UniProtKB - O08859 (TSG6_MOUSE)
Protein
Tumor necrosis factor-inducible gene 6 protein
Gene
Tnfaip6
Organism
Mus musculus (Mouse)
Status
Functioni
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.By similarity
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- negative regulation of inflammatory response Source: MGI
- ovulation Source: Ensembl
- positive regulation of cell migration Source: MGI
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor-inducible gene 6 proteinAlternative name(s): TNF-stimulated gene 6 protein Short name: TSG-6 Tumor necrosis factor alpha-induced protein 6 Short name: TNF alpha-induced protein 6 |
Gene namesi | Name:Tnfaip6 Synonyms:Tnfip6, Tsg6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1195266, Tnfaip6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | By similarityAdd BLAST | 17 | |
ChainiPRO_0000026693 | 18 – 275 | Tumor necrosis factor-inducible gene 6 proteinAdd BLAST | 258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 58 ↔ 127 | By similarity | ||
Disulfide bondi | 82 ↔ 103 | By similarity | ||
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 135 ↔ 161 | By similarity | ||
Disulfide bondi | 188 ↔ 210 | By similarity | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O08859 |
PRIDEi | O08859 |
ProteomicsDBi | 298145 |
PTM databases
GlyGeni | O08859, 2 sites |
iPTMneti | O08859 |
PhosphoSitePlusi | O08859 |
Expressioni
Developmental stagei
Expressed in cumulus cell-oocyte complexes during expansion in vivo.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000053475, Expressed in lumbar subsegment of spinal cord and 236 other tissues |
ExpressionAtlasi | O08859, baseline and differential |
Genevisiblei | O08859, MM |
Interactioni
Subunit structurei
Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000069231 |
Miscellaneous databases
RNActi | O08859, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 129 | LinkPROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 135 – 247 | CUBPROSITE-ProRule annotationAdd BLAST | 113 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1218, Eukaryota KOG3714, Eukaryota |
GeneTreei | ENSGT00940000157201 |
HOGENOMi | CLU_092089_0_0_1 |
InParanoidi | O08859 |
OMAi | ERWDVYC |
OrthoDBi | 934805at2759 |
PhylomeDBi | O08859 |
TreeFami | TF334173 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR000859, CUB_dom IPR000538, Link_dom IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00193, Xlink, 1 hit |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00445, LINK, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O08859-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT
60 70 80 90 100
YAEAKAVCEF EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG
110 120 130 140 150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKRIFKSPG
160 170 180 190 200
FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF DLEHDPGCLA DYVEIYDSYD
210 220 230 240 250
DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF QIKYVTVDPA
260 270
SKSSQAKNTS TTGNKKFLPG RFSHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83903 mRNA Translation: AAC53527.1 BC021155 mRNA Translation: AAH21155.1 |
CCDSi | CCDS16032.1 |
PIRi | JC6506 |
RefSeqi | NP_033424.1, NM_009398.2 |
Genome annotation databases
Ensembli | ENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475 |
GeneIDi | 21930 |
KEGGi | mmu:21930 |
UCSCi | uc008jqp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83903 mRNA Translation: AAC53527.1 BC021155 mRNA Translation: AAH21155.1 |
CCDSi | CCDS16032.1 |
PIRi | JC6506 |
RefSeqi | NP_033424.1, NM_009398.2 |
3D structure databases
BMRBi | O08859 |
SMRi | O08859 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000069231 |
PTM databases
GlyGeni | O08859, 2 sites |
iPTMneti | O08859 |
PhosphoSitePlusi | O08859 |
Proteomic databases
PaxDbi | O08859 |
PRIDEi | O08859 |
ProteomicsDBi | 298145 |
Protocols and materials databases
Antibodypediai | 33651, 185 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475 |
GeneIDi | 21930 |
KEGGi | mmu:21930 |
UCSCi | uc008jqp.1, mouse |
Organism-specific databases
CTDi | 7130 |
MGIi | MGI:1195266, Tnfaip6 |
Phylogenomic databases
eggNOGi | KOG1218, Eukaryota KOG3714, Eukaryota |
GeneTreei | ENSGT00940000157201 |
HOGENOMi | CLU_092089_0_0_1 |
InParanoidi | O08859 |
OMAi | ERWDVYC |
OrthoDBi | 934805at2759 |
PhylomeDBi | O08859 |
TreeFami | TF334173 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 21930, 1 hit in 52 CRISPR screens |
ChiTaRSi | Tnfaip6, mouse |
PROi | PR:O08859 |
RNActi | O08859, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053475, Expressed in lumbar subsegment of spinal cord and 236 other tissues |
ExpressionAtlasi | O08859, baseline and differential |
Genevisiblei | O08859, MM |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR000859, CUB_dom IPR000538, Link_dom IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 1 hit PF00193, Xlink, 1 hit |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00445, LINK, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSG6_MOUSE | |
Accessioni | O08859Primary (citable) accession number: O08859 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | July 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot