Zinc finger protein SNAI2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Adipose tissue mass is modulated by SLUG (SNAI2)."
    Perez-Mancera P.A., Bermejo-Rodriguez C., Gonzalez-Herrero I., Herranz M., Flores T., Jimenez R., Sanchez-Garcia I.
    Hum. Mol. Genet. 16:2972-2986(2007) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo."
    Roman A.C., Benitez D.A., Carvajal-Gonzalez J.M., Fernandez-Salguero P.M.
    Proc. Natl. Acad. Sci. U.S.A. 105:1632-1637(2008) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]
  • "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
  • "Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma."
    Wu W.S., Heinrichs S., Xu D., Garrison S.P., Zambetti G.P., Adams J.M., Look A.T.
    Cell 123:641-653(2005) [PubMed] [Europe PMC] [Abstract]
  • "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J. Cell Biol. 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: RGDInferred from sequence orthologyⁱ
  • "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein."
    Inukai T., Inoue A., Kurosawa H., Goi K., Shinjyo T., Ozawa K., Mao M., Inaba T., Look A.T.
    Mol. Cell 4:343-352(1999) [PubMed] [Europe PMC] [Abstract]
  • "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cartilage morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Multiple functions of Snail family genes during palate development in mice."
    Murray S.A., Oram K.F., Gridley T.
    Development 134:1789-1797(2007) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Multiple functions of Snail family genes during palate development in mice."
    Murray S.A., Oram K.F., Gridley T.
    Development 134:1789-1797(2007) [PubMed] [Europe PMC] [Abstract]
• cell migration involved in endocardial cushion formation Source: RGDInferred from sequence orthologyⁱ
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J. Cell Biol. 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to epidermal growth factor stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Erk5 controls Slug expression and keratinocyte activation during wound healing."
    Arnoux V., Nassour M., L'Helgoualc'h A., Hipskind R.A., Savagner P.
    Mol. Biol. Cell 19:4738-4749(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to fibroblast growth factor stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.2

    "The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition."
    Savagner P., Yamada K.M., Thiery J.P.
    J. Cell Biol. 137:1403-1419(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-172.
• cellular response to ionizing radiation Source: RGDInferred from sequence orthologyⁱ
  • "Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma."
    Wu W.S., Heinrichs S., Xu D., Garrison S.P., Zambetti G.P., Adams J.M., Look A.T.
    Cell 123:641-653(2005) [PubMed] [Europe PMC] [Abstract]
• desmosome disassembly Source: RGDInferred from sequence orthologyⁱ
  • Ref.2

    "The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition."
    Savagner P., Yamada K.M., Thiery J.P.
    J. Cell Biol. 137:1403-1419(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-172.
• epithelial to mesenchymal transition Source: RGDInferred from sequence orthologyⁱ
  • "Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis."
    Newkirk K.M., Parent A.E., Fossey S.L., Choi C., Chandler H.L., Rajala-Schultz P.J., Kusewitt D.F.
    Am. J. Pathol. 171:1629-1639(2007) [PubMed] [Europe PMC] [Abstract]
  • "Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin."
    Leong K.G., Niessen K., Kulic I., Raouf A., Eaves C., Pollet I., Karsan A.
    J. Exp. Med. 204:2935-2948(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition."
    Savagner P., Yamada K.M., Thiery J.P.
    J. Cell Biol. 137:1403-1419(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-172.
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGDInferred from sequence orthologyⁱ
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J. Cell Biol. 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• epithelium development Source: RGDInferred from sequence orthologyⁱ
  • "Erk5 controls Slug expression and keratinocyte activation during wound healing."
    Arnoux V., Nassour M., L'Helgoualc'h A., Hipskind R.A., Savagner P.
    Mol. Biol. Cell 19:4738-4749(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of anoikis Source: RGDInferred from sequence orthologyⁱ
  • "Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin."
    Leong K.G., Niessen K., Kulic I., Raouf A., Eaves C., Pollet I., Karsan A.
    J. Exp. Med. 204:2935-2948(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma."
    Wu W.S., Heinrichs S., Xu D., Garrison S.P., Zambetti G.P., Adams J.M., Look A.T.
    Cell 123:641-653(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
  • "Slug gene expression supports human osteoblast maturation."
    Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R.
    Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell adhesion involved in substrate-bound cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J. Cell Biol. 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter Source: RGDInferred from sequence orthologyⁱ
  • "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells."
    Tripathi M.K., Misra S., Chaudhuri G.
    Biochem. Biophys. Res. Commun. 329:508-515(2005) [PubMed] [Europe PMC] [Abstract]
  • "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
  • "Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin."
    Leong K.G., Niessen K., Kulic I., Raouf A., Eaves C., Pollet I., Karsan A.
    J. Exp. Med. 204:2935-2948(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of chondrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Slug gene expression supports human osteoblast maturation."
    Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R.
    Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA damage response, signal transduction by p53 class mediator Source: RGDInferred from sequence orthologyⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol. Cell. Biol. 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGDInferred from sequence orthologyⁱ
  • "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein."
    Inukai T., Inoue A., Kurosawa H., Goi K., Shinjyo T., Ozawa K., Mao M., Inaba T., Look A.T.
    Mol. Cell 4:343-352(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: RGDInferred from sequence orthologyⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol. Cell. Biol. 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of keratinocyte proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of stem cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration."
    Sun Y., Shao L., Bai H., Wang Z.Z., Wu W.S.
    Blood 115:1709-1717(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells."
    Schmidt C.R., Gi Y.J., Patel T.A., Coffey R.J., Beauchamp R.D., Pearson A.S.
    Surgery 138:306-312(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vitamin D biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells."
    Mittal M.K., Myers J.N., Misra S., Bailey C.K., Chaudhuri G.
    Biochem. Biophys. Res. Commun. 372:30-34(2008) [PubMed] [Europe PMC] [Abstract]
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vitamin D receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer."
    Larriba M.J., Martin-Villar E., Garcia J.M., Pereira F., Pena C., de Herreros A.G., Bonilla F., Munoz A.
    Carcinogenesis 30:1459-1468(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: RGDInferred from sequence orthologyⁱ
  • "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Slug is a direct Notch target required for initiation of cardiac cushion cellularization."
    Niessen K., Fu Y., Chang L., Hoodless P.A., McFadden D., Karsan A.
    J. Cell Biol. 182:315-325(2008) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts."
    Lambertini E., Franceschetti T., Torreggiani E., Penolazzi L., Pastore A., Pelucchi S., Gambari R., Piva R.
    BMC Mol. Biol. 11:13-13(2010) [PubMed] [Europe PMC] [Abstract]
• pigmentation Source: RGDInferred from sequence orthologyⁱ
  • "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol. Cell. Biol. 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Adipose tissue mass is modulated by SLUG (SNAI2)."
    Perez-Mancera P.A., Bermejo-Rodriguez C., Gonzalez-Herrero I., Herranz M., Flores T., Jimenez R., Sanchez-Garcia I.
    Hum. Mol. Genet. 16:2972-2986(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of histone acetylation Source: RGDInferred from sequence orthologyⁱ
  • "Adipose tissue mass is modulated by SLUG (SNAI2)."
    Perez-Mancera P.A., Bermejo-Rodriguez C., Gonzalez-Herrero I., Herranz M., Flores T., Jimenez R., Sanchez-Garcia I.
    Hum. Mol. Genet. 16:2972-2986(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of bicellular tight junction assembly Source: RGDInferred from sequence orthologyⁱ
  • "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress."
    Kajita M., McClinic K.N., Wade P.A.
    Mol. Cell. Biol. 24:7559-7566(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of branching involved in salivary gland morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Btbd7 regulates epithelial cell dynamics and branching morphogenesis."
    Onodera T., Sakai T., Hsu J.C., Matsumoto K., Chiorini J.A., Yamada K.M.
    Science 329:562-565(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of chemokine production Source: RGDInferred from sequence orthologyⁱ
  • "Slug contributes to the regulation of CXCL12 expression in human osteoblasts."
    Piva R., Manferdini C., Lambertini E., Torreggiani E., Penolazzi L., Gambari R., Pastore A., Pelucchi S., Gabusi E., Piacentini A., Filardo G., Facchini A., Lisignoli G.
    Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Slug gene expression supports human osteoblast maturation."
    Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R.
    Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract]
  • "Slug contributes to the regulation of CXCL12 expression in human osteoblasts."
    Piva R., Manferdini C., Lambertini E., Torreggiani E., Penolazzi L., Gambari R., Pastore A., Pelucchi S., Gabusi E., Piacentini A., Filardo G., Facchini A., Lisignoli G.
    Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to radiation Source: RGDInferred from sequence orthologyⁱ
  • "The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug."
    Perez-Losada J., Sanchez-Martin M., Perez-Caro M., Perez-Mancera P.A., Sanchez-Garcia I.
    Oncogene 22:4205-4211(2003) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: RGDInferred from sequence orthologyⁱ
  • "Multiple functions of Snail family genes during palate development in mice."
    Murray S.A., Oram K.F., Gridley T.
    Development 134:1789-1797(2007) [PubMed] [Europe PMC] [Abstract]
• sensory perception of sound Source: RGDInferred from sequence orthologyⁱ
  • "SLUG (SNAI2) deletions in patients with Waardenburg disease."
    Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I.
    Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract]
• white fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Adipose tissue mass is modulated by SLUG (SNAI2)."
    Perez-Mancera P.A., Bermejo-Rodriguez C., Gonzalez-Herrero I., Herranz M., Flores T., Jimenez R., Sanchez-Garcia I.
    Hum. Mol. Genet. 16:2972-2986(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLCESYPMP VIPKPEILTS 
        60         70         80         90        100
GAYSPITVWT SAVPFHSPLP SGLSPLTGYS SSLGRVSPLP SSDTSSKDHS 
       110        120        130        140        150
GSESPISDEE ERLQPKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH 
       160        170        180        190        200
CDAQARKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL 
       210        220        230        240        250
QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF 
       260 
SRMSLLHKHE ESGCCVAH                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families