UniProtKB - O08876 (KLF10_RAT)
Krueppel-like factor 10
Klf10
Functioni
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity).
Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity.
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 369 – 393 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 399 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 429 – 451 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- core promoter sequence-specific DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- bone mineralization Source: RGD
- cellular response to peptide Source: RGD
- cellular response to starvation Source: UniProtKB
- circadian rhythm Source: RGD
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of osteoclast differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of circadian rhythm Source: UniProtKB
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatic stem cell population maintenance Source: RGD
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 10Alternative name(s): Transforming growth factor-beta-inducible early growth response protein 1 Short name: TGFB-inducible early growth response protein 1 Short name: TIEG-1 Zinc finger transcription factor homolog CPG20 |
Gene namesi | Name:Klf10 Synonyms:Cpg20, Tieg, Tieg1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621652, Klf10 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047179 | 1 – 480 | Krueppel-like factor 10Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O08876 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSRNOG00000006118, Expressed in lung and 21 other tissues |
ExpressionAtlasi | O08876, baseline and differential |
Genevisiblei | O08876, RN |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 64 – 83 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 97 – 146 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 202 – 222 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 17 – 32 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 64 – 78 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 97 – 113 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 369 – 393 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 399 – 423 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 429 – 451 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | O08876 |
OMAi | CQPMVFM |
OrthoDBi | 582598at2759 |
PhylomeDBi | O08876 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MLNFGASLQQ ASEGKMELIS EKSKEGAHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEEDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA PAPPTGHFRS LSDAAKPPSI APFKEEEKSP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHI NVEATRKNIP
210 220 230 240 250
CAAVSPNRPK PEPSTAANGA EKAGTAPYDF AVPSSETVIC RSSQPAPTSP
260 270 280 290 300
VQKSVLMSSP TVSTGGVPPL PVICQMVPLP ANNSLVTTVV PSSPPSQPPA
310 320 330 340 350
VCSPVLFMGT QVPKGTVMFV VPQPVVQSPK PPVVSPNGTR LSPIAPAPGF
360 370 380 390 400
SPSAARVTPQ IDSSRVRSHI CSHPGCGKTY FKSSHLKAHV RTHTGEKPFS
410 420 430 440 450
CSWKGCERRF ARSDELSRHR RTHTGEKKFA CPMCDRRFMR SDHLTKHARR
460 470 480
HLSAKKLPNW QMEVSKLNDI ALPPATASAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JX73 | A0A0G2JX73_RAT | Krueppel-like factor 10 | Klf10 | 464 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78875 mRNA Translation: AAC99475.1 BC097309 mRNA Translation: AAH97309.1 |
RefSeqi | NP_112397.1, NM_031135.2 |
Genome annotation databases
Ensembli | ENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118 |
GeneIDi | 81813 |
KEGGi | rno:81813 |
UCSCi | RGD:621652, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78875 mRNA Translation: AAC99475.1 BC097309 mRNA Translation: AAH97309.1 |
RefSeqi | NP_112397.1, NM_031135.2 |
3D structure databases
SMRi | O08876 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008350 |
Proteomic databases
PaxDbi | O08876 |
Genome annotation databases
Ensembli | ENSRNOT00000008350; ENSRNOP00000008350; ENSRNOG00000006118 |
GeneIDi | 81813 |
KEGGi | rno:81813 |
UCSCi | RGD:621652, rat |
Organism-specific databases
CTDi | 7071 |
RGDi | 621652, Klf10 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | O08876 |
OMAi | CQPMVFM |
OrthoDBi | 582598at2759 |
PhylomeDBi | O08876 |
TreeFami | TF315506 |
Miscellaneous databases
PROi | PR:O08876 |
Gene expression databases
Bgeei | ENSRNOG00000006118, Expressed in lung and 21 other tissues |
ExpressionAtlasi | O08876, baseline and differential |
Genevisiblei | O08876, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF10_RAT | |
Accessioni | O08876Primary (citable) accession number: O08876 Secondary accession number(s): Q4QRA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | July 1, 1997 | |
Last modified: | September 29, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families