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Protein

Regulator of G-protein signaling 4

Gene

Rgs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 4
Short name:
RGS4
Gene namesi
Name:Rgs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108409 Rgs4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041861 – 205Regulator of G-protein signaling 4Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteineBy similarity1
Lipidationi12S-palmitoyl cysteineBy similarity1
Lipidationi95S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Either Cys-2 or Cys-12 or both are palmitoylated.By similarity
Phosphorylated by cyclic GMP-dependent protein kinase.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO08899
PRIDEiO08899

PTM databases

iPTMnetiO08899
PhosphoSitePlusiO08899

Expressioni

Tissue specificityi

Expressed at high levels in brain, moderately low levels in heart, and very low levels in lung, liver, and skeletal muscle.

Gene expression databases

CleanExiMM_RGS4

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ELMiO08899
STRINGi10090.ENSMUSP00000027991

Structurei

3D structure databases

ProteinModelPortaliO08899
SMRiO08899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 178RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO08899
KOiK16449
PhylomeDBiO08899

Family and domain databases

CDDicd08714 RGS_RGS4, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034952 RGS4
IPR034953 RGS_RGS4
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF184 PTHR10845:SF184, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O08899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR
60 70 80 90 100
VSQEEVKKWA ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
110 120 130 140 150
IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLQPTITCFD
160 170 180 190 200
EAQKKIFNLM ERDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL

VSQCA
Length:205
Mass (Da):23,289
Last modified:July 1, 1997 - v1
Checksum:i5D79581711A1F67C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5D078Q5D078_MOUSE
Regulator of G-protein signaling 4
Rgs4
205Annotation score:
D3YXR2D3YXR2_MOUSE
Regulator of G-protein-signaling 4
Rgs4
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162R → K in AAH03882 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004315 mRNA Translation: BAA20400.1
BC003882 mRNA Translation: AAH03882.1
CCDSiCCDS15465.1
RefSeqiNP_033088.2, NM_009062.3
UniGeneiMm.41642

Genome annotation databases

GeneIDi19736
KEGGimmu:19736

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004315 mRNA Translation: BAA20400.1
BC003882 mRNA Translation: AAH03882.1
CCDSiCCDS15465.1
RefSeqiNP_033088.2, NM_009062.3
UniGeneiMm.41642

3D structure databases

ProteinModelPortaliO08899
SMRiO08899
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiO08899
STRINGi10090.ENSMUSP00000027991

PTM databases

iPTMnetiO08899
PhosphoSitePlusiO08899

Proteomic databases

PaxDbiO08899
PRIDEiO08899

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19736
KEGGimmu:19736

Organism-specific databases

CTDi5999
MGIiMGI:108409 Rgs4

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO08899
KOiK16449
PhylomeDBiO08899

Miscellaneous databases

ChiTaRSiRgs4 mouse
PROiPR:O08899
SOURCEiSearch...

Gene expression databases

CleanExiMM_RGS4

Family and domain databases

CDDicd08714 RGS_RGS4, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034952 RGS4
IPR034953 RGS_RGS4
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF184 PTHR10845:SF184, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS4_MOUSE
AccessioniPrimary (citable) accession number: O08899
Secondary accession number(s): Q99L30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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