Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tuftelin

Gene

Tuft1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the mineralization and structural organization of enamel.By similarity

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • intracellular signal transduction Source: GO_Central

Keywordsi

Biological processBiomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Tuftelin
Gene namesi
Name:Tuft1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109572 Tuft1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831871 – 390TuftelinAdd BLAST390

Proteomic databases

PaxDbiO08970
PeptideAtlasiO08970
PRIDEiO08970

PTM databases

PhosphoSitePlusiO08970

Expressioni

Tissue specificityi

Ameloblasts, and also non-odontogenic tissues including kidney, lung, liver and testis.1 Publication

Developmental stagei

Expressed in tooth from E13, the bud stage. Continues to be expressed even when thick enamel is formed.

Gene expression databases

BgeeiENSMUSG00000005968 Expressed in 176 organ(s), highest expression level in tail skin
CleanExiMM_TUFT1
ExpressionAtlasiO08970 baseline and differential
GenevisibleiO08970 MM

Interactioni

Subunit structurei

Interacts with TFIP11. May form oligomers.1 Publication

Protein-protein interaction databases

IntActiO08970, 1 interactor
STRINGi10090.ENSMUSP00000006123

Structurei

3D structure databases

ProteinModelPortaliO08970
SMRiO08970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 126Sequence analysisAdd BLAST39
Coiled coili163 – 352Sequence analysisAdd BLAST190

Sequence similaritiesi

Belongs to the tuftelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGQQ Eukaryota
ENOG4111JYX LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000233720
HOVERGENiHBG056992
InParanoidiO08970
OMAiPPEVDTY
OrthoDBiEOG091G08H0
PhylomeDBiO08970
TreeFamiTF331627

Family and domain databases

InterProiView protein in InterPro
IPR024846 Tuftelin
PANTHERiPTHR23171:SF4 PTHR23171:SF4, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O08970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGTRNWCTL VDVHPESQTA GSVDILRLTL QSELTGDELE HIAQKAGRKT
60 70 80 90 100
YAMMPGHSSG HSLASELVES HDGHEEIIKV YLKGRSGDKM THEKNIDQLK
110 120 130 140 150
SEVQYIQEAR NCLQKLREDI SSKLDRSPGD PLRQQEIQVV LEKPNGFSQS
160 170 180 190 200
PMTLYSSPPE VDPSMSEDVE SLKKTVQELL VKLREAERRH QSDRVAFEVT
210 220 230 240 250
LSRYQREAEQ SNVALQREED RVEQKAAEIE ELQRRLLGME AEHQALLVKV
260 270 280 290 300
REGEMALEEL RIKNADCQTE REKSAALEKE VAGFREKIHH LDDMLKSQQR
310 320 330 340 350
KVRQMIEQLQ NSKAVIQSKD ATIQELKEKI AYLEAENLEM HDRMEHLIEK
360 370 380 390
QVSHGNFSTQ ARAKTENLGS VRISKPPSPK PMPLIRVVET
Length:390
Mass (Da):44,576
Last modified:November 1, 1998 - v2
Checksum:i968FA7BBE95DFEC1
GO
Isoform 2 (identifier: O08970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-45: Missing.

Show »
Length:365
Mass (Da):41,828
Checksum:i1EAF6EEF481129AF
GO
Isoform 3 (identifier: O08970-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-45: Missing.
     46-80: Missing.

Show »
Length:330
Mass (Da):38,084
Checksum:i7B74C7E4E5D600E7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDW8A0A0G2JDW8_MOUSE
Tuftelin
Tuft1
335Annotation score:
A0A0G2JG92A0A0G2JG92_MOUSE
Tuftelin
Tuft1
174Annotation score:
A0A0G2JG42A0A0G2JG42_MOUSE
Tuftelin
Tuft1
55Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00668721 – 45Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_00668846 – 80Missing in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047704 mRNA Translation: AAC04577.1
BC019213 mRNA Translation: AAH19213.1
AF002860 mRNA Translation: AAB60891.1
CCDSiCCDS17595.1 [O08970-1]
CCDS79975.1 [O08970-2]
RefSeqiNP_035786.1, NM_011656.3 [O08970-1]
UniGeneiMm.10214

Genome annotation databases

EnsembliENSMUST00000006123; ENSMUSP00000006123; ENSMUSG00000005968 [O08970-1]
ENSMUST00000196733; ENSMUSP00000143278; ENSMUSG00000005968 [O08970-2]
GeneIDi22156
KEGGimmu:22156
UCSCiuc008qgt.2 mouse [O08970-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047704 mRNA Translation: AAC04577.1
BC019213 mRNA Translation: AAH19213.1
AF002860 mRNA Translation: AAB60891.1
CCDSiCCDS17595.1 [O08970-1]
CCDS79975.1 [O08970-2]
RefSeqiNP_035786.1, NM_011656.3 [O08970-1]
UniGeneiMm.10214

3D structure databases

ProteinModelPortaliO08970
SMRiO08970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08970, 1 interactor
STRINGi10090.ENSMUSP00000006123

PTM databases

PhosphoSitePlusiO08970

Proteomic databases

PaxDbiO08970
PeptideAtlasiO08970
PRIDEiO08970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006123; ENSMUSP00000006123; ENSMUSG00000005968 [O08970-1]
ENSMUST00000196733; ENSMUSP00000143278; ENSMUSG00000005968 [O08970-2]
GeneIDi22156
KEGGimmu:22156
UCSCiuc008qgt.2 mouse [O08970-1]

Organism-specific databases

CTDi7286
MGIiMGI:109572 Tuft1

Phylogenomic databases

eggNOGiENOG410IGQQ Eukaryota
ENOG4111JYX LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000233720
HOVERGENiHBG056992
InParanoidiO08970
OMAiPPEVDTY
OrthoDBiEOG091G08H0
PhylomeDBiO08970
TreeFamiTF331627

Miscellaneous databases

PROiPR:O08970
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005968 Expressed in 176 organ(s), highest expression level in tail skin
CleanExiMM_TUFT1
ExpressionAtlasiO08970 baseline and differential
GenevisibleiO08970 MM

Family and domain databases

InterProiView protein in InterPro
IPR024846 Tuftelin
PANTHERiPTHR23171:SF4 PTHR23171:SF4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTUFT1_MOUSE
AccessioniPrimary (citable) accession number: O08970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again