Ubiquitin-protein ligase E3A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• metal ion binding Source: UniProtKB-KW
• transcription coactivator activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16254014
• ubiquitin protein ligase activity Source: MGIInferred from direct assayⁱ
  • 9182527
• ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processⁱ

• androgen receptor signaling pathway Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16254014
• cellular response to brain-derived neurotrophic factor stimulus Source: Ensembl
• negative regulation of dendritic spine morphogenesis Source: MGI
• ovarian follicle development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 11756548
• positive regulation of phosphatidylinositol 3-kinase signaling Source: MGIInferred from mutant phenotypeⁱ
  • 16254014
• positive regulation of protein ubiquitination Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 16254014
• progesterone receptor signaling pathway Source: UniProtKB
• prostate gland growth Source: MGIInferred from mutant phenotypeⁱ
  • 11756548
  • 16254014
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• protein autoubiquitination Source: MGI
• protein K48-linked ubiquitination Source: UniProtKB
• protein polyubiquitination Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein ubiquitination Source: MGIInferred from direct assayⁱ
  • 9182527
• regulation of circadian rhythm Source: UniProtKBInferred from mutant phenotypeⁱ
  • 24728990
• regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
• response to cocaine Source: Ensembl
• response to hydrogen peroxide Source: Ensembl
• response to progesterone Source: UniProtKB
• rhythmic process Source: UniProtKB-KW
• sperm entry Source: MGIInferred from mutant phenotypeⁱ
  • 11756548
• ubiquitin-dependent protein catabolic process Source: MGIInferred from direct assayⁱ
  • 16254014

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE 
        60         70         80         90        100
FCASCPTFLR MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG 
       110        120        130        140        150
ASNNSEIKMN KKEGKDFKDV IYLTEEKVYE IYEFCRESED YSPLIRVIGR 
       160        170        180        190        200
IFSSAEALVL SFRKVKQHTK EELKSLQEKD EDKDEDEKEK AACSAAAMEE 
       210        220        230        240        250
DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS LLANEKLETA 
       260        270        280        290        300
FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 
       310        320        330        340        350
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE 
       360        370        380        390        400
FNSRNLVNDD DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS 
       410        420        430        440        450
ELTLQELLGD ERRNKKGPRV DPLETELGVK TLDCRKPLIS FEEFINEPLN 
       460        470        480        490        500
DVLEMDKDYT FFKVETENKF SFMTCPFILN AVTKNLGLYY DNRIRMYSER 
       510        520        530        540        550
RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM ENPADLKKQL 
       560        570        580        590        600
YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 
       610        620        630        640        650
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH 
       660        670        680        690        700
PVLYQSLKDL LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI 
       710        720        730        740        750
TNENRKEFVN LYSDYILNKS VEKQFKAFRR GFHMVTNESP LKYLFRPEEI 
       760        770        780        790        800
ELLICGSRNL DFQALEETTE YDGGYTRESV VIREFWEIVH SFTDEQKRLF 
       810        820        830        840        850
LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN VLLLPEYSSK 
       860        870
EKLKERLLKA ITYAKGFGML                                  

        10         20         30         40         50
MKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM DNNAAAIKAL 
        60         70         80         90        100
ELYKINAKLC DPHPSKKGAS SAYLENSKGA SNNSEIKMNK KEGKDFKDVI 
       110        120        130        140        150
YLTEEKVYEI YEFCRESEDY SPLIRVIGRI FSSAEALVLS FRKVKQHTKE 
       160        170        180        190        200
ELKSLQEKDE DKDEDEKEKA ACSAAAMEED SEASSSRMGD SSQGDNNVQK 
       210        220        230        240        250
LGPDDVTVDI DAIRRVYSSL LANEKLETAF LNALVYLSPN VECDLTYHNV 
       260        270        280        290        300
YTRDPNYLNL FIIVMENSNL HSPEYLEMAL PLFCKAMCKL PLEAQGKLIR 
       310        320        330        340        350
LWSKYSADQI RRMMETFQQL ITYKVISNEF NSRNLVNDDD AIVAASKCLK 
       360        370        380        390        400
MVYYANVVGG DVDTNHNEED DEEPIPESSE LTLQELLGDE RRNKKGPRVD 
       410        420        430        440        450
PLETELGVKT LDCRKPLISF EEFINEPLND VLEMDKDYTF FKVETENKFS 
       460        470        480        490        500
FMTCPFILNA VTKNLGLYYD NRIRMYSERR ITVLYSLVQG QQLNPYLRLK 
       510        520        530        540        550
VRRDHIIDDA LVRLEMIAME NPADLKKQLY VEFEGEQGVD EGGVSKEFFQ 
       560        570        580        590        600
LVVEEIFNPD IGMFTYDEAT KLFWFNPSSF ETEGQFTLIG IVLGLAIYNN 
       610        620        630        640        650
CILDVHFPMV VYRKLMGKKG TFRDLGDSHP VLYQSLKDLL EYEGSVEDDM 
       660        670        680        690        700
MITFQISQTD LFGNPMMYDL KENGDKIPIT NENRKEFVNL YSDYILNKSV 
       710        720        730        740        750
EKQFKAFRRG FHMVTNESPL KYLFRPEEIE LLICGSRNLD FQALEETTEY 
       760        770        780        790        800
DGGYTRESVV IREFWEIVHS FTDEQKRLFL QFTTGTDRAP VGGLGKLKMI 
       810        820        830        840 
IAKNGPDTER LPTSHTCFNV LLLPEYSSKE KLKERLLKAI TYAKGFGML  

        10         20         30         40         50
MKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM DNNAAAIKAL 
        60         70         80         90        100
ELYKINAKLC DPHPSKKGAS SAYLENSKGA SNNSEIKMNK KEGKDFKDVI 
       110        120        130        140        150
YLTEEKVYEI YEFCRESEDY SPLIRVIGRI FSSAEALVLS FRKVKQHTKE 
       160        170        180        190        200
ELKSLQEKDE DKDEDEKEKA ACSAAAMEED SEASSSRMGD SSQGDNNVQK 
       210        220        230        240        250
LGPDDVTVDI DAIRRVYSSL LANEKLETAF LNALVYLSPN VECDLTYHNV 
       260        270        280        290        300
YTRDPNYLNL FIIVMENSNL HSPEYLEMAL PLFCKAMCKL PLEAQGKLIR 
       310        320        330        340        350
LWSKYSADQI RRMMETFQQL ITYKVISNEF NSRNLVNDDD AIVAASKCLK 
       360        370        380        390        400
MVYYANVVGG DVDTNHNEED DEEPIPESSE LTLQELLGDE RRNKKGPRVD 
       410        420        430        440        450
PLETELGVKT LDCRKPLISF EEFINEPLND VLEMDKDYTF FKVETENKFS 
       460        470        480        490        500
FMTCPFILNA VTKNLGLYYD NRIRMYSERR ITVLYSLVQG QQLNPYLRLK 
       510        520        530        540        550
VRRDHIIDDA LVRLEMIAME NPADLKKQLY VEFEGEQGVD EGGVSKEFFQ 
       560        570        580        590        600
LVVEEIFNPD IGMFTYDEAT KLFWFNPSSF ETEGQFTLIG IVLGLAIYNN 
       610        620        630        640        650
CILDVHFPMV VYRKLMGKKG TFRDLGDSHP VLYQSLKDLL EYEGSVEDDM 
       660        670        680        690        700
MITFQISQTD LFGNPMMYDL KENGDKIPIT NENRKEFVNL YSDYILNKSV 
       710        720        730        740        750
EKQFKAFRRG FHMVTNESPL KYLFRPEEIE LLICGSRNLD FQALEETTEY 
       760 
DGGYTRESVV IR                                          

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PATHWAY comments
   Index of metabolic and biosynthesis pathways