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Entry version 158 (18 Sep 2019)
Sequence version 2 (16 Jan 2004)
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Protein

Latent-transforming growth factor beta-binding protein 2

Gene

Ltbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an integral structural role in elastic-fiber architectural organization and/or assembly.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding, Heparin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2129379 Molecules associated with elastic fibres

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 2
Short name:
LTBP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ltbp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99502 Ltbp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35By similarityAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000764436 – 1813Latent-transforming growth factor beta-binding protein 2Add BLAST1778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi185 ↔ 195PROSITE-ProRule annotation
Disulfide bondi189 ↔ 201PROSITE-ProRule annotation
Disulfide bondi203 ↔ 212PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi385 ↔ 395PROSITE-ProRule annotation
Disulfide bondi389 ↔ 401PROSITE-ProRule annotation
Disulfide bondi403 ↔ 412PROSITE-ProRule annotation
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei491PhosphoserineCombined sources1
Disulfide bondi538 ↔ 560PROSITE-ProRule annotation
Disulfide bondi547 ↔ 573PROSITE-ProRule annotation
Disulfide bondi561 ↔ 576PROSITE-ProRule annotation
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi613 ↔ 624PROSITE-ProRule annotation
Disulfide bondi619 ↔ 633PROSITE-ProRule annotation
Disulfide bondi635 ↔ 648PROSITE-ProRule annotation
Disulfide bondi661 ↔ 683PROSITE-ProRule annotation
Disulfide bondi670 ↔ 696PROSITE-ProRule annotation
Disulfide bondi684 ↔ 699PROSITE-ProRule annotation
Disulfide bondi685 ↔ 711PROSITE-ProRule annotation
Disulfide bondi839 ↔ 852PROSITE-ProRule annotation
Disulfide bondi847 ↔ 861PROSITE-ProRule annotation
Disulfide bondi863 ↔ 876PROSITE-ProRule annotation
Disulfide bondi882 ↔ 893PROSITE-ProRule annotation
Disulfide bondi887 ↔ 902PROSITE-ProRule annotation
Disulfide bondi904 ↔ 919PROSITE-ProRule annotation
Disulfide bondi925 ↔ 936PROSITE-ProRule annotation
Disulfide bondi931 ↔ 945PROSITE-ProRule annotation
Disulfide bondi947 ↔ 959PROSITE-ProRule annotation
Disulfide bondi965 ↔ 976PROSITE-ProRule annotation
Disulfide bondi971 ↔ 985PROSITE-ProRule annotation
Disulfide bondi988 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1027 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1046 ↔ 1057PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1066PROSITE-ProRule annotation
Disulfide bondi1069 ↔ 1082PROSITE-ProRule annotation
Disulfide bondi1088 ↔ 1099PROSITE-ProRule annotation
Disulfide bondi1094 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1111 ↔ 1124PROSITE-ProRule annotation
Disulfide bondi1130 ↔ 1142PROSITE-ProRule annotation
Disulfide bondi1137 ↔ 1151PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1165PROSITE-ProRule annotation
Glycosylationi1161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1171 ↔ 1183PROSITE-ProRule annotation
Disulfide bondi1177 ↔ 1192PROSITE-ProRule annotation
Disulfide bondi1194 ↔ 1207PROSITE-ProRule annotation
Disulfide bondi1213 ↔ 1224PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1233PROSITE-ProRule annotation
Disulfide bondi1235 ↔ 1249PROSITE-ProRule annotation
Disulfide bondi1255 ↔ 1268PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1277PROSITE-ProRule annotation
Disulfide bondi1281 ↔ 1293PROSITE-ProRule annotation
Disulfide bondi1299 ↔ 1311PROSITE-ProRule annotation
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1305 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1322 ↔ 1335PROSITE-ProRule annotation
Disulfide bondi1341 ↔ 1353PROSITE-ProRule annotation
Disulfide bondi1348 ↔ 1362PROSITE-ProRule annotation
Disulfide bondi1364 ↔ 1378PROSITE-ProRule annotation
Disulfide bondi1405 ↔ 1428PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1440PROSITE-ProRule annotation
Glycosylationi1422N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1429 ↔ 1443PROSITE-ProRule annotation
Disulfide bondi1430 ↔ 1455PROSITE-ProRule annotation
Disulfide bondi1481 ↔ 1494PROSITE-ProRule annotation
Disulfide bondi1489 ↔ 1503PROSITE-ProRule annotation
Disulfide bondi1505 ↔ 1518PROSITE-ProRule annotation
Disulfide bondi1524 ↔ 1534PROSITE-ProRule annotation
Disulfide bondi1529 ↔ 1543PROSITE-ProRule annotation
Disulfide bondi1545 ↔ 1558PROSITE-ProRule annotation
Glycosylationi1560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1578 ↔ 1601PROSITE-ProRule annotation
Disulfide bondi1587 ↔ 1613PROSITE-ProRule annotation
Disulfide bondi1602 ↔ 1616PROSITE-ProRule annotation
Disulfide bondi1603 ↔ 1628PROSITE-ProRule annotation
Disulfide bondi1729 ↔ 1740PROSITE-ProRule annotation
Disulfide bondi1735 ↔ 1749PROSITE-ProRule annotation
Disulfide bondi1751 ↔ 1764PROSITE-ProRule annotation
Disulfide bondi1770 ↔ 1785PROSITE-ProRule annotation
Disulfide bondi1780 ↔ 1794PROSITE-ProRule annotation
Disulfide bondi1796 ↔ 1809PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-Glycosylated.By similarity
Contains hydroxylated asparagine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O08999

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08999

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08999

PRoteomics IDEntifications database

More...
PRIDEi
O08999

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08999

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08999

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the anterior chamber of the eye.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex.

Interacts with SDC4.

Interacts (via C-terminal domain) with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O08999, 2 interactors

Molecular INTeraction database

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MINTi
O08999

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000002073

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08999

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 213EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini381 – 413EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini536 – 588TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini609 – 649EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini659 – 711TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini835 – 877EGF-like 4PROSITE-ProRule annotationAdd BLAST43
Domaini878 – 920EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini921 – 960EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini961 – 1000EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1001 – 1041EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1042 – 1083EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1084 – 1125EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1126 – 1166EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1167 – 1208EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1209 – 1250EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1251 – 1294EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini1295 – 1336EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1337 – 1379EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1403 – 1455TB 3PROSITE-ProRule annotationAdd BLAST53
Domaini1477 – 1519EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1520 – 1559EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1576 – 1628TB 4PROSITE-ProRule annotationAdd BLAST53
Domaini1725 – 1765EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1766 – 1810EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 115Heparin-bindingBy similarityAdd BLAST22
Regioni226 – 243Heparin-bindingBy similarityAdd BLAST18
Regioni329 – 339Heparin-bindingBy similarityAdd BLAST11
Regioni1631 – 1813C-terminal domainBy similarityAdd BLAST183

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi847 – 1364Cys-richAdd BLAST518

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD9U Eukaryota
ENOG410XSTY LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293153

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08999

KEGG Orthology (KO)

More...
KOi
K08023

Database of Orthologous Groups

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OrthoDBi
1174178at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O08999

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 16 hits
PF12661 hEGF, 1 hit
PF00683 TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 20 hits
SM00179 EGF_CA, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 6 hits
SSF57581 SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00010 ASX_HYDROXYL, 12 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 10 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 16 hits
PS51364 TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O08999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPTTARCS GCIQRVRWRG FLPLVLAVLM GTSHAQRDSI GRYEPASRDA
60 70 80 90 100
NRLWHPVGSH PAAAAAKVYS LFREPDAPVP GLSPSEWNQP AQGNPGWLAE
110 120 130 140 150
AEARRPPRTQ QLRRVQPPVQ TRRSHPRGQQ QIAARAAPSV ARLETPQRPA
160 170 180 190 200
AARRGRLTGR NVCGGQCCPG WTTSNSTNHC IKPVCQPPCQ NRGSCSRPQV
210 220 230 240 250
CICRSGFRGA RCEEVIPEEE FDPQNARPVP RRSVERAPGP HRSSEARGSL
260 270 280 290 300
VTRIQPLVPP PSPPPSRRLS QPWPLQQHSG PSRTVRRYPA TGANGQLMSN
310 320 330 340 350
ALPSGLELRD SSPQAAHVNH LSPPWGLNLT EKIKKIKVVF TPTICKQTCA
360 370 380 390 400
RGRCANSCEK GDTTTLYSQG GHGHDPKSGF RIYFCQIPCL NGGRCIGRDE
410 420 430 440 450
CWCPANSTGK FCHLPVPQPD REPAGRGSRH RTLLEGPLKQ STFTLPLSNQ
460 470 480 490 500
LASVNPSLVK VQIHHPPEAS VQIHQVARVR GELDPVLEDN SVETRASHRP
510 520 530 540 550
HGNLGHSPWA SNSIPARAGE APRPPPVLSR HYGLLGQCYL STVNGQCANP
560 570 580 590 600
LGSLTSQEDC CGSVGTFWGV TSCAPCPPRQ EGPAFPVIEN GQLECPQGYK
610 620 630 640 650
RLNLSHCQDI NECLTLGLCK DSECVNTRGS YLCTCRPGLM LDPSRSRCVS
660 670 680 690 700
DKAVSMQQGL CYRSLGSGTC TLPLVHRITK QICCCSRVGK AWGSTCEQCP
710 720 730 740 750
LPGTEAFREI CPAGHGYTYS SSDIRLSMRK AEEEELASPL REQTEQSTAP
760 770 780 790 800
PPGQAERQPL RAATATWIEA ETLPDKGDSR AVQITTSAPH LPARVPGDAT
810 820 830 840 850
GRPAPSLPGQ GIPESPAEEQ VIPSSDVLVT HSPPDFDPCF AGASNICGPG
860 870 880 890 900
TCVSLPNGYR CVCSPGYQLH PSQDYCTDDN ECMRNPCEGR GRCVNSVGSY
910 920 930 940 950
SCLCYPGYTL VTLGDTQECQ DIDECEQPGV CSGGRCSNTE GSYHCECDRG
960 970 980 990 1000
YIMVRKGHCQ DINECRHPGT CPDGRCVNSP GSYTCLACEE GYVGQSGSCV
1010 1020 1030 1040 1050
DVNECLTPGI CTHGRCINME GSFRCSCEPG YEVTPDKKGC RDVDECASRA
1060 1070 1080 1090 1100
SCPTGLCLNT EGSFTCSACQ SGYWVNEDGT ACEDLDECAF PGVCPTGVCT
1110 1120 1130 1140 1150
NTVGSFSCKD CDQGYRPNPL GNRCEDVDEC EGPQSSCRGG ECKNTEGSYQ
1160 1170 1180 1190 1200
CLCHQGFQLV NGTMCEDVNE CVGEEHCAPH GECLNSLGSF FCLCAPGFAS
1210 1220 1230 1240 1250
AEGGTRCQDV DECAATDPCP GGHCVNTEGS FSCLCETASF QPSPDSGECL
1260 1270 1280 1290 1300
DIDECEDRED PVCGAWRCEN SPGSYRCILD CQPGFYVAPN GDCIDIDECA
1310 1320 1330 1340 1350
NDTVCGNHGF CDNTDGSFRC LCDQGFETSP SGWECVDVNE CELMMAVCGD
1360 1370 1380 1390 1400
ALCENVEGSF LCLCASDLEE YDAEEGHCRP RVAGAQRIPE VRTEDQAPSL
1410 1420 1430 1440 1450
IRMECYSEHN GGPPCSQILG QNSTQAECCC TQGARWGKAC APCPSEDSVE
1460 1470 1480 1490 1500
FSQLCPSGQG YIPVEGAWTF GQTMYTDADE CVLFGPALCQ NGRCSNIVPG
1510 1520 1530 1540 1550
YICLCNPGYH YDASSRKCQD HNECQDLACE NGECVNQEGS FHCLCNPPLT
1560 1570 1580 1590 1600
LDLSGQRCVN TTSSTEDFPD HDIHMDICWK KVTNDVCSQP LRGHHTTYTE
1610 1620 1630 1640 1650
CCCQDGEAWS QQCALCPPRS SEVYAQLCNV ARIEAERGAG IHFRPGYEYG
1660 1670 1680 1690 1700
PGLDDLPENL YGPDGAPFYN YLGPEDTAPE PPFSNPASQP GDNTPVLEPP
1710 1720 1730 1740 1750
LQPSELQPHY LASHSEPPAS FEGLQAEECG ILNGCENGRC VRVREGYTCD
1760 1770 1780 1790 1800
CFEGFQLDAP TLACVDVNEC EDLNGPARLC AHGHCENTEG SYRCHCSPGY
1810
VAEPGPPHCA AKE
Length:1,813
Mass (Da):195,829
Last modified:January 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD993DF6489AA27D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QNQ3E9QNQ3_MOUSE
Latent-transforming growth factor b...
Ltbp2
1,809Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1D6E9Q1D6_MOUSE
Latent-transforming growth factor b...
Ltbp2
1,766Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0VD84Q0VD84_MOUSE
Latent-transforming growth factor b...
Ltbp2
1,786Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UFW9F6UFW9_MOUSE
Latent-transforming growth factor b...
Ltbp2
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WSP3F6WSP3_MOUSE
Latent-transforming growth factor b...
Ltbp2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XGT5F6XGT5_MOUSE
Latent-transforming growth factor b...
Ltbp2
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB61611 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC35229 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14Q → R in BAC35229 (PubMed:16141072).Curated1
Sequence conflicti74E → G in BAC35229 (PubMed:16141072).Curated1
Sequence conflicti97W → R in BAC35229 (PubMed:16141072).Curated1
Sequence conflicti498H → R in BAC35229 (PubMed:16141072).Curated1
Sequence conflicti553S → E in BAC35229 (PubMed:16141072).Curated1
Sequence conflicti580 – 582Missing in BAC35229 (PubMed:16141072).Curated3
Sequence conflicti778D → L in BAC35229 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004874 mRNA Translation: AAB61611.1 Different initiation.
AK052980 mRNA Translation: BAC35229.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_038617.3, NM_013589.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16997

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004874 mRNA Translation: AAB61611.1 Different initiation.
AK052980 mRNA Translation: BAC35229.1 Different initiation.
RefSeqiNP_038617.3, NM_013589.3

3D structure databases

SMRiO08999
ModBaseiSearch...

Protein-protein interaction databases

IntActiO08999, 2 interactors
MINTiO08999
STRINGi10090.ENSMUSP00000002073

PTM databases

iPTMnetiO08999
PhosphoSitePlusiO08999

Proteomic databases

jPOSTiO08999
MaxQBiO08999
PaxDbiO08999
PRIDEiO08999

Genome annotation databases

GeneIDi16997
KEGGimmu:16997

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4053
MGIiMGI:99502 Ltbp2

Phylogenomic databases

eggNOGiENOG410KD9U Eukaryota
ENOG410XSTY LUCA
HOGENOMiHOG000293153
InParanoidiO08999
KOiK08023
OrthoDBi1174178at2759
PhylomeDBiO08999

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ltbp2 mouse

Protein Ontology

More...
PROi
PR:O08999

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 16 hits
PF12661 hEGF, 1 hit
PF00683 TB, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 20 hits
SM00179 EGF_CA, 18 hits
SUPFAMiSSF57184 SSF57184, 6 hits
SSF57581 SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00010 ASX_HYDROXYL, 12 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 10 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 16 hits
PS51364 TB, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08999
Secondary accession number(s): Q8C6W9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: September 18, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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