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Protein

STE20-like serine/threonine-protein kinase

Gene

Slk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates apoptosis and actin stress fiber dissolution.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-like serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
STE20-like kinase
Alternative name(s):
STE20-related serine/threonine-protein kinase
Short name:
STE20-related kinase
Gene namesi
Name:Slk
Synonyms:Sk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3780 Slk

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332411 – 1206STE20-like serine/threonine-protein kinaseAdd BLAST1206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei183PhosphothreonineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei340PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1
Modified residuei347PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei545PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei668PhosphoserineBy similarity1
Modified residuei776PhosphoserineBy similarity1
Modified residuei778PhosphoserineCombined sources1
Modified residuei813PhosphothreonineBy similarity1
Modified residuei817PhosphoserineBy similarity1
Modified residuei1065PhosphothreonineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3.By similarity
Autophosphorylated.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei438 – 439Cleavage; by caspase-3By similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO08815
PRIDEiO08815

PTM databases

iPTMnetiO08815
PhosphoSitePlusiO08815

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08815, 1 interactor
STRINGi10116.ENSRNOP00000015496

Structurei

3D structure databases

ProteinModelPortaliO08815
SMRiO08815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini874 – 909UVRPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili468 – 492Sequence analysisAdd BLAST25
Coiled coili825 – 1037Sequence analysisAdd BLAST213
Coiled coili1077 – 1151Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Lys4
Compositional biasi322 – 325Poly-Asp4

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
HOGENOMiHOG000236268
HOVERGENiHBG052712
InParanoidiO08815
KOiK08836

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08815-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK
60 70 80 90 100
AQNKETNVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY
110 120 130 140 150
ENNLWILIEF CAGGAVDAVM LELERPLTES QIQVVCKQTL EALNYLHDNK
160 170 180 190 200
IIHRDLKAGN ILFTLDGDIK LADFGVSAKN TRTIQRRDSF IGTPYWMAPE
210 220 230 240 250
VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP MRVLLKIAKS
260 270 280 290 300
EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV
310 320 330 340 350
RELIAEAKAE VTEEVEDGKE EDDDDETESA LPIPANKRAS SDLSIASSEE
360 370 380 390 400
DKLSQNACIL ESVSERTEHN TSGDKFSNKV LSEKPTPEGP EKTVDVDGPA
410 420 430 440 450
NDVNLETVAE PNDQAVGFHE NGREKKRPQL ESQPDTEDQQ TVDVNLVGEG
460 470 480 490 500
NDSNIVILET NTDCLKPEED RNEENQEIIE NKLTQSEEIK DIHIQTMDLV
510 520 530 540 550
SQETGEKEAD FQAIDNEVGF TKEETQEKLG KDDKTHKVVI SDITSEVGTD
560 570 580 590 600
EPPGDTQKSA EQSQDAEGGA GEEAPEPAQT LTEKATEGPE AHGAEEEPRS
610 620 630 640 650
GERVEDKQLE QQSAVCEGEG QVTSTSESTR ATTEEPETDE VDQVSESNSI
660 670 680 690 700
EELERLGVTG AEEQALGSKG EAATELDLER EENAQELPVK AEPQAPAASQ
710 720 730 740 750
ASEPPPVLIP SINIHSENTE NKGEMGALPK PETILPPEPE NGKGNDTDSG
760 770 780 790 800
TGSTVENSSS DLNLSISSFL SKTKDSGSVS LQETRRQKKT LKKTRKFIVD
810 820 830 840 850
GVEVSVTTSK IVTDSDSKTE ELRFLRRQEL RELRLLQKEE QKAQQQLNGK
860 870 880 890 900
LQQQREQIFR RFEQEMLSKK RQYDQEIENL EKQQKQTIER LEQEHTNRLR
910 920 930 940 950
DEAKRIKGEQ EKELSKFQNM LRNRKKEEQE FVQKQQQELD GALKKIIQQQ
960 970 980 990 1000
KAELANIERE CLNNKQQLLR AREAAIWELE ERHLQEKHQL LKQQLKDQYF
1010 1020 1030 1040 1050
IQRHQLLKRH EKETEQMQRY NQRLIEELKN RQTQERARLP KIQRSEAKTR
1060 1070 1080 1090 1100
MAMFKKSLRI NSTATPDQDR EKIKQFAAQE EKRQKNERMA QHQKHESQMR
1110 1120 1130 1140 1150
DLQLQCEANV RELHQLQNEK CHLLVEHETQ KLKELDEEHS QELKEWREKL
1160 1170 1180 1190 1200
RPRKKTLEEE FARKLQEQEV FFKMTGESEC LNPSAQSRGC LQTSHPSSTR

APAWAG
Length:1,206
Mass (Da):137,888
Last modified:July 1, 1997 - v1
Checksum:i8F5C6A19A3501FB9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7I8G3V7I8_RAT
RCG57812, isoform CRA_b
Slk rCG_57812
1,203Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165L → I (PubMed:2062320).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003357 mRNA Translation: BAA20077.1
PIRiPT0204
T34021
RefSeqiNP_062222.2, NM_019349.2
UniGeneiRn.228809
Rn.33275

Genome annotation databases

GeneIDi54308
KEGGirno:54308
UCSCiRGD:3780 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003357 mRNA Translation: BAA20077.1
PIRiPT0204
T34021
RefSeqiNP_062222.2, NM_019349.2
UniGeneiRn.228809
Rn.33275

3D structure databases

ProteinModelPortaliO08815
SMRiO08815
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08815, 1 interactor
STRINGi10116.ENSRNOP00000015496

PTM databases

iPTMnetiO08815
PhosphoSitePlusiO08815

Proteomic databases

PaxDbiO08815
PRIDEiO08815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54308
KEGGirno:54308
UCSCiRGD:3780 rat

Organism-specific databases

CTDi9748
RGDi3780 Slk

Phylogenomic databases

eggNOGiKOG0579 Eukaryota
ENOG410XPQN LUCA
HOGENOMiHOG000236268
HOVERGENiHBG052712
InParanoidiO08815
KOiK08836

Miscellaneous databases

PROiPR:O08815

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR022165 PKK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF12474 PKK, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50151 UVR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLK_RAT
AccessioniPrimary (citable) accession number: O08815
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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