UniProtKB - O08791 (COE3_MOUSE)
Protein
Transcription factor COE3
Gene
Ebf3
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional activator (PubMed:9151732). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 170 | C5-typeSequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor COE3Alternative name(s): Early B-cell factor 3 Short name: EBF-3 Olf-1/EBF-like 2 Short name: O/E-2 Short name: OE-2 |
Gene namesi | Name:Ebf3 Synonyms:Coe3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894289, Ebf3 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107833 | 1 – 596 | Transcription factor COE3Add BLAST | 596 |
Proteomic databases
MaxQBi | O08791 |
PaxDbi | O08791 |
PeptideAtlasi | O08791 |
PRIDEi | O08791 |
PTM databases
iPTMneti | O08791 |
PhosphoSitePlusi | O08791 |
Expressioni
Tissue specificityi
Highly expressed in adult olfactory epithelium. In embryo, expressed in epithalamus, hypothalamus, throughout the brainstem and near the ventricular zones of mesencephalon, in rostral rhombencephalon, in vomeronasal organ, at high level in developing retina, developing spinal cord, at low level in dorsal root ganglia, trigeminal ganglia, glossopharyngeal nerve ganglia. Not expressed in developing inner eat.
Developmental stagei
First detected at 9.5 dpc.
Gene expression databases
Bgeei | ENSMUSG00000010476, Expressed in midbrain and 280 other tissues |
Genevisiblei | O08791, MM |
Interactioni
Subunit structurei
Forms either a homodimer or a heterodimer with a related family member.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 163 | Interaction with DNABy similarity | 1 | |
Sitei | 172 | Interaction with DNABy similarity | 1 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 199360, 2 interactors |
IntActi | O08791, 2 interactors |
STRINGi | 10090.ENSMUSP00000101724 |
Miscellaneous databases
RNActi | O08791, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 263 – 346 | IPT/TIGAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 66 | Interaction with DNABy similarity | 4 | |
Regioni | 197 – 204 | Interaction with DNABy similarity | 8 | |
Regioni | 236 – 239 | Interaction with DNABy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 464 – 555 | Pro/Ser/Thr-richAdd BLAST | 92 |
Sequence similaritiesi
Belongs to the COE family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 170 | C5-typeSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3836, Eukaryota |
GeneTreei | ENSGT00950000182859 |
HOGENOMi | CLU_016320_3_1_1 |
InParanoidi | O08791 |
OMAi | YPSAGPR |
OrthoDBi | 817293at2759 |
PhylomeDBi | O08791 |
TreeFami | TF313391 |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform Long (identifier: O08791-1) [UniParc]FASTAAdd to basket
Also known as: 9L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFGIQENIPR GGTTMKEEPL GSGMNPVRSW MHTAGVVDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV DFVEKEKEPN
110 120 130 140 150
NEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAIV YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTAPSYLEN ATPCIKAISP SEGWTTGGAT VIIIGDNFFD GLQVVFGTML
310 320 330 340 350
VWSELITPHA IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFVYTALNE
360 370 380 390 400
PTIDYGFQRL QKVIPRHPGD PERLPKEVLL KRAADLVEAL YGMPHNNQEI
410 420 430 440 450
ILKRAADIAE ALYSVPRNHN QIPTLGNTPA HTGMMGVNSF SSQLAVNVSE
460 470 480 490 500
TSQANDQVGY SRNTSSVSPR GYVPSSTPQQ SNYNTVSTSM NGYGSGAMAN
510 520 530 540 550
LGVPGSPGFL NGSSANSPYG IVPSSPTMAA SSVTLPSNCS STHGIFSFSP
560 570 580 590
ANVISAVKQK SAFAPVVRPQ ASPPPSCTSA NGNGLQAMSG LVVPPM
Isoform Short (identifier: O08791-2) [UniParc]FASTAAdd to basket
Also known as: 0S
The sequence of this isoform differs from the canonical sequence as follows:
252-260: Missing.
521-557: IVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAV → M
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6NXL3 | Q6NXL3_MOUSE | Ebf3 protein | Ebf3 | 587 | Annotation score: | ||
Q3UUB6 | Q3UUB6_MOUSE | Transcription factor COE3 | Ebf3 | 344 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001115 | 252 – 260 | Missing in isoform Short. Curated | 9 | |
Alternative sequenceiVSP_001116 | 521 – 557 | IVPSS…VISAV → M in isoform Short. CuratedAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U92702 mRNA Translation: AAB58322.1 U92704 mRNA Translation: AAB58324.1 U82442 mRNA Translation: AAC64323.1 |
CCDSi | CCDS21946.1 [O08791-2] CCDS52422.1 [O08791-1] |
RefSeqi | NP_001106886.1, NM_001113415.1 [O08791-1] NP_034226.1, NM_010096.3 [O08791-2] |
Genome annotation databases
Ensembli | ENSMUST00000033378; ENSMUSP00000033378; ENSMUSG00000010476 [O08791-2] ENSMUST00000210774; ENSMUSP00000147829; ENSMUSG00000010476 [O08791-1] |
GeneIDi | 13593 |
KEGGi | mmu:13593 |
UCSCi | uc009ker.2, mouse [O08791-2] uc012fvm.1, mouse [O08791-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U92702 mRNA Translation: AAB58322.1 U92704 mRNA Translation: AAB58324.1 U82442 mRNA Translation: AAC64323.1 |
CCDSi | CCDS21946.1 [O08791-2] CCDS52422.1 [O08791-1] |
RefSeqi | NP_001106886.1, NM_001113415.1 [O08791-1] NP_034226.1, NM_010096.3 [O08791-2] |
3D structure databases
SMRi | O08791 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199360, 2 interactors |
IntActi | O08791, 2 interactors |
STRINGi | 10090.ENSMUSP00000101724 |
PTM databases
iPTMneti | O08791 |
PhosphoSitePlusi | O08791 |
Proteomic databases
MaxQBi | O08791 |
PaxDbi | O08791 |
PeptideAtlasi | O08791 |
PRIDEi | O08791 |
Protocols and materials databases
Antibodypediai | 32510, 175 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033378; ENSMUSP00000033378; ENSMUSG00000010476 [O08791-2] ENSMUST00000210774; ENSMUSP00000147829; ENSMUSG00000010476 [O08791-1] |
GeneIDi | 13593 |
KEGGi | mmu:13593 |
UCSCi | uc009ker.2, mouse [O08791-2] uc012fvm.1, mouse [O08791-1] |
Organism-specific databases
CTDi | 253738 |
MGIi | MGI:894289, Ebf3 |
Phylogenomic databases
eggNOGi | KOG3836, Eukaryota |
GeneTreei | ENSGT00950000182859 |
HOGENOMi | CLU_016320_3_1_1 |
InParanoidi | O08791 |
OMAi | YPSAGPR |
OrthoDBi | 817293at2759 |
PhylomeDBi | O08791 |
TreeFami | TF313391 |
Miscellaneous databases
BioGRID-ORCSi | 13593, 2 hits in 17 CRISPR screens |
ChiTaRSi | Ebf3, mouse |
PROi | PR:O08791 |
RNActi | O08791, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000010476, Expressed in midbrain and 280 other tissues |
Genevisiblei | O08791, MM |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COE3_MOUSE | |
Accessioni | O08791Primary (citable) accession number: O08791 Secondary accession number(s): O08793 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families