Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Max-interacting protein 1

Gene

Mxi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: RGD

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Max-interacting protein 1
Short name:
Max interactor 1
Gene namesi
Name:Mxi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3128 Mxi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272871 – 228Max-interacting protein 1Add BLAST228

Proteomic databases

PaxDbiO09015
PRIDEiO09015

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SMC3. Interacts with RNF17 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040770

Structurei

3D structure databases

ProteinModelPortaliO09015
SMRiO09015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 119bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IPD5 Eukaryota
ENOG4111MIN LUCA
HOGENOMiHOG000247060
HOVERGENiHBG006314
InParanoidiO09015
PhylomeDBiO09015

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O09015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERVKMINVQ PMLEAAEFLE RRERECEHGY ASSFPSMPSP RLQHSKPPRR
60 70 80 90 100
LSRAQKHSSG SSNTSTANRS THNELEKNRR AHLRLCLERL KVLIPLGPDC
110 120 130 140 150
TRHTTLGLLN KAKAHIKKLE EAERKSQHQL ENLEREQRFL KRRLEQLQGP
160 170 180 190 200
QEMERIRMDS IGSTISSDRS DSEREEIEVD VESTEFSHGE VDNISTTSIS
210 220
DIDDHSSLQS IGSDEGYSSA SVKLSFTS
Length:228
Mass (Da):26,022
Last modified:July 1, 1997 - v1
Checksum:iF03F800082B0F194
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q642D1Q642D1_RAT
MAX interactor 1
Mxi1 LOC100360467, rCG_57506
228Annotation score:
A0A096MJ60A0A096MJ60_RAT
Max interacting protein 1, isoform ...
Mxi1 rCG_57506
295Annotation score:
A0A096MJ49A0A096MJ49_RAT
Max interacting protein 1, isoform ...
Mxi1 rCG_57506
192Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003008 mRNA Translation: AAB61595.1
UniGeneiRn.37510

Genome annotation databases

UCSCiRGD:3128 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003008 mRNA Translation: AAB61595.1
UniGeneiRn.37510

3D structure databases

ProteinModelPortaliO09015
SMRiO09015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040770

Proteomic databases

PaxDbiO09015
PRIDEiO09015

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3128 rat

Organism-specific databases

RGDi3128 Mxi1

Phylogenomic databases

eggNOGiENOG410IPD5 Eukaryota
ENOG4111MIN LUCA
HOGENOMiHOG000247060
HOVERGENiHBG006314
InParanoidiO09015
PhylomeDBiO09015

Miscellaneous databases

PROiPR:O09015

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMXI1_RAT
AccessioniPrimary (citable) accession number: O09015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again