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Entry version 151 (02 Dec 2020)
Sequence version 1 (01 Jul 1997)
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Protein

Regulator of G-protein signaling 12

Gene

Rgs12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-418594, G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rgs12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3564, Rgs12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042141 – 1387Regulator of G-protein signaling 12Add BLAST1387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171PhosphoserineCombined sources1
Modified residuei194PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei524Omega-N-methylarginineBy similarity1
Modified residuei633Omega-N-methylarginineBy similarity1
Modified residuei661PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei850PhosphoserineBy similarity1
Modified residuei879PhosphoserineCombined sources1
Modified residuei943PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08774

PRoteomics IDEntifications database

More...
PRIDEi
O08774

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08774

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08774

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain cortex GABAergic neurons, in striatum and substantia nigra, and in the Purkinje cell layer in the cerebellum and hippocampus (at protein level) (PubMed:16819986). Expressed at high levels in brain and lung and lower levels in testis, heart, and spleen (PubMed:9168931).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
248512, 10 interactors

Protein interaction database and analysis system

More...
IntActi
O08774, 3 interactors

Molecular INTeraction database

More...
MINTi
O08774

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000045065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08774

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 97PDZPROSITE-ProRule annotationAdd BLAST77
Domaini227 – 339PIDPROSITE-ProRule annotationAdd BLAST113
Domaini715 – 832RGSPROSITE-ProRule annotationAdd BLAST118
Domaini962 – 1032RBD 1PROSITE-ProRule annotationAdd BLAST71
Domaini1034 – 1104RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini1187 – 1209GoLocoPROSITE-ProRule annotationAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1368 – 1373Poly-Pro6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08774

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O08774

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08742, RGS_RGS12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003109, GoLoco_motif
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR003116, RBD_dom
IPR016137, RGS
IPR037880, RGS12_RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188, GoLoco, 1 hit
PF00595, PDZ, 1 hit
PF02196, RBD, 2 hits
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00390, GoLoco, 1 hit
SM00228, PDZ, 1 hit
SM00462, PTB, 1 hit
SM00455, RBD, 2 hits
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877, GOLOCO, 1 hit
PS50106, PDZ, 1 hit
PS01179, PID, 1 hit
PS50898, RBD, 2 hits
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O08774-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRAGEPGKR QSGPAPPRVR SVEVARGRAG YGFTLSGQAP CVLSCVMRGS
60 70 80 90 100
PADFVGLRAG DQILAINEIN VKKASHEDVV KLIGKCSGVL RMVISEGSSH
110 120 130 140 150
VEPSSSDEEG GLCEGKGWLR PKLDSKALGI NRAERVVEEV QSGGIFNMIF
160 170 180 190 200
ESPSLCASGS EPLKLKQRSL SESAALRLDV GQDSLCTPHP SMLSKEEISK
210 220 230 240 250
VINDDSVFTV GLDNHDDFGL DASILNVAMV VGYLGSIELP STSSNLEHDS
260 270 280 290 300
LQAIRGCMRR LRAEQKIHSL VTMKVMHDCV QLVTDRAGVV AEYPAEKLAF
310 320 330 340 350
SAVCPDDRRF FGLVTMQTND DGCLAQEDEG ALRTSCHVFM VDPDLFHHKI
360 370 380 390 400
HQGIARRFGF ACTADPDTSG CLEFPASSLP VLQFISVLYR DMGELIEGVR
410 420 430 440 450
ARAFLDGDAD AHQNNSTSSN SDSGIGNFNQ EEKSNRVLVV DLGGGSSRHG
460 470 480 490 500
QGSSPGWESV SGRGSQPWSA PWNGTFCHDS EAGSPLETSP NTDRFWDLTK
510 520 530 540 550
HSGPVFHMEV PPATLRSSIP PSKRGATGSS CGFNQRWLPV HVLQEWQCGH
560 570 580 590 600
ASDQESYTDS TDGWSSVNCG TLPPPMSKIP ADRYRVEGSF AQAPLSTQKR
610 620 630 640 650
DWSRKAFGMQ NLFGPHRNVR KTKEDKKSSK LGRGVALAQT SQRTSARRSF
660 670 680 690 700
GRSRRFSLTR SLDDLESATV SDGELTGADL KDCISNNSLS SNASLPSVQS
710 720 730 740 750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEC
760 770 780 790 800
FSHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDILNAPHP
810 820 830 840 850
DMFKEQQLQI FNLMKFDSYT RFLKSQLYQE CVLAEVEGRT LPDSQQVPSS
860 870 880 890 900
PASKHSISSD HSNVSTPKKL SGKSKSGRSL NEDVGEEDSE KKRKGAFFSW
910 920 930 940 950
SRSRSTGRSQ KKKDHGDHAH DALHANGGLC RRESQGSVSS AGSLDLSEAC
960 970 980 990 1000
RTSALERDKA AKHCCVHLPD GTSCVVAVKS GFSIKEILSG LCERHGINGA
1010 1020 1030 1040 1050
AVDLFLVGGD KPLVLHQDSS ILATRDLRLG KRTLFRLDLV PINRSVGLKA
1060 1070 1080 1090 1100
KPTKPVTEVL RPVVAKYGLD LGSLLVRLSG EKEPLDLGAP ISSLDGQRVI
1110 1120 1130 1140 1150
LEERDPSRGK VSTEKQKGAP VKQSSAVNSS PRNHSAMGEE RTLGKSNSIK
1160 1170 1180 1190 1200
IRGENGKSAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
1210 1220 1230 1240 1250
RADDQRGLLR KEDLVLPEFL RLPPGSSELA LSSPPPVKGF SKRAVTSHGQ
1260 1270 1280 1290 1300
EGAVQTEESY SDSPATSPAS AQSPCSAYSP GSAHSPGSAH SPGSAHSTPG
1310 1320 1330 1340 1350
PPGTAQPGEK PTKPSCISTV QEGTTQAWRR LSPELEAGGI QTVEEEQVAD
1360 1370 1380
LTLMGEGDIS SPNSTLLPPP PLPQDTPGPT RPGTSRF
Length:1,387
Mass (Da):150,469
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i958047D106B08310
GO
Isoform 2 (identifier: O08774-2) [UniParc]FASTAAdd to basket
Also known as: PDZ-less

The sequence of this isoform differs from the canonical sequence as follows:
     1-648: Missing.
     649-666: SFGRSRRFSLTRSLDDLE → MNLEKGLSDDSDVFIDQQ

Show »
Length:739
Mass (Da):80,135
Checksum:i792AEB5E220E1143
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4AB55D4AB55_RAT
Regulator of G-protein-signaling 12
Rgs12
1,457Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V9H1G3V9H1_RAT
Regulator of G-protein signaling 12...
Rgs12 rCG_36076
1,387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K326A0A0G2K326_RAT
Regulator of G-protein signaling 12...
Rgs12 rCG_36076
739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056881 – 648Missing in isoform 2. CuratedAdd BLAST648
Alternative sequenceiVSP_005689649 – 666SFGRS…LDDLE → MNLEKGLSDDSDVFIDQQ in isoform 2. CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U92280 mRNA Translation: AAC53176.1
AF035151 mRNA Translation: AAC40154.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5502

NCBI Reference Sequences

More...
RefSeqi
NP_062212.1, NM_019339.1 [O08774-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:54292

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92280 mRNA Translation: AAC53176.1
AF035151 mRNA Translation: AAC40154.1
PIRiJC5502
RefSeqiNP_062212.1, NM_019339.1 [O08774-1]

3D structure databases

SMRiO08774
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi248512, 10 interactors
IntActiO08774, 3 interactors
MINTiO08774
STRINGi10116.ENSRNOP00000045065

PTM databases

iPTMnetiO08774
PhosphoSitePlusiO08774

Proteomic databases

PaxDbiO08774
PRIDEiO08774

Genome annotation databases

GeneIDi54292
KEGGirno:54292

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6002
RGDi3564, Rgs12

Phylogenomic databases

eggNOGiKOG3589, Eukaryota
InParanoidiO08774
PhylomeDBiO08774

Enzyme and pathway databases

ReactomeiR-RNO-418594, G alpha (i) signalling events

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O08774

Family and domain databases

CDDicd08742, RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR003109, GoLoco_motif
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR006020, PTB/PI_dom
IPR003116, RBD_dom
IPR016137, RGS
IPR037880, RGS12_RGS
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188, GoLoco, 1 hit
PF00595, PDZ, 1 hit
PF02196, RBD, 2 hits
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00390, GoLoco, 1 hit
SM00228, PDZ, 1 hit
SM00462, PTB, 1 hit
SM00455, RBD, 2 hits
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877, GOLOCO, 1 hit
PS50106, PDZ, 1 hit
PS01179, PID, 1 hit
PS50898, RBD, 2 hits
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS12_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08774
Secondary accession number(s): O88383
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: December 2, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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