Mnt

Functionⁱ

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 16103876
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12970171
DNA-binding transcription factor activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 12970171
- 16103876
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell aging
Source: MGI
Inferred from mutant phenotypeⁱ
- 12970171
negative regulation of apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 12970171
negative regulation of transcription by RNA polymerase II Source: MGI
regulation of cell cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 12970171
regulation of transcription, DNA-templated
Source: MGI
Inferred from mutant phenotypeⁱ
- 12970171
- 16103876

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Max-binding protein MNT Alternative name(s): Myc antagonist MNT Protein ROX
Gene namesⁱ	Name:Mnt Synonyms:Rox
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:109150 Mnt

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000127282	2 – 591	Max-binding protein MNTAdd BLAST		590

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O08789
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O08789
PaxDbⁱ	O08789
PeptideAtlas More...PeptideAtlasⁱ	O08789
PRIDEⁱ	O08789

PTM databases

iPTMnetⁱ	O08789
PhosphoSitePlusⁱ	O08789

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000000282 Expressed in 302 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_MNT
ExpressionAtlasⁱ	O08789 baseline and differential
Genevisibleⁱ	O08789 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201461, 3 interactors
IntActⁱ	O08789, 1 interactor
STRINGⁱ	10090.ENSMUSP00000000291

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08789
SMRⁱ	O08789
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	222 – 273	bHLHPROSITE-ProRule annotationAdd BLAST		52

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	273 – 301	Leucine-zipperAdd BLAST		29

Phylogenomic databases

eggNOGⁱ	KOG2483 Eukaryota ENOG4111VW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048287
HOGENOMⁱ	HOG000013115
HOVERGENⁱ	HBG006379
InParanoidⁱ	O08789
KEGG Orthology (KO) More...KOⁱ	K09115
OMAⁱ	AVIPMVP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PW2
TreeFamⁱ	TF315654

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O08789-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR 
        60         70         80         90        100
LAHALPVEEP RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP 
       110        120        130        140        150
QSLPPPPPLP PAAQPLPLAP RQPALVSTPG LSIKEPVTLP TRPQVPTPAP 
       160        170        180        190        200
LLPDAKTTVA PTGSPKPLQP LPAPILTIAP HPGVQPQLAP QQPPPPTLGT 
       210        220        230        240        250
LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE CFETLKRNIP 
       260        270        280        290        300
NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE 
       310        320        330        340        350
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA 
       360        370        380        390        400
GLGPPKLNHR PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV 
       410        420        430        440        450
QQQQPPQQKT PLPAPPPPPA TPTQTLVPAP AHLVATAGGG STVIAHTATT 
       460        470        480        490        500
HASVIQTVNH VLQGPGGKHI AHIAPSAPSP AVQLAPATPP IGHITVHPAT 
       510        520        530        540        550
LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG TAGLGPPATV 
       560        570        580        590 
MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A

Length:591

Mass (Da):63,274

Last modified:July 27, 2011 - v2

Checksum:ⁱ17C2B830381D2190

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5SWE2	Q5SWE2_MOUSE		Max-binding protein MNT Max-binding protein MNT	Mnt	207	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	379	P → T in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	392	A → V in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	402 – 403	QQ → EE in AAB38687 (PubMed:9000049).Curated	2
Sequence conflictⁱ	414	A → G in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	431	A → V in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	465	P → A in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	525	A → T in AAB38687 (PubMed:9000049).Curated	1
Sequence conflictⁱ	558	A → G in AAB38687 (PubMed:9000049).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77356 mRNA Translation: AAB38687.1 Y07609 mRNA Translation: CAA68878.1 AL604066 Genomic DNA Translation: CAI24245.1 CH466596 Genomic DNA Translation: EDL12780.1 BC054534 mRNA Translation: AAH54534.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25037.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034943.3, NM_010813.3
UniGeneⁱ	Mm.3759

Genome annotation databases

Ensemblⁱ	ENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282
GeneIDⁱ	17428
KEGGⁱ	mmu:17428
UCSC genome browser More...UCSCⁱ	uc011xzb.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08789	Max-binding protein MNT		HUMAN		582	UniRef90_Q99583
MAX network transcriptional repressor		GORGO		603
Uncharacterized protein		MANLE		593
max-binding protein MNT		DIPOR		593
Uncharacterized protein		MOUSE		591
+105

Protein	Similar proteins		Species	Score	Length	Source
O08789	Max-binding protein MNT		HUMAN		582	UniRef50_Q99583
MAX network transcriptional repressor		GORGO		603
Uncharacterized protein		MANLE		593
max-binding protein MNT		DIPOR		593
Uncharacterized protein		MOUSE		591
+133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77356 mRNA Translation: AAB38687.1 Y07609 mRNA Translation: CAA68878.1 AL604066 Genomic DNA Translation: CAI24245.1 CH466596 Genomic DNA Translation: EDL12780.1 BC054534 mRNA Translation: AAH54534.1
CCDSⁱ	CCDS25037.1
RefSeqⁱ	NP_034943.3, NM_010813.3
UniGeneⁱ	Mm.3759

3D structure databases

ProteinModelPortalⁱ	O08789
SMRⁱ	O08789
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201461, 3 interactors
IntActⁱ	O08789, 1 interactor
STRINGⁱ	10090.ENSMUSP00000000291

PTM databases

iPTMnetⁱ	O08789
PhosphoSitePlusⁱ	O08789

Proteomic databases

EPDⁱ	O08789
MaxQBⁱ	O08789
PaxDbⁱ	O08789
PeptideAtlasⁱ	O08789
PRIDEⁱ	O08789

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282
GeneIDⁱ	17428
KEGGⁱ	mmu:17428
UCSCⁱ	uc011xzb.1 mouse

Organism-specific databases

CTDⁱ	4335
MGIⁱ	MGI:109150 Mnt

Phylogenomic databases

eggNOGⁱ	KOG2483 Eukaryota ENOG4111VW9 LUCA
GeneTreeⁱ	ENSGT00510000048287
HOGENOMⁱ	HOG000013115
HOVERGENⁱ	HBG006379
InParanoidⁱ	O08789
KOⁱ	K09115
OMAⁱ	AVIPMVP
OrthoDBⁱ	EOG091G0PW2
TreeFamⁱ	TF315654

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O08789
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000282 Expressed in 302 organ(s), highest expression level in rostral migratory stream
CleanExⁱ	MM_MNT
ExpressionAtlasⁱ	O08789 baseline and differential
Genevisibleⁱ	O08789 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MNT_MOUSE
Accessionⁱ	O08789Primary (citable) accession number: O08789 Secondary accession number(s): P97349, Q6GTJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08789 (MNT_MOUSE)

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Max-binding protein MNT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ