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Protein

Synaptophysin-like protein 1

Gene

Sypl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 1
Alternative name(s):
Pantophysin
Gene namesi
Name:Sypl1
Synonyms:Pphn, Sypl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:108081 Sypl

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 117VesicularSequence analysisAdd BLAST63
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 151CytoplasmicSequence analysisAdd BLAST13
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 214VesicularSequence analysisAdd BLAST42
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 261CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791651 – 261Synaptophysin-like protein 1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO09117
PaxDbiO09117
PeptideAtlasiO09117
PRIDEiO09117

PTM databases

iPTMnetiO09117
PhosphoSitePlusiO09117

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020570 Expressed in 289 organ(s), highest expression level in cornea
CleanExiMM_SYPL
ExpressionAtlasiO09117 baseline and differential
GenevisibleiO09117 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075990

Structurei

3D structure databases

ProteinModelPortaliO09117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 239MARVELPROSITE-ProRule annotationAdd BLAST212

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9X Eukaryota
ENOG4111FYV LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiO09117
OMAiNWKSYVL
OrthoDBiEOG091G0ZEI
PhylomeDBiO09117
TreeFamiTF315804

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O09117-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKANMVRQ RFSRLSQRMS AFQINLNPLK EPLGFIKILE WFASIFAFAT
60 70 80 90 100
CGGFKGKTEI QVNCPKVGVN KNQTVTATFG YPFRLNQASF HTPPNVSVCD
110 120 130 140 150
VNWEKHVLIG DYSSSAQFYV TFAVFVFLYC IAALLLYVGY TNLYRDSRKL
160 170 180 190 200
PMIDFIVTLV ATFLWLVSSS AWAKALTDIK VATGHRIVEE LEICNPESGV
210 220 230 240 250
SCYFVSVTSM GSLNVSVIFG FLNMILWGGN AWFVYKETSL HSPSNTSASH
260
SQGGGPPTSG M
Length:261
Mass (Da):28,899
Last modified:October 10, 2003 - v2
Checksum:i5140C6B432B9E282
GO
Isoform 2 (identifier: O09117-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:243
Mass (Da):26,751
Checksum:i2A25876AA24F7582
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFU9D6RFU9_MOUSE
Synaptophysin-like protein
Sypl
79Annotation score:

Sequence cautioni

The sequence BAC33808 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → N in AAB39891 (PubMed:8707851).Curated1
Sequence conflicti202C → R in BAC35036 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085581 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081501 Genomic DNA Translation: AAB39891.1
AK049545 mRNA Translation: BAC33803.1
AK049556 mRNA Translation: BAC33808.1 Different initiation.
AK052556 mRNA Translation: BAC35036.1
BC060971 mRNA Translation: AAH60971.1
CCDSiCCDS25872.1 [O09117-1]
CCDS25873.1 [O09117-2]
RefSeqiNP_038663.2, NM_013635.3 [O09117-1]
NP_942003.1, NM_198710.3 [O09117-2]
UniGeneiMm.246304

Genome annotation databases

EnsembliENSMUST00000020885; ENSMUSP00000020885; ENSMUSG00000020570 [O09117-2]
ENSMUST00000076698; ENSMUSP00000075990; ENSMUSG00000020570 [O09117-1]
GeneIDi19027
KEGGimmu:19027
UCSCiuc007nih.2 mouse [O09117-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081501 Genomic DNA Translation: AAB39891.1
AK049545 mRNA Translation: BAC33803.1
AK049556 mRNA Translation: BAC33808.1 Different initiation.
AK052556 mRNA Translation: BAC35036.1
BC060971 mRNA Translation: AAH60971.1
CCDSiCCDS25872.1 [O09117-1]
CCDS25873.1 [O09117-2]
RefSeqiNP_038663.2, NM_013635.3 [O09117-1]
NP_942003.1, NM_198710.3 [O09117-2]
UniGeneiMm.246304

3D structure databases

ProteinModelPortaliO09117
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075990

PTM databases

iPTMnetiO09117
PhosphoSitePlusiO09117

Proteomic databases

MaxQBiO09117
PaxDbiO09117
PeptideAtlasiO09117
PRIDEiO09117

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020885; ENSMUSP00000020885; ENSMUSG00000020570 [O09117-2]
ENSMUST00000076698; ENSMUSP00000075990; ENSMUSG00000020570 [O09117-1]
GeneIDi19027
KEGGimmu:19027
UCSCiuc007nih.2 mouse [O09117-1]

Organism-specific databases

CTDi19027
MGIiMGI:108081 Sypl

Phylogenomic databases

eggNOGiENOG410IF9X Eukaryota
ENOG4111FYV LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiO09117
OMAiNWKSYVL
OrthoDBiEOG091G0ZEI
PhylomeDBiO09117
TreeFamiTF315804

Miscellaneous databases

ChiTaRSiSypl mouse
PROiPR:O09117
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020570 Expressed in 289 organ(s), highest expression level in cornea
CleanExiMM_SYPL
ExpressionAtlasiO09117 baseline and differential
GenevisibleiO09117 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL1_MOUSE
AccessioniPrimary (citable) accession number: O09117
Secondary accession number(s): Q8BQI8, Q8BQJ1, Q8C749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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