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Protein

Krueppel-like factor 10

Gene

Klf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Zinc finger transcription factor homolog CPG20
Gene namesi
Name:Klf10
Synonyms:Cpg20, Tieg, Tieg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621652 Klf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471791 – 480Krueppel-like factor 10Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1
Modified residuei249PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO08876
PRIDEiO08876

Expressioni

Inductioni

Up-regulated in response to glucose.1 Publication

Gene expression databases

BgeeiENSRNOG00000006118 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiO08876 baseline and differential
GenevisibleiO08876 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008350

Structurei

3D structure databases

ProteinModelPortaliO08876
SMRiO08876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri369 – 393C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri399 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri429 – 451C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiO08876
KOiK09209
OMAiQMVPLPT
OrthoDBiEOG091G1BN0
PhylomeDBiO08876
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNFGASLQQ ASEGKMELIS EKSKEGAHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEEDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA PAPPTGHFRS LSDAAKPPSI APFKEEEKSP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHI NVEATRKNIP
210 220 230 240 250
CAAVSPNRPK PEPSTAANGA EKAGTAPYDF AVPSSETVIC RSSQPAPTSP
260 270 280 290 300
VQKSVLMSSP TVSTGGVPPL PVICQMVPLP ANNSLVTTVV PSSPPSQPPA
310 320 330 340 350
VCSPVLFMGT QVPKGTVMFV VPQPVVQSPK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAARVTPQ IDSSRVRSHI CSHPGCGKTY FKSSHLKAHV RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPATASAQ
Length:480
Mass (Da):51,829
Last modified:July 1, 1997 - v1
Checksum:iEE6880C27F255029
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JX73A0A0G2JX73_RAT
Krueppel-like factor 10
Klf10
464Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78875 mRNA Translation: AAC99475.1
BC097309 mRNA Translation: AAH97309.1
RefSeqiNP_112397.1, NM_031135.2
UniGeneiRn.2398

Genome annotation databases

EnsembliENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118
GeneIDi81813
KEGGirno:81813
UCSCiRGD:621652 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78875 mRNA Translation: AAC99475.1
BC097309 mRNA Translation: AAH97309.1
RefSeqiNP_112397.1, NM_031135.2
UniGeneiRn.2398

3D structure databases

ProteinModelPortaliO08876
SMRiO08876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008350

Proteomic databases

PaxDbiO08876
PRIDEiO08876

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118
GeneIDi81813
KEGGirno:81813
UCSCiRGD:621652 rat

Organism-specific databases

CTDi7071
RGDi621652 Klf10

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiO08876
KOiK09209
OMAiQMVPLPT
OrthoDBiEOG091G1BN0
PhylomeDBiO08876
TreeFamiTF315506

Miscellaneous databases

PROiPR:O08876

Gene expression databases

BgeeiENSRNOG00000006118 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiO08876 baseline and differential
GenevisibleiO08876 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF10_RAT
AccessioniPrimary (citable) accession number: O08876
Secondary accession number(s): Q4QRA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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