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Protein

Interleukin-13 receptor subunit alpha-1

Gene

Il13ra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (By similarity).By similarity

GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • interleukin-13 receptor activity Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-1
Short name:
IL-13 receptor subunit alpha-1
Short name:
IL-13R subunit alpha-1
Short name:
IL-13R-alpha-1
Short name:
IL-13RA1
Alternative name(s):
Interleukin-13-binding protein
Novel cytokine receptor 4
Short name:
NR4
CD_antigen: CD213a1
Gene namesi
Name:Il13ra1
Synonyms:Il13r, Il13ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:105052 Il13ra1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 340ExtracellularSequence analysisAdd BLAST315
Transmembranei341 – 364HelicalSequence analysisAdd BLAST24
Topological domaini365 – 424CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001094026 – 424Interleukin-13 receptor subunit alpha-1Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 93Sequence analysis
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 142By similarity
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 183By similarity
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO09030
PaxDbiO09030
PRIDEiO09030

PTM databases

iPTMnetiO09030
PhosphoSitePlusiO09030

Expressioni

Tissue specificityi

Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000017057 Expressed in 246 organ(s), highest expression level in jejunum
CleanExiMM_IL13RA1
GenevisibleiO09030 MM

Interactioni

Subunit structurei

Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-1167N
STRINGi10090.ENSMUSP00000033418

Structurei

3D structure databases

ProteinModelPortaliO09030
SMRiO09030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 121Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST90
Domaini224 – 336Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi324 – 328WSXWS motif5
Motifi371 – 379Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH4K Eukaryota
ENOG410YM7M LUCA
GeneTreeiENSGT00530000063295
HOGENOMiHOG000230941
HOVERGENiHBG052060
InParanoidiO09030
KOiK05076
OMAiTLYYWHS
OrthoDBiEOG091G0FOF
PhylomeDBiO09030
TreeFamiTF331549

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01356 HEMATOPO_REC_S_F2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O09030-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPALLGEL LVLLLWTATV GQVAAATEVQ PPVTNLSVSV ENLCTIIWTW
60 70 80 90 100
SPPEGASPNC TLRYFSHFDD QQDKKIAPET HRKEELPLDE KICLQVGSQC
110 120 130 140 150
SANESEKPSP LVKKCISPPE GDPESAVTEL KCIWHNLSYM KCSWLPGRNT
160 170 180 190 200
SPDTHYTLYY WYSSLEKSRQ CENIYREGQH IACSFKLTKV EPSFEHQNVQ
210 220 230 240 250
IMVKDNAGKI RPSCKIVSLT SYVKPDPPHI KHLLLKNGAL LVQWKNPQNF
260 270 280 290 300
RSRCLTYEVE VNNTQTDRHN ILEVEEDKCQ NSESDRNMEG TSCFQLPGVL
310 320 330 340 350
ADAVYTVRVR VKTNKLCFDD NKLWSDWSEA QSIGKEQNST FYTTMLLTIP
360 370 380 390 400
VFVAVAVIIL LFYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD
410 420
IYEKQSKEET DSVVLIENLK KAAP
Length:424
Mass (Da):48,402
Last modified:July 1, 1997 - v1
Checksum:iEB8330A0DC82C9F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80963 mRNA Translation: AAB50695.1
BC052425 mRNA Translation: AAH52425.2
BC059939 mRNA Translation: AAH59939.1
CCDSiCCDS30057.1
RefSeqiNP_598751.3, NM_133990.5
UniGeneiMm.24208

Genome annotation databases

EnsembliENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057
GeneIDi16164
KEGGimmu:16164
UCSCiuc009sxj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80963 mRNA Translation: AAB50695.1
BC052425 mRNA Translation: AAH52425.2
BC059939 mRNA Translation: AAH59939.1
CCDSiCCDS30057.1
RefSeqiNP_598751.3, NM_133990.5
UniGeneiMm.24208

3D structure databases

ProteinModelPortaliO09030
SMRiO09030
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1167N
STRINGi10090.ENSMUSP00000033418

PTM databases

iPTMnetiO09030
PhosphoSitePlusiO09030

Proteomic databases

MaxQBiO09030
PaxDbiO09030
PRIDEiO09030

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033418; ENSMUSP00000033418; ENSMUSG00000017057
GeneIDi16164
KEGGimmu:16164
UCSCiuc009sxj.1 mouse

Organism-specific databases

CTDi3597
MGIiMGI:105052 Il13ra1

Phylogenomic databases

eggNOGiENOG410IH4K Eukaryota
ENOG410YM7M LUCA
GeneTreeiENSGT00530000063295
HOGENOMiHOG000230941
HOVERGENiHBG052060
InParanoidiO09030
KOiK05076
OMAiTLYYWHS
OrthoDBiEOG091G0FOF
PhylomeDBiO09030
TreeFamiTF331549

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

PROiPR:O09030
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017057 Expressed in 246 organ(s), highest expression level in jejunum
CleanExiMM_IL13RA1
GenevisibleiO09030 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01356 HEMATOPO_REC_S_F2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI13R1_MOUSE
AccessioniPrimary (citable) accession number: O09030
Secondary accession number(s): Q7TT27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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