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Protein

AH receptor-interacting protein

Gene

Aip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8937144 Aryl hydrocarbon receptor signalling

Names & Taxonomyi

Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
Gene namesi
Name:Aip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:109622 Aip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753401 – 330AH receptor-interacting proteinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08915
MaxQBiO08915
PaxDbiO08915
PeptideAtlasiO08915
PRIDEiO08915

2D gel databases

REPRODUCTION-2DPAGEiO08915

PTM databases

iPTMnetiO08915
PhosphoSitePlusiO08915

Expressioni

Gene expression databases

BgeeiENSMUSG00000024847 Expressed in 288 organ(s), highest expression level in ear vesicle
CleanExiMM_AIP
ExpressionAtlasiO08915 baseline and differential
GenevisibleiO08915 MM

Interactioni

Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198043, 2 interactors
CORUMiO08915
IntActiO08915, 4 interactors
MINTiO08915
STRINGi10090.ENSMUSP00000025767

Structurei

3D structure databases

ProteinModelPortaliO08915
SMRiO08915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 121PPIase FKBP-typeAdd BLAST91
Repeati179 – 212TPR 1Add BLAST34
Repeati231 – 264TPR 2Add BLAST34
Repeati265 – 298TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545 Eukaryota
ENOG410YGYV LUCA
GeneTreeiENSGT00390000001289
HOGENOMiHOG000007366
HOVERGENiHBG004198
InParanoidiO08915
KOiK17767
OMAiYEVIEHC
OrthoDBiEOG091G0C69
PhylomeDBiO08915
TreeFamiTF314507

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031208 AIP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11242:SF3 PTHR11242:SF3, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADLIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHFRT LHSDNEGSVI
60 70 80 90 100
DDSRTRGKPM ELIVGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HIEMLKVESP GTYQQDPWAM TDEEKAKAVP VIHQEGNRLY REGQVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELRALE TRIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,605
Last modified:July 1, 1997 - v1
Checksum:i25C61AB65F9064F2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW40D3YW40_MOUSE
AH receptor-interacting protein
Aip
172Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85489 mRNA Translation: AAB59009.1
AK146390 mRNA Translation: BAE27133.1
BC075614 mRNA Translation: AAH75614.1
CCDSiCCDS29415.1
RefSeqiNP_001263213.1, NM_001276284.1
NP_057875.1, NM_016666.3
XP_006531704.2, XM_006531641.3
XP_006531705.1, XM_006531642.3
UniGeneiMm.10433

Genome annotation databases

EnsembliENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847
ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847
ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319
ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319
GeneIDi11632
KEGGimmu:11632
UCSCiuc008fyp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85489 mRNA Translation: AAB59009.1
AK146390 mRNA Translation: BAE27133.1
BC075614 mRNA Translation: AAH75614.1
CCDSiCCDS29415.1
RefSeqiNP_001263213.1, NM_001276284.1
NP_057875.1, NM_016666.3
XP_006531704.2, XM_006531641.3
XP_006531705.1, XM_006531642.3
UniGeneiMm.10433

3D structure databases

ProteinModelPortaliO08915
SMRiO08915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198043, 2 interactors
CORUMiO08915
IntActiO08915, 4 interactors
MINTiO08915
STRINGi10090.ENSMUSP00000025767

PTM databases

iPTMnetiO08915
PhosphoSitePlusiO08915

2D gel databases

REPRODUCTION-2DPAGEiO08915

Proteomic databases

EPDiO08915
MaxQBiO08915
PaxDbiO08915
PeptideAtlasiO08915
PRIDEiO08915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025767; ENSMUSP00000025767; ENSMUSG00000024847
ENSMUST00000117831; ENSMUSP00000113807; ENSMUSG00000024847
ENSMUST00000180758; ENSMUSP00000137722; ENSMUSG00000097319
ENSMUST00000181243; ENSMUSP00000137847; ENSMUSG00000097319
GeneIDi11632
KEGGimmu:11632
UCSCiuc008fyp.2 mouse

Organism-specific databases

CTDi9049
MGIiMGI:109622 Aip

Phylogenomic databases

eggNOGiKOG0545 Eukaryota
ENOG410YGYV LUCA
GeneTreeiENSGT00390000001289
HOGENOMiHOG000007366
HOVERGENiHBG004198
InParanoidiO08915
KOiK17767
OMAiYEVIEHC
OrthoDBiEOG091G0C69
PhylomeDBiO08915
TreeFamiTF314507

Enzyme and pathway databases

ReactomeiR-MMU-8937144 Aryl hydrocarbon receptor signalling

Miscellaneous databases

ChiTaRSiAip mouse
PROiPR:O08915
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024847 Expressed in 288 organ(s), highest expression level in ear vesicle
CleanExiMM_AIP
ExpressionAtlasiO08915 baseline and differential
GenevisibleiO08915 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031208 AIP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11242:SF3 PTHR11242:SF3, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIP_MOUSE
AccessioniPrimary (citable) accession number: O08915
Secondary accession number(s): Q3UJM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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