Snap23

Functionⁱ

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	185 – 186	(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)1 Publication		2
Siteⁱ	202 – 203	(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)1 Publication		2

GO - Molecular functionⁱ

SNAP receptor activity Source: MGI
syntaxin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: MGI
exocytosis
Source: MGI
Inferred from mutant phenotypeⁱ
- 18505797
histamine secretion by mast cell Source: MGI
membrane fusion Source: MGI
protein-containing complex assembly Source: MGI
protein transport Source: MGI
regulation of exocytosis Source: MGI
synaptic vesicle fusion to presynaptic active zone membrane
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle priming
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle fusion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport Source: MGI
vesicle-mediated transport in synapse Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1236974 ER-Phagosome pathway R-MMU-421837 Clathrin derived vesicle budding R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-1236974 ER-Phagosome pathway
R-MMU-421837 Clathrin derived vesicle budding
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptosomal-associated protein 23 Short name: SNAP-23 Alternative name(s): Syndet Vesicle-membrane fusion protein SNAP-23
Gene namesⁱ	Name:Snap23 Synonyms:Sndt
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:109356 Snap23

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	119	P → A: Inhibits interaction with ZDHHC13 and ZDHHC17.		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213599	1 – 210	Synaptosomal-associated protein 23Add BLAST		210

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	5	PhosphoserineBy similarity	1
Modified residueⁱ	20	PhosphoserineCombined sources	1
Modified residueⁱ	23	PhosphoserineCombined sources	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Lipidationⁱ	79	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	80	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	83	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	85	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	87	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	110	PhosphoserineCombined sources	1
Modified residueⁱ	160	PhosphoserineCombined sources	1

Post-translational modificationⁱ

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 202-Thr-|-Arg-203 bond; the in vitro reaction is not highly efficient (PubMed:9886085).1 Publication

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 185-Arg-|-Ile-186 bond; the in vitro reaction is more efficient than that of BoNT/A (PubMed:9886085).1 Publication

Keywords - PTMⁱ

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	O09044
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O09044
PaxDbⁱ	O09044
PRIDEⁱ	O09044

PTM databases

iPTMnetⁱ	O09044
PhosphoSitePlusⁱ	O09044
SwissPalmⁱ	O09044

Expressionⁱ

Tissue specificityⁱ

Expressed in non-neuronal tissues.

Gene expression databases

Bgeeⁱ	ENSMUSG00000027287 Expressed in 283 organ(s), highest expression level in blood
CleanExⁱ	MM_SNAP23
ExpressionAtlasⁱ	O09044 baseline and differential
Genevisibleⁱ	O09044 MM

Interactionⁱ

Subunit structureⁱ

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (By similarity). Found in a complex with VAMP8 and STX1A (By similarity). Found in a complex with VAMP8 and STX4 in pancreas (PubMed:15363411). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (PubMed:9507000). Interacts with STX12 (PubMed:9507000). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Stx4	P70452	2	EBI-1812522,EBI-645716
Stx4	Q08850	4	EBI-1812522,EBI-918243	From Rattus norvegicus.
Vamp2	P63044	3	EBI-1812522,EBI-521920

GO - Molecular functionⁱ

SNAP receptor activity Source: MGI
syntaxin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203367, 11 interactors
CORUMⁱ	O09044
Database of interacting proteins More...DIPⁱ	DIP-41401N
IntActⁱ	O09044, 10 interactors
Molecular INTeraction database More...MINTⁱ	O09044
STRINGⁱ	10090.ENSMUSP00000112138

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O09044
SMRⁱ	O09044
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 76	t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST		63
Domainⁱ	145 – 207	t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 76	By similarityAdd BLAST		54

Sequence similaritiesⁱ

Belongs to the SNAP-25 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012186
HOGENOMⁱ	HOG000231599
HOVERGENⁱ	HBG056971
InParanoidⁱ	O09044
KEGG Orthology (KO) More...KOⁱ	K08508
OMAⁱ	IEQANIR
PhylomeDBⁱ	O09044

Family and domain databases

InterProⁱ	View protein in InterPro IPR000928 SNAP-25 IPR000727 T_SNARE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00835 SNAP-25, 1 hit
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

O09044-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDNLSPEEVQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE 
        60         70         80         90        100
QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCICPCNRT KNFESGKNYK 
       110        120        130        140        150
ATWGDGGDNS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE 
       160        170        180        190        200
MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA 
       210
NTRAKKLIDS

Length:210

Mass (Da):23,261

Last modified:July 1, 1997 - v1

Checksum:ⁱ6919E127E16BA2C9

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9D3L3	Q9D3L3_MOUSE	Synaptosomal-associated protein Synaptosomal-associated protein	Snap23	221	Annotation score:
B0R030	B0R030_MOUSE	Synaptosomal-associated protein Synaptosomal-associated protein	Snap23	161	Annotation score:
E9Q8A1	E9Q8A1_MOUSE	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	Snap23	98	Annotation score:
B0R029	B0R029_MOUSE	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	Snap23	85	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	6	P → S in AAB62932 (Ref. 3) Curated		1
Sequence conflictⁱ	204	A → P in AAB62932 (Ref. 3) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000822 mRNA Translation: BAA20345.1 U73143 mRNA Translation: AAB53597.1 AF007169 mRNA Translation: AAB62932.1 AF213257 AF213256 Genomic DNA Translation: AAF23503.1 AK019162 mRNA Translation: BAB31577.1 BC070456 mRNA Translation: AAH70456.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16622.1
PIRⁱ	JC5512
NCBI Reference Sequences More...RefSeqⁱ	NP_001171263.1, NM_001177792.1 NP_001171264.1, NM_001177793.1 NP_033248.1, NM_009222.3 XP_006499120.1, XM_006499057.3
UniGeneⁱ	Mm.245715

Genome annotation databases

Ensemblⁱ	ENSMUST00000028743; ENSMUSP00000028743; ENSMUSG00000027287 ENSMUST00000110711; ENSMUSP00000106339; ENSMUSG00000027287
GeneIDⁱ	20619
KEGGⁱ	mmu:20619
UCSC genome browser More...UCSCⁱ	uc008lwg.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O09044	Synaptosomal-associated protein		MOUSE		210	UniRef100_O09044
Synaptosomal-associated protein (Fragment)		MOUSE		161

Protein	Similar proteins		Species	Score	Length	Source
O09044	Synaptosomal-associated protein 23		RAT		210	UniRef90_O09044
Synaptosomal-associated protein		MOUSE		210
Synaptosomal-associated protein		ODORO		211
Synaptosomal-associated protein		DIPOR		211
Synaptosomal-associated protein		ERIEU		210
+11

Protein	Similar proteins		Species	Score	Length	Source
O09044	Synaptosomal-associated protein 23		RAT		210	UniRef50_O09044
Synaptosomal-associated protein		MOUSE		210
Synaptosomal-associated protein		DIPOR		211
Synaptosomal-associated protein		ODORO		211
Synaptosomal-associated protein		ERIEU		210
+397

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000822 mRNA Translation: BAA20345.1 U73143 mRNA Translation: AAB53597.1 AF007169 mRNA Translation: AAB62932.1 AF213257 AF213256 Genomic DNA Translation: AAF23503.1 AK019162 mRNA Translation: BAB31577.1 BC070456 mRNA Translation: AAH70456.1
CCDSⁱ	CCDS16622.1
PIRⁱ	JC5512
RefSeqⁱ	NP_001171263.1, NM_001177792.1 NP_001171264.1, NM_001177793.1 NP_033248.1, NM_009222.3 XP_006499120.1, XM_006499057.3
UniGeneⁱ	Mm.245715

3D structure databases

ProteinModelPortalⁱ	O09044
SMRⁱ	O09044
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203367, 11 interactors
CORUMⁱ	O09044
DIPⁱ	DIP-41401N
IntActⁱ	O09044, 10 interactors
MINTⁱ	O09044
STRINGⁱ	10090.ENSMUSP00000112138

PTM databases

iPTMnetⁱ	O09044
PhosphoSitePlusⁱ	O09044
SwissPalmⁱ	O09044

Proteomic databases

EPDⁱ	O09044
MaxQBⁱ	O09044
PaxDbⁱ	O09044
PRIDEⁱ	O09044

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028743; ENSMUSP00000028743; ENSMUSG00000027287 ENSMUST00000110711; ENSMUSP00000106339; ENSMUSG00000027287
GeneIDⁱ	20619
KEGGⁱ	mmu:20619
UCSCⁱ	uc008lwg.1 mouse

Organism-specific databases

CTDⁱ	8773
MGIⁱ	MGI:109356 Snap23

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
GeneTreeⁱ	ENSGT00390000012186
HOGENOMⁱ	HOG000231599
HOVERGENⁱ	HBG056971
InParanoidⁱ	O09044
KOⁱ	K08508
OMAⁱ	IEQANIR
PhylomeDBⁱ	O09044

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1236974 ER-Phagosome pathway R-MMU-421837 Clathrin derived vesicle budding R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-1236974 ER-Phagosome pathway
R-MMU-421837 Clathrin derived vesicle budding
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O09044
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027287 Expressed in 283 organ(s), highest expression level in blood
CleanExⁱ	MM_SNAP23
ExpressionAtlasⁱ	O09044 baseline and differential
Genevisibleⁱ	O09044 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000928 SNAP-25 IPR000727 T_SNARE_dom
Pfamⁱ	View protein in Pfam PF00835 SNAP-25, 1 hit
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNP23_MOUSE
Accessionⁱ	O09044Primary (citable) accession number: O09044 Secondary accession number(s): O35620
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O09044 (SNP23_MOUSE)

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Synaptosomal-associated protein 23

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Lysosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ