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Protein

Chorion-specific transcription factor GCMb

Gene

Gcm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Zinc 1PROSITE-ProRule annotation1
Metal bindingi87Zinc 2PROSITE-ProRule annotation1
Metal bindingi91Zinc 2PROSITE-ProRule annotation1
Metal bindingi118Zinc 2PROSITE-ProRule annotation1
Metal bindingi121Zinc 2PROSITE-ProRule annotation1
Metal bindingi130Zinc 1PROSITE-ProRule annotation1
Metal bindingi157Zinc 1PROSITE-ProRule annotation1
Metal bindingi159Zinc 1PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 174GCMPROSITE-ProRule annotationAdd BLAST156

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorion-specific transcription factor GCMb
Short name:
mGCMb1 Publication
Alternative name(s):
GCM motif protein 2
Glial cells missing homolog 2
Gene namesi
Name:Gcm2Combined sources
Synonyms:Gcmb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1861438 Gcm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266511 – 504Chorion-specific transcription factor GCMbAdd BLAST504

Proteomic databases

PaxDbiO09102
PRIDEiO09102

PTM databases

PhosphoSitePlusiO09102

Expressioni

Gene expression databases

CleanExiMM_GCM2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021791

Structurei

3D structure databases

ProteinModelPortaliO09102
SMRiO09102
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 393C-terminal conserved inhibitory domain (CCID)By similarityAdd BLAST15

Domaini

The C-terminal conserved inhibitory domain (CCID) negatively regulates the transcriptional activity of the protein.By similarity

Phylogenomic databases

eggNOGiENOG410IKM6 Eukaryota
ENOG4110IIJ LUCA
HOGENOMiHOG000112702
HOVERGENiHBG039461
InParanoidiO09102
KOiK21598
PhylomeDBiO09102
TreeFamiTF324146

Family and domain databases

InterProiView protein in InterPro
IPR036115 GCM_dom_sf
IPR003902 Tscrpt_reg_GCM
PfamiView protein in Pfam
PF03615 GCM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014393 GCM_motif, 1 hit
SUPFAMiSSF90073 SSF90073, 1 hit
PROSITEiView protein in PROSITE
PS50807 GCM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O09102-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPADSTQDED AVLSYGMKLT WDINDPQMPQ EPTHFDHFRE WPDGYVRFIY
60 70 80 90 100
SSQEKKAQRH LSGWAMRNTN NHNGHILKKS CLGVVVCARA CALKDGSHLQ
110 120 130 140 150
LRPAICDKAR LKQQKKACPN CHSPLELVPC RGHSGYPVTN FWRLDGNAIF
160 170 180 190 200
FQAKGVHDHP RPESKSETEG RRSALKRQMA SFYQPQKRRS EEPEARSTQD
210 220 230 240 250
IRGHLNSTAA LEPTELFDMT ADTSFPIPGQ PSPSFPNSDV HRVTCDLPTF
260 270 280 290 300
QGDIILPFQK YPNPSIYFPG PPWGYELASS GVTGSSPYST LYKDSSVVPD
310 320 330 340 350
DPDWIPLNSL QYNVSSYGSY ERTLDFTARY HSWKPTHGKP SLEEKVDCEQ
360 370 380 390 400
CQAVPTSPYY NLELPCRYLP VPAAGTQALQ TVITTTVAYQ AYQHPALKHS
410 420 430 440 450
DSMQEVSSLA SCTYASENLP MPIYPPALDP QEGVIQAASP SGRAPLKVPG
460 470 480 490 500
DCQAPRPTLD FPQEADPSGT DGADVWDVCL SGVGSVMGYL DRTGQPFSFD

NEDF
Length:504
Mass (Da):56,039
Last modified:July 25, 2003 - v2
Checksum:i2EBC3CFD8A120425
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J021A0A0R4J021_MOUSE
Chorion-specific transcription fact...
Gcm2
504Annotation score:
A0A286YD23A0A286YD23_MOUSE
Chorion-specific transcription fact...
Gcm2
183Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159H → R in BAA13649 (PubMed:8962155).Curated1
Sequence conflicti191E → G in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti241H → Y in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti297V → E in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti357S → L in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti376T → S in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti400S → G in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti436Q → R in BAA13649 (PubMed:8962155).Curated1
Sequence conflicti438A → V in AAC64782 (PubMed:9770492).Curated1
Sequence conflicti501N → D in BAA13649 (PubMed:8962155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88611 mRNA Translation: BAA13649.1
AF081556 mRNA Translation: AAC64782.1
AF081558 Genomic DNA Translation: AAC64784.1
BC110631 mRNA Translation: AAI10632.1
BC110632 mRNA Translation: AAI10633.1
CCDSiCCDS26472.1
RefSeqiNP_032130.2, NM_008104.2
UniGeneiMm.1399

Genome annotation databases

GeneIDi107889
KEGGimmu:107889
UCSCiuc007qey.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88611 mRNA Translation: BAA13649.1
AF081556 mRNA Translation: AAC64782.1
AF081558 Genomic DNA Translation: AAC64784.1
BC110631 mRNA Translation: AAI10632.1
BC110632 mRNA Translation: AAI10633.1
CCDSiCCDS26472.1
RefSeqiNP_032130.2, NM_008104.2
UniGeneiMm.1399

3D structure databases

ProteinModelPortaliO09102
SMRiO09102
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021791

PTM databases

PhosphoSitePlusiO09102

Proteomic databases

PaxDbiO09102
PRIDEiO09102

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107889
KEGGimmu:107889
UCSCiuc007qey.1 mouse

Organism-specific databases

CTDi9247
MGIiMGI:1861438 Gcm2

Phylogenomic databases

eggNOGiENOG410IKM6 Eukaryota
ENOG4110IIJ LUCA
HOGENOMiHOG000112702
HOVERGENiHBG039461
InParanoidiO09102
KOiK21598
PhylomeDBiO09102
TreeFamiTF324146

Miscellaneous databases

PROiPR:O09102
SOURCEiSearch...

Gene expression databases

CleanExiMM_GCM2

Family and domain databases

InterProiView protein in InterPro
IPR036115 GCM_dom_sf
IPR003902 Tscrpt_reg_GCM
PfamiView protein in Pfam
PF03615 GCM, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014393 GCM_motif, 1 hit
SUPFAMiSSF90073 SSF90073, 1 hit
PROSITEiView protein in PROSITE
PS50807 GCM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCM2_MOUSE
AccessioniPrimary (citable) accession number: O09102
Secondary accession number(s): Q2TB03, Q9QWX7, Q9Z289
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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