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Protein

Syntenin-1

Gene

Sdcbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-3928664 Ephrin signaling
R-MMU-447043 Neurofascin interactions
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Scaffold protein Pbp1
Syndecan-binding protein 1
Gene namesi
Name:Sdcbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1337026 Sdcbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4 – 5YP → AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 46-A--A-47 and 50-A--A-51. 1 Publication2
Mutagenesisi47 – 48YP → AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 51-A--A-52. 1 Publication2
Mutagenesisi51 – 52YP → AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 47-A--A-48. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001840022 – 299Syntenin-1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei47PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO08992
MaxQBiO08992
PaxDbiO08992
PeptideAtlasiO08992
PRIDEiO08992

PTM databases

iPTMnetiO08992
PhosphoSitePlusiO08992

Expressioni

Gene expression databases

BgeeiENSMUSG00000028249 Expressed in 304 organ(s), highest expression level in intestine
CleanExiMM_SDCBP
ExpressionAtlasiO08992 baseline and differential
GenevisibleiO08992 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA, IL5RA, NFASC, SDCBP2 and PTPRJ (By similarity). Interacts with PDCD6IP (PubMed:22660413). Forms a complex with PDCD6IP and SDC2 (By similarity). Interacts (via C-terminus) with TGFBR1 (By similarity). Binds to FZD7; this interaction is increased by inositol trisphosphate (IP3) (By similarity). Interacts with SMO (PubMed:25644602).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207300, 3 interactors
ComplexPortaliCPX-3283 Syndecan-1-syntenin-1-ALIX complex
IntActiO08992, 6 interactors
MINTiO08992
STRINGi10090.ENSMUSP00000029912

Structurei

3D structure databases

ProteinModelPortaliO08992
SMRiO08992
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 194PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini199 – 273PDZ 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 103Interaction with PDCD6IP1 PublicationAdd BLAST102
Regioni251 – 252phosphatidylinositol-4,5-bisphosphate-bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 7LYPX(n)L motif 11 Publication5
Motifi46 – 50LYPX(n)L motif 21 Publication5
Motifi50 – 54LYPX(n)L motif 31 Publication5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEB7 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00390000014465
HOGENOMiHOG000231604
HOVERGENiHBG053211
InParanoidiO08992
KOiK17254
OMAiRPFERSI
OrthoDBiEOG091G0HJI
PhylomeDBiO08992
TreeFamiTF327131

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030528 SDCBP
PANTHERiPTHR12345:SF10 PTHR12345:SF10, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O08992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL
60 70 80 90 100
YPELSQYMGL SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN
110 120 130 140 150
DAGIRRAEIK QGIREVILCK DQDGKIGLRL KSIDNGIFVQ LVQANSPASL
160 170 180 190 200
VGLRFGDQVL QINGENCAGW SSDKAHKVLK QAFGEKITMT IRDRPFERTV
210 220 230 240 250
TMHKDSSGHV GFIFKSGKIT SIVKDSSAAR NGLLTDHHIC EINGQNVIGL
260 270 280 290
KDAQIADILS TAGTVVTITI MPTFIFEHII KRMAPSIMKS LMDHTIPEV
Length:299
Mass (Da):32,379
Last modified:July 1, 1997 - v1
Checksum:i04FFF7A33A7F0195
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TMX0Q3TMX0_MOUSE
MCG4375, isoform CRA_b
Sdcbp mCG_4375
298Annotation score:
A2AKJ9A2AKJ9_MOUSE
Syntenin-1
Sdcbp
199Annotation score:
A2AKJ6A2AKJ6_MOUSE
Syntenin-1
Sdcbp
209Annotation score:
H3BLG5H3BLG5_MOUSE
Syntenin-1
Sdcbp
249Annotation score:
A2AKJ5A2AKJ5_MOUSE
Syntenin-1
Sdcbp
91Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003693 mRNA Translation: AAB61293.1
AK028429 mRNA Translation: BAC25946.1
AK033412 mRNA Translation: BAC28275.1
AK146085 mRNA Translation: BAE26889.1
AK150278 mRNA Translation: BAE29434.1
AK150321 mRNA Translation: BAE29466.1
AK150623 mRNA Translation: BAE29713.1
AK150721 mRNA Translation: BAE29799.1
AK150801 mRNA Translation: BAE29864.1
AK152017 mRNA Translation: BAE30879.1
AK152434 mRNA Translation: BAE31216.1
AK152552 mRNA Translation: BAE31306.1
AK159677 mRNA Translation: BAE35280.1
AK167513 mRNA Translation: BAE39588.1
AK168004 mRNA Translation: BAE39992.1
AK168777 mRNA Translation: BAE40613.1
AK169219 mRNA Translation: BAE40990.1
AK169687 mRNA Translation: BAE41305.1
AK171162 mRNA Translation: BAE42284.1
AL772306 Genomic DNA No translation available.
BC019400 mRNA Translation: AAH19400.1
CCDSiCCDS51110.1
RefSeqiNP_001091697.1, NM_001098227.1
NP_058087.2, NM_016807.2
XP_006538147.1, XM_006538084.3
UniGeneiMm.247473
Mm.491105

Genome annotation databases

EnsembliENSMUST00000029912; ENSMUSP00000029912; ENSMUSG00000028249
GeneIDi53378
KEGGimmu:53378
UCSCiuc008rxn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003693 mRNA Translation: AAB61293.1
AK028429 mRNA Translation: BAC25946.1
AK033412 mRNA Translation: BAC28275.1
AK146085 mRNA Translation: BAE26889.1
AK150278 mRNA Translation: BAE29434.1
AK150321 mRNA Translation: BAE29466.1
AK150623 mRNA Translation: BAE29713.1
AK150721 mRNA Translation: BAE29799.1
AK150801 mRNA Translation: BAE29864.1
AK152017 mRNA Translation: BAE30879.1
AK152434 mRNA Translation: BAE31216.1
AK152552 mRNA Translation: BAE31306.1
AK159677 mRNA Translation: BAE35280.1
AK167513 mRNA Translation: BAE39588.1
AK168004 mRNA Translation: BAE39992.1
AK168777 mRNA Translation: BAE40613.1
AK169219 mRNA Translation: BAE40990.1
AK169687 mRNA Translation: BAE41305.1
AK171162 mRNA Translation: BAE42284.1
AL772306 Genomic DNA No translation available.
BC019400 mRNA Translation: AAH19400.1
CCDSiCCDS51110.1
RefSeqiNP_001091697.1, NM_001098227.1
NP_058087.2, NM_016807.2
XP_006538147.1, XM_006538084.3
UniGeneiMm.247473
Mm.491105

3D structure databases

ProteinModelPortaliO08992
SMRiO08992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207300, 3 interactors
ComplexPortaliCPX-3283 Syndecan-1-syntenin-1-ALIX complex
IntActiO08992, 6 interactors
MINTiO08992
STRINGi10090.ENSMUSP00000029912

PTM databases

iPTMnetiO08992
PhosphoSitePlusiO08992

Proteomic databases

EPDiO08992
MaxQBiO08992
PaxDbiO08992
PeptideAtlasiO08992
PRIDEiO08992

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029912; ENSMUSP00000029912; ENSMUSG00000028249
GeneIDi53378
KEGGimmu:53378
UCSCiuc008rxn.1 mouse

Organism-specific databases

CTDi6386
MGIiMGI:1337026 Sdcbp

Phylogenomic databases

eggNOGiENOG410IEB7 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00390000014465
HOGENOMiHOG000231604
HOVERGENiHBG053211
InParanoidiO08992
KOiK17254
OMAiRPFERSI
OrthoDBiEOG091G0HJI
PhylomeDBiO08992
TreeFamiTF327131

Enzyme and pathway databases

ReactomeiR-MMU-3928664 Ephrin signaling
R-MMU-447043 Neurofascin interactions
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSdcbp mouse
PROiPR:O08992
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028249 Expressed in 304 organ(s), highest expression level in intestine
CleanExiMM_SDCBP
ExpressionAtlasiO08992 baseline and differential
GenevisibleiO08992 MM

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR030528 SDCBP
PANTHERiPTHR12345:SF10 PTHR12345:SF10, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSDCB1_MOUSE
AccessioniPrimary (citable) accession number: O08992
Secondary accession number(s): A2AKJ7, Q544P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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