UniProtKB - O08918 (CCNG2_MOUSE)
Protein
Cyclin-G2
Gene
Ccng2
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in growth regulation and in negative regulation of cell cycle progression.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cell cycle Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-G2 |
Gene namesi | Name:Ccng2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1095734, Ccng2 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080470 | 1 – 344 | Cyclin-G2Add BLAST | 344 |
Proteomic databases
PaxDbi | O08918 |
PRIDEi | O08918 |
PTM databases
iPTMneti | O08918 |
PhosphoSitePlusi | O08918 |
Expressioni
Tissue specificityi
Highest levels in intestine. Intermediate levels in spleen, brain and kidney. Low levels in testis, stomach, pancreas, liver, salivary gland and muscle. According to PubMed:9139721 also abundant in thymus.
Developmental stagei
Expression levels oscillate moderately through the cell cycle.
Inductioni
Activated in B-cells by agents causing growth inhibition or growth arrest.
Gene expression databases
Bgeei | ENSMUSG00000029385, Expressed in thymus and 296 other tissues |
Genevisiblei | O08918, MM |
Interactioni
Protein-protein interaction databases
DIPi | DIP-24180N |
STRINGi | 10090.ENSMUSP00000031331 |
Miscellaneous databases
RNActi | O08918, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000156423 |
HOGENOMi | CLU_062642_0_1_1 |
InParanoidi | O08918 |
OMAi | CWDESES |
OrthoDBi | 1015714at2759 |
PhylomeDBi | O08918 |
TreeFami | TF101007 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR028895, CCNG2 IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF60, PTHR10177:SF60, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
i Sequence
Sequence statusi: Complete.
O08918-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDLGAKHLA GGEGVQLFGL LNFYLEQEQR YQPREKGLIL MEATPENDNT
60 70 80 90 100
LCSRLRNAKV EDLRSLTNFF GSGTETFVLA VNILDRFLAL MKVKPKHLSC
110 120 130 140 150
IGVCCFLLAA RLAEEEGDVP PTHDVIRISQ CKCTASDIKR MEKIISEKLH
160 170 180 190 200
YELEATTALN FLHLYHAIVF CHTSERKEIL SLDKLEAQLK ACNCRVVFSK
210 220 230 240 250
ARPSVLALCL LNLEIETIKS VELLEILLLV KKHLKLSDTE FFYWRELVSK
260 270 280 290 300
CLAEYSSPRC CKPDLKKLVW IVSRRTAQNL HSSYYSVPEL PTIPEGGCFD
310 320 330 340
GSESEDSGED MSCGEESLSS SPPSDQECTF FFDFQVAQTL CFPP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U95826 mRNA Translation: AAB58693.1 AF005885 mRNA Translation: AAC28496.1 AF079877 Genomic DNA Translation: AAC32372.1 AB035264 Genomic DNA Translation: BAA87065.1 |
CCDSi | CCDS19437.1 |
RefSeqi | NP_031661.3, NM_007635.4 |
Genome annotation databases
Ensembli | ENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385 ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385 |
GeneIDi | 12452 |
KEGGi | mmu:12452 |
UCSCi | uc008yee.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U95826 mRNA Translation: AAB58693.1 AF005885 mRNA Translation: AAC28496.1 AF079877 Genomic DNA Translation: AAC32372.1 AB035264 Genomic DNA Translation: BAA87065.1 |
CCDSi | CCDS19437.1 |
RefSeqi | NP_031661.3, NM_007635.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-24180N |
STRINGi | 10090.ENSMUSP00000031331 |
PTM databases
iPTMneti | O08918 |
PhosphoSitePlusi | O08918 |
Proteomic databases
PaxDbi | O08918 |
PRIDEi | O08918 |
Protocols and materials databases
Antibodypediai | 13540, 131 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385 ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385 |
GeneIDi | 12452 |
KEGGi | mmu:12452 |
UCSCi | uc008yee.2, mouse |
Organism-specific databases
CTDi | 901 |
MGIi | MGI:1095734, Ccng2 |
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000156423 |
HOGENOMi | CLU_062642_0_1_1 |
InParanoidi | O08918 |
OMAi | CWDESES |
OrthoDBi | 1015714at2759 |
PhylomeDBi | O08918 |
TreeFami | TF101007 |
Miscellaneous databases
BioGRID-ORCSi | 12452, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ccng2, mouse |
PROi | PR:O08918 |
RNActi | O08918, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029385, Expressed in thymus and 296 other tissues |
Genevisiblei | O08918, MM |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR028895, CCNG2 IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF60, PTHR10177:SF60, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNG2_MOUSE | |
Accessioni | O08918Primary (citable) accession number: O08918 Secondary accession number(s): O35612 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families