Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Werner syndrome ATP-dependent helicase homolog

Gene

Wrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (By similarity).By similarity2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.1 Publication

Cofactori

Mg2+1 Publication, Mn2+1 Publication, Zn2+1 PublicationNote: Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro).1 Publication

Activity regulationi

Zinc ions stimulate the exonuclease activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Magnesium 1; catalyticCombined sources1 Publication1
Metal bindingi76Magnesium 2; catalyticCombined sources1 Publication1
Metal bindingi78Magnesium 1; catalyticCombined sources1 Publication1
Metal bindingi210Magnesium 1; catalyticCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi535 – 542ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Exonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
Werner syndrome ATP-dependent helicase homolog (EC:3.6.4.121 Publication)
Alternative name(s):
Exonuclease WRN (EC:3.1.-.-)
Gene namesi
Name:Wrn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:109635 Wrn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi185K → A: Loss of exonuclease activity. 1 Publication1
Mutagenesisi190R → A: Strongly reduced exonuclease activity. 1 Publication1
Mutagenesisi206Y → F: Loss of exonuclease activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002050461 – 1401Werner syndrome ATP-dependent helicase homologAdd BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki235Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei419PhosphoserineBy similarity1
Modified residuei433PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1364PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PRKDC.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO09053
PaxDbiO09053
PeptideAtlasiO09053
PRIDEiO09053

PTM databases

iPTMnetiO09053
PhosphoSitePlusiO09053

Expressioni

Tissue specificityi

Expressed ubiquitously in most organs at a low level, highly expressed in testis, ovary and spleen.2 Publications

Gene expression databases

BgeeiENSMUSG00000031583 Expressed in 249 organ(s), highest expression level in blood
CleanExiMM_WRN
ExpressionAtlasiO09053 baseline and differential
GenevisibleiO09053 MM

Interactioni

Subunit structurei

Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1. Interacts with PCNA; EXO1 and SUPV3L1 (By similarity). Interacts with PML (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Interaction with DNABy similarity1
Sitei1002Interaction with DNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-27642N
STRINGi10090.ENSMUSP00000033990

Structurei

Secondary structure

11401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO09053
SMRiO09053
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO09053

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 2233'-5' exonucleaseAdd BLAST173
Domaini522 – 688Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini713 – 866Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154
Domaini1115 – 1194HRDCPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 271Interaction with WRNIP11 PublicationAdd BLAST271
Regioni952 – 958Interaction with DNABy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi632 – 635DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1387 – 1390Poly-Ser4

Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
KOG4373 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00550000074520
HOGENOMiHOG000146447
HOVERGENiHBG000325
InParanoidiO09053
KOiK10900
OrthoDBiEOG091G0B07
TreeFamiTF312852

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR011545 DEAD/DEAH_box_helicase_dom
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR029491 Helicase_HTH
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF01612 DNA_pol_A_exo1, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF14493 HTH_40, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 1 hit
SSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O09053-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METTSLQRKF PEWMSMQSQR CATEEKACVQ KSVLEDNLPF LEFPGSIVYS
60 70 80 90 100
YEASDCSFLS EDISMRLSDG DVVGFDMEWP PIYKPGKRSR VAVIQLCVSE
110 120 130 140 150
SKCYLFHISS MSVFPQGLKM LLENKSIKKA GVGIEGDQWK LLRDFDVKLE
160 170 180 190 200
SFVELTDVAN EKLKCAETWS LNGLVKHVLG KQLLKDKSIR CSNWSNFPLT
210 220 230 240 250
EDQKLYAATD AYAGLIIYQK LGNLGDTAQV FALNKAEENL PLEMKKQLNS
260 270 280 290 300
ISEEMRDLAN RFPVTCRNLE TLQRVPVILK SISENLCSLR KVICGPTNTE
310 320 330 340 350
TRLKPGSSFN LLSSEDSAAA GEKEKQIGKH STFAKIKEEP WDPELDSLVK
360 370 380 390 400
QEEVDVFRNQ VKQEKGESEN EIEDNLLRED MERTCVIPSI SENELQDLEQ
410 420 430 440 450
QAKEEKYNDV SHQLSEHLSP NDDENDSSYI IESDEDLEME MLKSLENLNS
460 470 480 490 500
DVVEPTHSTW LEMGTNGRLP PEEEDGHGNE AIKEEQEEED HLLPEPNAKQ
510 520 530 540 550
INCLKTYFGH SSFKPVQWKV IHSVLEERRD NVVVMATGYG KSLCFQYPPV
560 570 580 590 600
YTGKIGIVIS PLISLMEDQV LQLELSNVPA CLLGSAQSKN ILGDVKLGKY
610 620 630 640 650
RVIYITPEFC SGNLDLLQQL DSSIGITLIA VDEAHCISEW GHDFRSSFRM
660 670 680 690 700
LGSLKTALPL VPVIALSATA SSSIREDIIS CLNLKDPQIT CTGFDRPNLY
710 720 730 740 750
LEVGRKTGNI LQDLKPFLVR KASSAWEFEG PTIIYCPSRK MTEQVTAELG
760 770 780 790 800
KLNLACRTYH AGMKISERKD VHHRFLRDEI QCVVATVAFG MGINKADIRK
810 820 830 840 850
VIHYGAPKEM ESYYQEIGRA GRDGLQSSCH LLWAPADFNT SRNLLIEIHD
860 870 880 890 900
EKFRLYKLKM MVKMEKYLHS SQCRRRIILS HFEDKCLQKA SLDIMGTEKC
910 920 930 940 950
CDNCRPRLNH CLTANNSEDA SQDFGPQAFQ LLSAVDILQE KFGIGIPILF
960 970 980 990 1000
LRGSNSQRLP DKYRGHRLFG AGKEQAESWW KTLSHHLIAE GFLVEVPKEN
1010 1020 1030 1040 1050
KYIKTCSLTK KGRKWLGEAS SQSPPSLLLQ ANEEMFPRKV LLPSSNPVSP
1060 1070 1080 1090 1100
ETTQHSSNQN PAGLTTKQSN LERTHSYKVP EKVSSGTNIP KKSAVMPSPG
1110 1120 1130 1140 1150
TSSSPLEPAI SAQELDARTG LYARLVEARQ KHANKMDVPP AILATNKVLL
1160 1170 1180 1190 1200
DMAKMRPTTV ENMKQIDGVS EGKAALLAPL LEVIKHFCQV TSVQTDLLSS
1210 1220 1230 1240 1250
AKPHKEQEKS QEMEKKDCSL PQSVAVTYTL FQEKKMPLHS IAENRLLPLT
1260 1270 1280 1290 1300
AAGMHLAQAV KAGYPLDMER AGLTPETWKI IMDVIRNPPI NSDMYKVKLI
1310 1320 1330 1340 1350
RMLVPENLDT YLIHMAIEIL QSGSDSRTQP PCDSSRKRRF PSSAESCESC
1360 1370 1380 1390 1400
KESKEAVTET KASSSESKRK LPEWFAKGNV PSADTGSSSS MAKTKKKGLF

S
Length:1,401
Mass (Da):157,204
Last modified:July 27, 2011 - v3
Checksum:i66DF2252B17C24C3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR54A0A1B0GR54_MOUSE
Werner syndrome ATP-dependent helic...
Wrn
1,158Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101S → N in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti101S → N in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti101S → N in AAC72359 (Ref. 2) Curated1
Sequence conflicti101S → N in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti228A → V in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti228A → V in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti228A → V in AAC72359 (Ref. 2) Curated1
Sequence conflicti228A → V in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti250S → L in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti250S → L in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti250S → L in AAC72359 (Ref. 2) Curated1
Sequence conflicti250S → L in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti452V → M in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti452V → M in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti452V → M in AAC72359 (Ref. 2) Curated1
Sequence conflicti452V → M in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti459T → K in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti459T → K in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti459T → K in AAC72359 (Ref. 2) Curated1
Sequence conflicti459T → K in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti468R → C in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti468R → C in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti468R → C in AAC72359 (Ref. 2) Curated1
Sequence conflicti468R → C in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti619Q → K in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti619Q → K in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti619Q → K in AAC72359 (Ref. 2) Curated1
Sequence conflicti619Q → K in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti800K → Q in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti800K → Q in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti844L → H in AAC72359 (Ref. 2) Curated1
Sequence conflicti955 – 988NSQRL…SHHLI → VSVSVIAPGTVSDSAFHCVA MALAFFRWLTSNPC in AAC72359 (Ref. 2) CuratedAdd BLAST34
Sequence conflicti1021S → L in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1021S → L in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1021S → L in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti1145T → A in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1145T → A in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1181L → V in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1181L → V in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1182E → G in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1182E → G in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1182E → G in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti1252A → V in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1252A → V in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1252A → V in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti1308L → I in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1308L → I in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1308L → I in AAF64490 (PubMed:10757812).Curated1
Sequence conflicti1356A → V in BAA20269 (PubMed:9143515).Curated1
Sequence conflicti1356A → V in BAA20270 (PubMed:9143515).Curated1
Sequence conflicti1356A → V in AAF64490 (PubMed:10757812).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86527 mRNA Translation: BAA20270.1
D86526 mRNA Translation: BAA20269.1
AF091215 mRNA Translation: AAC78077.1
AF091216 Genomic DNA Translation: AAC72359.1
AF241636 mRNA Translation: AAF64490.1
AC153789 Genomic DNA No translation available.
AC115809 Genomic DNA No translation available.
BC050921 mRNA Translation: AAH50921.1
BC060700 mRNA Translation: AAH60700.1
CCDSiCCDS22229.1
PIRiT17452
T30247
RefSeqiNP_001116294.1, NM_001122822.1
NP_035851.3, NM_011721.4
XP_006509154.1, XM_006509091.3
XP_017168151.1, XM_017312662.1
UniGeneiMm.228805

Genome annotation databases

EnsembliENSMUST00000033990; ENSMUSP00000033990; ENSMUSG00000031583
ENSMUST00000033991; ENSMUSP00000033991; ENSMUSG00000031583
GeneIDi22427
KEGGimmu:22427
UCSCiuc009ljw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86527 mRNA Translation: BAA20270.1
D86526 mRNA Translation: BAA20269.1
AF091215 mRNA Translation: AAC78077.1
AF091216 Genomic DNA Translation: AAC72359.1
AF241636 mRNA Translation: AAF64490.1
AC153789 Genomic DNA No translation available.
AC115809 Genomic DNA No translation available.
BC050921 mRNA Translation: AAH50921.1
BC060700 mRNA Translation: AAH60700.1
CCDSiCCDS22229.1
PIRiT17452
T30247
RefSeqiNP_001116294.1, NM_001122822.1
NP_035851.3, NM_011721.4
XP_006509154.1, XM_006509091.3
XP_017168151.1, XM_017312662.1
UniGeneiMm.228805

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E6LX-ray2.20A31-238[»]
2E6MX-ray2.00A31-238[»]
ProteinModelPortaliO09053
SMRiO09053
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-27642N
STRINGi10090.ENSMUSP00000033990

PTM databases

iPTMnetiO09053
PhosphoSitePlusiO09053

Proteomic databases

MaxQBiO09053
PaxDbiO09053
PeptideAtlasiO09053
PRIDEiO09053

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033990; ENSMUSP00000033990; ENSMUSG00000031583
ENSMUST00000033991; ENSMUSP00000033991; ENSMUSG00000031583
GeneIDi22427
KEGGimmu:22427
UCSCiuc009ljw.1 mouse

Organism-specific databases

CTDi7486
MGIiMGI:109635 Wrn

Phylogenomic databases

eggNOGiKOG0351 Eukaryota
KOG4373 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00550000074520
HOGENOMiHOG000146447
HOVERGENiHBG000325
InParanoidiO09053
KOiK10900
OrthoDBiEOG091G0B07
TreeFamiTF312852

Enzyme and pathway databases

ReactomeiR-MMU-5685938 HDR through Single Strand Annealing (SSA)
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-69473 G2/M DNA damage checkpoint

Miscellaneous databases

EvolutionaryTraceiO09053
PROiPR:O09053
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031583 Expressed in 249 organ(s), highest expression level in blood
CleanExiMM_WRN
ExpressionAtlasiO09053 baseline and differential
GenevisibleiO09053 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR011545 DEAD/DEAH_box_helicase_dom
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR029491 Helicase_HTH
IPR010997 HRDC-like_sf
IPR002121 HRDC_dom
IPR027417 P-loop_NTPase
IPR032284 RecQ_Zn-bd
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR018982 RQC_domain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF01612 DNA_pol_A_exo1, 1 hit
PF00271 Helicase_C, 1 hit
PF00570 HRDC, 1 hit
PF14493 HTH_40, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
PF09382 RQC, 1 hit
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00341 HRDC, 1 hit
SM00956 RQC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47819 SSF47819, 1 hit
SSF52540 SSF52540, 1 hit
SSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50967 HRDC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWRN_MOUSE
AccessioniPrimary (citable) accession number: O09053
Secondary accession number(s): O09050
, Q80YP9, Q9JKD4, Q9Z241, Q9Z242
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again