Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanylate cyclase activator 2B

Gene

Guca2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity).By similarity

GO - Molecular functioni

  • guanylate cyclase activator activity Source: GO_Central

GO - Biological processi

  • body fluid secretion Source: MGI
  • cGMP-mediated signaling Source: MGI
  • excretion Source: MGI
  • negative regulation of blood pressure Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase activator 2B
Cleaved into the following chain:
Uroguanylin
Short name:
UGN
Gene namesi
Name:Guca2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1270851 Guca2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001315022 – 91Add BLAST70
PeptideiPRO_000001315192 – 106UroguanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 75By similarity
Disulfide bondi95 ↔ 103By similarity
Disulfide bondi98 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO09051
PeptideAtlasiO09051
PRIDEiO09051

Expressioni

Tissue specificityi

Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.

Gene expression databases

BgeeiENSMUSG00000032978 Expressed in 46 organ(s), highest expression level in uterus
CleanExiMM_GUCA2B
ExpressionAtlasiO09051 baseline and differential
GenevisibleiO09051 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043203

Structurei

3D structure databases

ProteinModelPortaliO09051
SMRiO09051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M7 Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111420
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiO09051
OMAiQGFQVQL
TreeFamiTF330731

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O09051-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSQLWAAV VLLLLLQSAQ GVYIKYHGFQ VQLESVKKLN ELEEKEMSNP
60 70 80 90 100
QPRRSGLLPA VCHNPALPLD LQPVCASQEA ASTFKALRTI ATDECELCIN

VACTGC
Length:106
Mass (Da):11,628
Last modified:July 11, 2001 - v2
Checksum:i30FF1CCE9D293DA8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AA35A2AA35_MOUSE
Guanylate cyclase activator 2B
Guca2b
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17Q → R in AAB53314 (PubMed:9287995).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95182 Genomic DNA Translation: AAB82750.2
U90727 mRNA Translation: AAB53314.1
CCDSiCCDS18587.1
RefSeqiNP_032217.2, NM_008191.2
UniGeneiMm.278

Genome annotation databases

EnsembliENSMUST00000044426; ENSMUSP00000043203; ENSMUSG00000032978
GeneIDi14916
KEGGimmu:14916
UCSCiuc012dkg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95182 Genomic DNA Translation: AAB82750.2
U90727 mRNA Translation: AAB53314.1
CCDSiCCDS18587.1
RefSeqiNP_032217.2, NM_008191.2
UniGeneiMm.278

3D structure databases

ProteinModelPortaliO09051
SMRiO09051
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043203

Proteomic databases

PaxDbiO09051
PeptideAtlasiO09051
PRIDEiO09051

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044426; ENSMUSP00000043203; ENSMUSG00000032978
GeneIDi14916
KEGGimmu:14916
UCSCiuc012dkg.1 mouse

Organism-specific databases

CTDi2981
MGIiMGI:1270851 Guca2b

Phylogenomic databases

eggNOGiENOG410J3M7 Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111420
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiO09051
OMAiQGFQVQL
TreeFamiTF330731

Enzyme and pathway databases

ReactomeiR-MMU-8935690 Digestion

Miscellaneous databases

PROiPR:O09051
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032978 Expressed in 46 organ(s), highest expression level in uterus
CleanExiMM_GUCA2B
ExpressionAtlasiO09051 baseline and differential
GenevisibleiO09051 MM

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2B_MOUSE
AccessioniPrimary (citable) accession number: O09051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again