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Protein

Cytochrome P450 3A25

Gene

Cyp3a25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • response to bacterium Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-5423646 Aflatoxin activation and detoxification
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A25 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA25
Gene namesi
Name:Cyp3a25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1930638 Cyp3a25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3637781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518051 – 503Cytochrome P450 3A25Add BLAST503

Proteomic databases

MaxQBiO09158
PaxDbiO09158
PeptideAtlasiO09158
PRIDEiO09158

PTM databases

iPTMnetiO09158
PhosphoSitePlusiO09158
SwissPalmiO09158

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000029630 Expressed in 44 organ(s), highest expression level in liver
ExpressionAtlasiO09158 baseline and differential
GenevisibleiO09158 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065585

Structurei

3D structure databases

ProteinModelPortaliO09158
SMRiO09158
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiO09158
KOiK07424
OMAiACSITWA
OrthoDBiEOG091G0JNC
PhylomeDBiO09158
TreeFamiTF105087

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O09158-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELIPNLSIE TWVLLVTSLV LFYIYGTYSH GLFKKLGIPG PKPLPLLGTI
60 70 80 90 100
FNYYDGMWKF DEDCYKKYGK IWGFYEGPQP ILAIMDPEII KIVLVKECYS
110 120 130 140 150
VFTNRRFFGP VGFMKKAITI SEDEEWKRLR TLLSPTFTSG KLKEMFPIMR
160 170 180 190 200
QYGDILVRNL RREEEKGEPI SMKDIFGAYS MDVITGTSFG VNVDSLNNPQ
210 220 230 240 250
DPFVQKAKKI LKFKIFDPFL LSIILFPFLT PIYEMLNFSI FPRDSMNFFK
260 270 280 290 300
KFVKRMKKER LASNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAV
310 320 330 340 350
IFIFGGYDAT STSISLIMYE LATHPDVQKK LQDEIDRTLP NKAPVTYDAL
360 370 380 390 400
MDMEYLDMVV NESLRLYPIA IRLERVSKKD VEINGVFIPK GTVVMIPIYP
410 420 430 440 450
LHRNPEYWPE PQEFCPERFS KENKGNIDPY IYMPFGNGPR NCIGMRFALI
460 470 480 490 500
SIKLAVIGVL QNFTVQPCEE TQIPLKISRE PIFQPEKPII LKVVSRDKPR

TGS
Length:503
Mass (Da):58,122
Last modified:July 1, 1997 - v1
Checksum:i9EE9EAF1746595C8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJM4D6RJM4_MOUSE
Cytochrome P450 3A25
Cyp3a25
149Annotation score:
D3Z707D3Z707_MOUSE
Cytochrome P450 3A25
Cyp3a25 mCG_115420
137Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11995 mRNA Translation: CAA72720.1
BC028855 mRNA Translation: AAH28855.1
CCDSiCCDS19866.1
RefSeqiNP_062766.2, NM_019792.2
UniGeneiMm.301900
Mm.384461

Genome annotation databases

EnsembliENSMUST00000068317; ENSMUSP00000065585; ENSMUSG00000029630
GeneIDi56388
KEGGimmu:56388
UCSCiuc009amz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11995 mRNA Translation: CAA72720.1
BC028855 mRNA Translation: AAH28855.1
CCDSiCCDS19866.1
RefSeqiNP_062766.2, NM_019792.2
UniGeneiMm.301900
Mm.384461

3D structure databases

ProteinModelPortaliO09158
SMRiO09158
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065585

Chemistry databases

ChEMBLiCHEMBL3637781

PTM databases

iPTMnetiO09158
PhosphoSitePlusiO09158
SwissPalmiO09158

Proteomic databases

MaxQBiO09158
PaxDbiO09158
PeptideAtlasiO09158
PRIDEiO09158

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068317; ENSMUSP00000065585; ENSMUSG00000029630
GeneIDi56388
KEGGimmu:56388
UCSCiuc009amz.2 mouse

Organism-specific databases

CTDi56388
MGIiMGI:1930638 Cyp3a25

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiO09158
KOiK07424
OMAiACSITWA
OrthoDBiEOG091G0JNC
PhylomeDBiO09158
TreeFamiTF105087

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-5423646 Aflatoxin activation and detoxification
R-MMU-9027307 Biosynthesis of maresin-like SPMs

Miscellaneous databases

PROiPR:O09158
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029630 Expressed in 44 organ(s), highest expression level in liver
ExpressionAtlasiO09158 baseline and differential
GenevisibleiO09158 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP3AP_MOUSE
AccessioniPrimary (citable) accession number: O09158
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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