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Protein

Glutathione S-transferase omega-1

Gene

Gsto1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.By similarity
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32NucleophileBy similarity1
Binding sitei59GlutathioneBy similarity1
Binding sitei72Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156581 Methylation
R-MMU-156590 Glutathione conjugation
R-MMU-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-1 (EC:2.5.1.18By similarity)
Short name:
GSTO-1
Alternative name(s):
Glutathione S-transferase omega 1-1
Short name:
GSTO 1-1
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1By similarity)
Monomethylarsonic acid reductase (EC:1.20.4.2By similarity)
Short name:
MMA(V) reductase
S-(Phenacyl)glutathione reductase
Short name:
SPG-R
p28
Gene namesi
Name:Gsto1
Synonyms:Gstx, Gtsttl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1342273 Gsto1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001858852 – 240Glutathione S-transferase omega-1Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO09131
MaxQBiO09131
PaxDbiO09131
PeptideAtlasiO09131
PRIDEiO09131

2D gel databases

REPRODUCTION-2DPAGEiIPI00114285

PTM databases

iPTMnetiO09131
PhosphoSitePlusiO09131
SwissPalmiO09131

Expressioni

Gene expression databases

BgeeiENSMUSG00000025068 Expressed in 308 organ(s), highest expression level in camera-type eye
CleanExiMM_GSTO1
GenevisibleiO09131 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi200104, 1 interactor
IntActiO09131, 3 interactors
MINTiO09131
STRINGi10090.ENSMUSP00000026050

Structurei

3D structure databases

ProteinModelPortaliO09131
SMRiO09131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101GST N-terminalAdd BLAST80
Domaini106 – 227GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiO09131
KOiK00799
OMAiITLYTNH
OrthoDBiEOG091G0IEA
PhylomeDBiO09131
TreeFamiTF105325

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE
60 70 80 90 100
VININLKNKP EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK
110 120 130 140 150
KLFPDDPYKK ARQKMTLESF SKVPPLIASF VRSKRKEDSP NLREALENEF
160 170 180 190 200
KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF QRLEALELKE CLAHTPKLKL
210 220 230 240
WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL
Length:240
Mass (Da):27,498
Last modified:January 1, 1998 - v2
Checksum:i17FEB52DB4BBE506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80819 mRNA Translation: AAB70110.1
AK027922 mRNA Translation: BAC25667.1
AK146834 mRNA Translation: BAE27469.1
AK168383 mRNA Translation: BAE40311.1
BC085165 mRNA Translation: AAH85165.1
CCDSiCCDS29893.1
RefSeqiNP_034492.1, NM_010362.3
UniGeneiMm.378931

Genome annotation databases

EnsembliENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068
GeneIDi14873
KEGGimmu:14873
UCSCiuc008hvq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80819 mRNA Translation: AAB70110.1
AK027922 mRNA Translation: BAC25667.1
AK146834 mRNA Translation: BAE27469.1
AK168383 mRNA Translation: BAE40311.1
BC085165 mRNA Translation: AAH85165.1
CCDSiCCDS29893.1
RefSeqiNP_034492.1, NM_010362.3
UniGeneiMm.378931

3D structure databases

ProteinModelPortaliO09131
SMRiO09131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200104, 1 interactor
IntActiO09131, 3 interactors
MINTiO09131
STRINGi10090.ENSMUSP00000026050

PTM databases

iPTMnetiO09131
PhosphoSitePlusiO09131
SwissPalmiO09131

2D gel databases

REPRODUCTION-2DPAGEiIPI00114285

Proteomic databases

EPDiO09131
MaxQBiO09131
PaxDbiO09131
PeptideAtlasiO09131
PRIDEiO09131

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026050; ENSMUSP00000026050; ENSMUSG00000025068
GeneIDi14873
KEGGimmu:14873
UCSCiuc008hvq.1 mouse

Organism-specific databases

CTDi9446
MGIiMGI:1342273 Gsto1

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
HOGENOMiHOG000006560
HOVERGENiHBG051853
InParanoidiO09131
KOiK00799
OMAiITLYTNH
OrthoDBiEOG091G0IEA
PhylomeDBiO09131
TreeFamiTF105325

Enzyme and pathway databases

ReactomeiR-MMU-156581 Methylation
R-MMU-156590 Glutathione conjugation
R-MMU-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

PROiPR:O09131
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025068 Expressed in 308 organ(s), highest expression level in camera-type eye
CleanExiMM_GSTO1
GenevisibleiO09131 MM

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTO1_MOUSE
AccessioniPrimary (citable) accession number: O09131
Secondary accession number(s): Q3TH87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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