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Protein

N-glycosylase/DNA lyase

Gene

Ogg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149DNABy similarity1
Binding sitei154DNABy similarity1
Binding sitei204DNABy similarity1
Active sitei249Schiff-base intermediate with DNABy similarity1
Binding sitei2668-oxoguanine; via carbonyl oxygenBy similarity1
Binding sitei2688-oxoguanineBy similarity1
Binding sitei270DNABy similarity1
Binding sitei287DNABy similarity1
Binding sitei3158-oxoguanineBy similarity1
Binding sitei3198-oxoguanineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-110329 Cleavage of the damaged pyrimidine
R-MMU-110331 Cleavage of the damaged purine
R-MMU-110357 Displacement of DNA glycosylase by APEX1
R-MMU-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:Ogg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097693 Ogg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585921 – 345N-glycosylase/DNA lyaseAdd BLAST345

Proteomic databases

EPDiO08760
PaxDbiO08760
PeptideAtlasiO08760
PRIDEiO08760

PTM databases

PhosphoSitePlusiO08760

Expressioni

Tissue specificityi

Highest expression in testis.

Gene expression databases

BgeeiENSMUSG00000030271 Expressed in 146 organ(s), highest expression level in brown adipose tissue
CleanExiMM_OGG1
ExpressionAtlasiO08760 baseline and differential
GenevisibleiO08760 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201906, 2 interactors
IntActiO08760, 2 interactors
STRINGi10090.ENSMUSP00000032406

Structurei

3D structure databases

ProteinModelPortaliO08760
SMRiO08760
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-1 OGG1 family.Curated

Phylogenomic databases

eggNOGiKOG2875 Eukaryota
COG0122 LUCA
GeneTreeiENSGT00640000091554
HOVERGENiHBG001047
InParanoidiO08760
KOiK03660
OMAiEYAGYAQ
OrthoDBiEOG091G0AU6
PhylomeDBiO08760
TreeFamiTF323702

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
InterProiView protein in InterPro
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
IPR004577 Ogg1
IPR012904 OGG_N
PfamiView protein in Pfam
PF00730 HhH-GPD, 1 hit
PF07934 OGG_N, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit
TIGRFAMsiTIGR00588 ogg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

O08760-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFRSWLPSS MRHRTLSSSP ALWASIPCPR SELRLDLVLA SGQSFRWKEQ
60 70 80 90 100
SPAHWSGVLA DQVWTLTQTE DQLYCTVYRG DDSQVSRPTL EELETLHKYF
110 120 130 140 150
QLDVSLAQLY SHWASVDSHF QRVAQKFQGV RLLRQDPTEC LFSFICSSNN
160 170 180 190 200
NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPNLHALAGP EAETHLRKLG
210 220 230 240 250
LGYRARYVRA SAKAILEEQG GPAWLQQLRV APYEEAHKAL CTLPGVGAKV
260 270 280 290 300
ADCICLMALD KPQAVPVDVH VWQIAHRDYG WHPKTSQAKG PSPLANKELG
310 320 330 340
NFFRNLWGPY AGWAQAVLFS ADLRQPSLSR EPPAKRKKGS KRPEG
Length:345
Mass (Da):38,883
Last modified:December 1, 2000 - v2
Checksum:i75BB0DDB084E4947
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV11A0A0N4SV11_MOUSE
N-glycosylase/DNA lyase
Ogg1
137Annotation score:
A0A0N4SUR7A0A0N4SUR7_MOUSE
N-glycosylase/DNA lyase
Ogg1
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10S → Q in AAB61289 (PubMed:9187114).Curated1
Sequence conflicti23 – 25WAS → SVA in AAB61289 (PubMed:9187114).Curated3
Sequence conflicti239A → G in AAB61289 (PubMed:9187114).Curated1
Sequence conflicti299L → S in CAA73883 (Ref. 6) Curated1
Sequence conflicti329S → F in AAB81133 (PubMed:9207108).Curated1
Sequence conflicti336R → H in CAA73883 (Ref. 6) Curated1
Sequence conflicti336R → H in CAB65240 (Ref. 7) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003596 mRNA Translation: AAB61289.1
Y11247 mRNA Translation: CAA72117.1
U88621 mRNA Translation: AAB68616.1
U96711 mRNA Translation: AAB81133.1
AF000669 mRNA Translation: AAB63151.1
AF012916
, AF012912, AF012913, AF012914, AF012915 Genomic DNA Translation: AAB94512.1
Y13479 mRNA Translation: CAA73883.1
AJ001307 Genomic DNA Translation: CAB65240.1
CCDSiCCDS20414.1
PIRiT46962
RefSeqiNP_035087.3, NM_010957.4
UniGeneiMm.43612

Genome annotation databases

EnsembliENSMUST00000032406; ENSMUSP00000032406; ENSMUSG00000030271
GeneIDi18294
KEGGimmu:18294
UCSCiuc009dfh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOGG1_MOUSE
AccessioniPrimary (citable) accession number: O08760
Secondary accession number(s): O08733
, O08910, O08991, O35617, O35915, Q9QXE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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