We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O08858 (SSR5_MOUSE)
Protein
Somatostatin receptor type 5
Gene
Sstr5
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- somatostatin receptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- cellular response to glucocorticoid stimulus Source: GO_Central
- glucose homeostasis Source: MGI
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of cytokinesis Source: MGI
- regulation of insulin secretion Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 5Short name: SS-5-R Short name: SS5-R Short name: SS5R |
Gene namesi | Name:Sstr5 Synonyms:Smstr5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894282, Sstr5 |
VEuPathDBi | HostDB:ENSMUSG00000050824 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 64 – 73 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 74 – 99 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 100 – 110 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 111 – 132 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 133 – 154 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 195 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 196 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 221 – 246 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 247 – 272 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 273 – 282 | ExtracellularSequence analysis | 10 | |
Transmembranei | 283 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 308 – 362 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2733 |
DrugCentrali | O08858 |
GuidetoPHARMACOLOGYi | 359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070131 | 1 – 362 | Somatostatin receptor type 5Add BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 109 ↔ 184 | PROSITE-ProRule annotation | ||
Glycosylationi | 185 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 319 | S-palmitoyl cysteine; by ZDHHC51 Publication | 1 |
Post-translational modificationi
Palmitoylated at Cys-319 by ZDHHC5, but not ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | O08858 |
PRIDEi | O08858 |
PTM databases
GlyGeni | O08858, 3 sites |
PhosphoSitePlusi | O08858 |
SwissPalmi | O08858 |
Expressioni
Tissue specificityi
Expressed in adult brain but not in liver, heart, spleen, or kidney.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000050824, Expressed in brain and 60 other tissues |
Genevisiblei | O08858, MM |
Interactioni
Subunit structurei
Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2 (By similarity).
By similarityProtein-protein interaction databases
IntActi | O08858, 1 interactor |
MINTi | O08858 |
STRINGi | 10090.ENSMUSP00000051085 |
Chemistry databases
BindingDBi | O08858 |
Miscellaneous databases
RNActi | O08858, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 330 – 362 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 341 – 362 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160265 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | O08858 |
OMAi | PFFFINM |
OrthoDBi | 1011272at2759 |
PhylomeDBi | O08858 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001184, Somatstn_rcpt_5 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00591, SOMATOSTTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O08858-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPLSLTSTP SWNASAASSS SHNWSLVDPV SPMGARAVLV PVLYLLVCTV
60 70 80 90 100
GLGGNTLVIY VVLRYAKMKT VTNVYILNLA VADVLFMLGL PFLATQNAVS
110 120 130 140 150
YWPFGSFLCR LVMTLDGINQ FTSIFCLMVM SVDRYLAVVH PLRSARWRRP
160 170 180 190 200
RVAKLASAAV WVFSLLMSLP LLVFADVQEG WGTCNLSWPE PVGLWGAAFI
210 220 230 240 250
TYTSVLGFFG PLLVICLCYL LIVVKVKAAG MRVGSSRRRR SERKVTRMVV
260 270 280 290 300
VVVLVFVGCW LPFFIVNIVN LAFTLPEEPT SAGLYFFVVV LSYANSCANP
310 320 330 340 350
LLYGFLSDNF RQSFRKALCL RRGYGVEDAD AIEPRPDKSG RPQTTLPTRS
360
CEANGLMQTS RL
Sequence cautioni
The sequence AAB88302 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | T → A in AAC53353 (PubMed:9300821).Curated | 1 | |
Sequence conflicti | 7 | T → A in AAB61418 (Ref. 2) Curated | 1 | |
Sequence conflicti | 7 | T → A in AAB86492 (Ref. 3) Curated | 1 | |
Sequence conflicti | 7 | T → A in AAB88302 (Ref. 4) Curated | 1 | |
Sequence conflicti | 7 | T → A in AAI45944 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 7 | T → A in AAI50806 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 20 | S → G in AAC53353 (PubMed:9300821).Curated | 1 | |
Sequence conflicti | 20 | S → G in AAB61418 (Ref. 2) Curated | 1 | |
Sequence conflicti | 20 | S → G in AAB86492 (Ref. 3) Curated | 1 | |
Sequence conflicti | 20 | S → G in AAB88302 (Ref. 4) Curated | 1 | |
Sequence conflicti | 20 | S → G in AAI45944 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 20 | S → G in AAI50806 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 99 | V → VV in AAC53353 (PubMed:9300821).Curated | 1 | |
Sequence conflicti | 303 – 305 | YGF → LWL in AAB61418 (Ref. 2) Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82697 Genomic DNA Translation: AAC53353.1 AF004740 Genomic DNA Translation: AAB61418.1 AF030441 Genomic DNA Translation: AAB86492.1 AF035777 Genomic DNA Translation: AAB88302.1 Different initiation. AK133609 mRNA Translation: BAE21747.1 AK133767 mRNA Translation: BAE21829.1 AC131323 Genomic DNA No translation available. BC145943 mRNA Translation: AAI45944.1 BC150805 mRNA Translation: AAI50806.1 |
CCDSi | CCDS28520.1 |
RefSeqi | NP_001177937.1, NM_001191008.1 NP_035555.1, NM_011425.3 |
Genome annotation databases
Ensembli | ENSMUST00000051864; ENSMUSP00000051085; ENSMUSG00000050824 ENSMUST00000165183; ENSMUSP00000128787; ENSMUSG00000050824 |
GeneIDi | 20609 |
KEGGi | mmu:20609 |
UCSCi | uc008bax.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82697 Genomic DNA Translation: AAC53353.1 AF004740 Genomic DNA Translation: AAB61418.1 AF030441 Genomic DNA Translation: AAB86492.1 AF035777 Genomic DNA Translation: AAB88302.1 Different initiation. AK133609 mRNA Translation: BAE21747.1 AK133767 mRNA Translation: BAE21829.1 AC131323 Genomic DNA No translation available. BC145943 mRNA Translation: AAI45944.1 BC150805 mRNA Translation: AAI50806.1 |
CCDSi | CCDS28520.1 |
RefSeqi | NP_001177937.1, NM_001191008.1 NP_035555.1, NM_011425.3 |
3D structure databases
SMRi | O08858 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O08858, 1 interactor |
MINTi | O08858 |
STRINGi | 10090.ENSMUSP00000051085 |
Chemistry databases
BindingDBi | O08858 |
ChEMBLi | CHEMBL2733 |
DrugCentrali | O08858 |
GuidetoPHARMACOLOGYi | 359 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O08858, 3 sites |
PhosphoSitePlusi | O08858 |
SwissPalmi | O08858 |
Proteomic databases
PaxDbi | O08858 |
PRIDEi | O08858 |
Protocols and materials databases
Antibodypediai | 3358, 317 antibodies from 36 providers |
DNASUi | 20609 |
Genome annotation databases
Ensembli | ENSMUST00000051864; ENSMUSP00000051085; ENSMUSG00000050824 ENSMUST00000165183; ENSMUSP00000128787; ENSMUSG00000050824 |
GeneIDi | 20609 |
KEGGi | mmu:20609 |
UCSCi | uc008bax.2, mouse |
Organism-specific databases
CTDi | 6755 |
MGIi | MGI:894282, Sstr5 |
VEuPathDBi | HostDB:ENSMUSG00000050824 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160265 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | O08858 |
OMAi | PFFFINM |
OrthoDBi | 1011272at2759 |
PhylomeDBi | O08858 |
TreeFami | TF315737 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 20609, 0 hits in 64 CRISPR screens |
PROi | PR:O08858 |
RNActi | O08858, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050824, Expressed in brain and 60 other tissues |
Genevisiblei | O08858, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001184, Somatstn_rcpt_5 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00591, SOMATOSTTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR5_MOUSE | |
Accessioni | O08858Primary (citable) accession number: O08858 Secondary accession number(s): A6H6N8, O08998, Q3UZM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families