Tnfaip6

Protein namesⁱ	Recommended name: Tumor necrosis factor-inducible gene 6 protein Alternative name(s): TNF-stimulated gene 6 protein Short name: TSG-6 Tumor necrosis factor alpha-induced protein 6 Short name: TNF alpha-induced protein 6
Gene namesⁱ	Name:Tnfaip6 Synonyms:Tnfip6, Tsg6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1195266 Tnfaip6

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	By similarityAdd BLAST		17
ChainⁱPRO_0000026693	18 – 275	Tumor necrosis factor-inducible gene 6 proteinAdd BLAST		258

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	58 ↔ 127	By similarity
Disulfide bondⁱ	82 ↔ 103	By similarity
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	135 ↔ 161	By similarity
Disulfide bondⁱ	188 ↔ 210	By similarity
Glycosylationⁱ	258	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O08859
PRIDEⁱ	O08859

PTM databases

iPTMnetⁱ	O08859
PhosphoSitePlusⁱ	O08859

Expressionⁱ

Developmental stageⁱ

Expressed in cumulus cell-oocyte complexes during expansion in vivo.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000053475 Expressed in 213 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExⁱ	MM_TNFAIP6
ExpressionAtlasⁱ	O08859 baseline and differential
Genevisibleⁱ	O08859 MM

Interactionⁱ

Subunit structureⁱ

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069231

STRINGⁱ

10090.ENSMUSP00000069231

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08859
SMRⁱ	O08859
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 129	LinkPROSITE-ProRule annotationAdd BLAST		94
Domainⁱ	135 – 247	CUBPROSITE-ProRule annotationAdd BLAST		113

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1218 Eukaryota KOG3714 Eukaryota ENOG410ZI1H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000043074
HOVERGENⁱ	HBG006669
InParanoidⁱ	O08859
KEGG Orthology (KO) More...KOⁱ	K19018
OMAⁱ	CEYEGGH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	O08859
TreeFamⁱ	TF334173

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 1 hit
Gene3Dⁱ	2.60.120.290, 1 hit 3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR000859 CUB_dom IPR000538 Link_dom IPR035914 Sperma_CUB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00193 Xlink, 1 hit
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00445 LINK, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O08859-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVVLLCLCVL LWEEAHGWGF KNGIFHNSIW LEQAAGVYHR EARAGRYKLT 
        60         70         80         90        100
YAEAKAVCEF EGGRLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG 
       110        120        130        140        150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKRIFKSPG 
       160        170        180        190        200
FPNEYDDNQV CYWHIRLKYG QRIHLSFLDF DLEHDPGCLA DYVEIYDSYD 
       210        220        230        240        250
DVHGFVGRYC GDELPEDIIS TGNVMTLKFL SDASVTAGGF QIKYVTVDPA 
       260        270 
SKSSQAKNTS TTGNKKFLPG RFSHL

Length:275

Mass (Da):30,924

Last modified:July 1, 1997 - v1

Checksum:ⁱ1CD247228260B8F9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83903 mRNA Translation: AAC53527.1 BC021155 mRNA Translation: AAH21155.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16032.1
PIRⁱ	JC6506
NCBI Reference Sequences More...RefSeqⁱ	NP_033424.1, NM_009398.2
UniGeneⁱ	Mm.3509

Genome annotation databases

Ensemblⁱ	ENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475
GeneIDⁱ	21930
KEGGⁱ	mmu:21930
UCSC genome browser More...UCSCⁱ	uc008jqp.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
O08859	Tumor necrosis factor alpha induced protein 6		MOUSE		275	UniRef100_O08859

Protein	Similar proteins		Species	Score	Length	Source
O08859	Tumor necrosis factor-inducible gene 6 protein	)	HUMAN		277	UniRef90_P98066
Tumor necrosis factor-inducible gene 6 protein		RABIT		276
Uncharacterized protein		SHEEP		280
TNF alpha induced protein 6		BOVIN		280
Tumor necrosis factor-inducible 6 protein		wild yak		280
+89

Protein	Similar proteins		Species	Score	Length	Source
O08859	Tumor necrosis factor-inducible gene 6 protein	)	HUMAN		277	UniRef50_P98066
Tumor necrosis factor-inducible gene 6 protein		RABIT		276
Uncharacterized protein		SHEEP		280
TNF alpha induced protein 6		BOVIN		280
Tumor necrosis factor-inducible 6 protein		wild yak		280
+231

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U83903 mRNA Translation: AAC53527.1 BC021155 mRNA Translation: AAH21155.1
CCDSⁱ	CCDS16032.1
PIRⁱ	JC6506
RefSeqⁱ	NP_033424.1, NM_009398.2
UniGeneⁱ	Mm.3509

3D structure databases

ProteinModelPortalⁱ	O08859
SMRⁱ	O08859
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069231

STRINGⁱ

10090.ENSMUSP00000069231

PTM databases

iPTMnetⁱ	O08859
PhosphoSitePlusⁱ	O08859

Proteomic databases

PaxDbⁱ	O08859
PRIDEⁱ	O08859

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000065927; ENSMUSP00000069231; ENSMUSG00000053475
GeneIDⁱ	21930
KEGGⁱ	mmu:21930
UCSCⁱ	uc008jqp.1 mouse

Organism-specific databases

CTDⁱ	7130
MGIⁱ	MGI:1195266 Tnfaip6

Phylogenomic databases

eggNOGⁱ	KOG1218 Eukaryota KOG3714 Eukaryota ENOG410ZI1H LUCA
GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000043074
HOVERGENⁱ	HBG006669
InParanoidⁱ	O08859
KOⁱ	K19018
OMAⁱ	CEYEGGH
OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	O08859
TreeFamⁱ	TF334173

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O08859
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000053475 Expressed in 213 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExⁱ	MM_TNFAIP6
ExpressionAtlasⁱ	O08859 baseline and differential
Genevisibleⁱ	O08859 MM

Family and domain databases

CDDⁱ	cd00041 CUB, 1 hit
Gene3Dⁱ	2.60.120.290, 1 hit 3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR000859 CUB_dom IPR000538 Link_dom IPR035914 Sperma_CUB_dom_sf
Pfamⁱ	View protein in Pfam PF00431 CUB, 1 hit PF00193 Xlink, 1 hit
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00445 LINK, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS01241 LINK_1, 1 hit PS50963 LINK_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSG6_MOUSE
Accessionⁱ	O08859Primary (citable) accession number: O08859
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08859 (TSG6_MOUSE)

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Tumor necrosis factor-inducible gene 6 protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ