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Protein

Small proline-rich protein 3

Gene

Sprr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes.

GO - Molecular functioni

  • structural molecule activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 3
Alternative name(s):
Cornifin beta
Gene namesi
Name:Sprr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330237 Sprr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001500042 – 238Small proline-rich protein 3Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO09116
PaxDbiO09116
PRIDEiO09116

PTM databases

PhosphoSitePlusiO09116

Expressioni

Gene expression databases

BgeeiENSMUSG00000045539 Expressed in 34 organ(s), highest expression level in superior surface of tongue
CleanExiMM_SPRR3
GenevisibleiO09116 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056287

Structurei

3D structure databases

ProteinModelPortaliO09116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 5918
Repeati60 – 6728
Repeati68 – 7538
Repeati76 – 8348
Repeati84 – 9158
Repeati92 – 9968
Repeati100 – 10778
Repeati108 – 11588
Repeati116 – 12398
Repeati124 – 131108
Repeati132 – 139118
Repeati140 – 147128
Repeati148 – 155138
Repeati156 – 163148
Repeati164 – 17515Add BLAST12
Repeati176 – 183168
Repeati184 – 191178
Repeati192 – 199188
Repeati200 – 207198
Repeati208 – 215208
Repeati216 – 223218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 22321 X 8 AA approximate tandem repeatsAdd BLAST172

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1XG Eukaryota
ENOG410YQ1K LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiO09116
OMAiYTTIPGP
OrthoDBiEOG091G0YCF
PhylomeDBiO09116
TreeFamiTF338205

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYQQKQPF VPPPQPEQHQ VKQPCQPPPQ GKFVPIATSE PCHTDVPQPG
60 70 80 90 100
NTKIPEPCST KVPEPGNTVV LEPDYTTMPG PCSTNITEPD YTTIPGPCST
110 120 130 140 150
NITEPDYTTI PGPCSTNIPG PDRTVVPGSC STNITEPDYT TIPGPSSTKI
160 170 180 190 200
PDPGCAMVPG PSPSSTSEPS SEPCSINVRE PGYMNASEPT HAKVPDQGYT
210 220 230
KIPDQGSSKV PEPCQSRVPE VCPPTVTPVS AKQKTKQK
Length:238
Mass (Da):25,241
Last modified:July 1, 1997 - v1
Checksum:i8275A73B34892396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09227 Genomic DNA Translation: CAA70429.1
BC125629 mRNA Translation: AAI25630.1
CCDSiCCDS17558.1
RefSeqiNP_001191356.1, NM_001204427.1
NP_035608.1, NM_011478.2
UniGeneiMm.57092

Genome annotation databases

EnsembliENSMUST00000058142; ENSMUSP00000056287; ENSMUSG00000045539
GeneIDi20766
KEGGimmu:20766
UCSCiuc008qec.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09227 Genomic DNA Translation: CAA70429.1
BC125629 mRNA Translation: AAI25630.1
CCDSiCCDS17558.1
RefSeqiNP_001191356.1, NM_001204427.1
NP_035608.1, NM_011478.2
UniGeneiMm.57092

3D structure databases

ProteinModelPortaliO09116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056287

PTM databases

PhosphoSitePlusiO09116

Proteomic databases

MaxQBiO09116
PaxDbiO09116
PRIDEiO09116

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058142; ENSMUSP00000056287; ENSMUSG00000045539
GeneIDi20766
KEGGimmu:20766
UCSCiuc008qec.2 mouse

Organism-specific databases

CTDi6707
MGIiMGI:1330237 Sprr3

Phylogenomic databases

eggNOGiENOG410J1XG Eukaryota
ENOG410YQ1K LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiO09116
OMAiYTTIPGP
OrthoDBiEOG091G0YCF
PhylomeDBiO09116
TreeFamiTF338205

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:O09116
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045539 Expressed in 34 organ(s), highest expression level in superior surface of tongue
CleanExiMM_SPRR3
GenevisibleiO09116 MM

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPRR3_MOUSE
AccessioniPrimary (citable) accession number: O09116
Secondary accession number(s): Q059J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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