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Protein

Regulator of G-protein signaling 5

Gene

Rgs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 5
Short name:
RGS5
Gene namesi
Name:Rgs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1098434 Rgs5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041891 – 181Regulator of G-protein signaling 5Add BLAST181

Proteomic databases

PaxDbiO08850
PRIDEiO08850

PTM databases

PhosphoSitePlusiO08850

Expressioni

Tissue specificityi

Expressed in heart and muscle.

Gene expression databases

BgeeiENSMUSG00000026678 Expressed in 306 organ(s), highest expression level in brain blood vessel
CleanExiMM_RGS5
ExpressionAtlasiO08850 baseline and differential
GenevisibleiO08850 MM

Interactioni

Protein-protein interaction databases

ELMiO08850
STRINGi10090.ENSMUSP00000027997

Structurei

3D structure databases

ProteinModelPortaliO08850
SMRiO08850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 180RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO08850
KOiK16449
OMAiKRIYALM
OrthoDBiEOG091G0BDG
PhylomeDBiO08850
TreeFamiTF315837

Family and domain databases

CDDicd08717 RGS_RGS5, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR034955 RGS5
IPR034956 RGS_RGS5
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF42 PTHR10845:SF42, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08850-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA
60 70 80 90 100
HKPSLEEVLQ WRQSLDKLLQ NSYGFASFKS FLKSEFSEEN LEFWVACENY
110 120 130 140 150
KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPRS
160 170 180
FDLAQKRIYA LMEKDSLPRF VRSEFYKELI K
Length:181
Mass (Da):21,086
Last modified:August 14, 2001 - v2
Checksum:iB4B561CFE3DA9630
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWD0A0A0A6YWD0_MOUSE
Regulator of G-protein signaling 5,...
Rgs5 mCG_10644
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50KA → NG in AAB50618 (PubMed:9079700).Curated2
Sequence conflicti77S → T in AAB50618 (PubMed:9079700).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67188 mRNA Translation: AAB50618.1
AK004165 mRNA Translation: BAB23201.1
AK044096 mRNA Translation: BAC31773.1
AK054098 mRNA Translation: BAC35655.1
BC037683 mRNA Translation: AAH37683.1
CCDSiCCDS15464.1
RefSeqiNP_033089.2, NM_009063.4
UniGeneiMm.20954

Genome annotation databases

EnsembliENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678
GeneIDi19737
KEGGimmu:19737
UCSCiuc007dlm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67188 mRNA Translation: AAB50618.1
AK004165 mRNA Translation: BAB23201.1
AK044096 mRNA Translation: BAC31773.1
AK054098 mRNA Translation: BAC35655.1
BC037683 mRNA Translation: AAH37683.1
CCDSiCCDS15464.1
RefSeqiNP_033089.2, NM_009063.4
UniGeneiMm.20954

3D structure databases

ProteinModelPortaliO08850
SMRiO08850
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiO08850
STRINGi10090.ENSMUSP00000027997

PTM databases

PhosphoSitePlusiO08850

Proteomic databases

PaxDbiO08850
PRIDEiO08850

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678
GeneIDi19737
KEGGimmu:19737
UCSCiuc007dlm.1 mouse

Organism-specific databases

CTDi8490
MGIiMGI:1098434 Rgs5

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiO08850
KOiK16449
OMAiKRIYALM
OrthoDBiEOG091G0BDG
PhylomeDBiO08850
TreeFamiTF315837

Miscellaneous databases

ChiTaRSiRgs5 mouse
PROiPR:O08850
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026678 Expressed in 306 organ(s), highest expression level in brain blood vessel
CleanExiMM_RGS5
ExpressionAtlasiO08850 baseline and differential
GenevisibleiO08850 MM

Family and domain databases

CDDicd08717 RGS_RGS5, 1 hit
Gene3Di1.10.196.10, 1 hit
InterProiView protein in InterPro
IPR016137 RGS
IPR034955 RGS5
IPR034956 RGS_RGS5
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF42 PTHR10845:SF42, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS5_MOUSE
AccessioniPrimary (citable) accession number: O08850
Secondary accession number(s): Q543B1, Q9D0Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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