G-protein coupled estrogen receptor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts."
    Madeo A., Maggiolini M.
    Cancer Res. 70:6036-6046(2010) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats."
    Deschamps A.M., Murphy E.
    Am. J. Physiol. Heart Circ. Physiol. 297:H1806-13(2009) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• G protein-coupled receptor activity Source: UniProtKB-KW
• hormone binding Source: RGDInferred from direct assayⁱ
  • "Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells."
    Lucas T.F., Royer C., Siu E.R., Lazari M.F., Porto C.S.
    Biol. Reprod. 83:307-317(2010) [PubMed] [Europe PMC] [Abstract]
• steroid binding Source: RGDInferred from direct assayⁱ
  • "Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells."
    Lucas T.F., Royer C., Siu E.R., Lazari M.F., Porto C.S.
    Biol. Reprod. 83:307-317(2010) [PubMed] [Europe PMC] [Abstract]
• steroid hormone binding Source: UniProtKB
• steroid hormone receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.

GO - Biological processⁱ

• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
• apoptotic chromosome condensation Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• cell cycle Source: UniProtKB-KW
• cellular response to estradiol stimulus Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to glucose stimulus Source: UniProtKB
• cellular response to mineralocorticoid stimulus Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• cellular response to peptide hormone stimulus Source: UniProtKB
• cellular response to tumor necrosis factor Source: UniProtKB
• G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: UniProtKB-KW
• innate immune response Source: UniProtKB-KW
• intracellular steroid hormone receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells."
    Lucas T.F., Royer C., Siu E.R., Lazari M.F., Porto C.S.
    Biol. Reprod. 83:307-317(2010) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: RGDInferred from sequence orthologyⁱ
  • "GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice."
    Xu W., Cao J., Zhou Y., Wang L., Zhu G.
    Neurobiol Learn Mem 149:10-19(2018) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle arrest Source: UniProtKB
• negative regulation of cell cycle process Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA metabolic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• negative regulation of ERK1 and ERK2 cascade Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: UniProtKB
• negative regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: UniProtKB
• negative regulation of leukocyte activation Source: UniProtKB
• negative regulation of lipid biosynthetic process Source: UniProtKB
• negative regulation of protein kinase B signaling Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of vascular associated smooth muscle cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: UniProtKB
• nuclear fragmentation involved in apoptotic nuclear change Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel diameter Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• positive regulation of cardiac vascular smooth muscle cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation."
    Li F., Yu X., Szynkarski C.K., Meng C., Zhou B., Barhoumi R., White R.E., Heaps C.L., Stallone J.N., Han G.
    PLoS ONE 8:e64771-e64771(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: UniProtKB
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: UniProtKB
• positive regulation of endothelial cell apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• positive regulation of epidermal growth factor receptor signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells."
    Lucas T.F., Royer C., Siu E.R., Lazari M.F., Porto C.S.
    Biol. Reprod. 83:307-317(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
• positive regulation of inositol trisphosphate biosynthetic process Source: UniProtKB
• positive regulation of insulin secretion Source: UniProtKB
• positive regulation of MAPK cascade Source: UniProtKB
• positive regulation of neurogenesis Source: UniProtKB
• positive regulation of neurotransmitter secretion Source: UniProtKB
• positive regulation of phosphatidylinositol 3-kinase signaling Source: RGDInferred from direct assayⁱ
  • "Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats."
    Deschamps A.M., Murphy E.
    Am. J. Physiol. Heart Circ. Physiol. 297:H1806-13(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to plasma membrane Source: UniProtKB
• positive regulation of protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • Ref.11

    "Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation."
    Gros R., Ding Q., Liu B., Chorazyczewski J., Feldman R.D.
    Am. J. Physiol. 304:C532-C540(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: TISSUE SPECIFICITY.
• positive regulation of release of cytochrome c from mitochondria Source: UniProtKBInferred from direct assayⁱ
  • "Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells."
    Chimento A., Casaburi I., Bartucci M., Patrizii M., Dattilo R., Avena P., Ando S., Pezzi V., Sirianni R.
    Cell Death Dis 4:e747-e747(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• positive regulation of uterine smooth muscle contraction Source: UniProtKB
• regulation of cytosolic calcium ion concentration Source: UniProtKB
• steroid hormone mediated signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish."
    Thomas P., Alyea R., Pang Y., Peyton C., Dong J., Berg A.H.
    Steroids 75:595-602(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAATTPAQDV GVEIYLGPVW PAPSNSTPLA LNLSLALRED APGNLTGDLS 
        60         70         80         90        100
EHQQYVIALF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN 
       110        120        130        140        150
LAAADLILVA DSLIEVFNLD EQYYDIAVLC TFMSLFLQIN MYSSVFFLTW 
       160        170        180        190        200
MSFDRYLALA KAMRCGLFRT KHHARLSCGL IWMASVSATL VPFTAVHLRH 
       210        220        230        240        250
TEEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRA LIRAHRHRGL 
       260        270        280        290        300
RPRRQKALRM IFAVVLVFFI CWLPENVFIS VHLLQWAQPG DTPCKQSFRH 
       310        320        330        340        350
AYPLTGHIVN LAAFSNSCLS PLIYSFLGET FRDKLRLYVA QKTSLPALNR 
       360        370 
FCHATLKAVI PDSTEQSDVK FSSAV                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families