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Protein

Napsin-A

Gene

Napsa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in processing of pneumocyte surfactant precursors.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91PROSITE-ProRule annotation1
Active sitei278PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: GO_Central
  • endopeptidase activity Source: UniProtKB
  • peptidase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B1 3474
ReactomeiR-MMU-5683826 Surfactant metabolism

Protein family/group databases

MEROPSiA01.046

Names & Taxonomyi

Protein namesi
Recommended name:
Napsin-A (EC:3.4.23.-)
Alternative name(s):
KDAP-1
Kidney-derived aspartic protease-like protein
Short name:
KAP
Gene namesi
Name:Napsa
Synonyms:Kdap, Nap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109365 Napsa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000025999? – 419Napsin-A
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002599817 – ?Activation peptideSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 111By similarity
Glycosylationi128N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi269 ↔ 273By similarity
Disulfide bondi312 ↔ 349By similarity
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiO09043
PaxDbiO09043
PeptideAtlasiO09043
PRIDEiO09043

PTM databases

iPTMnetiO09043
PhosphoSitePlusiO09043

Expressioni

Tissue specificityi

Expressed at the highest levels in the kidney, at a moderate level in the lung, and at low levels in the spleen and adipose tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000002204 Expressed in 109 organ(s), highest expression level in metanephros
CleanExiMM_NAPSA
ExpressionAtlasiO09043 baseline and differential
GenevisibleiO09043 MM

Interactioni

Protein-protein interaction databases

IntActiO09043, 3 interactors
MINTiO09043
STRINGi10090.ENSMUSP00000002274

Structurei

3D structure databases

ProteinModelPortaliO09043
SMRiO09043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 394Peptidase A1PROSITE-ProRule annotationAdd BLAST322

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiO09043
KOiK08565
OMAiIILCSEI
OrthoDBiEOG091G0JP7
PhylomeDBiO09043
TreeFamiTF314990

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O09043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLLLLLLC LLLGNLEPEE AKLIRVPLQR IHLGHRILNP LNGWEQLAEL
60 70 80 90 100
SRTSTSGGNP SFVPLSKFMN TQYFGTIGLG TPPQNFTVVF DTGSSNLWVP
110 120 130 140 150
STRCHFFSLA CWFHHRFNPK ASSSFRPNGT KFAIQYGTGR LSGILSQDNL
160 170 180 190 200
TIGGIHDAFV TFGEALWEPS LIFALAHFDG ILGLGFPTLA VGGVQPPLDA
210 220 230 240 250
MVEQGLLEKP VFSFYLNRDS EGSDGGELVL GGSDPAHYVP PLTFIPVTIP
260 270 280 290 300
AYWQVHMESV KVGTGLSLCA QGCSAILDTG TSLITGPSEE IRALNKAIGG
310 320 330 340 350
YPFLNGQYFI QCSKTPTLPP VSFHLGGVWF NLTGQDYVIK ILQSDVGLCL
360 370 380 390 400
LGFQALDIPK PAGPLWILGD VFLGPYVAVF DRGDKNVGPR VGLARAQSRS
410
TDRAERRTTQ AQFFKRRPG
Length:419
Mass (Da):45,544
Last modified:July 1, 1997 - v1
Checksum:i715ED4532791143E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LIE6A0A140LIE6_MOUSE
Napsin-A
Napsa
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88899 mRNA Translation: BAA19004.1
AJ250718, AJ250719, AJ250720 Genomic DNA Translation: CAB82907.1
BC014813 mRNA Translation: AAH14813.1
CCDSiCCDS21212.1
RefSeqiNP_032463.1, NM_008437.1
UniGeneiMm.383181

Genome annotation databases

EnsembliENSMUST00000002274; ENSMUSP00000002274; ENSMUSG00000002204
GeneIDi16541
KEGGimmu:16541
UCSCiuc009gqe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88899 mRNA Translation: BAA19004.1
AJ250718, AJ250719, AJ250720 Genomic DNA Translation: CAB82907.1
BC014813 mRNA Translation: AAH14813.1
CCDSiCCDS21212.1
RefSeqiNP_032463.1, NM_008437.1
UniGeneiMm.383181

3D structure databases

ProteinModelPortaliO09043
SMRiO09043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO09043, 3 interactors
MINTiO09043
STRINGi10090.ENSMUSP00000002274

Protein family/group databases

MEROPSiA01.046

PTM databases

iPTMnetiO09043
PhosphoSitePlusiO09043

Proteomic databases

EPDiO09043
PaxDbiO09043
PeptideAtlasiO09043
PRIDEiO09043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002274; ENSMUSP00000002274; ENSMUSG00000002204
GeneIDi16541
KEGGimmu:16541
UCSCiuc009gqe.1 mouse

Organism-specific databases

CTDi9476
MGIiMGI:109365 Napsa

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiO09043
KOiK08565
OMAiIILCSEI
OrthoDBiEOG091G0JP7
PhylomeDBiO09043
TreeFamiTF314990

Enzyme and pathway databases

BRENDAi3.4.23.B1 3474
ReactomeiR-MMU-5683826 Surfactant metabolism

Miscellaneous databases

ChiTaRSiNapsa mouse
PROiPR:O09043
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002204 Expressed in 109 organ(s), highest expression level in metanephros
CleanExiMM_NAPSA
ExpressionAtlasiO09043 baseline and differential
GenevisibleiO09043 MM

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAPSA_MOUSE
AccessioniPrimary (citable) accession number: O09043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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