Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like 3

Gene

Insl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like 3
Alternative name(s):
Leydig insulin-like peptide
Short name:
Ley-I-L
Relaxin-like factor
Cleaved into the following 2 chains:
Gene namesi
Name:Insl3
Synonyms:Rlf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108427 Insl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Male mice exhibit bilateral abdominal cryptorchidism due to alteration of gubernaculum development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000016144? – 94C peptide likeSequence analysis
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PeptideiPRO_000001614316 – ?Insulin-like 3 B chain
PeptideiPRO_000001614597 – 122Insulin-like 3 A chainAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 107Interchain (between B and A chains)By similarity
Disulfide bondi41 ↔ 120Interchain (between B and A chains)By similarity
Disulfide bondi106 ↔ 111By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO09107
PRIDEiO09107

Expressioni

Tissue specificityi

Expressed exclusively in Leydig cells of the testis.

Gene expression databases

CleanExiMM_INSL3
MM_RLF

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034261

Structurei

3D structure databases

ProteinModelPortaliO09107
SMRiO09107
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IS Eukaryota
ENOG411140J LUCA
HOGENOMiHOG000113077
HOVERGENiHBG052133
InParanoidiO09107
PhylomeDBiO09107

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O09107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPLLLMLL ALGSALRSPQ PPEARAKLCG HHLVRTLVRV CGGPRWSPEA
60 70 80 90 100
TQPVETRDRE LLQWLEQRHL LHALVADVDP ALDPQLPRQA SQRQRRSAAT
110 120
NAVHRCCLTG CTQQDLLGLC PH
Length:122
Mass (Da):13,586
Last modified:November 16, 2001 - v2
Checksum:i10783AB4896CF103
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5RL10Q5RL10_MOUSE
Insulin-like 3
Insl3 mCG_10367
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → T in CAA64861 (Ref. 1) Curated1
Sequence conflicti54 – 58VETRD → CGDPG in CAA64861 (Ref. 1) Curated5
Sequence conflicti73A → S in CAA64861 (Ref. 1) Curated1
Sequence conflicti92 – 96QRQRR → HARG in CAA64861 (Ref. 1) Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95603 Genomic DNA Translation: CAA64861.1
S82815 mRNA Translation: AAB39365.1
AF136524 Genomic DNA Translation: AAD24585.1
CCDSiCCDS22404.1
UniGeneiMm.476857

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95603 Genomic DNA Translation: CAA64861.1
S82815 mRNA Translation: AAB39365.1
AF136524 Genomic DNA Translation: AAD24585.1
CCDSiCCDS22404.1
UniGeneiMm.476857

3D structure databases

ProteinModelPortaliO09107
SMRiO09107
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034261

Proteomic databases

PaxDbiO09107
PRIDEiO09107

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108427 Insl3

Phylogenomic databases

eggNOGiENOG410J0IS Eukaryota
ENOG411140J LUCA
HOGENOMiHOG000113077
HOVERGENiHBG052133
InParanoidiO09107
PhylomeDBiO09107

Miscellaneous databases

PROiPR:O09107
SOURCEiSearch...

Gene expression databases

CleanExiMM_INSL3
MM_RLF

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINSL3_MOUSE
AccessioniPrimary (citable) accession number: O09107
Secondary accession number(s): P97744
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 16, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again