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UniProtKB - O08789 (MNT_MOUSE)
Protein
Max-binding protein MNT
Gene
Mnt
Organism
Mus musculus (Mouse)
Status
Functioni
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- cell aging Source: MGI
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell cycle Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Max-binding protein MNTAlternative name(s): Myc antagonist MNT Protein ROX |
Gene namesi | Name:Mnt Synonyms:Rox |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109150, Mnt |
VEuPathDBi | HostDB:ENSMUSG00000000282 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000127282 | 2 – 591 | Max-binding protein MNTAdd BLAST | 590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O08789 |
MaxQBi | O08789 |
PaxDbi | O08789 |
PeptideAtlasi | O08789 |
PRIDEi | O08789 |
ProteomicsDBi | 295572 |
PTM databases
iPTMneti | O08789 |
PhosphoSitePlusi | O08789 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000282, Expressed in rostral migratory stream and 323 other tissues |
ExpressionAtlasi | O08789, baseline and differential |
Genevisiblei | O08789, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 201461, 6 interactors |
IntActi | O08789, 1 interactor |
STRINGi | 10090.ENSMUSP00000000291 |
Miscellaneous databases
RNActi | O08789, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 222 – 273 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 122 | DisorderedSequence analysisAdd BLAST | 106 | |
Regioni | 182 – 223 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 273 – 301 | Leucine-zipperAdd BLAST | 29 | |
Regioni | 321 – 426 | DisorderedSequence analysisAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 46 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 61 – 88 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 98 – 118 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 186 – 200 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 208 – 223 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 374 – 393 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 406 – 425 | Pro residuesSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00510000048287 |
HOGENOMi | CLU_020165_1_0_1 |
InParanoidi | O08789 |
OMAi | GPPKLNH |
OrthoDBi | 445807at2759 |
TreeFami | TF315654 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O08789-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR
60 70 80 90 100
LAHALPVEEP RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP
110 120 130 140 150
QSLPPPPPLP PAAQPLPLAP RQPALVSTPG LSIKEPVTLP TRPQVPTPAP
160 170 180 190 200
LLPDAKTTVA PTGSPKPLQP LPAPILTIAP HPGVQPQLAP QQPPPPTLGT
210 220 230 240 250
LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE CFETLKRNIP
260 270 280 290 300
NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE
310 320 330 340 350
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA
360 370 380 390 400
GLGPPKLNHR PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV
410 420 430 440 450
QQQQPPQQKT PLPAPPPPPA TPTQTLVPAP AHLVATAGGG STVIAHTATT
460 470 480 490 500
HASVIQTVNH VLQGPGGKHI AHIAPSAPSP AVQLAPATPP IGHITVHPAT
510 520 530 540 550
LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG TAGLGPPATV
560 570 580 590
MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5SWE2 | Q5SWE2_MOUSE | Max-binding protein MNT | Mnt | 207 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 379 | P → T in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 392 | A → V in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 402 – 403 | QQ → EE in AAB38687 (PubMed:9000049).Curated | 2 | |
Sequence conflicti | 414 | A → G in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 431 | A → V in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 465 | P → A in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 525 | A → T in AAB38687 (PubMed:9000049).Curated | 1 | |
Sequence conflicti | 558 | A → G in AAB38687 (PubMed:9000049).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77356 mRNA Translation: AAB38687.1 Y07609 mRNA Translation: CAA68878.1 AL604066 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12780.1 BC054534 mRNA Translation: AAH54534.1 |
CCDSi | CCDS25037.1 |
RefSeqi | NP_034943.3, NM_010813.3 |
Genome annotation databases
Ensembli | ENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282 |
GeneIDi | 17428 |
KEGGi | mmu:17428 |
UCSCi | uc011xzb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77356 mRNA Translation: AAB38687.1 Y07609 mRNA Translation: CAA68878.1 AL604066 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12780.1 BC054534 mRNA Translation: AAH54534.1 |
CCDSi | CCDS25037.1 |
RefSeqi | NP_034943.3, NM_010813.3 |
3D structure databases
AlphaFoldDBi | O08789 |
SMRi | O08789 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201461, 6 interactors |
IntActi | O08789, 1 interactor |
STRINGi | 10090.ENSMUSP00000000291 |
PTM databases
iPTMneti | O08789 |
PhosphoSitePlusi | O08789 |
Proteomic databases
EPDi | O08789 |
MaxQBi | O08789 |
PaxDbi | O08789 |
PeptideAtlasi | O08789 |
PRIDEi | O08789 |
ProteomicsDBi | 295572 |
Protocols and materials databases
Antibodypediai | 22924, 136 antibodies from 31 providers |
DNASUi | 17428 |
Genome annotation databases
Ensembli | ENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282 |
GeneIDi | 17428 |
KEGGi | mmu:17428 |
UCSCi | uc011xzb.1, mouse |
Organism-specific databases
CTDi | 4335 |
MGIi | MGI:109150, Mnt |
VEuPathDBi | HostDB:ENSMUSG00000000282 |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
GeneTreei | ENSGT00510000048287 |
HOGENOMi | CLU_020165_1_0_1 |
InParanoidi | O08789 |
OMAi | GPPKLNH |
OrthoDBi | 445807at2759 |
TreeFami | TF315654 |
Miscellaneous databases
BioGRID-ORCSi | 17428, 14 hits in 75 CRISPR screens |
ChiTaRSi | Mnt, mouse |
PROi | PR:O08789 |
RNActi | O08789, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000282, Expressed in rostral migratory stream and 323 other tissues |
ExpressionAtlasi | O08789, baseline and differential |
Genevisiblei | O08789, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MNT_MOUSE | |
Accessioni | O08789Primary (citable) accession number: O08789 Secondary accession number(s): P97349, Q6GTJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot