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Protein

GDNF family receptor alpha-2

Gene

Gfra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.1 Publication
Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein autophosphorylation Source: MGI
  • nervous system development Source: MGI
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDNF family receptor alpha-2
Short name:
GDNF receptor alpha-2
Short name:
GDNFR-alpha-2
Short name:
GFR-alpha-2
Alternative name(s):
GDNF receptor beta
Short name:
GDNFR-beta
Neurturin receptor alpha
Short name:
NRTNR-alpha
Short name:
NTNR-alpha
TGF-beta-related neurotrophic factor receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gfra2Imported
Synonyms:Gdnfrb, Trnr21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1195462 Gfra2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001078722 – 443GDNF family receptor alpha-2Add BLAST422
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000010788444 – 464Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi443GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08842

PeptideAtlas

More...
PeptideAtlasi
O08842

PRoteomics IDEntifications database

More...
PRIDEi
O08842

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08842

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08842

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney (PubMed:9875703). In brain, isoform 1 is most abundant, isoform 2 slightly less and isoform 3 is lowest. No significant levels of isoform 1, isoform 2 or isoform 3 expression in testis (PubMed:12829325).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low level in the ventral mesencephalon at E14. Highly expressed in the developing dorsal root ganglia (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all highly expressed in the late embryonic development (E15 and E17) (PubMed:12829325).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022103 Expressed in 227 organ(s), highest expression level in left lung lobe

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08842 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022699

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O08842

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08842

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU4F Eukaryota
ENOG410XPTA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008695

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051725

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08842

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSGPCRA

Database of Orthologous Groups

More...
OrthoDBi
482696at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331647

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003504 GDNF_rcpt_a2
IPR017372 Glial_neurotroph_fac_rcpt_a1/2

The PANTHER Classification System

More...
PANTHERi
PTHR10269 PTHR10269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02351 GDNF, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038071 GDNF_family_receptor_alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01318 GDNFRALPHA2
PR01316 GDNFRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00907 GDNF, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110035 SSF110035, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.1 Publication

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O08842-1) [UniParc]FASTAAdd to basket
Also known as: Long, 2a2 Publications

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILANAFCLF FFLDETLRSL ASPSSPQGSE LHGWRPQVDC VRANELCAAE
60 70 80 90 100
SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK
110 120 130 140 150
KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA
160 170 180 190 200
DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC
210 220 230 240 250
HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN
260 270 280 290 300
CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM
310 320 330 340 350
IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLK DFTENPCLRN
360 370 380 390 400
AIQAFGNGTD VNMSPKGPTF SATQAPRVEK TPSLPDDLSD STSLGTSVIT
410 420 430 440 450
TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLY SGSCRARLST
460
ALTALPLLMV TLAQ
Length:464
Mass (Da):51,727
Last modified:September 18, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A7FB495FA58C61F
GO
Isoform 2 (identifier: O08842-2) [UniParc]FASTAAdd to basket
Also known as: Short, 2c2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     14-146: Missing.

Show »
Length:331
Mass (Da):36,634
Checksum:i63FDA76F5CE275F9
GO
Isoform 3 (identifier: O08842-3) [UniParc]FASTAAdd to basket
Also known as: 2b2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     14-118: Missing.

Show »
Length:359
Mass (Da):39,827
Checksum:i971446EA933F601E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ61A0A2I3BQ61_MOUSE
GDNF family receptor alpha-2
Gfra2
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC53548 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAC82464 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAC82465 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAK97483 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157K → E in AAC82464 (PubMed:9875703).Curated1
Sequence conflicti157K → E in AAC82465 (PubMed:9875703).Curated1
Sequence conflicti387D → E in AAK97483 (PubMed:12829325).Curated1
Sequence conflicti388L → I in AAK97483 (PubMed:12829325).Curated1
Sequence conflicti391S → G in AAK97483 (PubMed:12829325).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00166214 – 146Missing in isoform 2. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_05752014 – 118Missing in isoform 3. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF002701 mRNA Translation: AAC53548.1 Sequence problems.
AF079107 mRNA Translation: AAC82464.1 Sequence problems.
AF079108 mRNA Translation: AAC82465.1 Sequence problems.
AF398416
, AF398411, AF398412, AF398413, AF398414, AF398415 Genomic DNA Translation: AAK97483.1 Sequence problems.
AK138512 mRNA Translation: BAE23689.1
AC124202 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35876.1
BC138561 mRNA Translation: AAI38562.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27263.1 [O08842-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001289023.1, NM_001302094.1 [O08842-3]
NP_001289024.1, NM_001302095.1 [O08842-2]
NP_032141.2, NM_008115.3 [O08842-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.32619

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022699; ENSMUSP00000022699; ENSMUSG00000022103 [O08842-1]
ENSMUST00000227697; ENSMUSP00000154391; ENSMUSG00000022103 [O08842-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14586

UCSC genome browser

More...
UCSCi
uc007uoz.2 mouse [O08842-1]
uc007upb.2 mouse [O08842-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002701 mRNA Translation: AAC53548.1 Sequence problems.
AF079107 mRNA Translation: AAC82464.1 Sequence problems.
AF079108 mRNA Translation: AAC82465.1 Sequence problems.
AF398416
, AF398411, AF398412, AF398413, AF398414, AF398415 Genomic DNA Translation: AAK97483.1 Sequence problems.
AK138512 mRNA Translation: BAE23689.1
AC124202 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35876.1
BC138561 mRNA Translation: AAI38562.1
CCDSiCCDS27263.1 [O08842-1]
RefSeqiNP_001289023.1, NM_001302094.1 [O08842-3]
NP_001289024.1, NM_001302095.1 [O08842-2]
NP_032141.2, NM_008115.3 [O08842-1]
UniGeneiMm.32619

3D structure databases

ProteinModelPortaliO08842
SMRiO08842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022699

PTM databases

iPTMnetiO08842
PhosphoSitePlusiO08842

Proteomic databases

PaxDbiO08842
PeptideAtlasiO08842
PRIDEiO08842

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022699; ENSMUSP00000022699; ENSMUSG00000022103 [O08842-1]
ENSMUST00000227697; ENSMUSP00000154391; ENSMUSG00000022103 [O08842-2]
GeneIDi14586
KEGGimmu:14586
UCSCiuc007uoz.2 mouse [O08842-1]
uc007upb.2 mouse [O08842-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2675
MGIiMGI:1195462 Gfra2

Phylogenomic databases

eggNOGiENOG410IU4F Eukaryota
ENOG410XPTA LUCA
GeneTreeiENSGT00940000156168
HOGENOMiHOG000008695
HOVERGENiHBG051725
InParanoidiO08842
OMAiNSGPCRA
OrthoDBi482696at2759
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gfra2 mouse

Protein Ontology

More...
PROi
PR:O08842

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022103 Expressed in 227 organ(s), highest expression level in left lung lobe
GenevisibleiO08842 MM

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003504 GDNF_rcpt_a2
IPR017372 Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PIRSFiPIRSF038071 GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01318 GDNFRALPHA2
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGFRA2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08842
Secondary accession number(s): Q3UUD8
, Q920Y3, Q9Z2A2, Q9Z2A3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: January 16, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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