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UniProtKB - O08852 (PKD1_MOUSE)

Protein

Polycystin-1

Gene

Pkd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.3 Publications

GO - Molecular functioni

  • calcium channel activity Source: BHF-UCL
  • carbohydrate binding Source: UniProtKB-KW
  • ion channel binding Source: MGI
  • protein domain specific binding Source: MGI
  • protein kinase binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

MEROPSiP02.036

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystin-1
Alternative name(s):
Autosomal dominant polycystic kidney disease 1 protein homolog
Gene namesi
Name:Pkd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:97603 Pkd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3067 – 3087HelicalSequence analysisAdd BLAST21
Transmembranei3273 – 3293HelicalSequence analysisAdd BLAST21
Transmembranei3316 – 3336HelicalSequence analysisAdd BLAST21
Transmembranei3550 – 3570HelicalSequence analysisAdd BLAST21
Transmembranei3573 – 3593HelicalSequence analysisAdd BLAST21
Transmembranei3664 – 3684HelicalSequence analysisAdd BLAST21
Transmembranei3887 – 3907HelicalSequence analysisAdd BLAST21
Transmembranei3929 – 3949HelicalSequence analysisAdd BLAST21
Transmembranei3970 – 3990HelicalSequence analysisAdd BLAST21
Transmembranei4018 – 4038HelicalSequence analysisAdd BLAST21
Transmembranei4075 – 4095HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Disruption phenotypei

Knockin mice expressing non-cleavable PKD1 show a hypomorphic phenotype. They are viable, show rapid cystic dilation in renal collecting duct and distal convoluted tubule, but not in the proximal portion of the nephron, during the postnatal period, and die with severe uremia, mostly at 3 weeks of age. Additionally, they show dilation of the common bile duct and intrahepatic biliary ducts, but develop a normal pancreas within their life span.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000035405424 – 4293Polycystin-1Add BLAST4270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi436 ↔ 529By similarity
Disulfide bondi507 ↔ 521By similarity
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi635 ↔ 648By similarity
Disulfide bondi642 ↔ 660By similarity
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi859N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi884N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1004N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1643N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1788N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1876N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2713N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2873N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2986N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3780N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei4156Phosphoserine; by PRKX; in vitroBy similarity1

Post-translational modificationi

After synthesis, undergoes autoproteolytic cleavage between Leu-3040 and Thr-3041 in the GPS domain (By similarity). Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement (By similarity). This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain (By similarity). PKD1 is ubiquitously and incompletely cleaved in wild-type mice, so that uncleaved and cleaved PKD1 molecules coexist. The differential patterns of cleavage during embryonic development, as well as in adult mice, suggest different functions of uncleaved and cleaved molecules.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei3040 – 3041Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO08852
PaxDbiO08852
PRIDEiO08852

PTM databases

iPTMnetiO08852
PhosphoSitePlusiO08852
SwissPalmiO08852

Expressioni

Gene expression databases

BgeeiENSMUSG00000032855 Expressed in 111 organ(s), highest expression level in metanephros
GenevisibleiO08852 MM

Interactioni

Subunit structurei

Interacts with PKD2. Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney (By similarity). Interacts with NPHP1 (via SH3 domain) (PubMed:20856870). Interacts with PKD2L1 (PubMed:15548533). Interacts with BBS1, BBS4, BBS5 and TTC8. Interacts with RGS7 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PKD2Q13563-12EBI-6666305,EBI-9837017From a different organism.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi202204, 3 interactors
DIPiDIP-44233N
IntActiO08852, 8 interactors
MINTiO08852
STRINGi10090.ENSMUSP00000049296

Structurei

3D structure databases

ProteinModelPortaliO08852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 67LRRNTAdd BLAST44
Repeati68 – 91LRR 1Add BLAST24
Repeati92 – 113LRR 2Add BLAST22
Domaini125 – 178LRRCTAdd BLAST54
Domaini177 – 271WSCPROSITE-ProRule annotationAdd BLAST95
Domaini272 – 359PKD 1PROSITE-ProRule annotationAdd BLAST88
Domaini415 – 530C-type lectinPROSITE-ProRule annotationAdd BLAST116
Domaini633 – 666LDL-receptor class A; atypicalAdd BLAST34
Domaini849 – 922PKD 2PROSITE-ProRule annotationAdd BLAST74
Domaini929 – 1014PKD 3PROSITE-ProRule annotationAdd BLAST86
Domaini1017 – 1123PKD 4PROSITE-ProRule annotationAdd BLAST107
Domaini1121 – 1209PKD 5PROSITE-ProRule annotationAdd BLAST89
Domaini1207 – 1292PKD 6PROSITE-ProRule annotationAdd BLAST86
Domaini1288 – 1377PKD 7PROSITE-ProRule annotationAdd BLAST90
Domaini1376 – 1463PKD 8PROSITE-ProRule annotationAdd BLAST88
Domaini1462 – 1545PKD 9PROSITE-ProRule annotationAdd BLAST84
Domaini1544 – 1629PKD 10PROSITE-ProRule annotationAdd BLAST86
Domaini1630 – 1718PKD 11PROSITE-ProRule annotationAdd BLAST89
Domaini1716 – 1802PKD 12PROSITE-ProRule annotationAdd BLAST87
Domaini1804 – 1886PKD 13PROSITE-ProRule annotationAdd BLAST83
Domaini1885 – 1970PKD 14PROSITE-ProRule annotationAdd BLAST86
Domaini1972 – 2053PKD 15PROSITE-ProRule annotationAdd BLAST82
Domaini2056 – 2144PKD 16PROSITE-ProRule annotationAdd BLAST89
Domaini2142 – 2828REJPROSITE-ProRule annotationAdd BLAST687
Domaini3004 – 3053GPSPROSITE-ProRule annotationAdd BLAST50
Domaini3110 – 3225PLATPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4210 – 4241Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3581 – 3585Poly-Ser5
Compositional biasi4153 – 4194Ser-richAdd BLAST42

Domaini

The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.

Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00700000104221
HOGENOMiHOG000168445
HOVERGENiHBG049412
InParanoidiO08852
KOiK04985
OMAiDVVFRWT
OrthoDBiEOG091G004D
TreeFamiTF316484

Family and domain databases

Gene3Di2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit
SUPFAMiSSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR00864 PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O08852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN 
        60         70         80         90        100
CSGRWLQTLG PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN 
       110        120        130        140        150
NRISTLEEGV FANLFNLSEI NLSGNPFECN CGLAWLPRWA KEHQVHVVQS 
       160        170        180        190        200
EATTCRGPIP LAGQPLLSIP LLDNACGEEY VACLPDNSSG AVAAVPFYFA 
       210        220        230        240        250
HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS SAACSSWCSS 
       260        270        280        290        300
ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI 
       310        320        330        340        350
SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV 
       360        370        380        390        400
QVEATPTVLE LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ 
       410        420        430        440        450
VVHPLCPLDT EIFPGNGHCY RLVAEKAPWL QAQEQCRTWA GAALAMVDSP 
       460        470        480        490        500
AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD PRGEAFSLES CQNWLPGEPH 
       510        520        530        540        550
PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT ENFVMGMSGG 
       560        570        580        590        600
GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE 
       610        620        630        640        650
PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP 
       660        670        680        690        700
FDASCNSHVC INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ 
       710        720        730        740        750
DVPMLPGDLI GLQHDAGPGT LLQCPLASSC PGQALYLSTN ASDWMTNLPV 
       760        770        780        790        800
HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP NPGLQHPGHY EVRATVGNSV 
       810        820        830        840        850
SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV LQVDSGANAT 
       860        870        880        890        900
ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD 
       910        920        930        940        950
HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM 
       960        970        980        990       1000
VEAGSDVAFR WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT 
      1010       1020       1030       1040       1050
VNYNVTVERM NKMHGLWVSA VPTVLPPNAT LALTGGVLVD SAVEVAFLWN 
      1060       1070       1080       1090       1100
FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL VEHNTTHIYT TPGEYNLTVL 
      1110       1120       1130       1140       1150
VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF SPYPLPSTDG 
      1160       1170       1180       1190       1200
VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI 
      1210       1220       1230       1240       1250
RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP 
      1260       1270       1280       1290       1300
EATVQHVYLR AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP 
      1310       1320       1330       1340       1350
TQPSAQLMAH VTGDPVHYLF DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP 
      1360       1370       1380       1390       1400
LALVLSSHVN KAHYFTSICV EPEIRNITLQ PERQFVKLGD EARLVAYSWP 
      1410       1420       1430       1440       1450
PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT VSNNISSTND 
      1460       1470       1480       1490       1500
SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS 
      1510       1520       1530       1540       1550
QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS 
      1560       1570       1580       1590       1600
RTVVPLNGSV SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT 
      1610       1620       1630       1640       1650
FNIIVTAENE VGSAQDSIFI YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA 
      1660       1670       1680       1690       1700
AVRDGTNISY SWTAQQEGSL ITLFGSGKCF SLTSLKASTY YVHLRATNML 
      1710       1720       1730       1740       1750
GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA GGSGVVYTWY 
      1760       1770       1780       1790       1800
LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG 
      1810       1820       1830       1840       1850
GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV 
      1860       1870       1880       1890       1900
RFSTAGSFSL QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP 
      1910       1920       1930       1940       1950
VHFEILLAAG SALTFRLQVG GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN 
      1960       1970       1980       1990       2000
HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM ATGTEKNFTA RVQRGSRVAY 
      2010       2020       2030       2040       2050
AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN ELGGVNLTLM 
      2060       2070       2080       2090       2100
VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK 
      2110       2120       2130       2140       2150
TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA 
      2160       2170       2180       2190       2200
LPLQVLMRRS QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM 
      2210       2220       2230       2240       2250
VLPGVDVSRP QLVVPRLALP VGHYCFVFVV SFGDTPLARS IQANVTVAAE 
      2260       2270       2280       2290       2300
RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP NLEDGDQTPL NFHWACVAST 
      2310       2320       2330       2340       2350
QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK AGRKEEATNQ 
      2360       2370       2380       2390       2400
TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC 
      2410       2420       2430       2440       2450
WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS 
      2460       2470       2480       2490       2500
GEEEGCASIR LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG 
      2510       2520       2530       2540       2550
GAPLVYALLL KRCRQSYCEN FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV 
      2560       2570       2580       2590       2600
VQDQLGAAVV ALNRSLTIVL PEPSGNPADL VPWLHSLTAS VLPGLLKQAD 
      2610       2620       2630       2640       2650
PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN ITETLISLRV 
      2660       2670       2680       2690       2700
NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG 
      2710       2720       2730       2740       2750
TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL 
      2760       2770       2780       2790       2800
SSALMRILMR SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH 
      2810       2820       2830       2840       2850
FSIPEAFSGA LSNLSDVVQL IFLVDSNPFP FGYISNYTVS TKVASMAFQT 
      2860       2870       2880       2890       2900
QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ SSHNPVGSTI VQPQTSVSAV 
      2910       2920       2930       2940       2950
VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS VSQPNEYNCS 
      2960       2970       2980       2990       3000
ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV 
      3010       3020       3030       3040       3050
GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP 
      3060       3070       3080       3090       3100
PSHVQFIFPE PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV 
      3110       3120       3130       3140       3150
IPFCGKGGRF KYEILVKTGW SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR 
      3160       3170       3180       3190       3200
AFHRNSLDIF QIATPHSLGS VWKIRVWHDN KGLSPAWFLQ HIIVRDLQSA 
      3210       3220       3230       3240       3250
RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL LVAELQRGFF 
      3260       3270       3280       3290       3300
DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS 
      3310       3320       3330       3340       3350
MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT 
      3360       3370       3380       3390       3400
PTGQQALDVD SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC 
      3410       3420       3430       3440       3450
WPSSEGTLSW PDLLSDPSVV SSTLQRLTQG RPGCMLGSEE DGASLVSPSL 
      3460       3470       3480       3490       3500
PAKYLSASDE DLIHQVLADG ANNLVPTQDT LLETDLLTSL SSVPGEKTET 
      3510       3520       3530       3540       3550
LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL PAWCAPLAHG 
      3560       3570       3580       3590       3600
LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL 
      3610       3620       3630       3640       3650
EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE 
      3660       3670       3680       3690       3700
ARKVKRLHDM LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD 
      3710       3720       3730       3740       3750
SQAFLAITRS DEFWPWMSHV FLPYVHGNQS SPELGPPRLR QVRLQEAFCP 
      3760       3770       3780       3790       3800
DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN GSETWAYSAP DLLGAWYWGY 
      3810       3820       3830       3840       3850
CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV FVELTRYSPA 
      3860       3870       3880       3890       3900
VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF 
      3910       3920       3930       3940       3950
ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD 
      3960       3970       3980       3990       4000
RQWTHFVQDH PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR 
      4010       4020       4030       4040       4050
QWSVFGKTLC RALPELMGAT LGLVLLGVAY AQMAILLISS GADTLYNMAR 
      4060       4070       4080       4090       4100
AFLVLCPGAR VPTLCPSESW YLSPLLCVGL WALRVWGALR LGAILLRWRY 
      4110       4120       4130       4140       4150
HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR HKVRFEGMDP 
      4160       4170       4180       4190       4200
LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP 
      4210       4220       4230       4240       4250
EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP 
      4260       4270       4280       4290 
GCFPGSQPAL PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST
Length:4,293
Mass (Da):466,577
Last modified:July 27, 2011 - v2
Checksum:iFA12403171DBBCE0
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRZ6A0A2I3BRZ6_MOUSE
Polycystin-1
Pkd1
1,231Annotation score:
A0A2I3BRL4A0A2I3BRL4_MOUSE
Polycystin-1
Pkd1
234Annotation score:
A0A2I3BQG6A0A2I3BQG6_MOUSE
Polycystin-1
Pkd1
72Annotation score:
A0A2I3BPP4A0A2I3BPP4_MOUSE
Polycystin-1
Pkd1
237Annotation score:
A0A2I3BRP8A0A2I3BRP8_MOUSE
Polycystin-1
Pkd1
27Annotation score:
A0A2I3BQ02A0A2I3BQ02_MOUSE
Polycystin-1
Pkd1
80Annotation score:
A0A2I3BQE7A0A2I3BQE7_MOUSE
Polycystin-1
Pkd1
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → P in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti771R → Q in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti871E → D in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1180A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1292H → R in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1632A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1684S → A in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1770A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2085R → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2507A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3956F → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3962R → H in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti4237Q → R in AAC53207 (PubMed:9107672).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.
CCDSiCCDS28485.1
RefSeqiNP_038658.2, NM_013630.2
UniGeneiMm.290442
Mm.30435

Genome annotation databases

EnsembliENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855
GeneIDi18763
KEGGimmu:18763
UCSCiuc008awv.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Polycystin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.
CCDSiCCDS28485.1
RefSeqiNP_038658.2, NM_013630.2
UniGeneiMm.290442
Mm.30435

3D structure databases

ProteinModelPortaliO08852
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202204, 3 interactors
DIPiDIP-44233N
IntActiO08852, 8 interactors
MINTiO08852
STRINGi10090.ENSMUSP00000049296

Protein family/group databases

MEROPSiP02.036

PTM databases

iPTMnetiO08852
PhosphoSitePlusiO08852
SwissPalmiO08852

Proteomic databases

MaxQBiO08852
PaxDbiO08852
PRIDEiO08852

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855
GeneIDi18763
KEGGimmu:18763
UCSCiuc008awv.1 mouse

Organism-specific databases

CTDi5310
MGIiMGI:97603 Pkd1

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00700000104221
HOGENOMiHOG000168445
HOVERGENiHBG049412
InParanoidiO08852
KOiK04985
OMAiDVVFRWT
OrthoDBiEOG091G004D
TreeFamiTF316484

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiPkd1 mouse
PROiPR:O08852
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032855 Expressed in 111 organ(s), highest expression level in metanephros
GenevisibleiO08852 MM

Family and domain databases

Gene3Di2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit
SUPFAMiSSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR00864 PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKD1_MOUSE
AccessioniPrimary (citable) accession number: O08852
Secondary accession number(s): E9QJR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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