UniProtKB - O08843 (LST1_MOUSE)
Protein
Leukocyte-specific transcript 1 protein
Gene
Lst1
Organism
Mus musculus (Mouse)
Status
Functioni
Possible role in modulating immune responses. Has an inhibitory effect on lymphocyte proliferation. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation.1 PublicationBy similarity1 Publication
GO - Biological processi
- cell morphogenesis Source: InterPro
- dendrite development Source: UniProtKB
- immune response Source: InterPro
- negative regulation of lymphocyte proliferation Source: UniProtKB
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Biological process | Cell shape, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte-specific transcript 1 proteinAlternative name(s): Protein B144 |
Gene namesi | Name:Lst1 Synonyms:B144 |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096324, Lst1 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass membrane protein By similarity
Note: Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.By similarity
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084509 | 1 – 95 | Leukocyte-specific transcript 1 proteinAdd BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O08843 |
MaxQBi | O08843 |
PaxDbi | O08843 |
PRIDEi | O08843 |
PTM databases
iPTMneti | O08843 |
PhosphoSitePlusi | O08843 |
SwissPalmi | O08843 |
Expressioni
Tissue specificityi
Expressed in spleen and at lower levels in thymus and liver.1 Publication
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000094949 |
Miscellaneous databases
RNActi | O08843, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the LST1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TDBU, Eukaryota |
InParanoidi | O08843 |
PhylomeDBi | O08843 |
Family and domain databases
InterProi | View protein in InterPro IPR007775, Leukocyte-sp_tscrpt_1_LST1 |
PANTHERi | PTHR15452, PTHR15452, 1 hit |
Pfami | View protein in Pfam PF05083, LST1, 1 hit |
PIRSFi | PIRSF037638, Leukocyte-sp_tscrpt_1_LST1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: O08843-1) [UniParc]FASTAAdd to basket
Also known as: m17r1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDDNGSGNN CTTNHFLLYG SLGLGGLLLL LVIILFICLC GFSQRVKRLE
60 70 80 90
RNAQVSGQEP HYASLQQLPV SSSDITDMKE DLSTDYACIA RSTPT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB8JJ61 | B8JJ61_MOUSE | Leukocyte-specific transcript 1 pro... | Lst1 | 93 | Annotation score: |
Sequence cautioni
The sequence AAA37273 differs from that shown. Reason: Frameshift.Curated
The sequence AAC82482 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | H → D (PubMed:9367684).Curated | 1 | |
Sequence conflicti | 15 | H → D (Ref. 3) Curated | 1 | |
Sequence conflicti | 19 | Y → N (PubMed:9367684).Curated | 1 | |
Sequence conflicti | 19 | Y → N (Ref. 3) Curated | 1 | |
Sequence conflicti | 41 | G → R (PubMed:9367684).Curated | 1 | |
Sequence conflicti | 41 | G → R (Ref. 3) Curated | 1 | |
Sequence conflicti | 53 – 54 | Missing (Ref. 3) Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050588 | 53 – 66 | Missing in isoform 2. 2 PublicationsAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18187 mRNA Translation: AAA37273.1 Frameshift. AF000427 mRNA Translation: AAB87001.1 AF000428 mRNA Translation: AAB87002.1 AF109719 Genomic DNA Translation: AAC82482.1 Sequence problems. |
PIRi | I49515 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M18187 mRNA Translation: AAA37273.1 Frameshift. AF000427 mRNA Translation: AAB87001.1 AF000428 mRNA Translation: AAB87002.1 AF109719 Genomic DNA Translation: AAC82482.1 Sequence problems. |
PIRi | I49515 |
3D structure databases
SMRi | O08843 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000094949 |
PTM databases
iPTMneti | O08843 |
PhosphoSitePlusi | O08843 |
SwissPalmi | O08843 |
Proteomic databases
jPOSTi | O08843 |
MaxQBi | O08843 |
PaxDbi | O08843 |
PRIDEi | O08843 |
Organism-specific databases
MGIi | MGI:1096324, Lst1 |
Phylogenomic databases
eggNOGi | ENOG502TDBU, Eukaryota |
InParanoidi | O08843 |
PhylomeDBi | O08843 |
Miscellaneous databases
ChiTaRSi | Lst1, mouse |
PROi | PR:O08843 |
RNActi | O08843, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR007775, Leukocyte-sp_tscrpt_1_LST1 |
PANTHERi | PTHR15452, PTHR15452, 1 hit |
Pfami | View protein in Pfam PF05083, LST1, 1 hit |
PIRSFi | PIRSF037638, Leukocyte-sp_tscrpt_1_LST1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LST1_MOUSE | |
Accessioni | O08843Primary (citable) accession number: O08843 Secondary accession number(s): O08844, Q9Z1H3, Q9Z1R0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 22, 2003 |
Last sequence update: | July 1, 1997 | |
Last modified: | October 7, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families