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Protein

Serpin B8

Gene

Serpinb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has an important role in epithelial desmosome-mediated cell-cell adhesion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei339 – 340Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.013

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:894657 Serpinb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941121 – 374Serpin B8Add BLAST374

Proteomic databases

MaxQBiO08800
PaxDbiO08800
PeptideAtlasiO08800
PRIDEiO08800

PTM databases

iPTMnetiO08800
PhosphoSitePlusiO08800

Expressioni

Gene expression databases

BgeeiENSMUSG00000026315 Expressed in 110 organ(s), highest expression level in zone of skin
ExpressionAtlasiO08800 baseline and differential
GenevisibleiO08800 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000514

Structurei

3D structure databases

ProteinModelPortaliO08800
SMRiO08800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiO08800
KOiK13965
OMAiCDFLPAF
OrthoDBiEOG091G0ION
PhylomeDBiO08800
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O08800-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDLSEANGS FAISLLKILS EKDKSRNLFF CPMSVSSALA MVYLGAKGNT
60 70 80 90 100
ATQMSEVLGL SGNGDVHQSF QTLLAEINKT DTQYLLKSAC RLFGEESCDF
110 120 130 140 150
LSTFKESCHK FYQAGLEELS FAKDTEGCRK HINDWVSEKT EGKISEVLSP
160 170 180 190 200
GTVCPLTKLV LVNAMYFKGK WKAQFDRKYT RGMPFKTNQE KKTVQMMFKH
210 220 230 240 250
AKFKMGHVDE VNMQVLALPY AEEELSMVIL LPDESTDLAV VEKALTYEKL
260 270 280 290 300
RAWTNPETLT ESQVQVFLPR LKLEESYDLE TVLQNLGMTD AFEETRADFS
310 320 330 340 350
GMTTKKNVPV SKVAHKCFVE VNEEGTEAAA ATAVIRNARC CRTEPRFCAD
360 370
HPFLFFIWHH KTSSILFCGR FSSP
Length:374
Mass (Da):42,150
Last modified:December 1, 2001 - v2
Checksum:iF8B2ABB47AA47378
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Y0I8F6Y0I8_MOUSE
Serpin B8
Serpinb8
41Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96703 mRNA Translation: AAB57815.2
AK036811 mRNA Translation: BAC29588.1
BC025121 mRNA Translation: AAH25121.1
CCDSiCCDS15220.1
RefSeqiNP_035589.1, NM_011459.4
UniGeneiMm.83909

Genome annotation databases

EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315
ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315
GeneIDi20725
KEGGimmu:20725
UCSCiuc007chs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96703 mRNA Translation: AAB57815.2
AK036811 mRNA Translation: BAC29588.1
BC025121 mRNA Translation: AAH25121.1
CCDSiCCDS15220.1
RefSeqiNP_035589.1, NM_011459.4
UniGeneiMm.83909

3D structure databases

ProteinModelPortaliO08800
SMRiO08800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000514

Protein family/group databases

MEROPSiI04.013

PTM databases

iPTMnetiO08800
PhosphoSitePlusiO08800

Proteomic databases

MaxQBiO08800
PaxDbiO08800
PeptideAtlasiO08800
PRIDEiO08800

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315
ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315
GeneIDi20725
KEGGimmu:20725
UCSCiuc007chs.2 mouse

Organism-specific databases

CTDi5271
MGIiMGI:894657 Serpinb8

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiO08800
KOiK13965
OMAiCDFLPAF
OrthoDBiEOG091G0ION
PhylomeDBiO08800
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Miscellaneous databases

PROiPR:O08800
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026315 Expressed in 110 organ(s), highest expression level in zone of skin
ExpressionAtlasiO08800 baseline and differential
GenevisibleiO08800 MM

Family and domain databases

InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB8_MOUSE
AccessioniPrimary (citable) accession number: O08800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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