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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Gene

Ndufb11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Alternative name(s):
Complex I-ESSS
Short name:
CI-ESSS
NADH-ubiquinone oxidoreductase ESSS subunit
Neuronal protein 15.6
Short name:
Np15.6
Short name:
p15.6
Gene namesi
Name:Ndufb11
Synonyms:Np15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1349919 Ndufb11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000002005830 – 151NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialAdd BLAST122

Proteomic databases

EPDiO09111
MaxQBiO09111
PaxDbiO09111
PeptideAtlasiO09111
PRIDEiO09111
TopDownProteomicsiO09111

PTM databases

iPTMnetiO09111
PhosphoSitePlusiO09111

Expressioni

Gene expression databases

BgeeiENSMUSG00000031059 Expressed in 299 organ(s), highest expression level in diaphragm
GenevisibleiO09111 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi222383, 2 interactors
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiO09111
IntActiO09111, 2 interactors
STRINGi10090.ENSMUSP00000112320

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiO09111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB11 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4808 Eukaryota
ENOG41120A5 LUCA
GeneTreeiENSGT00390000003022
HOGENOMiHOG000049196
HOVERGENiHBG004073
InParanoidiO09111
KOiK11351
OMAiRMQEWAR
OrthoDBiEOG091G0WTH
PhylomeDBiO09111
TreeFamiTF314671

Family and domain databases

InterProiView protein in InterPro
IPR019329 NADH_UbQ_OxRdtase_ESSS_su
PANTHERiPTHR13327 PTHR13327, 1 hit
PfamiView protein in Pfam
PF10183 ESSS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARLLSLYG RCLSAAGAMR GLPAARVRWE SSRAVIAPSG VEKKRQREPT
60 70 80 90 100
MQWQEDPEPE DENVYAKNPD FHGYDSDPVV DVWNMRAVFF FGFSIVLVFG
110 120 130 140 150
TTFVAYVPDY RMQEWARREA ERLVKYREVN GLPIMESNYF DPSKIQLPED

D
Length:151
Mass (Da):17,444
Last modified:June 27, 2003 - v2
Checksum:iABF2C84E326F23A6
GO

Sequence cautioni

The sequence AAH27265 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25760 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA69961 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08702 mRNA Translation: CAA69961.1 Different initiation.
AK028121 mRNA Translation: BAC25760.1 Different initiation.
BC027265 mRNA Translation: AAH27265.1 Different initiation.
CCDSiCCDS53012.1
RefSeqiNP_062308.2, NM_019435.4
XP_006527617.1, XM_006527554.1
UniGeneiMm.30084

Genome annotation databases

EnsembliENSMUST00000116621; ENSMUSP00000112320; ENSMUSG00000031059
GeneIDi104130
KEGGimmu:104130
UCSCiuc009ste.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08702 mRNA Translation: CAA69961.1 Different initiation.
AK028121 mRNA Translation: BAC25760.1 Different initiation.
BC027265 mRNA Translation: AAH27265.1 Different initiation.
CCDSiCCDS53012.1
RefSeqiNP_062308.2, NM_019435.4
XP_006527617.1, XM_006527554.1
UniGeneiMm.30084

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G2Jelectron microscopy3.30g1-151[»]
6G72electron microscopy3.90g1-151[»]
SMRiO09111
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222383, 2 interactors
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiO09111
IntActiO09111, 2 interactors
STRINGi10090.ENSMUSP00000112320

PTM databases

iPTMnetiO09111
PhosphoSitePlusiO09111

Proteomic databases

EPDiO09111
MaxQBiO09111
PaxDbiO09111
PeptideAtlasiO09111
PRIDEiO09111
TopDownProteomicsiO09111

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116621; ENSMUSP00000112320; ENSMUSG00000031059
GeneIDi104130
KEGGimmu:104130
UCSCiuc009ste.2 mouse

Organism-specific databases

CTDi54539
MGIiMGI:1349919 Ndufb11

Phylogenomic databases

eggNOGiKOG4808 Eukaryota
ENOG41120A5 LUCA
GeneTreeiENSGT00390000003022
HOGENOMiHOG000049196
HOVERGENiHBG004073
InParanoidiO09111
KOiK11351
OMAiRMQEWAR
OrthoDBiEOG091G0WTH
PhylomeDBiO09111
TreeFamiTF314671

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:O09111
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031059 Expressed in 299 organ(s), highest expression level in diaphragm
GenevisibleiO09111 MM

Family and domain databases

InterProiView protein in InterPro
IPR019329 NADH_UbQ_OxRdtase_ESSS_su
PANTHERiPTHR13327 PTHR13327, 1 hit
PfamiView protein in Pfam
PF10183 ESSS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUBB_MOUSE
AccessioniPrimary (citable) accession number: O09111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 27, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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