UniProtKB - O09131 (GSTO1_MOUSE)
Protein
Glutathione S-transferase omega-1
Gene
Gsto1
Organism
Mus musculus (Mouse)
Status
Functioni
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.By similarity
Catalytic activityi
- EC:2.5.1.18By similarity
- EC:1.8.5.1By similarity
- 2 glutathione + H+ + methylarsonate = glutathione disulfide + H2O + methylarsonous acidBy similarityEC:1.20.4.2By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 32 | NucleophileBy similarity | 1 | |
Binding sitei | 59 | GlutathioneBy similarity | 1 | |
Binding sitei | 72 | Glutathione; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
- glutathione transferase activity Source: UniProtKB
- methylarsonate reductase activity Source: UniProtKB-EC
- oxidoreductase activity Source: UniProtKB
GO - Biological processi
- cellular response to arsenic-containing substance Source: UniProtKB
- L-ascorbic acid biosynthetic process Source: MGI
- L-ascorbic acid metabolic process Source: UniProtKB
- negative regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
- oxidation-reduction process Source: GO_Central
- positive regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
- xenobiotic catabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-156581, Methylation R-MMU-156590, Glutathione conjugation R-MMU-196836, Vitamin C (ascorbate) metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase omega-1 (EC:2.5.1.18By similarity)Short name: GSTO-1 Alternative name(s): |
Gene namesi | Name:Gsto1 Synonyms:Gstx, Gtsttl |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1342273, Gsto1 |
Subcellular locationi
Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- basement membrane Source: MGI
Nucleus
- nuclear membrane Source: MGI
- nucleoplasm Source: MGI
Other locations
- axon Source: MGI
- cell body Source: MGI
- cytoplasm Source: UniProtKB
- myelin sheath Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000185885 | 2 – 240 | Glutathione S-transferase omega-1Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 57 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineCombined sources | 1 | |
Modified residuei | 152 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3712 |
EPDi | O09131 |
jPOSTi | O09131 |
MaxQBi | O09131 |
PaxDbi | O09131 |
PeptideAtlasi | O09131 |
PRIDEi | O09131 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00114285 |
PTM databases
iPTMneti | O09131 |
PhosphoSitePlusi | O09131 |
SwissPalmi | O09131 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025068, Expressed in camera-type eye and 324 other tissues |
ExpressionAtlasi | O09131, baseline and differential |
Genevisiblei | O09131, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 200104, 3 interactors |
IntActi | O09131, 3 interactors |
MINTi | O09131 |
STRINGi | 10090.ENSMUSP00000026050 |
Miscellaneous databases
RNActi | O09131, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 101 | GST N-terminalAdd BLAST | 80 | |
Domaini | 106 – 227 | GST C-terminalAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 86 | Glutathione bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0406, Eukaryota |
GeneTreei | ENSGT00940000155351 |
HOGENOMi | CLU_011226_9_2_1 |
InParanoidi | O09131 |
OMAi | ITLYTNH |
OrthoDBi | 1225872at2759 |
PhylomeDBi | O09131 |
TreeFami | TF105325 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR005442, GST_omega IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF13417, GST_N_3, 1 hit |
PRINTSi | PR01625, GSTRNSFRASEO |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O09131-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE
60 70 80 90 100
VININLKNKP EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK
110 120 130 140 150
KLFPDDPYKK ARQKMTLESF SKVPPLIASF VRSKRKEDSP NLREALENEF
160 170 180 190 200
KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF QRLEALELKE CLAHTPKLKL
210 220 230 240
WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BAB1 | A0A494BAB1_MOUSE | Glutathione-dependent dehydroascorb... | Gsto1 | 166 | Annotation score: | ||
A0A494B9X6 | A0A494B9X6_MOUSE | Glutathione S-transferase omega-1 | Gsto1 | 108 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U80819 mRNA Translation: AAB70110.1 AK027922 mRNA Translation: BAC25667.1 AK146834 mRNA Translation: BAE27469.1 AK168383 mRNA Translation: BAE40311.1 BC085165 mRNA Translation: AAH85165.1 |
CCDSi | CCDS29893.1 |
RefSeqi | NP_034492.1, NM_010362.3 |
Genome annotation databases
Ensembli | ENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068 |
GeneIDi | 14873 |
KEGGi | mmu:14873 |
UCSCi | uc008hvq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U80819 mRNA Translation: AAB70110.1 AK027922 mRNA Translation: BAC25667.1 AK146834 mRNA Translation: BAE27469.1 AK168383 mRNA Translation: BAE40311.1 BC085165 mRNA Translation: AAH85165.1 |
CCDSi | CCDS29893.1 |
RefSeqi | NP_034492.1, NM_010362.3 |
3D structure databases
SMRi | O09131 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200104, 3 interactors |
IntActi | O09131, 3 interactors |
MINTi | O09131 |
STRINGi | 10090.ENSMUSP00000026050 |
PTM databases
iPTMneti | O09131 |
PhosphoSitePlusi | O09131 |
SwissPalmi | O09131 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00114285 |
Proteomic databases
CPTACi | non-CPTAC-3712 |
EPDi | O09131 |
jPOSTi | O09131 |
MaxQBi | O09131 |
PaxDbi | O09131 |
PeptideAtlasi | O09131 |
PRIDEi | O09131 |
Protocols and materials databases
Antibodypediai | 31606, 272 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068 |
GeneIDi | 14873 |
KEGGi | mmu:14873 |
UCSCi | uc008hvq.1, mouse |
Organism-specific databases
CTDi | 9446 |
MGIi | MGI:1342273, Gsto1 |
Phylogenomic databases
eggNOGi | KOG0406, Eukaryota |
GeneTreei | ENSGT00940000155351 |
HOGENOMi | CLU_011226_9_2_1 |
InParanoidi | O09131 |
OMAi | ITLYTNH |
OrthoDBi | 1225872at2759 |
PhylomeDBi | O09131 |
TreeFami | TF105325 |
Enzyme and pathway databases
Reactomei | R-MMU-156581, Methylation R-MMU-156590, Glutathione conjugation R-MMU-196836, Vitamin C (ascorbate) metabolism |
Miscellaneous databases
BioGRID-ORCSi | 14873, 1 hit in 17 CRISPR screens |
ChiTaRSi | Gsto1, mouse |
PROi | PR:O09131 |
RNActi | O09131, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025068, Expressed in camera-type eye and 324 other tissues |
ExpressionAtlasi | O09131, baseline and differential |
Genevisiblei | O09131, MM |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR005442, GST_omega IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF13417, GST_N_3, 1 hit |
PRINTSi | PR01625, GSTRNSFRASEO |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTO1_MOUSE | |
Accessioni | O09131Primary (citable) accession number: O09131 Secondary accession number(s): Q3TH87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families