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Protein

Zinc finger protein SNAI2

Gene

Snai2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 264C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to fibroblast growth factor stimulus Source: RGD
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • regulation of transcription, DNA-templated Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI2
Alternative name(s):
Neural crest transcription factor Slug
Protein snail homolog 2
Gene namesi
Name:Snai2
Synonyms:Slug, Slugh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3722 Snai2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470341 – 268Zinc finger protein SNAI2Add BLAST268

Post-translational modificationi

GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.By similarity

Proteomic databases

PaxDbiO08954
PRIDEiO08954

Expressioni

Gene expression databases

BgeeiENSRNOG00000047699 Expressed in 8 organ(s), highest expression level in liver
GenevisibleiO08954 RN

Interactioni

Subunit structurei

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1 and TNPO1. May interact (via zinc fingers) with IPO7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064195

Structurei

3D structure databases

ProteinModelPortaliO08954
SMRiO08954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 264C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOVERGENiHBG007477
InParanoidiO08954
KOiK05706
OMAiYSPITMW
OrthoDBiEOG091G0Q0V
PhylomeDBiO08954

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

O08954-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLCESYPMP VIPKPEILTS
60 70 80 90 100
GAYSPITVWT SAVPFHSPLP SGLSPLTGYS SSLGRVSPLP SSDTSSKDHS
110 120 130 140 150
GSESPISDEE ERLQPKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH
160 170 180 190 200
CDAQARKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL
210 220 230 240 250
QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF
260
SRMSLLHKHE ESGCCVAH
Length:268
Mass (Da):29,936
Last modified:December 6, 2005 - v2
Checksum:i92B6325E54CEFD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497973 mRNA Translation: AAM19227.1
U97061 mRNA Translation: AAB58706.1
RefSeqiNP_037167.1, NM_013035.1
UniGeneiRn.43117

Genome annotation databases

EnsembliENSRNOT00000073049; ENSRNOP00000064195; ENSRNOG00000047699
GeneIDi25554
KEGGirno:25554

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497973 mRNA Translation: AAM19227.1
U97061 mRNA Translation: AAB58706.1
RefSeqiNP_037167.1, NM_013035.1
UniGeneiRn.43117

3D structure databases

ProteinModelPortaliO08954
SMRiO08954
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064195

Proteomic databases

PaxDbiO08954
PRIDEiO08954

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073049; ENSRNOP00000064195; ENSRNOG00000047699
GeneIDi25554
KEGGirno:25554

Organism-specific databases

CTDi6591
RGDi3722 Snai2

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOVERGENiHBG007477
InParanoidiO08954
KOiK05706
OMAiYSPITMW
OrthoDBiEOG091G0Q0V
PhylomeDBiO08954

Miscellaneous databases

PROiPR:O08954

Gene expression databases

BgeeiENSRNOG00000047699 Expressed in 8 organ(s), highest expression level in liver
GenevisibleiO08954 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNAI2_RAT
AccessioniPrimary (citable) accession number: O08954
Secondary accession number(s): Q8R482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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