UniProtKB - O08773 (RGS14_RAT)

BLAST

>sp|O08773|RGS14_RAT Regulator of G-protein signaling 14 OS=Rattus norvegicus OX=10116 GN=Rgs14 PE=1 SV=1
MPGKPKHLGVPNGRMVLAVSDGELTSTSGSQAQGEGRGSSLSIHSLPSGPSSPFSTDEQP
VASWAQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDTKQLAQEAHN
IYHEFLSSQALSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLY
QECLLAEAEGRPLREPGSSHLGSPDTARKKPKLKPGKSLPLGVEELGQLPLAEGRPLRKS
FRREMPGGAVNSALRRESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSGEGESESRPGK
YCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGKEQKALVLDQDCTV
LADQEVRLENRITFQLELVGLERVVRISAKPTKRLQEALQPILAKHGLSLDQVVLHRPGE
KQLVDLENLVSSVASQTLVLDTLPDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSL
SVEDASGSTGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFLQLPSQRPGSQ
EAPP

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History
Entry version 138 (10 Oct 2018)
Sequence version 1 (01 Jul 1997)
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Protein

Regulator of G-protein signaling 14

Gene

Rgs14

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) (PubMed:11976690). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance.8 Publications

GO - Molecular functionⁱ

GDP-dissociation inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15337739
G-protein alpha-subunit binding
Source: RGD
Inferred from physical interactionⁱ
- 11387333
GTPase activating protein binding Source: Ensembl
GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15337739
microtubule binding Source: UniProtKB
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19878719
receptor signaling complex scaffold activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19319189

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB
chromosome segregation Source: UniProtKB
intracellular signal transduction Source: InterPro
learning Source: UniProtKB
long-term memory Source: UniProtKB
long-term synaptic potentiation Source: UniProtKB
mitotic cell cycle Source: Ensembl
negative regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 19878719
negative regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
negative regulation of MAP kinase activity Source: UniProtKB
negative regulation of synaptic plasticity Source: UniProtKB
nucleocytoplasmic transport
Source: UniProtKB
Inferred from direct assayⁱ
- 16870394
platelet-derived growth factor receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 19878719
positive regulation of neurogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19319189
regulation of DNA-templated transcription in response to stress Source: UniProtKB
regulation of G-protein coupled receptor protein signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 11976690
response to oxidative stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21255223
spindle organization Source: UniProtKB
visual learning
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19574389
zygote asymmetric cell division Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, GTPase activation, Signal transduction inhibitor
Biological process	Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 14 Short name: RGS14
Gene namesⁱ	Name:Rgs14
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 17

Organism-specific databases

Rat genome database More...RGDⁱ	620003 Rgs14

RGDⁱ

620003 Rgs14

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	258	S → A: Inhibits phosphorylation; when associated with A-494. 1 Publication	1
Mutagenesisⁱ	333	R → L: Abolishes the inhibition of PDGF-mediated ERK1/ERK2 phosphorylation. Inhibits interaction with HRAS and does not colocalize with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1. 1 Publication	1
Mutagenesisⁱ	406	H → A: Does not inhibit interaction and colocalization with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1. 1 Publication	1
Mutagenesisⁱ	494	T → A: Does not increase the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1. Inhibits phosphorylation; when associated with A-258. 1 Publication	1
Mutagenesisⁱ	494	T → D: Increases the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1. 1 Publication	1
Mutagenesisⁱ	494	T → E: Increases the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1. 1 Publication	1
Mutagenesisⁱ	508	Q → L: Inhibits the interaction with GNAI1. 1 Publication	1
Mutagenesisⁱ	518	L → Y: Increases the interaction with GNAI1. 1 Publication	1
Mutagenesisⁱ	525	V → W: Increases the interaction with GNAI1. 1 Publication	1
Mutagenesisⁱ	529	F → W: Increases the interaction with GNAI1. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204219	1 – 544	Regulator of G-protein signaling 14Add BLAST		544

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	20	PhosphoserineCombined sources	1
Modified residueⁱ	42	PhosphoserineBy similarity	1
Modified residueⁱ	45	PhosphoserineBy similarity	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	199	PhosphoserineBy similarity	1
Modified residueⁱ	203	PhosphoserineCombined sources	1
Modified residueⁱ	218	PhosphoserineCombined sources	1
Modified residueⁱ	286	PhosphoserineCombined sources	1
Modified residueⁱ	481	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O08773
PRIDEⁱ	O08773

PTM databases

iPTMnetⁱ	O08773
PhosphoSitePlusⁱ	O08773

Expressionⁱ

Tissue specificityⁱ

Expressed in neurons of the V2 secondary visual cortex area (at protein level). Expressed at high levels in the brain cortex, hippocampus, striatum, thalamus and substantia nigra, in the lung, and spleen. Low expression has been found in heart, liver, skeletal muscle and testis.2 Publications

Gene expression databases

Bgeeⁱ	ENSRNOG00000015616 Expressed in 9 organ(s), highest expression level in spleen
Genevisibleⁱ	O08773 RN

Interactionⁱ

Subunit structureⁱ

Interacts with GNAI1, GNAI2 and GNAI3 (PubMed:11387333, PubMed:16870394, PubMed:17603074, PubMed:21158412, PubMed:11976690). Interacts with GNAO1 (By similarity). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization. Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI. Associates with microtubules (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (PubMed:19319189). Interacts with RIC8A (via C-terminus) (PubMed:21158412). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF (PubMed:19878719). Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially) (PubMed:19319189).By similarity7 Publications

GO - Molecular functionⁱ

G-protein alpha-subunit binding
Source: RGD
Inferred from physical interactionⁱ
- 11387333
GTPase activating protein binding Source: Ensembl
microtubule binding Source: UniProtKB
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19878719
receptor signaling complex scaffold activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19319189

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000021596

STRINGⁱ

10116.ENSRNOP00000021596

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	497 – 505	Combined sources	9
Turnⁱ	506 – 509	Combined sources	4
Helixⁱ	510 – 513	Combined sources	4
Helixⁱ	521 – 524	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	O08773
SMRⁱ	O08773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O08773

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	67 – 184	RGSPROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	300 – 371	RBD 1PROSITE-ProRule annotationAdd BLAST	72
Domainⁱ	373 – 443	RBD 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	497 – 519	GoLocoPROSITE-ProRule annotationAdd BLAST	23

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	297 – 424	Necessary for interaction with RABGEF1By similarityAdd BLAST		128

Domainⁱ

The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.1 Publication

The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3.1 Publication

The RBD domains are necessary for localization to the nucleus and centrosomes.1 Publication

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049111
HOVERGENⁱ	HBG061568
InParanoidⁱ	O08773
KEGG Orthology (KO) More...KOⁱ	K17706
OMAⁱ	TGKRQTC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O08773
TreeFamⁱ	TF328814

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08743 RGS_RGS14, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR003116 RBD_dom IPR016137 RGS IPR030776 RGS14 IPR037881 RGS14_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR10845:SF179 PTHR10845:SF179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O08773-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGKPKHLGV PNGRMVLAVS DGELTSTSGS QAQGEGRGSS LSIHSLPSGP 
        60         70         80         90        100
SSPFSTDEQP VASWAQSFER LLQDPRGLAY FTEFLKKEFS AENVTFWQAC 
       110        120        130        140        150
ERFQQIPASD TKQLAQEAHN IYHEFLSSQA LSPVNIDRQA WLSEEVLAQP 
       160        170        180        190        200
RPDMFRAQQL QIFNLMKFDS YARFVKSPLY QECLLAEAEG RPLREPGSSH 
       210        220        230        240        250
LGSPDTARKK PKLKPGKSLP LGVEELGQLP LAEGRPLRKS FRREMPGGAV 
       260        270        280        290        300
NSALRRESQG SLNSSASLDL GFLAFVSSKS ESHRKSLGSG EGESESRPGK 
       310        320        330        340        350
YCCVYLPDGT ASLALARPGL TIRDMLAGIC EKRGLSLPDI KVYLVGKEQK 
       360        370        380        390        400
ALVLDQDCTV LADQEVRLEN RITFQLELVG LERVVRISAK PTKRLQEALQ 
       410        420        430        440        450
PILAKHGLSL DQVVLHRPGE KQLVDLENLV SSVASQTLVL DTLPDAKTRE 
       460        470        480        490        500
ASSIPPCRSQ GCLPRTQTKD SHLPPLSSSL SVEDASGSTG KRQTCDIEGL 
       510        520        530        540 
VELLNRVQSS GAHDQRGLLR KEDLVLPEFL QLPSQRPGSQ EAPP

Length:544

Mass (Da):59,492

Last modified:July 1, 1997 - v1

Checksum:ⁱFF6B24BD2F593B4E

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U92279 mRNA Translation: AAC53175.1
PIRⁱ	JC5503
NCBI Reference Sequences More...RefSeqⁱ	NP_446216.1, NM_053764.1
UniGeneⁱ	Rn.9795

Genome annotation databases

Ensemblⁱ	ENSRNOT00000021596; ENSRNOP00000021596; ENSRNOG00000015616 ENSRNOT00000090536; ENSRNOP00000073077; ENSRNOG00000015616
GeneIDⁱ	114705
KEGGⁱ	rno:114705
UCSC genome browser More...UCSCⁱ	RGD:620003 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O08773	Rgs14 protein		RAT		375	UniRef100_O08773

Protein	Similar proteins		Species	Score	Length	Source
O08773	Regulator of G-protein signaling 14	)	MOUSE		547	UniRef90_P97492
Rgs14 protein		RAT		375
UPI000A317CE2		MUSCR		547
UPI000A30EEB3		MUSPA		546
UPI0005ABA817		MOUSE		551
+1

Protein	Similar proteins		Species	Score	Length	Source
O08773	Regulator of G-protein signaling 14	)	MOUSE		547	UniRef50_P97492
Rgs14 protein		RAT		375
Regulator of G-protein signaling 14		FUKDA		570
Uncharacterized protein		CAVPO		570
Regulator of G-protein signaling 14		HETGA		565
+149

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U92279 mRNA Translation: AAC53175.1
PIRⁱ	JC5503
RefSeqⁱ	NP_446216.1, NM_053764.1
UniGeneⁱ	Rn.9795

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KJY	X-ray	2.70	B/D	496-531	[»]
ProteinModelPortalⁱ	O08773
SMRⁱ	O08773
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000021596

STRINGⁱ

10116.ENSRNOP00000021596

PTM databases

iPTMnetⁱ	O08773
PhosphoSitePlusⁱ	O08773

Proteomic databases

PaxDbⁱ	O08773
PRIDEⁱ	O08773

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000021596; ENSRNOP00000021596; ENSRNOG00000015616 ENSRNOT00000090536; ENSRNOP00000073077; ENSRNOG00000015616
GeneIDⁱ	114705
KEGGⁱ	rno:114705
UCSCⁱ	RGD:620003 rat

Organism-specific databases

CTDⁱ	10636
RGDⁱ	620003 Rgs14

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049111
HOVERGENⁱ	HBG061568
InParanoidⁱ	O08773
KOⁱ	K17706
OMAⁱ	TGKRQTC
OrthoDBⁱ	EOG091G0BDG
PhylomeDBⁱ	O08773
TreeFamⁱ	TF328814

Miscellaneous databases

EvolutionaryTraceⁱ	O08773
Protein Ontology More...PROⁱ	PR:O08773

Gene expression databases

Bgeeⁱ	ENSRNOG00000015616 Expressed in 9 organ(s), highest expression level in spleen
Genevisibleⁱ	O08773 RN

Family and domain databases

CDDⁱ	cd08743 RGS_RGS14, 1 hit
Gene3Dⁱ	1.10.196.10, 2 hits
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR003116 RBD_dom IPR016137 RGS IPR030776 RGS14 IPR037881 RGS14_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR10845:SF179 PTHR10845:SF179, 1 hit
Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS14_RAT
Accessionⁱ	O08773Primary (citable) accession number: O08773
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 1, 1997
	Last modified:	October 10, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - O08773 (RGS14_RAT)

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Regulator of G-protein signaling 14

Rgs14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Plasma membrane

Other locations

Cytoskeleton

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ