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UniProtKB - O08852 (PKD1_MOUSE)

Entry version 171 (25 May 2022)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Polycystin-1

Gene

Pkd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity).

Involved in renal tubulogenesis (PubMed:24939912).

Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735).

Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584).

The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway
LigandLectin

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.036

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystin-1Curated
Alternative name(s):
Autosomal dominant polycystic kidney disease 1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97603, Pkd1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000032855

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 3066ExtracellularCuratedAdd BLAST3043
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3067 – 3087HelicalBy similarityAdd BLAST21
Topological domaini3088 – 3269CytoplasmicCuratedAdd BLAST182
Transmembranei3270 – 3290HelicalBy similarityAdd BLAST21
Topological domaini3291 – 3315ExtracellularCuratedAdd BLAST25
Transmembranei3316 – 3336HelicalBy similarityAdd BLAST21
Topological domaini3337 – 3549CytoplasmicCuratedAdd BLAST213
Transmembranei3550 – 3570HelicalBy similarityAdd BLAST21
Topological domaini3571 – 3572ExtracellularCurated2
Transmembranei3573 – 3593HelicalBy similarityAdd BLAST21
Topological domaini3594 – 3655CytoplasmicCuratedAdd BLAST62
Transmembranei3656 – 3676HelicalBy similarityAdd BLAST21
Topological domaini3677 – 3891ExtracellularCuratedAdd BLAST215
Transmembranei3892 – 3912HelicalBy similarityAdd BLAST21
Topological domaini3913 – 3925CytoplasmicCuratedAdd BLAST13
Transmembranei3926 – 3946HelicalBy similarityAdd BLAST21
Topological domaini3947 – 3974ExtracellularCuratedAdd BLAST28
Transmembranei3975 – 3995HelicalBy similarityAdd BLAST21
Topological domaini3996 – 4017CytoplasmicCuratedAdd BLAST22
Transmembranei4018 – 4038HelicalBy similarityAdd BLAST21
Topological domaini4039 – 4080ExtracellularCuratedAdd BLAST42
Transmembranei4081 – 4100HelicalBy similarityAdd BLAST20
Topological domaini4101 – 4293CytoplasmicCuratedAdd BLAST193

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockin mice expressing non-cleavable PKD1 show a hypomorphic phenotype. They are viable, show rapid cystic dilation in renal collecting duct and distal convoluted tubule, but not in the proximal portion of the nephron, during the postnatal period, and die with severe uremia, mostly at 3 weeks of age. Additionally, they show dilation of the common bile duct and intrahepatic biliary ducts, but develop a normal pancreas within their life span.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000035405424 – 4293Polycystin-1Add BLAST4270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi436 ↔ 529By similarity
Disulfide bondi507 ↔ 521By similarity
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi635 ↔ 648By similarity
Disulfide bondi642 ↔ 660By similarity
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi859N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi884N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1004N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1643N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1788N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1876N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2713N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2873N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2986N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3780N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4156Phosphoserine; by PRKX; in vitroBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

After synthesis, undergoes autoproteolytic cleavage between Leu-3040 and Thr-3041 in the GPS domain (PubMed:25405894). Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement (By similarity). This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain (By similarity). PKD1 is ubiquitously and incompletely cleaved in wild-type mice, so that uncleaved and cleaved PKD1 molecules coexist. The differential patterns of cleavage during embryonic development, as well as in adult mice, suggest different functions of uncleaved and cleaved molecules (PubMed:18003909).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3040 – 3041Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O08852

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O08852

PRoteomics IDEntifications database

More...PRIDEi		O08852

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		289438

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O08852, 63 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O08852

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O08852

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O08852

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032855, Expressed in metanephros and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O08852, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O08852, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PKD2; the interaction is required for ciliary localization (PubMed:25405894).

Component of a heterotetrameric channel complex with PKD2; the tetramer contains one PKD1 chain and three PKD2 chains (By similarity).

Interacts with PKD2L1 (PubMed:15548533).

Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney.

Interacts (via extracellular domain) with WNT3A, WNT4 and WNT9B (By similarity).

Interacts with WNT5A, DVL1 and DVL2 (PubMed:27214281).

Interacts with NPHP1 (via SH3 domain) (PubMed:20856870).

Interacts with BBS1, BBS4, BBS5 and TTC8.

Interacts with RGS7 (By similarity).

Interacts (via C-terminal domain) with RABEP1; the interaction connects PKD1:PKD2 to GGA1 and ARL3 that mediate the ciliary targeting (PubMed:25405894).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		202204, 3 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4041, PKD1-PKD2 Polycystin complex

Database of interacting proteins

More...DIPi		DIP-44233N

Protein interaction database and analysis system

More...IntActi		O08852, 8 interactors

Molecular INTeraction database

More...MINTi		O08852

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000049296

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O08852, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O08852

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 67LRRNTAdd BLAST44
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 91LRR 1Add BLAST24
Repeati92 – 113LRR 2Add BLAST22
Domaini125 – 178LRRCTAdd BLAST54
Domaini177 – 271WSCPROSITE-ProRule annotationAdd BLAST95
Domaini272 – 359PKD 1PROSITE-ProRule annotationAdd BLAST88
Domaini415 – 530C-type lectinPROSITE-ProRule annotationAdd BLAST116
Domaini633 – 666LDL-receptor class A; atypicalAdd BLAST34
Domaini849 – 922PKD 2PROSITE-ProRule annotationAdd BLAST74
Domaini929 – 1014PKD 3PROSITE-ProRule annotationAdd BLAST86
Domaini1017 – 1123PKD 4PROSITE-ProRule annotationAdd BLAST107
Domaini1121 – 1209PKD 5PROSITE-ProRule annotationAdd BLAST89
Domaini1207 – 1292PKD 6PROSITE-ProRule annotationAdd BLAST86
Domaini1288 – 1377PKD 7PROSITE-ProRule annotationAdd BLAST90
Domaini1376 – 1463PKD 8PROSITE-ProRule annotationAdd BLAST88
Domaini1462 – 1545PKD 9PROSITE-ProRule annotationAdd BLAST84
Domaini1544 – 1629PKD 10PROSITE-ProRule annotationAdd BLAST86
Domaini1630 – 1718PKD 11PROSITE-ProRule annotationAdd BLAST89
Domaini1716 – 1802PKD 12PROSITE-ProRule annotationAdd BLAST87
Domaini1804 – 1886PKD 13PROSITE-ProRule annotationAdd BLAST83
Domaini1885 – 1970PKD 14PROSITE-ProRule annotationAdd BLAST86
Domaini1972 – 2053PKD 15PROSITE-ProRule annotationAdd BLAST82
Domaini2056 – 2144PKD 16PROSITE-ProRule annotationAdd BLAST89
Domaini2142 – 2828REJPROSITE-ProRule annotationAdd BLAST687
Domaini3004 – 3053GPSPROSITE-ProRule annotationAdd BLAST50
Domaini3110 – 3225PLATPROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni613 – 632DisorderedSequence analysisAdd BLAST20
Regioni4150 – 4197DisorderedSequence analysisAdd BLAST48
Regioni4235 – 4293DisorderedSequence analysisAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4210 – 4241Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4154 – 4197Polar residuesSequence analysisAdd BLAST44
Compositional biasi4261 – 4293Polar residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3599, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158702

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000173_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O08852

Identification of Orthologs from Complete Genome Data

More...OMAi		LEAMMRI

Database of Orthologous Groups

More...OrthoDBi		1276906at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O08852

TreeFam database of animal gene trees

More...TreeFami		TF316484

Family and domain databases

Conserved Domains Database

More...CDDi		cd01752, PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000483, Cys-rich_flank_reg_C
IPR000203, GPS
IPR013783, Ig-like_fold
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR000434, PC1
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR006228, Polycystin_cat
IPR014010, REJ_dom
IPR002889, WSC_carb-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00059, Lectin_C, 1 hit
PF13855, LRR_8, 1 hit
PF00801, PKD, 14 hits
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
PF01822, WSC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00500, POLYCYSTIN1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00369, LRR_TYP, 1 hit
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SM00089, PKD, 15 hits
SM00321, WSC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49299, SSF49299, 13 hits
SSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00864, PCC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS51450, LRR, 3 hits
PS50093, PKD, 12 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit
PS51212, WSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O08852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN 
        60         70         80         90        100
CSGRWLQTLG PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN 
       110        120        130        140        150
NRISTLEEGV FANLFNLSEI NLSGNPFECN CGLAWLPRWA KEHQVHVVQS 
       160        170        180        190        200
EATTCRGPIP LAGQPLLSIP LLDNACGEEY VACLPDNSSG AVAAVPFYFA 
       210        220        230        240        250
HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS SAACSSWCSS 
       260        270        280        290        300
ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI 
       310        320        330        340        350
SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV 
       360        370        380        390        400
QVEATPTVLE LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ 
       410        420        430        440        450
VVHPLCPLDT EIFPGNGHCY RLVAEKAPWL QAQEQCRTWA GAALAMVDSP 
       460        470        480        490        500
AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD PRGEAFSLES CQNWLPGEPH 
       510        520        530        540        550
PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT ENFVMGMSGG 
       560        570        580        590        600
GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE 
       610        620        630        640        650
PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP 
       660        670        680        690        700
FDASCNSHVC INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ 
       710        720        730        740        750
DVPMLPGDLI GLQHDAGPGT LLQCPLASSC PGQALYLSTN ASDWMTNLPV 
       760        770        780        790        800
HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP NPGLQHPGHY EVRATVGNSV 
       810        820        830        840        850
SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV LQVDSGANAT 
       860        870        880        890        900
ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD 
       910        920        930        940        950
HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM 
       960        970        980        990       1000
VEAGSDVAFR WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT 
      1010       1020       1030       1040       1050
VNYNVTVERM NKMHGLWVSA VPTVLPPNAT LALTGGVLVD SAVEVAFLWN 
      1060       1070       1080       1090       1100
FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL VEHNTTHIYT TPGEYNLTVL 
      1110       1120       1130       1140       1150
VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF SPYPLPSTDG 
      1160       1170       1180       1190       1200
VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI 
      1210       1220       1230       1240       1250
RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP 
      1260       1270       1280       1290       1300
EATVQHVYLR AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP 
      1310       1320       1330       1340       1350
TQPSAQLMAH VTGDPVHYLF DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP 
      1360       1370       1380       1390       1400
LALVLSSHVN KAHYFTSICV EPEIRNITLQ PERQFVKLGD EARLVAYSWP 
      1410       1420       1430       1440       1450
PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT VSNNISSTND 
      1460       1470       1480       1490       1500
SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS 
      1510       1520       1530       1540       1550
QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS 
      1560       1570       1580       1590       1600
RTVVPLNGSV SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT 
      1610       1620       1630       1640       1650
FNIIVTAENE VGSAQDSIFI YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA 
      1660       1670       1680       1690       1700
AVRDGTNISY SWTAQQEGSL ITLFGSGKCF SLTSLKASTY YVHLRATNML 
      1710       1720       1730       1740       1750
GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA GGSGVVYTWY 
      1760       1770       1780       1790       1800
LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG 
      1810       1820       1830       1840       1850
GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV 
      1860       1870       1880       1890       1900
RFSTAGSFSL QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP 
      1910       1920       1930       1940       1950
VHFEILLAAG SALTFRLQVG GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN 
      1960       1970       1980       1990       2000
HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM ATGTEKNFTA RVQRGSRVAY 
      2010       2020       2030       2040       2050
AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN ELGGVNLTLM 
      2060       2070       2080       2090       2100
VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK 
      2110       2120       2130       2140       2150
TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA 
      2160       2170       2180       2190       2200
LPLQVLMRRS QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM 
      2210       2220       2230       2240       2250
VLPGVDVSRP QLVVPRLALP VGHYCFVFVV SFGDTPLARS IQANVTVAAE 
      2260       2270       2280       2290       2300
RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP NLEDGDQTPL NFHWACVAST 
      2310       2320       2330       2340       2350
QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK AGRKEEATNQ 
      2360       2370       2380       2390       2400
TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC 
      2410       2420       2430       2440       2450
WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS 
      2460       2470       2480       2490       2500
GEEEGCASIR LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG 
      2510       2520       2530       2540       2550
GAPLVYALLL KRCRQSYCEN FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV 
      2560       2570       2580       2590       2600
VQDQLGAAVV ALNRSLTIVL PEPSGNPADL VPWLHSLTAS VLPGLLKQAD 
      2610       2620       2630       2640       2650
PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN ITETLISLRV 
      2660       2670       2680       2690       2700
NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG 
      2710       2720       2730       2740       2750
TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL 
      2760       2770       2780       2790       2800
SSALMRILMR SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH 
      2810       2820       2830       2840       2850
FSIPEAFSGA LSNLSDVVQL IFLVDSNPFP FGYISNYTVS TKVASMAFQT 
      2860       2870       2880       2890       2900
QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ SSHNPVGSTI VQPQTSVSAV 
      2910       2920       2930       2940       2950
VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS VSQPNEYNCS 
      2960       2970       2980       2990       3000
ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV 
      3010       3020       3030       3040       3050
GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP 
      3060       3070       3080       3090       3100
PSHVQFIFPE PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV 
      3110       3120       3130       3140       3150
IPFCGKGGRF KYEILVKTGW SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR 
      3160       3170       3180       3190       3200
AFHRNSLDIF QIATPHSLGS VWKIRVWHDN KGLSPAWFLQ HIIVRDLQSA 
      3210       3220       3230       3240       3250
RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL LVAELQRGFF 
      3260       3270       3280       3290       3300
DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS 
      3310       3320       3330       3340       3350
MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT 
      3360       3370       3380       3390       3400
PTGQQALDVD SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC 
      3410       3420       3430       3440       3450
WPSSEGTLSW PDLLSDPSVV SSTLQRLTQG RPGCMLGSEE DGASLVSPSL 
      3460       3470       3480       3490       3500
PAKYLSASDE DLIHQVLADG ANNLVPTQDT LLETDLLTSL SSVPGEKTET 
      3510       3520       3530       3540       3550
LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL PAWCAPLAHG 
      3560       3570       3580       3590       3600
LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL 
      3610       3620       3630       3640       3650
EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE 
      3660       3670       3680       3690       3700
ARKVKRLHDM LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD 
      3710       3720       3730       3740       3750
SQAFLAITRS DEFWPWMSHV FLPYVHGNQS SPELGPPRLR QVRLQEAFCP 
      3760       3770       3780       3790       3800
DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN GSETWAYSAP DLLGAWYWGY 
      3810       3820       3830       3840       3850
CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV FVELTRYSPA 
      3860       3870       3880       3890       3900
VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF 
      3910       3920       3930       3940       3950
ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD 
      3960       3970       3980       3990       4000
RQWTHFVQDH PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR 
      4010       4020       4030       4040       4050
QWSVFGKTLC RALPELMGAT LGLVLLGVAY AQMAILLISS GADTLYNMAR 
      4060       4070       4080       4090       4100
AFLVLCPGAR VPTLCPSESW YLSPLLCVGL WALRVWGALR LGAILLRWRY 
      4110       4120       4130       4140       4150
HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR HKVRFEGMDP 
      4160       4170       4180       4190       4200
LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP 
      4210       4220       4230       4240       4250
EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP 
      4260       4270       4280       4290 
GCFPGSQPAL PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST
Length:4,293
Mass (Da):466,577
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA12403171DBBCE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRZ6A0A2I3BRZ6_MOUSE
Polycystin-1
Pkd1
1,231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRL4A0A2I3BRL4_MOUSE
Polycystin-1
Pkd1
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQG6A0A2I3BQG6_MOUSE
Polycystin-1
Pkd1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPP4A0A2I3BPP4_MOUSE
Polycystin-1
Pkd1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRP8A0A2I3BRP8_MOUSE
Polycystin-1
Pkd1
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ02A0A2I3BQ02_MOUSE
Polycystin-1
Pkd1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQE7A0A2I3BQE7_MOUSE
Polycystin-1
Pkd1
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3L → P in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti771R → Q in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti871E → D in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1180A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1292H → R in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1632A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1684S → A in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1770A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2085R → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2507A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3956F → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3962R → H in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti4237Q → R in AAC53207 (PubMed:9107672).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28485.1

NCBI Reference Sequences

More...RefSeqi		NP_038658.2, NM_013630.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18763

UCSC genome browser

More...UCSCi		uc008awv.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Polycystin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.
CCDSiCCDS28485.1
RefSeqiNP_038658.2, NM_013630.2

3D structure databases

SMRiO08852
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202204, 3 interactors
ComplexPortaliCPX-4041, PKD1-PKD2 Polycystin complex
DIPiDIP-44233N
IntActiO08852, 8 interactors
MINTiO08852
STRINGi10090.ENSMUSP00000049296

Protein family/group databases

MEROPSiP02.036

PTM databases

GlyGeniO08852, 63 sites
iPTMnetiO08852
PhosphoSitePlusiO08852
SwissPalmiO08852

Proteomic databases

MaxQBiO08852
PaxDbiO08852
PRIDEiO08852
ProteomicsDBi289438

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23502, 205 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		18763

Genome annotation databases

EnsembliENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855
GeneIDi18763
KEGGimmu:18763
UCSCiuc008awv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5310
MGIiMGI:97603, Pkd1
VEuPathDBiHostDB:ENSMUSG00000032855

Phylogenomic databases

eggNOGiKOG3599, Eukaryota
GeneTreeiENSGT00940000158702
HOGENOMiCLU_000173_0_0_1
InParanoidiO08852
OMAiLEAMMRI
OrthoDBi1276906at2759
PhylomeDBiO08852
TreeFamiTF316484

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18763, 2 hits in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pkd1, mouse

Protein Ontology

More...PROi		PR:O08852
RNActiO08852, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032855, Expressed in metanephros and 147 other tissues
ExpressionAtlasiO08852, baseline and differential
GenevisibleiO08852, MM

Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
Gene3Di2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000483, Cys-rich_flank_reg_C
IPR000203, GPS
IPR013783, Ig-like_fold
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR000434, PC1
IPR022409, PKD/Chitinase_dom
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR006228, Polycystin_cat
IPR014010, REJ_dom
IPR002889, WSC_carb-bd
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
PF13855, LRR_8, 1 hit
PF00801, PKD, 14 hits
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
PF01822, WSC, 1 hit
PRINTSiPR00500, POLYCYSTIN1
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SM00369, LRR_TYP, 1 hit
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SM00089, PKD, 15 hits
SM00321, WSC, 1 hit
SUPFAMiSSF49299, SSF49299, 13 hits
SSF49723, SSF49723, 1 hit
SSF56436, SSF56436, 1 hit
TIGRFAMsiTIGR00864, PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS50221, GPS, 1 hit
PS51450, LRR, 3 hits
PS50093, PKD, 12 hits
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit
PS51212, WSC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08852
Secondary accession number(s): E9QJR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 27, 2011
Last modified: May 25, 2022
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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