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Protein

Cyclin-G2

Gene

Ccng2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in growth regulation and in negative regulation of cell cycle progression.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of cell cycle Source: MGI

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-G2
Gene namesi
Name:Ccng2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1095734 Ccng2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804701 – 344Cyclin-G2Add BLAST344

Proteomic databases

PaxDbiO08918
PRIDEiO08918

PTM databases

iPTMnetiO08918
PhosphoSitePlusiO08918

Expressioni

Tissue specificityi

Highest levels in intestine. Intermediate levels in spleen, brain and kidney. Low levels in testis, stomach, pancreas, liver, salivary gland and muscle. According to PubMed:9139721 also abundant in thymus.

Developmental stagei

Expression levels oscillate moderately through the cell cycle.

Inductioni

Activated in B-cells by agents causing growth inhibition or growth arrest.

Gene expression databases

BgeeiENSMUSG00000029385 Expressed in 282 organ(s), highest expression level in ganglionic eminence
CleanExiMM_CCNG2
ExpressionAtlasiO08918 baseline and differential
GenevisibleiO08918 MM

Interactioni

Protein-protein interaction databases

DIPiDIP-24180N
STRINGi10090.ENSMUSP00000031331

Structurei

3D structure databases

ProteinModelPortaliO08918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000059559
HOVERGENiHBG050839
InParanoidiO08918
KOiK10146
OMAiDLWSLTS
OrthoDBiEOG091G0HQN
PhylomeDBiO08918
TreeFamiTF101007

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028895 CCNG2
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF60 PTHR10177:SF60, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequencei

Sequence statusi: Complete.

O08918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDLGAKHLA GGEGVQLFGL LNFYLEQEQR YQPREKGLIL MEATPENDNT
60 70 80 90 100
LCSRLRNAKV EDLRSLTNFF GSGTETFVLA VNILDRFLAL MKVKPKHLSC
110 120 130 140 150
IGVCCFLLAA RLAEEEGDVP PTHDVIRISQ CKCTASDIKR MEKIISEKLH
160 170 180 190 200
YELEATTALN FLHLYHAIVF CHTSERKEIL SLDKLEAQLK ACNCRVVFSK
210 220 230 240 250
ARPSVLALCL LNLEIETIKS VELLEILLLV KKHLKLSDTE FFYWRELVSK
260 270 280 290 300
CLAEYSSPRC CKPDLKKLVW IVSRRTAQNL HSSYYSVPEL PTIPEGGCFD
310 320 330 340
GSESEDSGED MSCGEESLSS SPPSDQECTF FFDFQVAQTL CFPP
Length:344
Mass (Da):38,848
Last modified:December 1, 2000 - v3
Checksum:iF6A02698C286D853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95826 mRNA Translation: AAB58693.1
AF005885 mRNA Translation: AAC28496.1
AF079877 Genomic DNA Translation: AAC32372.1
AB035264 Genomic DNA Translation: BAA87065.1
CCDSiCCDS19437.1
RefSeqiNP_031661.3, NM_007635.4
UniGeneiMm.3527

Genome annotation databases

EnsembliENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385
ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385
GeneIDi12452
KEGGimmu:12452
UCSCiuc008yee.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95826 mRNA Translation: AAB58693.1
AF005885 mRNA Translation: AAC28496.1
AF079877 Genomic DNA Translation: AAC32372.1
AB035264 Genomic DNA Translation: BAA87065.1
CCDSiCCDS19437.1
RefSeqiNP_031661.3, NM_007635.4
UniGeneiMm.3527

3D structure databases

ProteinModelPortaliO08918
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24180N
STRINGi10090.ENSMUSP00000031331

PTM databases

iPTMnetiO08918
PhosphoSitePlusiO08918

Proteomic databases

PaxDbiO08918
PRIDEiO08918

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385
ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385
GeneIDi12452
KEGGimmu:12452
UCSCiuc008yee.2 mouse

Organism-specific databases

CTDi901
MGIiMGI:1095734 Ccng2

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00530000062971
HOGENOMiHOG000059559
HOVERGENiHBG050839
InParanoidiO08918
KOiK10146
OMAiDLWSLTS
OrthoDBiEOG091G0HQN
PhylomeDBiO08918
TreeFamiTF101007

Miscellaneous databases

PROiPR:O08918
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029385 Expressed in 282 organ(s), highest expression level in ganglionic eminence
CleanExiMM_CCNG2
ExpressionAtlasiO08918 baseline and differential
GenevisibleiO08918 MM

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028895 CCNG2
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF60 PTHR10177:SF60, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNG2_MOUSE
AccessioniPrimary (citable) accession number: O08918
Secondary accession number(s): O35612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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