UniProtKB - O08784 (TCOF_MOUSE)

BLAST

>sp|O08784|TCOF_MOUSE Treacle protein OS=Mus musculus OX=10090 GN=Tcof1 PE=1 SV=1
MAEARKRRELLPLIYHHLLQAGYVRAAREVKEQSGQKSFLTQPVTLLDIYTHWQQTSELG
QKQKAEDDETLQAKKSRVSDPVSSSESSDQEKEEEAATERAKATPRPTPVNSATAALPSK
VKEKGKTKTANKTVNSVSHPGSGKTVVHLLSGKSPKKSAEPLANTVLASETEEEGNAQAL
GPTAKSGTVSAGQGSSSSEDSSISSDETDVEVKSPAKPAQAKASAAPAKDPPARTAPGPT
KLGNVAPTPAKPARAAAAAAAAAVAAAAAAAAEESESSEEDSDSEDEAPAGLPSQVKASG
KGPHVRADSVSAKGISGKGPILATPGKTGPAATQAKAERPEKDSETSSEDDSDSEDEMPV
TVNTPQARTSGKSPRARGTSAPAKESSQKGAPAVTPGKARPVAAQAGKPEAKSSEESESD
SGETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPGKVGSAALRVQMVK
KEDVSESSSAELDSDGPGSPAKAKASLALPQKVRPVATQVKTDRGKGHSGSSEESSDSEE
EAAPAASAAQAKPALEKQMKASSRKGTPASATGASTSSHCKAGAVTSSASLSSPALAKGT
QRSDVDSSSESESEGAAPSTPRVQGKSGGKGLQGKAALGQGVAPVHTQKTGPSVKAMAQE
DSESLEEDSSSEEEDETPAQATPLGRLPQAKANPPPTKTPPASASGKAVAAPTKGKPPVP
NSTVSARGQRSVPAAGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEETPAQIKPVGK
TSQVRAASAPAKESPKKGAHPGTPGKTGSSATQAQPGKTEDSDSSSEESDSDTEMPSAQA
IKSPPVSVNRNSSPAVPAPTPEGVQAVNTTKKASGTTAQSSSSESEDGDEDLIPATQPST
YALRTSVTTPAALSRAASQPSKSEQSSRMPKGKKAKAAASAQTSSAVETLPMMPPQSAPI
QPKATNKLGKSKLPEKQQLAPGYPKAPRSSEDSSDTSSEDEEDAKRPQMPKSAHRLDPDP
SQKETVVEETPTESSEDEMVAPSQSLLSGYMTPGLTVANSQASKATPRPDSNSLASSAPA
TKDNPDGKQKSKSQHAADTALPKTGRKEASSGSTPQKPKKLKKSTSSSPAPTQTLPNSIT
QRLLEQAWPLSEAQVQASVVKVLTELLEQERLKATEAIKESGKKSQKRKLSGDLEAGAPK
NKKKKEQPVPRASAVSPEKAPMTSKAKSKLDKGSAGGKGKGSPGPQGAKEKPDGELLGIK
LESGEQSDPKSKSKKKKSLKKKKDKEKKEKKKGKKSLAKDSASPIQKKKKKKKKSAEPAV

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History
Entry version 144 (07 Nov 2018)
Sequence version 1 (01 Jul 1997)
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Protein

Treacle protein

Gene

Tcof1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.By similarity

GO - Molecular functionⁱ

protein heterodimerization activity Source: MGI
RNA polymerase I core binding Source: UniProtKB
scaffold protein binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neural crest cell development Source: UniProtKB
neural crest formation Source: UniProtKB
nucleolar large rRNA transcription by RNA polymerase I
Source: MGI
Inferred from mutant phenotypeⁱ
- 15249688
regulation of translation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Treacle protein Alternative name(s): Treacher Collins syndrome protein homolog
Gene namesⁱ	Name:Tcof1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:892003 Tcof1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072460	1 – 1320	Treacle proteinAdd BLAST		1320

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	83	PhosphoserineBy similarity	1
Modified residueⁱ	85	PhosphoserineBy similarity	1
Modified residueⁱ	87	PhosphoserineBy similarity	1
Modified residueⁱ	88	PhosphoserineBy similarity	1
Modified residueⁱ	104	PhosphothreonineCombined sources	1
Cross-linkⁱ	126	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	132	N6-acetyllysineCombined sources	1
Modified residueⁱ	151	PhosphoserineBy similarity	1
Modified residueⁱ	153	N6-acetyllysineBy similarity	1
Modified residueⁱ	154	PhosphoserineCombined sources	1
Modified residueⁱ	169	PhosphoserineCombined sources	1
Modified residueⁱ	171	PhosphothreonineCombined sources	1
Modified residueⁱ	301	N6-acetyllysineBy similarity	1
Modified residueⁱ	318	N6-acetyllysineCombined sources	1
Modified residueⁱ	324	PhosphothreonineCombined sources	1
Modified residueⁱ	327	N6-acetyllysineCombined sources	1
Modified residueⁱ	386	PhosphoserineBy similarity	1
Modified residueⁱ	413	PhosphoserineCombined sources	1
Modified residueⁱ	414	PhosphoserineCombined sources	1
Modified residueⁱ	433	PhosphoserineBy similarity	1
Modified residueⁱ	443	PhosphoserineBy similarity	1
Modified residueⁱ	521	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	521	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	590	PhosphoserineCombined sources	1
Modified residueⁱ	593	PhosphoserineCombined sources	1
Modified residueⁱ	626	N6-acetyllysineCombined sources	1
Modified residueⁱ	630	N6-acetyllysineCombined sources	1
Cross-linkⁱ	635	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	655	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	655	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	655	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	662	PhosphoserineBy similarity	1
Modified residueⁱ	664	PhosphoserineBy similarity	1
Modified residueⁱ	669	PhosphoserineBy similarity	1
Modified residueⁱ	671	PhosphoserineBy similarity	1
Modified residueⁱ	760	PhosphoserineBy similarity	1
Modified residueⁱ	761	PhosphoserineBy similarity	1
Modified residueⁱ	765	PhosphoserineBy similarity	1
Modified residueⁱ	767	PhosphoserineBy similarity	1
Modified residueⁱ	794	PhosphoserineBy similarity	1
Modified residueⁱ	853	PhosphoserineBy similarity	1
Modified residueⁱ	860	PhosphothreonineCombined sources	1
Modified residueⁱ	869	PhosphothreonineBy similarity	1
Modified residueⁱ	922	N6-acetyllysineCombined sources	1
Modified residueⁱ	976	N6-acetyllysineCombined sources	1
Modified residueⁱ	1034	PhosphoserineBy similarity	1
Modified residueⁱ	1066	PhosphothreonineCombined sources	1
Cross-linkⁱ	1082	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	1092	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1191	PhosphoserineCombined sources	1
Modified residueⁱ	1216	PhosphoserineCombined sources	1
Modified residueⁱ	1242	PhosphoserineBy similarity	1
Modified residueⁱ	1249	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	1249	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	1301	PhosphoserineCombined sources	1
Modified residueⁱ	1303	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O08784
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O08784
PaxDbⁱ	O08784
PeptideAtlas More...PeptideAtlasⁱ	O08784
PRIDEⁱ	O08784

PTM databases

iPTMnetⁱ	O08784
PhosphoSitePlusⁱ	O08784

Miscellaneous databases

PMAP-CutDBⁱ

O08784

Expressionⁱ

Tissue specificityⁱ

Ubiquitous in adult and embryonic tissues.1 Publication

Developmental stageⁱ

Expression elevated at 11 dpc when the branchial arches and facial swellings are present.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000024613 Expressed in 290 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	O08784 baseline and differential
Genevisibleⁱ	O08784 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer; heterodimerizes with NOLC1 following monoubiquitination. Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with NOP56 in an RNA-independent manner.By similarity

GO - Molecular functionⁱ

protein heterodimerization activity Source: MGI
RNA polymerase I core binding Source: UniProtKB
scaffold protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204043, 3 interactors
IntActⁱ	O08784, 3 interactors
Molecular INTeraction database More...MINTⁱ	O08784
STRINGⁱ	10090.ENSMUSP00000135639

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O08784
SMRⁱ	O08784
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 38	LisHPROSITE-ProRule annotationAdd BLAST	33
Repeatⁱ	212 – 295	1Add BLAST	84
Repeatⁱ	296 – 366	2Add BLAST	71
Repeatⁱ	367 – 436	3Add BLAST	70
Repeatⁱ	437 – 505	4Add BLAST	69
Repeatⁱ	506 – 550	5Add BLAST	45
Repeatⁱ	551 – 624	6Add BLAST	74
Repeatⁱ	625 – 680	7Add BLAST	56
Repeatⁱ	681 – 714	8Add BLAST	34
Repeatⁱ	715 – 774	9Add BLAST	60
Repeatⁱ	775 – 839	10Add BLAST	65

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	212 – 839	10 X approximate tandem repeatsAdd BLAST		628

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	195 – 198	Poly-Ser	4
Compositional biasⁱ	216 – 272	Ala-richAdd BLAST	57
Compositional biasⁱ	253 – 272	Poly-AlaAdd BLAST	20
Compositional biasⁱ	880 – 885	Poly-Ser	6
Compositional biasⁱ	1179 – 1314	Lys-richAdd BLAST	136
Compositional biasⁱ	1200 – 1205	Poly-Lys	6
Compositional biasⁱ	1270 – 1277	Poly-Lys	8
Compositional biasⁱ	1280 – 1288	Poly-Lys	9
Compositional biasⁱ	1307 – 1314	Poly-Lys	8

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF55 Eukaryota ENOG411183W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111382
HOGENOMⁱ	HOG000154524
HOVERGENⁱ	HBG006664
InParanoidⁱ	O08784
KEGG Orthology (KO) More...KOⁱ	K14562
PhylomeDBⁱ	O08784
TreeFamⁱ	TF341730

Family and domain databases

InterProⁱ	View protein in InterPro IPR006594 LisH IPR017859 Treacle IPR003993 Treacle_dom
PANTHERⁱ	PTHR20787 PTHR20787, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03546 Treacle, 2 hits
SMARTⁱ	View protein in SMART SM00667 LisH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50896 LISH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

O08784-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY 
        60         70         80         90        100
THWQQTSELG QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER 
       110        120        130        140        150
AKATPRPTPV NSATAALPSK VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL 
       160        170        180        190        200
SGKSPKKSAE PLANTVLASE TEEEGNAQAL GPTAKSGTVS AGQGSSSSED 
       210        220        230        240        250
SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT KLGNVAPTPA 
       260        270        280        290        300
KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG 
       310        320        330        340        350
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED 
       360        370        380        390        400
DSDSEDEMPV TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR 
       410        420        430        440        450
PVAAQAGKPE AKSSEESESD SGETPAAATL TTSPAKVKPL GKSSQVRPVS 
       460        470        480        490        500
TVTPGSSGKG ANLPCPGKVG SAALRVQMVK KEDVSESSSA ELDSDGPGSP 
       510        520        530        540        550
AKAKASLALP QKVRPVATQV KTDRGKGHSG SSEESSDSEE EAAPAASAAQ 
       560        570        580        590        600
AKPALEKQMK ASSRKGTPAS ATGASTSSHC KAGAVTSSAS LSSPALAKGT 
       610        620        630        640        650
QRSDVDSSSE SESEGAAPST PRVQGKSGGK GLQGKAALGQ GVAPVHTQKT 
       660        670        680        690        700
GPSVKAMAQE DSESLEEDSS SEEEDETPAQ ATPLGRLPQA KANPPPTKTP 
       710        720        730        740        750
PASASGKAVA APTKGKPPVP NSTVSARGQR SVPAAGKAGA PATQAQKGPV 
       760        770        780        790        800
AGTGEDSESS SKEESDSEEE TPAQIKPVGK TSQVRAASAP AKESPKKGAH 
       810        820        830        840        850
PGTPGKTGSS ATQAQPGKTE DSDSSSEESD SDTEMPSAQA IKSPPVSVNR 
       860        870        880        890        900
NSSPAVPAPT PEGVQAVNTT KKASGTTAQS SSSESEDGDE DLIPATQPST 
       910        920        930        940        950
YALRTSVTTP AALSRAASQP SKSEQSSRMP KGKKAKAAAS AQTSSAVETL 
       960        970        980        990       1000
PMMPPQSAPI QPKATNKLGK SKLPEKQQLA PGYPKAPRSS EDSSDTSSED 
      1010       1020       1030       1040       1050
EEDAKRPQMP KSAHRLDPDP SQKETVVEET PTESSEDEMV APSQSLLSGY 
      1060       1070       1080       1090       1100
MTPGLTVANS QASKATPRPD SNSLASSAPA TKDNPDGKQK SKSQHAADTA 
      1110       1120       1130       1140       1150
LPKTGRKEAS SGSTPQKPKK LKKSTSSSPA PTQTLPNSIT QRLLEQAWPL 
      1160       1170       1180       1190       1200
SEAQVQASVV KVLTELLEQE RLKATEAIKE SGKKSQKRKL SGDLEAGAPK 
      1210       1220       1230       1240       1250
NKKKKEQPVP RASAVSPEKA PMTSKAKSKL DKGSAGGKGK GSPGPQGAKE 
      1260       1270       1280       1290       1300
KPDGELLGIK LESGEQSDPK SKSKKKKSLK KKKDKEKKEK KKGKKSLAKD 
      1310       1320
SASPIQKKKK KKKKSAEPAV

Length:1,320

Mass (Da):135,001

Last modified:July 1, 1997 - v1

Checksum:ⁱ34D87F5F5D300758

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BL37	H3BL37_MOUSE	Treacle protein Treacle protein	Tcof1	1,356	Annotation score:
H3BIX0	H3BIX0_MOUSE	Treacle protein Treacle protein	Tcof1	1,056	Annotation score:
F6R3V4	F6R3V4_MOUSE	Treacle protein Treacle protein	Tcof1	1,013	Annotation score:
H3BK88	H3BK88_MOUSE	Treacle protein Treacle protein	Tcof1	167	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	35	G → A in AAB60933 (PubMed:9158147).Curated		1
Sequence conflictⁱ	125 – 142	Missing in AAB60933 (PubMed:9158147).CuratedAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001794 mRNA Translation: AAB71347.1 U81030 mRNA Translation: AAB60933.1 BC060105 mRNA Translation: AAH60105.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37836.1
PIRⁱ	JC5630
NCBI Reference Sequences More...RefSeqⁱ	NP_035682.1, NM_011552.3
UniGeneⁱ	Mm.486251

Genome annotation databases

Ensemblⁱ	ENSMUST00000176630; ENSMUSP00000135476; ENSMUSG00000024613
GeneIDⁱ	21453
KEGGⁱ	mmu:21453
UCSC genome browser More...UCSCⁱ	uc008fbb.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08784	Treacle protein		CRIGR		1245	UniRef50_O08784
Treacle protein		MOUSE		1356
Treacle ribosome biogenesis factor 1		RAT		1395
UPI000A30C5A0		MUSPA		1318
UPI00067B195D		MICOH		1329
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001794 mRNA Translation: AAB71347.1 U81030 mRNA Translation: AAB60933.1 BC060105 mRNA Translation: AAH60105.1
CCDSⁱ	CCDS37836.1
PIRⁱ	JC5630
RefSeqⁱ	NP_035682.1, NM_011552.3
UniGeneⁱ	Mm.486251

3D structure databases

ProteinModelPortalⁱ	O08784
SMRⁱ	O08784
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204043, 3 interactors
IntActⁱ	O08784, 3 interactors
MINTⁱ	O08784
STRINGⁱ	10090.ENSMUSP00000135639

PTM databases

iPTMnetⁱ	O08784
PhosphoSitePlusⁱ	O08784

Proteomic databases

EPDⁱ	O08784
MaxQBⁱ	O08784
PaxDbⁱ	O08784
PeptideAtlasⁱ	O08784
PRIDEⁱ	O08784

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000176630; ENSMUSP00000135476; ENSMUSG00000024613
GeneIDⁱ	21453
KEGGⁱ	mmu:21453
UCSCⁱ	uc008fbb.2 mouse

Organism-specific databases

CTDⁱ	6949
MGIⁱ	MGI:892003 Tcof1

Phylogenomic databases

eggNOGⁱ	ENOG410IF55 Eukaryota ENOG411183W LUCA
GeneTreeⁱ	ENSGT00730000111382
HOGENOMⁱ	HOG000154524
HOVERGENⁱ	HBG006664
InParanoidⁱ	O08784
KOⁱ	K14562
PhylomeDBⁱ	O08784
TreeFamⁱ	TF341730

Miscellaneous databases

PMAP-CutDBⁱ	O08784
Protein Ontology More...PROⁱ	PR:O08784
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024613 Expressed in 290 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	O08784 baseline and differential
Genevisibleⁱ	O08784 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006594 LisH IPR017859 Treacle IPR003993 Treacle_dom
PANTHERⁱ	PTHR20787 PTHR20787, 1 hit
Pfamⁱ	View protein in Pfam PF03546 Treacle, 2 hits
SMARTⁱ	View protein in SMART SM00667 LisH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50896 LISH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCOF_MOUSE
Accessionⁱ	O08784Primary (citable) accession number: O08784 Secondary accession number(s): O08857
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O08784 (TCOF_MOUSE)

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Treacle protein

Tcof1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ