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Protein

Phosphatidylinositol-glycan biosynthesis class F protein

Gene

Pigf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.1 Publication

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • phosphotransferase activity, for other substituted phosphate groups Source: MGI

GO - Biological processi

  • GPI anchor biosynthetic process Source: UniProtKB

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayi
UPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol-glycan biosynthesis class F protein
Short name:
PIG-F
Gene namesi
Name:Pigf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99462 Pigf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917601 – 219Phosphatidylinositol-glycan biosynthesis class F proteinAdd BLAST219

Proteomic databases

EPDiO09101
PaxDbiO09101
PRIDEiO09101

Expressioni

Gene expression databases

BgeeiENSMUSG00000024145 Expressed in 280 organ(s), highest expression level in primary oocyte
GenevisibleiO09101 MM

Interactioni

Subunit structurei

Forms a complex with PIGG and PIGO. PIGF is required to stabilize PIGG and PIGO.1 Publication

Protein-protein interaction databases

BioGridi202156, 2 interactors
STRINGi10090.ENSMUSP00000024957

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGF family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3144 Eukaryota
ENOG4111B1J LUCA
GeneTreeiENSGT00390000016617
HOGENOMiHOG000082526
HOVERGENiHBG031820
InParanoidiO09101
KOiK05287
OMAiWPISCSL
OrthoDBiEOG091G0HMT
PhylomeDBiO09101
TreeFamiTF323878

Family and domain databases

InterProiView protein in InterPro
IPR009580 GPI_biosynthesis_protein_Pig-F
PfamiView protein in Pfam
PF06699 PIG-F, 1 hit

Sequencei

Sequence statusi: Complete.

O09101-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDTDIKRLL YTNLLCVFSI FLSIFIPSFF VDNFSVLEAH LTWLCICSAS
60 70 80 90 100
VTTVNLLSYL VVKPNVSSKR SSLSHKVTRA LKCCVCFLMS CFLLHIIFVL
110 120 130 140 150
YGAPLIELVL ETFLFAVVLS TFTTVPCLCL LGPNLKAWLR VFSRNGVTSI
160 170 180 190 200
WENSLQITTI SSFTGAWLGA FPIPLDWERP WQVWPISCTL GATFGYVAGL
210
VISPLWIYWN RKQLTYKNN
Length:219
Mass (Da):24,825
Last modified:July 1, 1997 - v1
Checksum:iBD78A77E69C5BC1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50264 mRNA Translation: BAA08818.1
CCDSiCCDS29011.1
RefSeqiNP_032864.1, NM_008838.1
XP_006523894.1, XM_006523831.2
UniGeneiMm.219685

Genome annotation databases

EnsembliENSMUST00000024957; ENSMUSP00000024957; ENSMUSG00000024145
GeneIDi18701
KEGGimmu:18701
UCSCiuc008dun.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50264 mRNA Translation: BAA08818.1
CCDSiCCDS29011.1
RefSeqiNP_032864.1, NM_008838.1
XP_006523894.1, XM_006523831.2
UniGeneiMm.219685

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202156, 2 interactors
STRINGi10090.ENSMUSP00000024957

Proteomic databases

EPDiO09101
PaxDbiO09101
PRIDEiO09101

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024957; ENSMUSP00000024957; ENSMUSG00000024145
GeneIDi18701
KEGGimmu:18701
UCSCiuc008dun.1 mouse

Organism-specific databases

CTDi5281
MGIiMGI:99462 Pigf

Phylogenomic databases

eggNOGiKOG3144 Eukaryota
ENOG4111B1J LUCA
GeneTreeiENSGT00390000016617
HOGENOMiHOG000082526
HOVERGENiHBG031820
InParanoidiO09101
KOiK05287
OMAiWPISCSL
OrthoDBiEOG091G0HMT
PhylomeDBiO09101
TreeFamiTF323878

Enzyme and pathway databases

UniPathwayi
UPA00196

ReactomeiR-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI)

Miscellaneous databases

PROiPR:O09101
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024145 Expressed in 280 organ(s), highest expression level in primary oocyte
GenevisibleiO09101 MM

Family and domain databases

InterProiView protein in InterPro
IPR009580 GPI_biosynthesis_protein_Pig-F
PfamiView protein in Pfam
PF06699 PIG-F, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIGF_MOUSE
AccessioniPrimary (citable) accession number: O09101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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