UniProtKB - O08850 (RGS5_MOUSE)
Protein
Regulator of G-protein signaling 5
Gene
Rgs5
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
GO - Molecular functioni
- GTPase activator activity Source: MGI
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of signal transduction Source: UniProtKB-KW
- negative regulation of vascular associated smooth muscle cell proliferation Source: MGI
- signal transduction Source: MGI
Keywordsi
Molecular function | Signal transduction inhibitor |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of G-protein signaling 5Short name: RGS5 |
Gene namesi | Name:Rgs5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1098434, Rgs5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204189 | 1 – 181 | Regulator of G-protein signaling 5Add BLAST | 181 |
Proteomic databases
PaxDbi | O08850 |
PRIDEi | O08850 |
PTM databases
PhosphoSitePlusi | O08850 |
Expressioni
Tissue specificityi
Expressed in heart and muscle.
Gene expression databases
Bgeei | ENSMUSG00000026678, Expressed in brain blood vessel and 320 other tissues |
Genevisiblei | O08850, MM |
Interactioni
Protein-protein interaction databases
ELMi | O08850 |
STRINGi | 10090.ENSMUSP00000027997 |
Miscellaneous databases
RNActi | O08850, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 180 | RGSPROSITE-ProRule annotationAdd BLAST | 117 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157380 |
HOGENOMi | CLU_059863_3_0_1 |
InParanoidi | O08850 |
OMAi | MAQKRIF |
OrthoDBi | 1416350at2759 |
PhylomeDBi | O08850 |
TreeFami | TF315837 |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O08850-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA
60 70 80 90 100
HKPSLEEVLQ WRQSLDKLLQ NSYGFASFKS FLKSEFSEEN LEFWVACENY
110 120 130 140 150
KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPRS
160 170 180
FDLAQKRIYA LMEKDSLPRF VRSEFYKELI K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YWD0 | A0A0A6YWD0_MOUSE | Regulator of G-protein-signaling 5 | Rgs5 | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 – 50 | KA → NG in AAB50618 (PubMed:9079700).Curated | 2 | |
Sequence conflicti | 77 | S → T in AAB50618 (PubMed:9079700).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67188 mRNA Translation: AAB50618.1 AK004165 mRNA Translation: BAB23201.1 AK044096 mRNA Translation: BAC31773.1 AK054098 mRNA Translation: BAC35655.1 BC037683 mRNA Translation: AAH37683.1 |
CCDSi | CCDS15464.1 |
RefSeqi | NP_033089.2, NM_009063.4 |
Genome annotation databases
Ensembli | ENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678 |
GeneIDi | 19737 |
KEGGi | mmu:19737 |
UCSCi | uc007dlm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67188 mRNA Translation: AAB50618.1 AK004165 mRNA Translation: BAB23201.1 AK044096 mRNA Translation: BAC31773.1 AK054098 mRNA Translation: BAC35655.1 BC037683 mRNA Translation: AAH37683.1 |
CCDSi | CCDS15464.1 |
RefSeqi | NP_033089.2, NM_009063.4 |
3D structure databases
SMRi | O08850 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | O08850 |
STRINGi | 10090.ENSMUSP00000027997 |
PTM databases
PhosphoSitePlusi | O08850 |
Proteomic databases
PaxDbi | O08850 |
PRIDEi | O08850 |
Protocols and materials databases
Antibodypediai | 982, 365 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027997; ENSMUSP00000027997; ENSMUSG00000026678 |
GeneIDi | 19737 |
KEGGi | mmu:19737 |
UCSCi | uc007dlm.1, mouse |
Organism-specific databases
CTDi | 8490 |
MGIi | MGI:1098434, Rgs5 |
Phylogenomic databases
eggNOGi | KOG3589, Eukaryota |
GeneTreei | ENSGT00940000157380 |
HOGENOMi | CLU_059863_3_0_1 |
InParanoidi | O08850 |
OMAi | MAQKRIF |
OrthoDBi | 1416350at2759 |
PhylomeDBi | O08850 |
TreeFami | TF315837 |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 19737, 0 hits in 17 CRISPR screens |
ChiTaRSi | Rgs5, mouse |
PROi | PR:O08850 |
RNActi | O08850, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026678, Expressed in brain blood vessel and 320 other tissues |
Genevisiblei | O08850, MM |
Family and domain databases
CDDi | cd08717, RGS_RGS5, 1 hit |
Gene3Di | 1.10.196.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR034955, RGS5 IPR034956, RGS_RGS5 IPR036305, RGS_sf IPR024066, RGS_subdom1/3 |
PANTHERi | PTHR10845:SF42, PTHR10845:SF42, 1 hit |
Pfami | View protein in Pfam PF00615, RGS, 1 hit |
PRINTSi | PR01301, RGSPROTEIN |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
PROSITEi | View protein in PROSITE PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGS5_MOUSE | |
Accessioni | O08850Primary (citable) accession number: O08850 Secondary accession number(s): Q543B1, Q9D0Z2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | August 14, 2001 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot