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Protein

GDNF family receptor alpha-2

Gene

Gfra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.1 Publication
Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein autophosphorylation Source: MGI
  • nervous system development Source: MGI
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-2
Short name:
GDNF receptor alpha-2
Short name:
GDNFR-alpha-2
Short name:
GFR-alpha-2
Alternative name(s):
GDNF receptor beta
Short name:
GDNFR-beta
Neurturin receptor alpha
Short name:
NRTNR-alpha
Short name:
NTNR-alpha
TGF-beta-related neurotrophic factor receptor 2
Gene namesi
Name:Gfra2Imported
Synonyms:Gdnfrb, Trnr21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1195462 Gfra2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001078722 – 443GDNF family receptor alpha-2Add BLAST422
PropeptideiPRO_0000010788444 – 464Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi443GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO08842
PeptideAtlasiO08842
PRIDEiO08842

PTM databases

iPTMnetiO08842
PhosphoSitePlusiO08842

Expressioni

Tissue specificityi

Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney (PubMed:9875703). In brain, isoform 1 is most abundant, isoform 2 slightly less and isoform 3 is lowest. No significant levels of isoform 1, isoform 2 or isoform 3 expression in testis (PubMed:12829325).3 Publications

Developmental stagei

Expressed at low level in the ventral mesencephalon at E14. Highly expressed in the developing dorsal root ganglia (PubMed:9182803). Isoform 1, isoform 2 and isoform 3 are all highly expressed in the late embryonic development (E15 and E17) (PubMed:12829325).2 Publications

Gene expression databases

BgeeiENSMUSG00000022103 Expressed in 227 organ(s), highest expression level in left lung lobe
GenevisibleiO08842 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022699

Structurei

3D structure databases

ProteinModelPortaliO08842
SMRiO08842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IU4F Eukaryota
ENOG410XPTA LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000008695
HOVERGENiHBG051725
InParanoidiO08842
OMAiSLCRTDH
OrthoDBiEOG091G087B
TreeFamiTF331647

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003504 GDNF_rcpt_a2
IPR017372 Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PIRSFiPIRSF038071 GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01318 GDNFRALPHA2
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.1 Publication

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O08842-1) [UniParc]FASTAAdd to basket
Also known as: Long, 2a2 Publications

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILANAFCLF FFLDETLRSL ASPSSPQGSE LHGWRPQVDC VRANELCAAE
60 70 80 90 100
SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK
110 120 130 140 150
KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA
160 170 180 190 200
DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC
210 220 230 240 250
HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN
260 270 280 290 300
CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM
310 320 330 340 350
IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLK DFTENPCLRN
360 370 380 390 400
AIQAFGNGTD VNMSPKGPTF SATQAPRVEK TPSLPDDLSD STSLGTSVIT
410 420 430 440 450
TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLY SGSCRARLST
460
ALTALPLLMV TLAQ
Length:464
Mass (Da):51,727
Last modified:September 18, 2013 - v2
Checksum:i3A7FB495FA58C61F
GO
Isoform 2 (identifier: O08842-2) [UniParc]FASTAAdd to basket
Also known as: Short, 2c2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     14-146: Missing.

Show »
Length:331
Mass (Da):36,634
Checksum:i63FDA76F5CE275F9
GO
Isoform 3 (identifier: O08842-3) [UniParc]FASTAAdd to basket
Also known as: 2b2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     14-118: Missing.

Show »
Length:359
Mass (Da):39,827
Checksum:i971446EA933F601E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ61A0A2I3BQ61_MOUSE
GDNF family receptor alpha-2
Gfra2
309Annotation score:

Sequence cautioni

The sequence AAC53548 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAC82464 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAC82465 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated
The sequence AAK97483 differs from that shown. Reason: Erroneous termination at position 464. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157K → E in AAC82464 (PubMed:9875703).Curated1
Sequence conflicti157K → E in AAC82465 (PubMed:9875703).Curated1
Sequence conflicti387D → E in AAK97483 (PubMed:12829325).Curated1
Sequence conflicti388L → I in AAK97483 (PubMed:12829325).Curated1
Sequence conflicti391S → G in AAK97483 (PubMed:12829325).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00166214 – 146Missing in isoform 2. 2 PublicationsAdd BLAST133
Alternative sequenceiVSP_05752014 – 118Missing in isoform 3. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002701 mRNA Translation: AAC53548.1 Sequence problems.
AF079107 mRNA Translation: AAC82464.1 Sequence problems.
AF079108 mRNA Translation: AAC82465.1 Sequence problems.
AF398416
, AF398411, AF398412, AF398413, AF398414, AF398415 Genomic DNA Translation: AAK97483.1 Sequence problems.
AK138512 mRNA Translation: BAE23689.1
AC124202 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35876.1
BC138561 mRNA Translation: AAI38562.1
CCDSiCCDS27263.1 [O08842-1]
RefSeqiNP_001289023.1, NM_001302094.1 [O08842-3]
NP_001289024.1, NM_001302095.1 [O08842-2]
NP_032141.2, NM_008115.3 [O08842-1]
UniGeneiMm.32619

Genome annotation databases

EnsembliENSMUST00000022699; ENSMUSP00000022699; ENSMUSG00000022103 [O08842-1]
ENSMUST00000227697; ENSMUSP00000154391; ENSMUSG00000022103 [O08842-2]
GeneIDi14586
KEGGimmu:14586
UCSCiuc007uoz.2 mouse [O08842-1]
uc007upb.2 mouse [O08842-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002701 mRNA Translation: AAC53548.1 Sequence problems.
AF079107 mRNA Translation: AAC82464.1 Sequence problems.
AF079108 mRNA Translation: AAC82465.1 Sequence problems.
AF398416
, AF398411, AF398412, AF398413, AF398414, AF398415 Genomic DNA Translation: AAK97483.1 Sequence problems.
AK138512 mRNA Translation: BAE23689.1
AC124202 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL35876.1
BC138561 mRNA Translation: AAI38562.1
CCDSiCCDS27263.1 [O08842-1]
RefSeqiNP_001289023.1, NM_001302094.1 [O08842-3]
NP_001289024.1, NM_001302095.1 [O08842-2]
NP_032141.2, NM_008115.3 [O08842-1]
UniGeneiMm.32619

3D structure databases

ProteinModelPortaliO08842
SMRiO08842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022699

PTM databases

iPTMnetiO08842
PhosphoSitePlusiO08842

Proteomic databases

PaxDbiO08842
PeptideAtlasiO08842
PRIDEiO08842

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022699; ENSMUSP00000022699; ENSMUSG00000022103 [O08842-1]
ENSMUST00000227697; ENSMUSP00000154391; ENSMUSG00000022103 [O08842-2]
GeneIDi14586
KEGGimmu:14586
UCSCiuc007uoz.2 mouse [O08842-1]
uc007upb.2 mouse [O08842-2]

Organism-specific databases

CTDi2675
MGIiMGI:1195462 Gfra2

Phylogenomic databases

eggNOGiENOG410IU4F Eukaryota
ENOG410XPTA LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000008695
HOVERGENiHBG051725
InParanoidiO08842
OMAiSLCRTDH
OrthoDBiEOG091G087B
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

ChiTaRSiGfra2 mouse
PROiPR:O08842
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022103 Expressed in 227 organ(s), highest expression level in left lung lobe
GenevisibleiO08842 MM

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003504 GDNF_rcpt_a2
IPR017372 Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PIRSFiPIRSF038071 GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01318 GDNFRALPHA2
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGFRA2_MOUSE
AccessioniPrimary (citable) accession number: O08842
Secondary accession number(s): Q3UUD8
, Q920Y3, Q9Z2A2, Q9Z2A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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