Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polycystin-1

Gene

Pkd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis (PubMed:24939912). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:12514735). Acts as a regulator of cilium length, together with PKD2 (PubMed:20096584). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.036

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystin-1Curated
Alternative name(s):
Autosomal dominant polycystic kidney disease 1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97603 Pkd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 3066ExtracellularCuratedAdd BLAST3043
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3067 – 3087HelicalBy similarityAdd BLAST21
Topological domaini3088 – 3269CytoplasmicCuratedAdd BLAST182
Transmembranei3270 – 3290HelicalBy similarityAdd BLAST21
Topological domaini3291 – 3315ExtracellularCuratedAdd BLAST25
Transmembranei3316 – 3336HelicalBy similarityAdd BLAST21
Topological domaini3337 – 3549CytoplasmicCuratedAdd BLAST213
Transmembranei3550 – 3570HelicalBy similarityAdd BLAST21
Topological domaini3571 – 3572ExtracellularCurated2
Transmembranei3573 – 3593HelicalBy similarityAdd BLAST21
Topological domaini3594 – 3655CytoplasmicCuratedAdd BLAST62
Transmembranei3656 – 3676HelicalBy similarityAdd BLAST21
Topological domaini3677 – 3891ExtracellularCuratedAdd BLAST215
Transmembranei3892 – 3912HelicalBy similarityAdd BLAST21
Topological domaini3913 – 3925CytoplasmicCuratedAdd BLAST13
Transmembranei3926 – 3946HelicalBy similarityAdd BLAST21
Topological domaini3947 – 3974ExtracellularCuratedAdd BLAST28
Transmembranei3975 – 3995HelicalBy similarityAdd BLAST21
Topological domaini3996 – 4017CytoplasmicCuratedAdd BLAST22
Transmembranei4018 – 4038HelicalBy similarityAdd BLAST21
Topological domaini4039 – 4080ExtracellularCuratedAdd BLAST42
Transmembranei4081 – 4100HelicalBy similarityAdd BLAST20
Topological domaini4101 – 4293CytoplasmicCuratedAdd BLAST193

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockin mice expressing non-cleavable PKD1 show a hypomorphic phenotype. They are viable, show rapid cystic dilation in renal collecting duct and distal convoluted tubule, but not in the proximal portion of the nephron, during the postnatal period, and die with severe uremia, mostly at 3 weeks of age. Additionally, they show dilation of the common bile duct and intrahepatic biliary ducts, but develop a normal pancreas within their life span.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000035405424 – 4293Polycystin-1Add BLAST4270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi436 ↔ 529By similarity
Disulfide bondi507 ↔ 521By similarity
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi635 ↔ 648By similarity
Disulfide bondi642 ↔ 660By similarity
Glycosylationi662N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi848N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi859N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi884N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi998N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1004N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1643N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1788N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1831N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1876N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1987N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2713N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2749N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2873N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2986N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3728N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3780N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4156Phosphoserine; by PRKX; in vitroBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

After synthesis, undergoes autoproteolytic cleavage between Leu-3040 and Thr-3041 in the GPS domain (PubMed:25405894). Cleavage at the GPS domain occurs through a cis-autoproteolytic mechanism involving an ester-intermediate via N-O acyl rearrangement (By similarity). This process takes place in the early secretory pathway, depends on initial N-glycosylation, and requires the REJ domain (By similarity). PKD1 is ubiquitously and incompletely cleaved in wild-type mice, so that uncleaved and cleaved PKD1 molecules coexist. The differential patterns of cleavage during embryonic development, as well as in adult mice, suggest different functions of uncleaved and cleaved molecules (PubMed:18003909).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3040 – 3041Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08852

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08852

PRoteomics IDEntifications database

More...
PRIDEi
O08852

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08852

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08852

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O08852

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032855 Expressed in 111 organ(s), highest expression level in metanephros

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08852 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PKD2; the interaction is required for ciliary localization (PubMed:25405894). Component of a heterotetrameric channel complex with PKD2; the tetramer contains one PKD1 chain and three PKD2 chains (By similarity). Interacts with PKD2L1 (PubMed:15548533). Interacts with PRKX; involved in differentiation and controlled morphogenesis of the kidney. Interacts (via extracellular domain) with WNT3A, WNT4 and WNT9B (By similarity). Interacts with WNT5A, DVL1 and DVL2 (PubMed:27214281). Interacts with NPHP1 (via SH3 domain) (PubMed:20856870). Interacts with BBS1, BBS4, BBS5 and TTC8. Interacts with RGS7 (By similarity). Interacts (via C-terminal domain) with RABEP1; the interaction connects PKD1:PKD2 to GGA1 and ARL3 that mediate the ciliary targeting (PubMed:25405894).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PKD2Q13563-12EBI-6666305,EBI-9837017From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202204, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-44233N

Protein interaction database and analysis system

More...
IntActi
O08852, 8 interactors

Molecular INTeraction database

More...
MINTi
O08852

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000049296

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O08852

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 67LRRNTAdd BLAST44
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 91LRR 1Add BLAST24
Repeati92 – 113LRR 2Add BLAST22
Domaini125 – 178LRRCTAdd BLAST54
Domaini177 – 271WSCPROSITE-ProRule annotationAdd BLAST95
Domaini272 – 359PKD 1PROSITE-ProRule annotationAdd BLAST88
Domaini415 – 530C-type lectinPROSITE-ProRule annotationAdd BLAST116
Domaini633 – 666LDL-receptor class A; atypicalAdd BLAST34
Domaini849 – 922PKD 2PROSITE-ProRule annotationAdd BLAST74
Domaini929 – 1014PKD 3PROSITE-ProRule annotationAdd BLAST86
Domaini1017 – 1123PKD 4PROSITE-ProRule annotationAdd BLAST107
Domaini1121 – 1209PKD 5PROSITE-ProRule annotationAdd BLAST89
Domaini1207 – 1292PKD 6PROSITE-ProRule annotationAdd BLAST86
Domaini1288 – 1377PKD 7PROSITE-ProRule annotationAdd BLAST90
Domaini1376 – 1463PKD 8PROSITE-ProRule annotationAdd BLAST88
Domaini1462 – 1545PKD 9PROSITE-ProRule annotationAdd BLAST84
Domaini1544 – 1629PKD 10PROSITE-ProRule annotationAdd BLAST86
Domaini1630 – 1718PKD 11PROSITE-ProRule annotationAdd BLAST89
Domaini1716 – 1802PKD 12PROSITE-ProRule annotationAdd BLAST87
Domaini1804 – 1886PKD 13PROSITE-ProRule annotationAdd BLAST83
Domaini1885 – 1970PKD 14PROSITE-ProRule annotationAdd BLAST86
Domaini1972 – 2053PKD 15PROSITE-ProRule annotationAdd BLAST82
Domaini2056 – 2144PKD 16PROSITE-ProRule annotationAdd BLAST89
Domaini2142 – 2828REJPROSITE-ProRule annotationAdd BLAST687
Domaini3004 – 3053GPSPROSITE-ProRule annotationAdd BLAST50
Domaini3110 – 3225PLATPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4210 – 4241Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3581 – 3585Poly-Ser5
Compositional biasi4153 – 4194Ser-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599 Eukaryota
ENOG410XTGE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158702

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168445

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG049412

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08852

KEGG Orthology (KO)

More...
KOi
K04985

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVVFRWT

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316484

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00500 POLYCYSTIN1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00864 PCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O08852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGAPALLA LALGLGLWLG ALAGDPGRGC GPCPLPCFCG PAPDAACRVN
60 70 80 90 100
CSGRWLQTLG PSLRIPADAT ALDLSHNLLQ TLDIGLLVNL SALVELDLSN
110 120 130 140 150
NRISTLEEGV FANLFNLSEI NLSGNPFECN CGLAWLPRWA KEHQVHVVQS
160 170 180 190 200
EATTCRGPIP LAGQPLLSIP LLDNACGEEY VACLPDNSSG AVAAVPFYFA
210 220 230 240 250
HEGPLETEAC SAFCFSAGEG LAALSEQNQC LCGAGQASNS SAACSSWCSS
260 270 280 290 300
ISLSLNSACG GPTLLQHTFP ASPGATLVGP HGPLASGQPA DFHITSSLPI
310 320 330 340 350
SSTRWNFGDG SPEVDMASPA ATHFYVLPGS YHMTVVLALG AGSALLETEV
360 370 380 390 400
QVEATPTVLE LVCPSFVHSN ESLELGIRHR GGSALEVTYS ILALDKEPAQ
410 420 430 440 450
VVHPLCPLDT EIFPGNGHCY RLVAEKAPWL QAQEQCRTWA GAALAMVDSP
460 470 480 490 500
AIQHFLVSKV TRSLDVWIGF SSVEGTEGLD PRGEAFSLES CQNWLPGEPH
510 520 530 540 550
PATAEHCVRL GPAGQCNTDL CSAPHSYVCE LRPGGPVWDT ENFVMGMSGG
560 570 580 590 600
GLSGPLHPLA QQETVQGPLR PVEVMVFPGL SPSREAFLTA AEFSTQKLEE
610 620 630 640 650
PAQMRLQVYR PSGGAAAVPE GSSEPDNRTE PAPKCVPEEL WCPGANVCIP
660 670 680 690 700
FDASCNSHVC INGSVSRLGL SRASYTLWKE FFFSVPAGPP TQYLVTLHSQ
710 720 730 740 750
DVPMLPGDLI GLQHDAGPGT LLQCPLASSC PGQALYLSTN ASDWMTNLPV
760 770 780 790 800
HLEEAWAGPV CSLQLLLVTE RLTPLLGLGP NPGLQHPGHY EVRATVGNSV
810 820 830 840 850
SRQNLSCSFS VVSPIAGLRV IHPIPLDGHI YVPTNGSVLV LQVDSGANAT
860 870 880 890 900
ATAQWFGGNI SAPFEDACPP EVDFLKQDCT EEANGTLFSV LMLPRLKEGD
910 920 930 940 950
HTVEIVAQNG ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM
960 970 980 990 1000
VEAGSDVAFR WTIDDKQSLT FHNTVFNVIY QSAAIFKLSL TASNHVSNIT
1010 1020 1030 1040 1050
VNYNVTVERM NKMHGLWVSA VPTVLPPNAT LALTGGVLVD SAVEVAFLWN
1060 1070 1080 1090 1100
FGDGEQVLRQ FKPPYDESFQ VPDPTVAQVL VEHNTTHIYT TPGEYNLTVL
1110 1120 1130 1140 1150
VSNTYENLTQ QVTVSVRTVL PNVAIGMSSN VLVAGQPITF SPYPLPSTDG
1160 1170 1180 1190 1200
VLYTWDFGDG SPVLIQSQPV LNHTYSMTGA YRITLEVNNT VSSVTAHADI
1210 1220 1230 1240 1250
RVFQELHGLT VYLSPSVEQG APMVVSASVE SGDNITWTFD MGDGTVFTGP
1260 1270 1280 1290 1300
EATVQHVYLR AQNFTVTVEA ANPAGHLSQS LHVQVFVLEV LHIEPSTCIP
1310 1320 1330 1340 1350
TQPSAQLMAH VTGDPVHYLF DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP
1360 1370 1380 1390 1400
LALVLSSHVN KAHYFTSICV EPEIRNITLQ PERQFVKLGD EARLVAYSWP
1410 1420 1430 1440 1450
PFPYRYTWDF GTEDTTHTQT GGSEVKFIYR EPGSYLVIVT VSNNISSTND
1460 1470 1480 1490 1500
SAFVEVQEPV LVTGIRINGS HVLELQQPYL LSAMGSGSPA TYLWELGDGS
1510 1520 1530 1540 1550
QSEGPEVTHI YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS
1560 1570 1580 1590 1600
RTVVPLNGSV SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT
1610 1620 1630 1640 1650
FNIIVTAENE VGSAQDSIFI YVLQFIEGLQ VAGGDNGCCF PTNYTLQLQA
1660 1670 1680 1690 1700
AVRDGTNISY SWTAQQEGSL ITLFGSGKCF SLTSLKASTY YVHLRATNML
1710 1720 1730 1740 1750
GSAAANRTID FVEPVESLIL SASPNPAAVN MSLTLCAELA GGSGVVYTWY
1760 1770 1780 1790 1800
LEEGLSWKTS MPSTTHTFAA PGLHLVRVTA ENQLGSVNAT VEVAIQVPVG
1810 1820 1830 1840 1850
GLSIRTSEPD SIFVAAGSTL PFWGQLAEGT NVTWCWTLPG GSKDSQYIAV
1860 1870 1880 1890 1900
RFSTAGSFSL QLNASNAVSW VSAMYNLTVE EPIVNLMLWA SSKVVAPGQP
1910 1920 1930 1940 1950
VHFEILLAAG SALTFRLQVG GSVPEVLPSP HFSHSFFRVG DHLVNVQAEN
1960 1970 1980 1990 2000
HVSHAQAQVR ILVLEAVVGL QVPNCCEPGM ATGTEKNFTA RVQRGSRVAY
2010 2020 2030 2040 2050
AWYFSLQKVQ GDSLVILSGR DVTYTPVAAG LLEIHVRAFN ELGGVNLTLM
2060 2070 2080 2090 2100
VEVQDIIQYV TLQSGRCFTN RSARFEAATS PSPRRVTYHW DFGDGTPVQK
2110 2120 2130 2140 2150
TEEFWADHYY LRPGDYHVEV NATNLVSFFV AQATVTVQVL ACREPEVEVA
2160 2170 2180 2190 2200
LPLQVLMRRS QRNYLEAHVD LRNCVSYQTE YRWEIYRTAS CQRPGRMAQM
2210 2220 2230 2240 2250
VLPGVDVSRP QLVVPRLALP VGHYCFVFVV SFGDTPLARS IQANVTVAAE
2260 2270 2280 2290 2300
RLVPIIEGGS YRVWSDTQDL VLDGSKSYDP NLEDGDQTPL NFHWACVAST
2310 2320 2330 2340 2350
QSETGGCVLN FGPRGSSVVT IPLERLEAGV EYTFNLIVWK AGRKEEATNQ
2360 2370 2380 2390 2400
TVLIRSGRVP IVSLECVSCK AQAVYEVSRS SYVYLEGHCH NCSRGYKQGC
2410 2420 2430 2440 2450
WAARTFSNKT LVLNETTTST GSTGMNLVVR PGALRDGEGY IFTLTVLGHS
2460 2470 2480 2490 2500
GEEEGCASIR LSPNRPPLGG SCRLFPLDSV RGLTTKVHFE CTGWRDAEDG
2510 2520 2530 2540 2550
GAPLVYALLL KRCRQSYCEN FCIYKGSLST YGAVLPPGFQ PLFVVSLAVV
2560 2570 2580 2590 2600
VQDQLGAAVV ALNRSLTIVL PEPSGNPADL VPWLHSLTAS VLPGLLKQAD
2610 2620 2630 2640 2650
PQHVIEYSLA LITVLNEYEQ APDVSEPNVE QQLRAQMRKN ITETLISLRV
2660 2670 2680 2690 2700
NTVDDIQQIT AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG
2710 2720 2730 2740 2750
TLTPTTIADS ILNITGDLIH LASLDMQGPQ PLELGVEPPS LMVASKAYNL
2760 2770 2780 2790 2800
SSALMRILMR SRVLNEEPLT LAGEEIVALG KRSDPLSLLC YGKALGPSCH
2810 2820 2830 2840 2850
FSIPEAFSGA LSNLSDVVQL IFLVDSNPFP FGYISNYTVS TKVASMAFQT
2860 2870 2880 2890 2900
QTGTQIPIEQ LAAERAITVK VPNNSDQAAQ SSHNPVGSTI VQPQTSVSAV
2910 2920 2930 2940 2950
VTADNSNPQA GLHLRITYTV LNERYLSAEP EPYLAVYLHS VSQPNEYNCS
2960 2970 2980 2990 3000
ASRRISLEVL EGADHRLYTF FIAPGTGTLD RSYYLNLTSH FHWSALEVSV
3010 3020 3030 3040 3050
GLYTSLCQYF SEEMMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP
3060 3070 3080 3090 3100
PSHVQFIFPE PSASINYIVL LTCVICLVTY VVMAMILRKL DQLDVSRVRV
3110 3120 3130 3140 3150
IPFCGKGGRF KYEILVKTGW SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR
3160 3170 3180 3190 3200
AFHRNSLDIF QIATPHSLGS VWKIRVWHDN KGLSPAWFLQ HIIVRDLQSA
3210 3220 3230 3240 3250
RSTFFLVNDW LSVETEANGG LVEKEVLAAN EAALWQFQRL LVAELQRGFF
3260 3270 3280 3290 3300
DKHIWLSIWD RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVRDTTYS
3310 3320 3330 3340 3350
MGPVSSLISP GVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT
3360 3370 3380 3390 3400
PTGQQALDVD SYLDPSVLDS SLLTLSGLTE AFAGQVKNDL FLEDAKSLVC
3410 3420 3430 3440 3450
WPSSEGTLSW PDLLSDPSVV SSTLQRLTQG RPGCMLGSEE DGASLVSPSL
3460 3470 3480 3490 3500
PAKYLSASDE DLIHQVLADG ANNLVPTQDT LLETDLLTSL SSVPGEKTET
3510 3520 3530 3540 3550
LILQTVGEER PASMGLSWEQ SPVTRLSRTG LVEGFQKRLL PAWCAPLAHG
3560 3570 3580 3590 3600
LSLLLVAVAV AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL
3610 3620 3630 3640 3650
EALYFSLVAK RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE
3660 3670 3680 3690 3700
ARKVKRLHDM LKRLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD
3710 3720 3730 3740 3750
SQAFLAITRS DEFWPWMSHV FLPYVHGNQS SPELGPPRLR QVRLQEAFCP
3760 3770 3780 3790 3800
DPSSSEHMCS AAGSLSTSDY GIGWQSVVQN GSETWAYSAP DLLGAWYWGY
3810 3820 3830 3840 3850
CAVYDSGGYI QELGLSLEES RARLGFLQLH NWLDSRSRAV FVELTRYSPA
3860 3870 3880 3890 3900
VGLHAAVTLR LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF
3910 3920 3930 3940 3950
ALYFSMAEVQ TWRKDGCACT ARPDTWARCL LVILTAATGL VRLAQLGIAD
3960 3970 3980 3990 4000
RQWTHFVQDH PRHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQQLRFVR
4010 4020 4030 4040 4050
QWSVFGKTLC RALPELMGAT LGLVLLGVAY AQMAILLISS GADTLYNMAR
4060 4070 4080 4090 4100
AFLVLCPGAR VPTLCPSESW YLSPLLCVGL WALRVWGALR LGAILLRWRY
4110 4120 4130 4140 4150
HALRGELYRP AWEPQDYEMV ELFLRRLRLW MGFSKVKEFR HKVRFEGMDP
4160 4170 4180 4190 4200
LPSRSSRGSK SSPVVLPPSS GSEASHPSTS SSQPDGPSAS LSRSTLKLEP
4210 4220 4230 4240 4250
EPSRLHAVFE SLLVQFDRLN QATEDVYQLE QQLQSLQGHG HNGPPSSPSP
4260 4270 4280 4290
GCFPGSQPAL PSRLSRASQG LDQTVGPNRV SLWPNNKVHP SST
Length:4,293
Mass (Da):466,577
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA12403171DBBCE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRZ6A0A2I3BRZ6_MOUSE
Polycystin-1
Pkd1
1,231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRL4A0A2I3BRL4_MOUSE
Polycystin-1
Pkd1
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQG6A0A2I3BQG6_MOUSE
Polycystin-1
Pkd1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPP4A0A2I3BPP4_MOUSE
Polycystin-1
Pkd1
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRP8A0A2I3BRP8_MOUSE
Polycystin-1
Pkd1
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQE7A0A2I3BQE7_MOUSE
Polycystin-1
Pkd1
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BQ02A0A2I3BQ02_MOUSE
Polycystin-1
Pkd1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3L → P in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti771R → Q in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti871E → D in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1180A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1292H → R in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1632A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1684S → A in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti1770A → T in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2085R → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti2507A → V in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3956F → C in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti3962R → H in AAC53207 (PubMed:9107672).Curated1
Sequence conflicti4237Q → R in AAC53207 (PubMed:9107672).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28485.1

NCBI Reference Sequences

More...
RefSeqi
NP_038658.2, NM_013630.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.290442
Mm.30435

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18763

UCSC genome browser

More...
UCSCi
uc008awv.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Polycystin-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70209 mRNA Translation: AAC53207.1
AC132367 Genomic DNA No translation available.
CCDSiCCDS28485.1
RefSeqiNP_038658.2, NM_013630.2
UniGeneiMm.290442
Mm.30435

3D structure databases

ProteinModelPortaliO08852
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202204, 3 interactors
DIPiDIP-44233N
IntActiO08852, 8 interactors
MINTiO08852
STRINGi10090.ENSMUSP00000049296

Protein family/group databases

MEROPSiP02.036

PTM databases

iPTMnetiO08852
PhosphoSitePlusiO08852
SwissPalmiO08852

Proteomic databases

MaxQBiO08852
PaxDbiO08852
PRIDEiO08852

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035565; ENSMUSP00000049296; ENSMUSG00000032855
GeneIDi18763
KEGGimmu:18763
UCSCiuc008awv.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5310
MGIiMGI:97603 Pkd1

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00940000158702
HOGENOMiHOG000168445
HOVERGENiHBG049412
InParanoidiO08852
KOiK04985
OMAiDVVFRWT
OrthoDBi1276906at2759
TreeFamiTF316484

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pkd1 mouse

Protein Ontology

More...
PROi
PR:O08852

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032855 Expressed in 111 organ(s), highest expression level in metanephros
GenevisibleiO08852 MM

Family and domain databases

Gene3Di2.60.40.10, 9 hits
3.10.100.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit
SUPFAMiSSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR00864 PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08852
Secondary accession number(s): E9QJR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again