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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

Fut1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.By similarity

Miscellaneous

In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase.

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • galactoside 2-alpha-L-fucosyltransferase activity Source: MGI

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • fucosylation Source: MGI
  • protein glycosylation Source: GO_Central

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.69 3474
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT11 Glycosyltransferase Family 11

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.344By similarity)
Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:Fut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109375 Fut1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini27 – 376LumenalSequence analysisAdd BLAST350

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490981 – 376Galactoside 2-alpha-L-fucosyltransferase 1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO09160
PRIDEiO09160

PTM databases

iPTMnetiO09160
PhosphoSitePlusiO09160

Expressioni

Tissue specificityi

In the adult, highly expressed in pancreas, testis and epididymis and to a lesser extent in thymus, lung, stomach, small intestine, colon, spleen and uterus. Not expressed in brain, heart, skeletal muscle, kidney, liver and bone marrow.

Gene expression databases

CleanExiMM_FUT1

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008605

Structurei

3D structure databases

ProteinModelPortaliO09160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKR Eukaryota
ENOG4111HG3 LUCA
HOVERGENiHBG004338
InParanoidiO09160
PhylomeDBiO09160

Family and domain databases

InterProiView protein in InterPro
IPR002516 Glyco_trans_11
PANTHERiPTHR11927 PTHR11927, 1 hit
PfamiView protein in Pfam
PF01531 Glyco_transf_11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O09160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPSRRQLC LTFLLVCVLS AGSFFFHLNG GNFFRNGLTL SVLCSDYHLL
60 70 80 90 100
KSPVAMVCLP HPLQTSNGSP SCPEQSSSLS GTWTITPGGR FGNQMGQYAT
110 120 130 140 150
LLALAQLNGR QAFIQPEMHA ALAPVFRISL PVLDPEVDSL TPWQHLVLHD
160 170 180 190 200
WMSEEYSHLE DPFLKLSGFP CSWTFFHHLR EQIRREFTLH NHLREGAQYL
210 220 230 240 250
LSGLRIGPAS PAHTFVGVHV RRGDYLEVMP NRWKGVVGDR AYLQQAMDWF
260 270 280 290 300
RARHKDPIFV VTSNGMKWCL ENIDTSHGDV VFAGNGQEGT PGKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF RPEAAFLPEW
360 370
VGINADLSPL QAQFDPWKPD SLFRLV
Length:376
Mass (Da):42,255
Last modified:July 1, 1997 - v1
Checksum:i21F1D24CFE204106
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97327P97327_MOUSE
L-Fucosyltransferase
Fut1 FUT1, H, mCG_23182
377Annotation score:
Q32MG3Q32MG3_MOUSE
L-Fucosyltransferase
Fut1
322Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90553 Genomic DNA Translation: AAC53492.1
UniGeneiMm.491495
Mm.56933

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90553 Genomic DNA Translation: AAC53492.1
UniGeneiMm.491495
Mm.56933

3D structure databases

ProteinModelPortaliO09160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008605

Protein family/group databases

CAZyiGT11 Glycosyltransferase Family 11

PTM databases

iPTMnetiO09160
PhosphoSitePlusiO09160

Proteomic databases

PaxDbiO09160
PRIDEiO09160

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109375 Fut1

Phylogenomic databases

eggNOGiENOG410IFKR Eukaryota
ENOG4111HG3 LUCA
HOVERGENiHBG004338
InParanoidiO09160
PhylomeDBiO09160

Enzyme and pathway databases

UniPathwayi
UPA00378

BRENDAi2.4.1.69 3474

Miscellaneous databases

PROiPR:O09160
SOURCEiSearch...

Gene expression databases

CleanExiMM_FUT1

Family and domain databases

InterProiView protein in InterPro
IPR002516 Glyco_trans_11
PANTHERiPTHR11927 PTHR11927, 1 hit
PfamiView protein in Pfam
PF01531 Glyco_transf_11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUT1_MOUSE
AccessioniPrimary (citable) accession number: O09160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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