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 125ExtracellularSequence analysisAdd BLAST11
Transmembranei126 – 147HelicalSequence analysisAdd BLAST22
Topological domaini148 – 153CytoplasmicSequence analysis6

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Abnormal myelination and optic nerve morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568061 – 153Myelin and lymphocyte proteinAdd BLAST153

Post-translational modificationi

Lipoprotein.By similarity

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiO09198
PRIDEiO09198

Expressioni

Tissue specificityi

Expressed in the spinal cord, brain, kidney and gastrointestinal tract especially in the stomach and caecum. Highly expressed by myelinating glial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000027375 Expressed in 232 organ(s), highest expression level in ventral horn of spinal cord
GenevisibleiO09198 MM

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 151MARVELPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiO09198
OMAiLIQGWVM
OrthoDBiEOG091G0OS1
PhylomeDBiO09198
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O09198-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAAASGGS TLPSGFSVFT TFPDLLFVCE FVFGGLVWIL IASSLVPLPL
60 70 80 90 100
AQGWVMFVSV FCFVATTSLM ILYIIGTHGG ETSWITLDAA YHCVAALFYL
110 120 130 140 150
SASVLEALAT ISMFDGFTYK HYHENIAAVV FAYVVTLIYV VHAVFSLIRW

KSS
Length:153
Mass (Da):16,596
Last modified:July 1, 1997 - v1
Checksum:i5EED415344669B4B
GO
Isoform 2 (identifier: O09198-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,556
Checksum:i82ADEBB69D494C1E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03125332 – 87Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07626 mRNA Translation: CAA68907.1
Y07627
, Y07628, Y07629, Y07630 Genomic DNA Translation: CAA68908.1
Y07812 mRNA Translation: CAA69143.1
AK004639 mRNA Translation: BAB23430.1
AK019046 mRNA Translation: BAB31523.1
AK158653 mRNA Translation: BAE34599.1
AK169172 mRNA Translation: BAE40951.1
AL731831, AL844204 Genomic DNA Translation: CAM13438.1
AL731831, AL844204 Genomic DNA Translation: CAM13439.1
AL844204, AL731831 Genomic DNA Translation: CAM16966.1
AL844204, AL731831 Genomic DNA Translation: CAM16967.1
BC006826 mRNA Translation: AAH06826.1
CCDSiCCDS16707.1 [O09198-1]
CCDS50705.1 [O09198-2]
RefSeqiNP_001164658.1, NM_001171187.1 [O09198-2]
NP_034892.1, NM_010762.5 [O09198-1]
UniGeneiMm.39040

Genome annotation databases

EnsembliENSMUST00000028853; ENSMUSP00000028853; ENSMUSG00000027375 [O09198-2]
ENSMUST00000028854; ENSMUSP00000028854; ENSMUSG00000027375 [O09198-1]
GeneIDi17153
KEGGimmu:17153
UCSCiuc008mfv.2 mouse [O09198-1]
uc008mfw.2 mouse [O09198-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07626 mRNA Translation: CAA68907.1
Y07627
, Y07628, Y07629, Y07630 Genomic DNA Translation: CAA68908.1
Y07812 mRNA Translation: CAA69143.1
AK004639 mRNA Translation: BAB23430.1
AK019046 mRNA Translation: BAB31523.1
AK158653 mRNA Translation: BAE34599.1
AK169172 mRNA Translation: BAE40951.1
AL731831, AL844204 Genomic DNA Translation: CAM13438.1
AL731831, AL844204 Genomic DNA Translation: CAM13439.1
AL844204, AL731831 Genomic DNA Translation: CAM16966.1
AL844204, AL731831 Genomic DNA Translation: CAM16967.1
BC006826 mRNA Translation: AAH06826.1
CCDSiCCDS16707.1 [O09198-1]
CCDS50705.1 [O09198-2]
RefSeqiNP_001164658.1, NM_001171187.1 [O09198-2]
NP_034892.1, NM_010762.5 [O09198-1]
UniGeneiMm.39040

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO09198
PRIDEiO09198

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028853; ENSMUSP00000028853; ENSMUSG00000027375 [O09198-2]
ENSMUST00000028854; ENSMUSP00000028854; ENSMUSG00000027375 [O09198-1]
GeneIDi17153
KEGGimmu:17153
UCSCiuc008mfv.2 mouse [O09198-1]
uc008mfw.2 mouse [O09198-2]

Organism-specific databases

CTDi4118
MGIiMGI:892970 Mal

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiO09198
OMAiLIQGWVM
OrthoDBiEOG091G0OS1
PhylomeDBiO09198
TreeFamiTF316174

Miscellaneous databases

PROiPR:O09198
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027375 Expressed in 232 organ(s), highest expression level in ventral horn of spinal cord
GenevisibleiO09198 MM

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAL_MOUSE
AccessioniPrimary (citable) accession number: O09198
Secondary accession number(s): O08819
, O09109, Q545Q7, Q9D2R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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