UniProtKB - O08790 (FPRS1_MOUSE)
Protein
Formyl peptide receptor-related sequence 1
Gene
Fpr-s1
Organism
Mus musculus (Mouse)
Status
Functioni
Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication
GO - Molecular functioni
- complement receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- N-formyl peptide receptor activity Source: GO_Central
- signaling receptor activity Source: MGI
GO - Biological processi
- chemotaxis Source: MGI
- complement receptor mediated signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: MGI
- inflammatory response Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Names & Taxonomyi
Protein namesi | Recommended name: Formyl peptide receptor-related sequence 1Alternative name(s): FMLP-related receptor I Short name: FMLP-R-I Formyl peptide receptor related sequence 1 Formyl peptide receptor-like 1 Lipoxin A4 receptor Short name: LXA4 receptor N-formyl peptide receptor 2 N-formyl peptide receptor 3 |
Gene namesi | Name:Fpr-s1 Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1194495, Fpr3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 51 – 61 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 62 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 84 – 100 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 101 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 140 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 163 – 205 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 206 – 226 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 242 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 243 – 266 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 267 – 286 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 287 – 306 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 307 – 351 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069453 | 1 – 351 | Formyl peptide receptor-related sequence 1Add BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 176 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O08790 |
PRIDEi | O08790 |
PTM databases
GlyGeni | O08790, 2 sites |
Expressioni
Tissue specificityi
Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications
Gene expression databases
Bgeei | ENSMUSG00000079700, Expressed in skeletal muscle tissue and 23 other tissues |
Genevisiblei | O08790, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093316 |
Chemistry databases
BindingDBi | O08790 |
Miscellaneous databases
RNActi | O08790, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | O08790 |
OMAi | NTFNWIN |
OrthoDBi | 910274at2759 |
PhylomeDBi | O08790 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O08790-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV
60 70 80 90 100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL
110 120 130 140 150
VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW
160 170 180 190 200
IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT
210 220 230 240 250
RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA
I
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | T → S in AAC53198 (PubMed:9151906).Curated | 1 | |
Sequence conflicti | 8 | P → H in AAC53198 (PubMed:9151906).Curated | 1 | |
Sequence conflicti | 13 | D → E in AAC53198 (PubMed:9151906).Curated | 1 | |
Sequence conflicti | 16 | I → V in AAC53198 (PubMed:9151906).Curated | 1 | |
Sequence conflicti | 142 – 145 | Missing in AAC34584 (PubMed:9722950).Curated | 4 | |
Sequence conflicti | 226 | T → Y in AAC34584 (PubMed:9722950).Curated | 1 | |
Sequence conflicti | 240 | F → S in AAC34584 (PubMed:9722950).Curated | 1 | |
Sequence conflicti | 300 | I → M in AAC34584 (PubMed:9722950).Curated | 1 | |
Sequence conflicti | 322 | Q → P in AAC34584 (PubMed:9722950).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78299 mRNA Translation: AAC53198.1 AF071179 Genomic DNA Translation: AAC34584.1 |
CCDSi | CCDS28420.1 |
RefSeqi | NP_032068.2, NM_008042.2 |
Genome annotation databases
Ensembli | ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700 ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700 |
GeneIDi | 14294 |
KEGGi | mmu:14294 |
UCSCi | uc008apv.1, mouse |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight A sickly smell - Issue 114 of February 2010 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78299 mRNA Translation: AAC53198.1 AF071179 Genomic DNA Translation: AAC34584.1 |
CCDSi | CCDS28420.1 |
RefSeqi | NP_032068.2, NM_008042.2 |
3D structure databases
SMRi | O08790 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093316 |
Chemistry databases
BindingDBi | O08790 |
ChEMBLi | CHEMBL3407315 |
GuidetoPHARMACOLOGYi | 224 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O08790, 2 sites |
Proteomic databases
PaxDbi | O08790 |
PRIDEi | O08790 |
Protocols and materials databases
DNASUi | 14294 |
Genome annotation databases
Ensembli | ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700 ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700 |
GeneIDi | 14294 |
KEGGi | mmu:14294 |
UCSCi | uc008apv.1, mouse |
Organism-specific databases
CTDi | 2359 |
MGIi | MGI:1194495, Fpr3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | O08790 |
OMAi | NTFNWIN |
OrthoDBi | 910274at2759 |
PhylomeDBi | O08790 |
TreeFami | TF330976 |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Miscellaneous databases
BioGRID-ORCSi | 14294, 0 hits in 17 CRISPR screens |
ChiTaRSi | Fpr3, mouse |
PROi | PR:O08790 |
RNActi | O08790, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079700, Expressed in skeletal muscle tissue and 23 other tissues |
Genevisiblei | O08790, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FPRS1_MOUSE | |
Accessioni | O08790Primary (citable) accession number: O08790 Secondary accession number(s): O88535 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | September 1, 2009 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries