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Protein

Formyl peptide receptor-related sequence 1

Gene

Fpr-s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: GO_Central
  • signaling receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 1
Alternative name(s):
FMLP-related receptor I
Short name:
FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name:
LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3
Gene namesi
Name:Fpr-s1
Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194495 Fpr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 306Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini307 – 351CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3407315
GuidetoPHARMACOLOGYi224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694531 – 351Formyl peptide receptor-related sequence 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08790
PRIDEiO08790

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications

Gene expression databases

BgeeiENSMUSG00000079700 Expressed in 18 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO08790 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093316

Chemistry databases

BindingDBiO08790

Structurei

3D structure databases

ProteinModelPortaliO08790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
InParanoidiO08790
KOiK04173
OMAiLAKRVIM
OrthoDBiEOG091G09ZK
PhylomeDBiO08790
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV
60 70 80 90 100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL
110 120 130 140 150
VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW
160 170 180 190 200
IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT
210 220 230 240 250
RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA

I
Length:351
Mass (Da):39,523
Last modified:September 1, 2009 - v2
Checksum:i295618B0ED0F98D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3T → S in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti8P → H in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti13D → E in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti16I → V in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti142 – 145Missing in AAC34584 (PubMed:9722950).Curated4
Sequence conflicti226T → Y in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti240F → S in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti300I → M in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti322Q → P in AAC34584 (PubMed:9722950).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA Translation: AAC53198.1
AF071179 Genomic DNA Translation: AAC34584.1
CCDSiCCDS28420.1
RefSeqiNP_032068.2, NM_008042.2
UniGeneiMm.378918
Mm.491469

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700
GeneIDi14294
KEGGimmu:14294
UCSCiuc008apv.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA Translation: AAC53198.1
AF071179 Genomic DNA Translation: AAC34584.1
CCDSiCCDS28420.1
RefSeqiNP_032068.2, NM_008042.2
UniGeneiMm.378918
Mm.491469

3D structure databases

ProteinModelPortaliO08790
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093316

Chemistry databases

BindingDBiO08790
ChEMBLiCHEMBL3407315
GuidetoPHARMACOLOGYi224

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO08790
PRIDEiO08790

Protocols and materials databases

DNASUi14294
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700
GeneIDi14294
KEGGimmu:14294
UCSCiuc008apv.1 mouse

Organism-specific databases

CTDi2359
MGIiMGI:1194495 Fpr3

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
InParanoidiO08790
KOiK04173
OMAiLAKRVIM
OrthoDBiEOG091G09ZK
PhylomeDBiO08790
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:O08790
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079700 Expressed in 18 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO08790 MM

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFPRS1_MOUSE
AccessioniPrimary (citable) accession number: O08790
Secondary accession number(s): O88535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 1, 2009
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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