Fpr-s1

Functionⁱ

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
N-formyl peptide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12218158

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemotaxis
Source: MGI
Traceable author statementⁱ
- 12470609
complement receptor mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 12470609
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-416476 G alpha (q) signalling events R-MMU-418594 G alpha (i) signalling events R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Formyl peptide receptor-related sequence 1 Alternative name(s): FMLP-related receptor I Short name: FMLP-R-I Formyl peptide receptor related sequence 1 Formyl peptide receptor-like 1 Lipoxin A4 receptor Short name: LXA4 receptor N-formyl peptide receptor 2 N-formyl peptide receptor 3
Gene namesⁱ	Name:Fpr-s1 Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1194495 Fpr3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 50	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	51 – 61	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	62 – 83	Helical; Name=2Sequence analysisAdd BLAST	22
Topological domainⁱ	84 – 100	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	101 – 121	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	122 – 140	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	141 – 162	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	163 – 205	ExtracellularSequence analysisAdd BLAST	43
Transmembraneⁱ	206 – 226	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	227 – 242	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	243 – 266	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	267 – 286	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	287 – 306	Helical; Name=7Sequence analysisAdd BLAST	20
Topological domainⁱ	307 – 351	CytoplasmicSequence analysisAdd BLAST	45

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3407315
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	224

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069453	1 – 351	Formyl peptide receptor-related sequence 1Add BLAST		351

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	98 ↔ 176	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O08790
PRIDEⁱ	O08790

Expressionⁱ

Tissue specificityⁱ

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000079700 Expressed in 18 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	O08790 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093316

STRINGⁱ

10090.ENSMUSP00000093316

Chemistry databases

BindingDBⁱ

O08790

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08790
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II0H Eukaryota ENOG410YB48 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118990
HOGENOMⁱ	HOG000234122
InParanoidⁱ	O08790
KEGG Orthology (KO) More...KOⁱ	K04173
OMAⁱ	LAKRVIM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09ZK
PhylomeDBⁱ	O08790
TreeFamⁱ	TF330976

Family and domain databases

InterProⁱ	View protein in InterPro IPR000826 Formyl_rcpt-rel IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24225 PTHR24225, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O08790-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV 
        60         70         80         90        100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL 
       110        120        130        140        150
VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW 
       160        170        180        190        200
IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT 
       210        220        230        240        250
RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF 
       260        270        280        290        300
FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI 
       310        320        330        340        350
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA 

I

Length:351

Mass (Da):39,523

Last modified:September 1, 2009 - v2

Checksum:ⁱ295618B0ED0F98D6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	T → S in AAC53198 (PubMed:9151906).Curated	1
Sequence conflictⁱ	8	P → H in AAC53198 (PubMed:9151906).Curated	1
Sequence conflictⁱ	13	D → E in AAC53198 (PubMed:9151906).Curated	1
Sequence conflictⁱ	16	I → V in AAC53198 (PubMed:9151906).Curated	1
Sequence conflictⁱ	142 – 145	Missing in AAC34584 (PubMed:9722950).Curated	4
Sequence conflictⁱ	226	T → Y in AAC34584 (PubMed:9722950).Curated	1
Sequence conflictⁱ	240	F → S in AAC34584 (PubMed:9722950).Curated	1
Sequence conflictⁱ	300	I → M in AAC34584 (PubMed:9722950).Curated	1
Sequence conflictⁱ	322	Q → P in AAC34584 (PubMed:9722950).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78299 mRNA Translation: AAC53198.1 AF071179 Genomic DNA Translation: AAC34584.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28420.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032068.2, NM_008042.2
UniGeneⁱ	Mm.378918 Mm.491469

Genome annotation databases

Ensemblⁱ	ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700 ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700
GeneIDⁱ	14294
KEGGⁱ	mmu:14294
UCSC genome browser More...UCSCⁱ	uc008apv.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08790	N-formyl peptide receptor 2		HUMAN		351	UniRef50_P25090
N-formyl peptide receptor 2 (Fragment)		GORGO		348
N-formyl peptide receptor 2 (Fragment)		MACMU		348
N-formyl peptide receptor 2 (Fragment)		PONPY		348
N-formyl peptide receptor 2 (Fragment)		PANTR		348
+303

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78299 mRNA Translation: AAC53198.1 AF071179 Genomic DNA Translation: AAC34584.1
CCDSⁱ	CCDS28420.1
RefSeqⁱ	NP_032068.2, NM_008042.2
UniGeneⁱ	Mm.378918 Mm.491469

3D structure databases

ProteinModelPortalⁱ	O08790
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093316

STRINGⁱ

10090.ENSMUSP00000093316

Chemistry databases

BindingDBⁱ	O08790
ChEMBLⁱ	CHEMBL3407315
GuidetoPHARMACOLOGYⁱ	224

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Proteomic databases

PaxDbⁱ	O08790
PRIDEⁱ	O08790

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	14294
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700 ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700
GeneIDⁱ	14294
KEGGⁱ	mmu:14294
UCSCⁱ	uc008apv.1 mouse

Organism-specific databases

CTDⁱ	2359
MGIⁱ	MGI:1194495 Fpr3

Phylogenomic databases

eggNOGⁱ	ENOG410II0H Eukaryota ENOG410YB48 LUCA
GeneTreeⁱ	ENSGT00760000118990
HOGENOMⁱ	HOG000234122
InParanoidⁱ	O08790
KOⁱ	K04173
OMAⁱ	LAKRVIM
OrthoDBⁱ	EOG091G09ZK
PhylomeDBⁱ	O08790
TreeFamⁱ	TF330976

Enzyme and pathway databases

Reactomeⁱ	R-MMU-416476 G alpha (q) signalling events R-MMU-418594 G alpha (i) signalling events R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O08790
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079700 Expressed in 18 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	O08790 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000826 Formyl_rcpt-rel IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24225 PTHR24225, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FPRS1_MOUSE
Accessionⁱ	O08790Primary (citable) accession number: O08790 Secondary accession number(s): O88535
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 1, 2009
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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Supporting data

UniProtKB - O08790 (FPRS1_MOUSE)

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Formyl peptide receptor-related sequence 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ