Ccng2

Functionⁱ

May play a role in growth regulation and in negative regulation of cell cycle progression.

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein phosphorylation Source: GOC
regulation of cell cycle
Source: MGI
Inferred from direct assayⁱ
- 12930811
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic nuclear division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division, Mitosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-G2
Gene namesⁱ	Name:Ccng2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1095734 Ccng2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080470	1 – 344	Cyclin-G2Add BLAST		344

Proteomic databases

PaxDbⁱ	O08918
PRIDEⁱ	O08918

PTM databases

iPTMnetⁱ	O08918
PhosphoSitePlusⁱ	O08918

Expressionⁱ

Tissue specificityⁱ

Highest levels in intestine. Intermediate levels in spleen, brain and kidney. Low levels in testis, stomach, pancreas, liver, salivary gland and muscle. According to PubMed:9139721 also abundant in thymus.

Developmental stageⁱ

Expression levels oscillate moderately through the cell cycle.

Inductionⁱ

Activated in B-cells by agents causing growth inhibition or growth arrest.

Gene expression databases

Bgeeⁱ	ENSMUSG00000029385 Expressed in 282 organ(s), highest expression level in ganglionic eminence
CleanExⁱ	MM_CCNG2
ExpressionAtlasⁱ	O08918 baseline and differential
Genevisibleⁱ	O08918 MM

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-24180N
STRINGⁱ	10090.ENSMUSP00000031331

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08918
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin G subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062971
HOGENOMⁱ	HOG000059559
HOVERGENⁱ	HBG050839
InParanoidⁱ	O08918
KEGG Orthology (KO) More...KOⁱ	K10146
OMAⁱ	DLWSLTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HQN
PhylomeDBⁱ	O08918
TreeFamⁱ	TF101007

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR028895 CCNG2 IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF60 PTHR10177:SF60, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O08918-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKDLGAKHLA GGEGVQLFGL LNFYLEQEQR YQPREKGLIL MEATPENDNT 
        60         70         80         90        100
LCSRLRNAKV EDLRSLTNFF GSGTETFVLA VNILDRFLAL MKVKPKHLSC 
       110        120        130        140        150
IGVCCFLLAA RLAEEEGDVP PTHDVIRISQ CKCTASDIKR MEKIISEKLH 
       160        170        180        190        200
YELEATTALN FLHLYHAIVF CHTSERKEIL SLDKLEAQLK ACNCRVVFSK 
       210        220        230        240        250
ARPSVLALCL LNLEIETIKS VELLEILLLV KKHLKLSDTE FFYWRELVSK 
       260        270        280        290        300
CLAEYSSPRC CKPDLKKLVW IVSRRTAQNL HSSYYSVPEL PTIPEGGCFD 
       310        320        330        340 
GSESEDSGED MSCGEESLSS SPPSDQECTF FFDFQVAQTL CFPP

Length:344

Mass (Da):38,848

Last modified:December 1, 2000 - v3

Checksum:ⁱF6A02698C286D853

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U95826 mRNA Translation: AAB58693.1 AF005885 mRNA Translation: AAC28496.1 AF079877 Genomic DNA Translation: AAC32372.1 AB035264 Genomic DNA Translation: BAA87065.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19437.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031661.3, NM_007635.4
UniGeneⁱ	Mm.3527

Genome annotation databases

Ensemblⁱ	ENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385 ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385
GeneIDⁱ	12452
KEGGⁱ	mmu:12452
UCSC genome browser More...UCSCⁱ	uc008yee.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08918	Cyclin G2		MOUSE		344	UniRef100_O08918

Protein	Similar proteins		Species	Score	Length	Source
O08918	Cyclin G2		MOUSE		344	UniRef90_O08918
UPI00038BB910		MICOH		344
UPI000A310D63		MUSPA		344
Uncharacterized protein		MOUSE		344
Uncharacterized protein		MOUSE		344
+1

Protein	Similar proteins		Species	Score	Length	Source
O08918	Cyclin-G2		HUMAN		344	UniRef50_Q16589
CCNG2 isoform 1		PANTR		344
Uncharacterized protein		PANPA		344
Cyclin-G2		TUPCH		392
Cyclin-G2		HETGA		345
+311

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U95826 mRNA Translation: AAB58693.1 AF005885 mRNA Translation: AAC28496.1 AF079877 Genomic DNA Translation: AAC32372.1 AB035264 Genomic DNA Translation: BAA87065.1
CCDSⁱ	CCDS19437.1
RefSeqⁱ	NP_031661.3, NM_007635.4
UniGeneⁱ	Mm.3527

3D structure databases

ProteinModelPortalⁱ	O08918
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-24180N
STRINGⁱ	10090.ENSMUSP00000031331

PTM databases

iPTMnetⁱ	O08918
PhosphoSitePlusⁱ	O08918

Proteomic databases

PaxDbⁱ	O08918
PRIDEⁱ	O08918

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385 ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385
GeneIDⁱ	12452
KEGGⁱ	mmu:12452
UCSCⁱ	uc008yee.2 mouse

Organism-specific databases

CTDⁱ	901
MGIⁱ	MGI:1095734 Ccng2

Phylogenomic databases

eggNOGⁱ	KOG0653 Eukaryota COG5024 LUCA
GeneTreeⁱ	ENSGT00530000062971
HOGENOMⁱ	HOG000059559
HOVERGENⁱ	HBG050839
InParanoidⁱ	O08918
KOⁱ	K10146
OMAⁱ	DLWSLTS
OrthoDBⁱ	EOG091G0HQN
PhylomeDBⁱ	O08918
TreeFamⁱ	TF101007

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O08918
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029385 Expressed in 282 organ(s), highest expression level in ganglionic eminence
CleanExⁱ	MM_CCNG2
ExpressionAtlasⁱ	O08918 baseline and differential
Genevisibleⁱ	O08918 MM

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR028895 CCNG2 IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF60 PTHR10177:SF60, 1 hit
Pfamⁱ	View protein in Pfam PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNG2_MOUSE
Accessionⁱ	O08918Primary (citable) accession number: O08918 Secondary accession number(s): O35612
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08918 (CCNG2_MOUSE)

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Cyclin-G2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ