UniProtKB - O08852 (PKD1_MOUSE)
Polycystin-1
Pkd1
Functioni
GO - Molecular functioni
- calcium channel activity Source: BHF-UCL
- carbohydrate binding Source: UniProtKB-KW
- cation channel activity Source: MGI
- ion channel binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
- Wnt-activated receptor activity Source: MGI
GO - Biological processi
- blood vessel development Source: MGI
- branching morphogenesis of an epithelial tube Source: UniProtKB
- calcium ion transmembrane transport Source: BHF-UCL
- calcium ion transport Source: MGI
- cartilage condensation Source: MGI
- cell-cell adhesion Source: MGI
- cell-cell signaling by wnt Source: MGI
- cell cycle arrest Source: MGI
- cytoplasmic sequestering of transcription factor Source: BHF-UCL
- detection of mechanical stimulus Source: MGI
- digestive tract development Source: Ensembl
- embryonic placenta development Source: BHF-UCL
- establishment of cell polarity Source: MGI
- genitalia development Source: Ensembl
- heart development Source: MGI
- in utero embryonic development Source: MGI
- kidney development Source: BHF-UCL
- liver development Source: MGI
- lung epithelium development Source: Ensembl
- lymph vessel morphogenesis Source: MGI
- mesonephric duct development Source: Ensembl
- metanephric ascending thin limb development Source: Ensembl
- metanephric collecting duct development Source: Ensembl
- metanephric distal tubule morphogenesis Source: Ensembl
- metanephric proximal tubule development Source: Ensembl
- neural tube development Source: Ensembl
- nitrogen compound metabolic process Source: MGI
- peptidyl-serine phosphorylation Source: UniProtKB
- placenta blood vessel development Source: BHF-UCL
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of protein binding Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein export from nucleus Source: UniProtKB
- protein heterotetramerization Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: MGI
- regulation of cell adhesion Source: MGI
- regulation of G1/S transition of mitotic cell cycle Source: MGI
- regulation of mitotic spindle organization Source: MGI
- regulation of proteasomal protein catabolic process Source: MGI
- response to fluid shear stress Source: MGI
- skin development Source: Ensembl
- spinal cord development Source: Ensembl
Keywordsi
Biological process | Wnt signaling pathway |
Ligand | Lectin |
Protein family/group databases
MEROPSi | P02.036 |
Names & Taxonomyi
Protein namesi | Recommended name: Polycystin-1CuratedAlternative name(s): Autosomal dominant polycystic kidney disease 1 protein homolog |
Gene namesi | Name:Pkd1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97603, Pkd1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- cilium 3 Publications
Note: PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autocatalytic cleavage at the GPS domain (PubMed:12514735, PubMed:25405894). PKD1:PKD2 interaction is required to reach the Golgi apparatus from endoplasmic reticulum and then traffic to the cilia (PubMed:25405894). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (PubMed:24939912). Cell surface localization requires GANAB (By similarity).By similarity3 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleus Source: MGI
Plasma Membrane
- basolateral plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- lateral plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- calcium channel complex Source: MGI
- cation channel complex Source: UniProtKB
- cell surface Source: UniProtKB
- cilium Source: UniProtKB
- cytoplasm Source: BHF-UCL
- membrane Source: MGI
- motile cilium Source: MGI
- polycystin complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 3066 | ExtracellularCuratedAdd BLAST | 3043 | |
Transmembranei | 3067 – 3087 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3088 – 3269 | CytoplasmicCuratedAdd BLAST | 182 | |
Transmembranei | 3270 – 3290 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3291 – 3315 | ExtracellularCuratedAdd BLAST | 25 | |
Transmembranei | 3316 – 3336 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3337 – 3549 | CytoplasmicCuratedAdd BLAST | 213 | |
Transmembranei | 3550 – 3570 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3571 – 3572 | ExtracellularCurated | 2 | |
Transmembranei | 3573 – 3593 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3594 – 3655 | CytoplasmicCuratedAdd BLAST | 62 | |
Transmembranei | 3656 – 3676 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3677 – 3891 | ExtracellularCuratedAdd BLAST | 215 | |
Transmembranei | 3892 – 3912 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3913 – 3925 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 3926 – 3946 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3947 – 3974 | ExtracellularCuratedAdd BLAST | 28 | |
Transmembranei | 3975 – 3995 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 3996 – 4017 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 4018 – 4038 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 4039 – 4080 | ExtracellularCuratedAdd BLAST | 42 | |
Transmembranei | 4081 – 4100 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 4101 – 4293 | CytoplasmicCuratedAdd BLAST | 193 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000354054 | 24 – 4293 | Polycystin-1Add BLAST | 4270 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 436 ↔ 529 | By similarity | ||
Disulfide bondi | 507 ↔ 521 | By similarity | ||
Glycosylationi | 627 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 635 ↔ 648 | By similarity | ||
Disulfide bondi | 642 ↔ 660 | By similarity | ||
Glycosylationi | 662 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 740 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 804 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 835 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 848 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 859 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 884 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 915 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 998 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1004 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1028 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1084 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1096 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1234 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1263 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1342 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1376 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1444 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1535 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1557 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1643 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1657 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1706 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1730 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1788 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1831 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1863 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1876 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1987 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2046 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2070 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2244 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2349 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2391 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2414 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2563 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2640 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2713 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2749 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2813 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2836 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2873 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2948 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2986 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3728 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3780 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 4156 | Phosphoserine; by PRKX; in vitroBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 3040 – 3041 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | O08852 |
PaxDbi | O08852 |
PRIDEi | O08852 |
PTM databases
GlyGeni | O08852, 63 sites |
iPTMneti | O08852 |
PhosphoSitePlusi | O08852 |
SwissPalmi | O08852 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032855, Expressed in metanephros and 138 other tissues |
ExpressionAtlasi | O08852, baseline and differential |
Genevisiblei | O08852, MM |
Interactioni
Subunit structurei
Interacts with PKD2; the interaction is required for ciliary localization (PubMed:25405894).
Component of a heterotetrameric channel complex with PKD2; the tetramer contains one PKD1 chain and three PKD2 chains (By similarity).
Interacts with PKD2L1 (PubMed:15548533).
Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney.
Interacts (via extracellular domain) with WNT3A, WNT4 and WNT9B (By similarity).
Interacts with WNT5A, DVL1 and DVL2 (PubMed:27214281).
Interacts with NPHP1 (via SH3 domain) (PubMed:20856870).
Interacts with BBS1, BBS4, BBS5 and TTC8.
Interacts with RGS7 (By similarity).
Interacts (via C-terminal domain) with RABEP1; the interaction connects PKD1:PKD2 to GGA1 and ARL3 that mediate the ciliary targeting (PubMed:25405894).
By similarity4 PublicationsBinary interactionsi
O08852
With | #Exp. | IntAct |
---|---|---|
PKD2 - isoform 1 [Q13563-1] from Homo sapiens. | 2 | EBI-6666305,EBI-9837017 |
GO - Molecular functioni
- ion channel binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202204, 3 interactors |
ComplexPortali | CPX-4041, PKD1-PKD2 Polycystin complex |
DIPi | DIP-44233N |
IntActi | O08852, 8 interactors |
MINTi | O08852 |
STRINGi | 10090.ENSMUSP00000049296 |
Miscellaneous databases
RNActi | O08852, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 67 | LRRNTAdd BLAST | 44 | |
Repeati | 68 – 91 | LRR 1Add BLAST | 24 | |
Repeati | 92 – 113 | LRR 2Add BLAST | 22 | |
Domaini | 125 – 178 | LRRCTAdd BLAST | 54 | |
Domaini | 177 – 271 | WSCPROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 272 – 359 | PKD 1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 415 – 530 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 633 – 666 | LDL-receptor class A; atypicalAdd BLAST | 34 | |
Domaini | 849 – 922 | PKD 2PROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 929 – 1014 | PKD 3PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 1017 – 1123 | PKD 4PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 1121 – 1209 | PKD 5PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1207 – 1292 | PKD 6PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 1288 – 1377 | PKD 7PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 1376 – 1463 | PKD 8PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 1462 – 1545 | PKD 9PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 1544 – 1629 | PKD 10PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 1630 – 1718 | PKD 11PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 1716 – 1802 | PKD 12PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 1804 – 1886 | PKD 13PROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 1885 – 1970 | PKD 14PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 1972 – 2053 | PKD 15PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 2056 – 2144 | PKD 16PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 2142 – 2828 | REJPROSITE-ProRule annotationAdd BLAST | 687 | |
Domaini | 3004 – 3053 | GPSPROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 3110 – 3225 | PLATPROSITE-ProRule annotationAdd BLAST | 116 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 4210 – 4241 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3581 – 3585 | Poly-Ser | 5 | |
Compositional biasi | 4153 – 4194 | Ser-richAdd BLAST | 42 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3599, Eukaryota |
GeneTreei | ENSGT00940000158702 |
HOGENOMi | CLU_000173_0_0_1 |
InParanoidi | O08852 |
OMAi | VACLPDN |
OrthoDBi | 1276906at2759 |
TreeFami | TF316484 |
Family and domain databases
CDDi | cd01752, PLAT_polycystin, 1 hit |
Gene3Di | 2.60.40.10, 9 hits 3.10.100.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR000483, Cys-rich_flank_reg_C IPR000203, GPS IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR000434, PC1 IPR022409, PKD/Chitinase_dom IPR002859, PKD/REJ-like IPR013122, PKD1_2_channel IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042060, PLAT_polycystin1 IPR006228, Polycystin_cat IPR014010, REJ_dom IPR002889, WSC_carb-bd |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF13855, LRR_8, 1 hit PF00801, PKD, 14 hits PF08016, PKD_channel, 1 hit PF01477, PLAT, 1 hit PF02010, REJ, 1 hit PF01822, WSC, 1 hit |
PRINTSi | PR00500, POLYCYSTIN1 |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00303, GPS, 1 hit SM00308, LH2, 1 hit SM00369, LRR_TYP, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00089, PKD, 15 hits SM00321, WSC, 1 hit |
SUPFAMi | SSF49299, SSF49299, 13 hits SSF49723, SSF49723, 1 hit SSF56436, SSF56436, 1 hit |
TIGRFAMsi | TIGR00864, PCC, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit PS50221, GPS, 1 hit PS51450, LRR, 3 hits PS50093, PKD, 12 hits PS50095, PLAT, 1 hit PS51111, REJ, 1 hit PS51212, WSC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN
60 70 80 90 100
CSGRWLQTLG PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN
110 120 130 140 150
NRISTLEEGV FANLFNLSEI NLSGNPFECN CGLAWLPRWA KEHQVHVVQS
160 170 180 190 200
EATTCRGPIP LAGQPLLSIP LLDNACGEEY VACLPDNSSG AVAAVPFYFA
210 220 230 240 250
HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS SAACSSWCSS
260 270 280 290 300
ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI
310 320 330 340 350
SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV
360 370 380 390 400
QVEATPTVLE LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ
410 420 430 440 450
VVHPLCPLDT EIFPGNGHCY RLVAEKAPWL QAQEQCRTWA GAALAMVDSP
460 470 480 490 500
AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD PRGEAFSLES CQNWLPGEPH
510 520 530 540 550
PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT ENFVMGMSGG
560 570 580 590 600
GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE
610 620 630 640 650
PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP
660 670 680 690 700
FDASCNSHVC INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ
710 720 730 740 750
DVPMLPGDLI GLQHDAGPGT LLQCPLASSC PGQALYLSTN ASDWMTNLPV
760 770 780 790 800
HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP NPGLQHPGHY EVRATVGNSV
810 820 830 840 850
SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV LQVDSGANAT
860 870 880 890 900
ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD
910 920 930 940 950
HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM
960 970 980 990 1000
VEAGSDVAFR WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT
1010 1020 1030 1040 1050
VNYNVTVERM NKMHGLWVSA VPTVLPPNAT LALTGGVLVD SAVEVAFLWN
1060 1070 1080 1090 1100
FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL VEHNTTHIYT TPGEYNLTVL
1110 1120 1130 1140 1150
VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF SPYPLPSTDG
1160 1170 1180 1190 1200
VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI
1210 1220 1230 1240 1250
RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP
1260 1270 1280 1290 1300
EATVQHVYLR AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP
1310 1320 1330 1340 1350
TQPSAQLMAH VTGDPVHYLF DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP
1360 1370 1380 1390 1400
LALVLSSHVN KAHYFTSICV EPEIRNITLQ PERQFVKLGD EARLVAYSWP
1410 1420 1430 1440 1450
PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT VSNNISSTND
1460 1470 1480 1490 1500
SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS
1510 1520 1530 1540 1550
QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS
1560 1570 1580 1590 1600
RTVVPLNGSV SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT
1610 1620 1630 1640 1650
FNIIVTAENE VGSAQDSIFI YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA
1660 1670 1680 1690 1700
AVRDGTNISY SWTAQQEGSL ITLFGSGKCF SLTSLKASTY YVHLRATNML
1710 1720 1730 1740 1750
GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA GGSGVVYTWY
1760 1770 1780 1790 1800
LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG
1810 1820 1830 1840 1850
GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV
1860 1870 1880 1890 1900
RFSTAGSFSL QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP
1910 1920 1930 1940 1950
VHFEILLAAG SALTFRLQVG GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN
1960 1970 1980 1990 2000
HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM ATGTEKNFTA RVQRGSRVAY
2010 2020 2030 2040 2050
AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN ELGGVNLTLM
2060 2070 2080 2090 2100
VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK
2110 2120 2130 2140 2150
TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA
2160 2170 2180 2190 2200
LPLQVLMRRS QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM
2210 2220 2230 2240 2250
VLPGVDVSRP QLVVPRLALP VGHYCFVFVV SFGDTPLARS IQANVTVAAE
2260 2270 2280 2290 2300
RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP NLEDGDQTPL NFHWACVAST
2310 2320 2330 2340 2350
QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK AGRKEEATNQ
2360 2370 2380 2390 2400
TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC
2410 2420 2430 2440 2450
WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS
2460 2470 2480 2490 2500
GEEEGCASIR LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG
2510 2520 2530 2540 2550
GAPLVYALLL KRCRQSYCEN FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV
2560 2570 2580 2590 2600
VQDQLGAAVV ALNRSLTIVL PEPSGNPADL VPWLHSLTAS VLPGLLKQAD
2610 2620 2630 2640 2650
PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN ITETLISLRV
2660 2670 2680 2690 2700
NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG
2710 2720 2730 2740 2750
TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL
2760 2770 2780 2790 2800
SSALMRILMR SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH
2810 2820 2830 2840 2850
FSIPEAFSGA LSNLSDVVQL IFLVDSNPFP FGYISNYTVS TKVASMAFQT
2860 2870 2880 2890 2900
QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ SSHNPVGSTI VQPQTSVSAV
2910 2920 2930 2940 2950
VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS VSQPNEYNCS
2960 2970 2980 2990 3000
ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV
3010 3020 3030 3040 3050
GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP
3060 3070 3080 3090 3100
PSHVQFIFPE PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV
3110 3120 3130 3140 3150
IPFCGKGGRF KYEILVKTGW SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR
3160 3170 3180 3190 3200
AFHRNSLDIF QIATPHSLGS VWKIRVWHDN KGLSPAWFLQ HIIVRDLQSA
3210 3220 3230 3240 3250
RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL LVAELQRGFF
3260 3270 3280 3290 3300
DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS
3310 3320 3330 3340 3350
MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT
3360 3370 3380 3390 3400
PTGQQALDVD SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC
3410 3420 3430 3440 3450
WPSSEGTLSW PDLLSDPSVV SSTLQRLTQG RPGCMLGSEE DGASLVSPSL
3460 3470 3480 3490 3500
PAKYLSASDE DLIHQVLADG ANNLVPTQDT LLETDLLTSL SSVPGEKTET
3510 3520 3530 3540 3550
LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL PAWCAPLAHG
3560 3570 3580 3590 3600
LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL
3610 3620 3630 3640 3650
EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE
3660 3670 3680 3690 3700
ARKVKRLHDM LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD
3710 3720 3730 3740 3750
SQAFLAITRS DEFWPWMSHV FLPYVHGNQS SPELGPPRLR QVRLQEAFCP
3760 3770 3780 3790 3800
DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN GSETWAYSAP DLLGAWYWGY
3810 3820 3830 3840 3850
CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV FVELTRYSPA
3860 3870 3880 3890 3900
VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF
3910 3920 3930 3940 3950
ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD
3960 3970 3980 3990 4000
RQWTHFVQDH PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR
4010 4020 4030 4040 4050
QWSVFGKTLC RALPELMGAT LGLVLLGVAY AQMAILLISS GADTLYNMAR
4060 4070 4080 4090 4100
AFLVLCPGAR VPTLCPSESW YLSPLLCVGL WALRVWGALR LGAILLRWRY
4110 4120 4130 4140 4150
HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR HKVRFEGMDP
4160 4170 4180 4190 4200
LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP
4210 4220 4230 4240 4250
EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP
4260 4270 4280 4290
GCFPGSQPAL PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BRZ6 | A0A2I3BRZ6_MOUSE | Polycystin-1 | Pkd1 | 1,231 | Annotation score: | ||
A0A2I3BRL4 | A0A2I3BRL4_MOUSE | Polycystin-1 | Pkd1 | 234 | Annotation score: | ||
A0A2I3BQG6 | A0A2I3BQG6_MOUSE | Polycystin-1 | Pkd1 | 72 | Annotation score: | ||
A0A2I3BPP4 | A0A2I3BPP4_MOUSE | Polycystin-1 | Pkd1 | 237 | Annotation score: | ||
A0A2I3BRP8 | A0A2I3BRP8_MOUSE | Polycystin-1 | Pkd1 | 27 | Annotation score: | ||
A0A2I3BQ02 | A0A2I3BQ02_MOUSE | Polycystin-1 | Pkd1 | 80 | Annotation score: | ||
A0A2I3BQE7 | A0A2I3BQE7_MOUSE | Polycystin-1 | Pkd1 | 27 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | L → P in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 771 | R → Q in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 871 | E → D in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 1180 | A → T in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 1292 | H → R in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 1632 | A → V in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 1684 | S → A in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 1770 | A → T in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 2085 | R → C in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 2507 | A → V in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 3956 | F → C in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 3962 | R → H in AAC53207 (PubMed:9107672).Curated | 1 | |
Sequence conflicti | 4237 | Q → R in AAC53207 (PubMed:9107672).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70209 mRNA Translation: AAC53207.1 AC132367 Genomic DNA No translation available. |
CCDSi | CCDS28485.1 |
RefSeqi | NP_038658.2, NM_013630.2 |
Genome annotation databases
Ensembli | ENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855 |
GeneIDi | 18763 |
KEGGi | mmu:18763 |
UCSCi | uc008awv.1, mouse |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Polycystin-1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70209 mRNA Translation: AAC53207.1 AC132367 Genomic DNA No translation available. |
CCDSi | CCDS28485.1 |
RefSeqi | NP_038658.2, NM_013630.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 202204, 3 interactors |
ComplexPortali | CPX-4041, PKD1-PKD2 Polycystin complex |
DIPi | DIP-44233N |
IntActi | O08852, 8 interactors |
MINTi | O08852 |
STRINGi | 10090.ENSMUSP00000049296 |
Protein family/group databases
MEROPSi | P02.036 |
PTM databases
GlyGeni | O08852, 63 sites |
iPTMneti | O08852 |
PhosphoSitePlusi | O08852 |
SwissPalmi | O08852 |
Proteomic databases
MaxQBi | O08852 |
PaxDbi | O08852 |
PRIDEi | O08852 |
Protocols and materials databases
Antibodypediai | 23502, 194 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855 |
GeneIDi | 18763 |
KEGGi | mmu:18763 |
UCSCi | uc008awv.1, mouse |
Organism-specific databases
CTDi | 5310 |
MGIi | MGI:97603, Pkd1 |
Phylogenomic databases
eggNOGi | KOG3599, Eukaryota |
GeneTreei | ENSGT00940000158702 |
HOGENOMi | CLU_000173_0_0_1 |
InParanoidi | O08852 |
OMAi | VACLPDN |
OrthoDBi | 1276906at2759 |
TreeFami | TF316484 |
Miscellaneous databases
BioGRID-ORCSi | 18763, 0 hits in 17 CRISPR screens |
ChiTaRSi | Pkd1, mouse |
PROi | PR:O08852 |
RNActi | O08852, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032855, Expressed in metanephros and 138 other tissues |
ExpressionAtlasi | O08852, baseline and differential |
Genevisiblei | O08852, MM |
Family and domain databases
CDDi | cd01752, PLAT_polycystin, 1 hit |
Gene3Di | 2.60.40.10, 9 hits 3.10.100.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR000483, Cys-rich_flank_reg_C IPR000203, GPS IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR000434, PC1 IPR022409, PKD/Chitinase_dom IPR002859, PKD/REJ-like IPR013122, PKD1_2_channel IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR042060, PLAT_polycystin1 IPR006228, Polycystin_cat IPR014010, REJ_dom IPR002889, WSC_carb-bd |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF13855, LRR_8, 1 hit PF00801, PKD, 14 hits PF08016, PKD_channel, 1 hit PF01477, PLAT, 1 hit PF02010, REJ, 1 hit PF01822, WSC, 1 hit |
PRINTSi | PR00500, POLYCYSTIN1 |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00303, GPS, 1 hit SM00308, LH2, 1 hit SM00369, LRR_TYP, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00089, PKD, 15 hits SM00321, WSC, 1 hit |
SUPFAMi | SSF49299, SSF49299, 13 hits SSF49723, SSF49723, 1 hit SSF56436, SSF56436, 1 hit |
TIGRFAMsi | TIGR00864, PCC, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit PS50221, GPS, 1 hit PS51450, LRR, 3 hits PS50093, PKD, 12 hits PS50095, PLAT, 1 hit PS51111, REJ, 1 hit PS51212, WSC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PKD1_MOUSE | |
Accessioni | O08852Primary (citable) accession number: O08852 Secondary accession number(s): E9QJR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families