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Protein

Extracellular superoxide dismutase [Cu-Zn]

Gene

Sod3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi128Copper; catalyticBy similarity1
Metal bindingi130Copper; catalyticBy similarity1
Metal bindingi145Copper; catalyticBy similarity1
Metal bindingi145Zinc; structuralBy similarity1
Metal bindingi153Zinc; structuralBy similarity1
Metal bindingi156Zinc; structuralBy similarity1
Metal bindingi159Zinc; structuralBy similarity1
Metal bindingi195Copper; catalyticBy similarity1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • superoxide dismutase activity Source: MGI
  • superoxide dismutase copper chaperone activity Source: GO_Central
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • removal of superoxide radicals Source: GO_Central
  • response to copper ion Source: MGI
  • response to hypoxia Source: MGI

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Short name:
EC-SOD
Gene namesi
Name:Sod3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103181 Sod3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
PropeptideiPRO_000003285616 – 241 Publication9
ChainiPRO_000003285725 – 251Extracellular superoxide dismutase [Cu-Zn]Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 222By similarity
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 221By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO09164
PaxDbiO09164
PeptideAtlasiO09164
PRIDEiO09164

PTM databases

iPTMnetiO09164
PhosphoSitePlusiO09164
SwissPalmiO09164
UniCarbKBiO09164

Expressioni

Gene expression databases

BgeeiENSMUSG00000072941 Expressed in 177 organ(s), highest expression level in aorta
CleanExiMM_SOD3
ExpressionAtlasiO09164 baseline and differential
GenevisibleiO09164 MM

Interactioni

Protein-protein interaction databases

BioGridi203389, 1 interactor
IntActiO09164, 1 interactor
MINTiO09164
STRINGi10090.ENSMUSP00000098768

Structurei

3D structure databases

ProteinModelPortaliO09164
SMRiO09164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
InParanoidiO09164
KOiK16627
OMAiSQGCDST
OrthoDBiEOG091G13ID
PhylomeDBiO09164
TreeFamiTF105133

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09164-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAFLFYGLL LAACGSVTMS NPGESSFDLA DRLDPVEKID RLDLVEKIGD
60 70 80 90 100
THAKVLEIWM ELGRRREVDA AEMHAICRVQ PSATLPPDQP QITGLVLFRQ
110 120 130 140 150
LGPGSRLEAY FSLEGFPAEQ NASNRAIHVH EFGDLSQGCD STGPHYNPME
160 170 180 190 200
VPHPQHPGDF GNFVVRNGQL WRHRVGLTAS LAGPHAILGR SVVVHAGEDD
210 220 230 240 250
LGKGGNQASL QNGNAGRRLA CCVVGTSSSA AWESQTKERK KRRRESECKT

T
Length:251
Mass (Da):27,392
Last modified:July 1, 1997 - v1
Checksum:i9EAF850E458966C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38261 mRNA Translation: AAB51106.1
D50856 mRNA Translation: BAA23493.1
AF223251 Genomic DNA Translation: AAF27932.1
CCDSiCCDS19283.1
RefSeqiNP_035565.1, NM_011435.3
UniGeneiMm.2407

Genome annotation databases

EnsembliENSMUST00000101208; ENSMUSP00000098768; ENSMUSG00000072941
GeneIDi20657
KEGGimmu:20657
UCSCiuc008xkl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38261 mRNA Translation: AAB51106.1
D50856 mRNA Translation: BAA23493.1
AF223251 Genomic DNA Translation: AAF27932.1
CCDSiCCDS19283.1
RefSeqiNP_035565.1, NM_011435.3
UniGeneiMm.2407

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZ2model-A120-228[»]
2DZ3model-A84-228[»]
ProteinModelPortaliO09164
SMRiO09164
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203389, 1 interactor
IntActiO09164, 1 interactor
MINTiO09164
STRINGi10090.ENSMUSP00000098768

PTM databases

iPTMnetiO09164
PhosphoSitePlusiO09164
SwissPalmiO09164
UniCarbKBiO09164

Proteomic databases

EPDiO09164
PaxDbiO09164
PeptideAtlasiO09164
PRIDEiO09164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101208; ENSMUSP00000098768; ENSMUSG00000072941
GeneIDi20657
KEGGimmu:20657
UCSCiuc008xkl.1 mouse

Organism-specific databases

CTDi6649
MGIiMGI:103181 Sod3

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
InParanoidiO09164
KOiK16627
OMAiSQGCDST
OrthoDBiEOG091G13ID
PhylomeDBiO09164
TreeFamiTF105133

Enzyme and pathway databases

ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

PROiPR:O09164
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072941 Expressed in 177 organ(s), highest expression level in aorta
CleanExiMM_SOD3
ExpressionAtlasiO09164 baseline and differential
GenevisibleiO09164 MM

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSODE_MOUSE
AccessioniPrimary (citable) accession number: O09164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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