Gsto1

Functionⁱ

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.By similarity

Catalytic activityⁱ

RX + glutathione = HX + R-S-glutathione.By similarity

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.By similarity

Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H₂O.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	32	NucleophileBy similarity	1
Binding siteⁱ	59	GlutathioneBy similarity	1
Binding siteⁱ	72	Glutathione; via amide nitrogen and carbonyl oxygenBy similarity	1

GO - Molecular functionⁱ

glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
glutathione transferase activity Source: UniProtKB
methylarsonate reductase activity Source: UniProtKB-EC
oxidoreductase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to arsenic-containing substance Source: UniProtKB
L-ascorbic acid biosynthetic process Source: MGI
L-ascorbic acid metabolic process Source: UniProtKB
negative regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
xenobiotic catabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase, Transferase

Molecular function

Oxidoreductase, Transferase

Enzyme and pathway databases

Reactomeⁱ	R-MMU-156581 Methylation R-MMU-156590 Glutathione conjugation R-MMU-196836 Vitamin C (ascorbate) metabolism

Reactomeⁱ

R-MMU-156581 Methylation
R-MMU-156590 Glutathione conjugation
R-MMU-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutathione S-transferase omega-1 (EC:2.5.1.18By similarity) Short name: GSTO-1 Alternative name(s): Glutathione S-transferase omega 1-1 Short name: GSTO 1-1 Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1By similarity) Monomethylarsonic acid reductase (EC:1.20.4.2By similarity) Short name: MMA(V) reductase S-(Phenacyl)glutathione reductase Short name: SPG-R p28
Gene namesⁱ	Name:Gsto1 Synonyms:Gstx, Gtsttl
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1342273 Gsto1

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000185885	2 – 240	Glutathione S-transferase omega-1Add BLAST		239

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	57	N6-acetyllysineBy similarity	1
Modified residueⁱ	129	PhosphoserineCombined sources	1
Modified residueⁱ	152	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O09131
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O09131
PaxDbⁱ	O09131
PeptideAtlas More...PeptideAtlasⁱ	O09131
PRIDEⁱ	O09131

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00114285

REPRODUCTION-2DPAGEⁱ

IPI00114285

PTM databases

iPTMnetⁱ	O09131
PhosphoSitePlusⁱ	O09131
SwissPalmⁱ	O09131

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000025068 Expressed in 308 organ(s), highest expression level in camera-type eye
CleanExⁱ	MM_GSTO1
Genevisibleⁱ	O09131 MM

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

BioGridⁱ	200104, 1 interactor
IntActⁱ	O09131, 3 interactors
Molecular INTeraction database More...MINTⁱ	O09131
STRINGⁱ	10090.ENSMUSP00000026050

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O09131
SMRⁱ	O09131
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 101	GST N-terminalAdd BLAST		80
Domainⁱ	106 – 227	GST C-terminalAdd BLAST		122

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	85 – 86	Glutathione bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0406 Eukaryota ENOG410XSIX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005479
HOGENOMⁱ	HOG000006560
HOVERGENⁱ	HBG051853
InParanoidⁱ	O09131
KEGG Orthology (KO) More...KOⁱ	K00799
OMAⁱ	ITLYTNH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IEA
PhylomeDBⁱ	O09131
TreeFamⁱ	TF105325

Family and domain databases

InterProⁱ	View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR004046 GST_C IPR005442 GST_omega IPR036249 Thioredoxin-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00043 GST_C, 1 hit PF13417 GST_N_3, 1 hit
PRINTSⁱ	PR01625 GSTRNSFRASEO
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O09131-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE 
        60         70         80         90        100
VININLKNKP EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK 
       110        120        130        140        150
KLFPDDPYKK ARQKMTLESF SKVPPLIASF VRSKRKEDSP NLREALENEF 
       160        170        180        190        200
KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF QRLEALELKE CLAHTPKLKL 
       210        220        230        240
WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL

Length:240

Mass (Da):27,498

Last modified:January 1, 1998 - v2

Checksum:ⁱ17FEB52DB4BBE506

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U80819 mRNA Translation: AAB70110.1 AK027922 mRNA Translation: BAC25667.1 AK146834 mRNA Translation: BAE27469.1 AK168383 mRNA Translation: BAE40311.1 BC085165 mRNA Translation: AAH85165.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29893.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034492.1, NM_010362.3
UniGeneⁱ	Mm.378931

Genome annotation databases

Ensemblⁱ	ENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068
GeneIDⁱ	14873
KEGGⁱ	mmu:14873
UCSC genome browser More...UCSCⁱ	uc008hvq.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O09131	Glutathione S-transferase omega-2	)	HUMAN		243	UniRef50_Q9H4Y5
Glutathione S-transferase omega-1		PIG		241
Glutathione S-transferase omega-2		RAT		248
Glutathione S-transferase omega-2		MOUSE		248
Glutathione S-transferase O2		MACFA		243
+321

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U80819 mRNA Translation: AAB70110.1 AK027922 mRNA Translation: BAC25667.1 AK146834 mRNA Translation: BAE27469.1 AK168383 mRNA Translation: BAE40311.1 BC085165 mRNA Translation: AAH85165.1
CCDSⁱ	CCDS29893.1
RefSeqⁱ	NP_034492.1, NM_010362.3
UniGeneⁱ	Mm.378931

3D structure databases

ProteinModelPortalⁱ	O09131
SMRⁱ	O09131
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200104, 1 interactor
IntActⁱ	O09131, 3 interactors
MINTⁱ	O09131
STRINGⁱ	10090.ENSMUSP00000026050

PTM databases

iPTMnetⁱ	O09131
PhosphoSitePlusⁱ	O09131
SwissPalmⁱ	O09131

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00114285

REPRODUCTION-2DPAGEⁱ

IPI00114285

Proteomic databases

EPDⁱ	O09131
MaxQBⁱ	O09131
PaxDbⁱ	O09131
PeptideAtlasⁱ	O09131
PRIDEⁱ	O09131

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068
GeneIDⁱ	14873
KEGGⁱ	mmu:14873
UCSCⁱ	uc008hvq.1 mouse

Organism-specific databases

CTDⁱ	9446
MGIⁱ	MGI:1342273 Gsto1

Phylogenomic databases

eggNOGⁱ	KOG0406 Eukaryota ENOG410XSIX LUCA
GeneTreeⁱ	ENSGT00390000005479
HOGENOMⁱ	HOG000006560
HOVERGENⁱ	HBG051853
InParanoidⁱ	O09131
KOⁱ	K00799
OMAⁱ	ITLYTNH
OrthoDBⁱ	EOG091G0IEA
PhylomeDBⁱ	O09131
TreeFamⁱ	TF105325

Enzyme and pathway databases

Reactomeⁱ	R-MMU-156581 Methylation R-MMU-156590 Glutathione conjugation R-MMU-196836 Vitamin C (ascorbate) metabolism

Reactomeⁱ

R-MMU-156581 Methylation
R-MMU-156590 Glutathione conjugation
R-MMU-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O09131
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025068 Expressed in 308 organ(s), highest expression level in camera-type eye
CleanExⁱ	MM_GSTO1
Genevisibleⁱ	O09131 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR040079 Glutathione_S-Trfase IPR004045 Glutathione_S-Trfase_N IPR004046 GST_C IPR005442 GST_omega IPR036249 Thioredoxin-like_sf
Pfamⁱ	View protein in Pfam PF00043 GST_C, 1 hit PF13417 GST_N_3, 1 hit
PRINTSⁱ	PR01625 GSTRNSFRASEO
SFLDⁱ	SFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSTO1_MOUSE
Accessionⁱ	O09131Primary (citable) accession number: O09131 Secondary accession number(s): Q3TH87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O09131 (GSTO1_MOUSE)

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Glutathione S-transferase omega-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ