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Entry version 134 (02 Dec 2020)
Sequence version 2 (23 Oct 2007)
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Protein

Zinc finger protein 423

Gene

Znf423

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri75 – 101C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 294C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri303 – 326C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri331 – 353C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 460C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri468 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri507 – 530C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 567C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 615C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri659 – 681C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 742C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri747 – 770C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri777 – 800C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri808 – 830C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 857C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 935C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri957 – 979C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri986 – 1008C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1091 – 1109C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1147 – 1170C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1195 – 1217C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1256 – 1279C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 423
Alternative name(s):
Olf1/EBF-associated zinc finger protein
Short name:
rOAZ
Smad- and Olf-interacting zinc finger protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf423
Synonyms:Oaz, Zfp423
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
621664, Zfp423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003085971 – 1311Zinc finger protein 423Add BLAST1311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei631PhosphoserineBy similarity1
Modified residuei1081PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08961

PRoteomics IDEntifications database

More...
PRIDEi
O08961

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, eye, olfactory epithelium, spleen and heart. Expressed in the basal layer, consisting of neural precursor cells and immature sensory neurons of the olfactory epithelium, but not in the mature receptor cells.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PARP1, SMAD1 and SMAD4 (By similarity).

Interacts with EBF1.

Interacts with CEP290 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
250171, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020028

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
O08961

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08961

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri75 – 101C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 294C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri303 – 326C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri331 – 353C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 460C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri468 – 491C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri507 – 530C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 567C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri590 – 615C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri659 – 681C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 742C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri747 – 770C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri777 – 800C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri808 – 830C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri834 – 857C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 935C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri957 – 979C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri986 – 1008C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1047 – 1069C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1091 – 1109C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1147 – 1170C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1195 – 1217C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1225 – 1247C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1256 – 1279C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1286 – 1309C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08961

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O08961

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08961-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPR SVKVEEGEAS DFSLAWDSSV AAAGGLEGES ECDRKSSRAL
60 70 80 90 100
EDRNSVTSQE ERNEDDEDVE DESIYTCDHC QQDFESLADL TDHRAHRCPG
110 120 130 140 150
DGDDDPQLSW VASSPSSKDV ASPTQMIGDG CDLGLGEEEG GTGLPYPCQF
160 170 180 190 200
CDKSFIRLSY LKRHEQIHSD KLPFKCTFCS RLFKHKRSRD RHIKLHTGDK
210 220 230 240 250
KYHCHECEAA FSRRDHLKIH LKTHSSSKPF KCSVCKRGFS STSSLQSHMQ
260 270 280 290 300
AHKKNKEHLA KSEKEAKKDD FMCDYCEDTF SQTEELEKHV LTLHPQLSEK
310 320 330 340 350
ADLQCIHCPE VFVDESTLLA HIHQAHANQK HKCPMCPEQF SSVEGVYCHL
360 370 380 390 400
DSHRQPDSSN HSVSPDPVLG SVASMSSATP DSTPDPVLGS VASMSSATPD
410 420 430 440 450
SSASVERGST PDSTLKPLRG QKKMRDDGQS WSKVVYSCPY CSKRDFTSLA
460 470 480 490 500
VLEIHLKTIH ADKPQQSHTC QICLDSMPTL YNLNEHVRKL HKSHAYPVMQ
510 520 530 540 550
FGNISAFHCN YCPEMFADIN SLQEHIRVSH CGPNANPPDG NNAFFCNQCS
560 570 580 590 600
MGFLTESSLT EHIQQAHCSV GSTKLESPVI QPTQSFMEVY SCPYCTNSPI
610 620 630 640 650
FGSILKLTKH IKENHKNIPL AHSKKSKAEQ SPVSSDVEVS SPKRQRLSGS
660 670 680 690 700
ANSISNGEYP CNQCDLKFSN FESFQTHLKL HLELLLRKQA CPQCKEDFDS
710 720 730 740 750
QESLLQHLTV HYMTTSTHYV CESCDKQFSS VDDLQKHLLD MHTFVLYHCT
760 770 780 790 800
LCQEVFDSKV SIQVHLAVKH SNEKKMYRCT ACNWDFRKEA DLQVHVKHSH
810 820 830 840 850
LGNPAKAHKC IFCGETFSTE VELQCHITTH SKKYNCRFCS KAFHAVLLLE
860 870 880 890 900
KHLREKHCVF DPAAENGTAN GVPPTSTKKA EPADLQGMLL KNPEAPNSHE
910 920 930 940 950
ASEDDVDASE PMYGCDICGA AYTMEVLLQN HRLRDHNIRP GEDDGSRKKA
960 970 980 990 1000
EFIKGSHKCN VCSRTFFSEN GLREHLQTHR GPAKHYMCPI CGERFPSLLT
1010 1020 1030 1040 1050
LTEHKVTHSK SLDTGTCRIC KMPLQSEEEF IEHCQMHPDL RNSLTGFRCV
1060 1070 1080 1090 1100
VCMQTVTSTL ELKIHGTFHM QKLAGSSAAS SPNGQGLQKL YKCALCLKEF
1110 1120 1130 1140 1150
RSKQDLVRLD VNGLPYGLCA GCMARSANGQ VGGLAPPEPA DRPCAGLRCP
1160 1170 1180 1190 1200
ECNVKFESAE DLESHMQVDH RDLTPETSGP RKGAQTSPVP RKKTYQCIKC
1210 1220 1230 1240 1250
QMTFENEREI QIHVANHMIE EGINHECKLC NQMFDSPAKL LCHLIEHSFE
1260 1270 1280 1290 1300
GMGGTFKCPV CFTVFVQANK LQQHIFAVHG QEDKIYDCSQ CPQKFFFQTE
1310
LQNHTMSQHA Q
Length:1,311
Mass (Da):147,227
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A5680DA502B7E36
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LR04F1LR04_RAT
Zinc finger protein 423
Zfp423 rCG_44267
1,167Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA42353 differs from that shown. Reason: Frameshift.Curated
The sequence AAB58646 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L03386 mRNA Translation: AAA42353.1 Frameshift.
U92564 mRNA Translation: AAB58646.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
T33754
T34020

NCBI Reference Sequences

More...
RefSeqi
NP_446035.2, NM_053583.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:94188

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03386 mRNA Translation: AAA42353.1 Frameshift.
U92564 mRNA Translation: AAB58646.1 Different initiation.
PIRiT33754
T34020
RefSeqiNP_446035.2, NM_053583.2

3D structure databases

BMRBiO08961
SMRiO08961
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi250171, 1 interactor
STRINGi10116.ENSRNOP00000020028

Proteomic databases

PaxDbiO08961
PRIDEiO08961

Genome annotation databases

GeneIDi94188
KEGGirno:94188

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
94187
RGDi621664, Zfp423

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
InParanoidiO08961
OrthoDBi1318335at2759
PhylomeDBiO08961

Miscellaneous databases

Protein Ontology

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PROi
PR:O08961

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN423_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08961
Secondary accession number(s): Q63681
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 2, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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