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Protein

Ras-related protein M-Ras

Gene

Mras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Muscle and microspikes Ras
Ras-related protein R-Ras3
X-Ras
Gene namesi
Name:Mras
Synonyms:Xras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1100856 Mras

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826551 – 205Ras-related protein M-RasAdd BLAST205
PropeptideiPRO_0000281305206 – 208Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO08989
PeptideAtlasiO08989
PRIDEiO08989

PTM databases

iPTMnetiO08989
PhosphoSitePlusiO08989

Expressioni

Gene expression databases

BgeeiENSMUSG00000032470 Expressed in 231 organ(s), highest expression level in hypothalamus
CleanExiMM_MRAS
ExpressionAtlasiO08989 baseline and differential
GenevisibleiO08989 MM

Interactioni

Subunit structurei

Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts with RGL3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201483, 2 interactors
IntActiO08989, 1 interactor
STRINGi10090.ENSMUSP00000035045

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO08989
SMRiO08989
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08989

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector region9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Poly-Lys7

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiO08989
KOiK07831
OMAiWVIMDVL
OrthoDBiEOG091G0UAU
PhylomeDBiO08989
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08989-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSAVPSEN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKVTRDQ GKEMATKYNI
160 170 180 190 200
PYIETSAKDP PLNVDKTFHD LVRVIRQQVP EKNQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,901
Last modified:July 1, 1997 - v1
Checksum:i975CFDD1FDF37FCF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2V6D3Z2V6_MOUSE
Ras-related protein M-Ras
Mras
130Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA Translation: BAA20538.1
AF043581 mRNA Translation: AAD02277.1
AF031159 mRNA Translation: AAD01926.1
BC024389 mRNA Translation: AAH24389.1
CCDSiCCDS23433.1
RefSeqiNP_032650.1, NM_008624.3
XP_006510888.1, XM_006510825.2
UniGeneiMm.2045

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470
GeneIDi17532
KEGGimmu:17532
UCSCiuc009rec.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004879 mRNA Translation: BAA20538.1
AF043581 mRNA Translation: AAD02277.1
AF031159 mRNA Translation: AAD01926.1
BC024389 mRNA Translation: AAH24389.1
CCDSiCCDS23433.1
RefSeqiNP_032650.1, NM_008624.3
XP_006510888.1, XM_006510825.2
UniGeneiMm.2045

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X1RX-ray1.30A1-178[»]
1X1SX-ray2.20A1-178[»]
3KKOX-ray1.90A/B/P1-178[»]
3KKPX-ray1.35A1-178[»]
3KKQX-ray1.20A1-178[»]
3PIRX-ray2.75A1-178[»]
3PITX-ray1.55A1-178[»]
ProteinModelPortaliO08989
SMRiO08989
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201483, 2 interactors
IntActiO08989, 1 interactor
STRINGi10090.ENSMUSP00000035045

PTM databases

iPTMnetiO08989
PhosphoSitePlusiO08989

Proteomic databases

PaxDbiO08989
PeptideAtlasiO08989
PRIDEiO08989

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035045; ENSMUSP00000035045; ENSMUSG00000032470
ENSMUST00000119472; ENSMUSP00000112407; ENSMUSG00000032470
ENSMUST00000122384; ENSMUSP00000113275; ENSMUSG00000032470
GeneIDi17532
KEGGimmu:17532
UCSCiuc009rec.1 mouse

Organism-specific databases

CTDi22808
MGIiMGI:1100856 Mras

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiO08989
KOiK07831
OMAiWVIMDVL
OrthoDBiEOG091G0UAU
PhylomeDBiO08989
TreeFamiTF312796

Miscellaneous databases

ChiTaRSiMras mouse
EvolutionaryTraceiO08989
PROiPR:O08989
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032470 Expressed in 231 organ(s), highest expression level in hypothalamus
CleanExiMM_MRAS
ExpressionAtlasiO08989 baseline and differential
GenevisibleiO08989 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASM_MOUSE
AccessioniPrimary (citable) accession number: O08989
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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