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UniProtKB - O08759 (UBE3A_MOUSE)

Entry version 163 (02 Jun 2021)
Sequence version 2 (01 Apr 2015)
Previous versions | rss
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Protein

Ubiquitin-protein ligase E3A

Gene

Ube3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:20211139, PubMed:24728990).

Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity).

Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).

Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139).

Synergizes with WBP2 in enhancing PGR activity (By similarity).

By similarity2 Publications

Miscellaneous

The Ube3a locus is imprinted with silencing of the paternal allele in hippocampus and cerebellum in mice.1 Publication
A cysteine residue is required for ubiquitin-thioester formation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei838Glycyl thioester intermediatePROSITE-ProRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri42 – 81C4-type; atypicalBy similarityAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processBiological rhythms, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-protein ligase E3A (EC:2.3.2.261 Publication)
Alternative name(s):
HECT-type ubiquitin transferase E3A
Oncogenic protein-associated protein E6-AP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ube3a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:105098, Ube3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice with maternal deficiency display autism spectrum disorders, characterized by motor dysfunction, inducible seizures and a context-dependent learning deficit (PubMed:9808466, PubMed:11895368). Long-term potentiation (LTP) is severely impaired despite normal baseline synaptic transmission and neuroanatomy (PubMed:9808466). The cytoplasmic abundance of p53/TP53 is increased in postmitotic neurons (PubMed:9808466). Accumulation of ARC protein in neurons, resulting in the excessive internalization of AMPA receptors (AMPARs) at synapses and impaired synaptic function (PubMed:20211139).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi838C → A: Abolishes catalytic activity. Abolishes ability to ubiquitinate ARC. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949811 – 870Ubiquitin-protein ligase E3AAdd BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei654Phosphotyrosine; by ABL1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-654 by ABL1 impairs E3 ligase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O08759

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O08759

MaxQB - The MaxQuant DataBase

More...MaxQBi		O08759

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O08759

PeptideAtlas

More...PeptideAtlasi		O08759

PRoteomics IDEntifications database

More...PRIDEi		O08759

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		298183 [O08759-1]
298184 [O08759-2]
298185 [O08759-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O08759

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O08759

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O08759

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Most abundant in brain, heart and thymus.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to neuronal activity.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025326, Expressed in vas deferens and 311 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O08759, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The active form is probably a homotrimer. Binds UBQLN1 and UBQLN2.

Interacts with the 26S proteasome.

Interacts with BPY2.

Interacts with HIF1AN, MAPK6 AND NEURL4; interaction with MAPK6 may be mediated by NEURL4.

Interacts with the proteasomal subunit PSMD4.

Interacts with ARNTL/BMAL1 (PubMed:24728990).

Interacts with ARC (PubMed:20211139).

Interacts with ESR1 and WBP2 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O08759, 3 interactors

Molecular INTeraction database

More...MINTi		O08759

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000103161

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O08759, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O08759

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini542 – 870HECTPROSITE-ProRule annotationAdd BLAST329

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 223DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 196Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi207 – 221Polar residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 81C4-type; atypicalBy similarityAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0941, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155050

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002173_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O08759

Identification of Orthologs from Complete Genome Data

More...OMAi		FEMVTDE

Database of Orthologous Groups

More...OrthoDBi		339404at2759

TreeFam database of animal gene trees

More...TreeFami		TF315189

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.286.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032353, AZUL
IPR042556, AZUL_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR017134, UBE3A

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16558, AZUL, 1 hit
PF00632, HECT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037201, Ubiquitin-protein_ligase_E6-AP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O08759-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE 
        60         70         80         90        100
FCASCPTFLR MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG 
       110        120        130        140        150
ASNNSEIKMN KKEGKDFKDV IYLTEEKVYE IYEFCRESED YSPLIRVIGR 
       160        170        180        190        200
IFSSAEALVL SFRKVKQHTK EELKSLQEKD EDKDEDEKEK AACSAAAMEE 
       210        220        230        240        250
DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS LLANEKLETA 
       260        270        280        290        300
FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 
       310        320        330        340        350
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE 
       360        370        380        390        400
FNSRNLVNDD DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS 
       410        420        430        440        450
ELTLQELLGD ERRNKKGPRV DPLETELGVK TLDCRKPLIS FEEFINEPLN 
       460        470        480        490        500
DVLEMDKDYT FFKVETENKF SFMTCPFILN AVTKNLGLYY DNRIRMYSER 
       510        520        530        540        550
RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM ENPADLKKQL 
       560        570        580        590        600
YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 
       610        620        630        640        650
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH 
       660        670        680        690        700
PVLYQSLKDL LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI 
       710        720        730        740        750
TNENRKEFVN LYSDYILNKS VEKQFKAFRR GFHMVTNESP LKYLFRPEEI 
       760        770        780        790        800
ELLICGSRNL DFQALEETTE YDGGYTRESV VIREFWEIVH SFTDEQKRLF 
       810        820        830        840        850
LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN VLLLPEYSSK 
       860        870
EKLKERLLKA ITYAKGFGML
Length:870
Mass (Da):99,819
Last modified:April 1, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC6BBDDD5AE9C164
GO
Isoform 2 (identifier: O08759-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:849
Mass (Da):97,584
Checksum:i840AD5E681DBB45E
GO
Isoform 3 (identifier: O08759-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     784-870: Missing.

Show »
Length:762
Mass (Da):87,700
Checksum:iBB189D5380C3F25B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUK0A0A0J9YUK0_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUY4A0A0J9YUY4_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVG1A0A0J9YVG1_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHS2A0A140LHS2_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUF2A0A0J9YUF2_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTX6A0A0J9YTX6_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI50A0A140LI50_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YV26A0A0J9YV26_MOUSE
Ubiquitin-protein ligase E3A
Ube3a
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB47756 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7R → S in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti171E → D in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti285V → L in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti327S → T in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti368K → N in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti444F → S in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti470F → G in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti519R → T in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti581D → N in AAB47756 (PubMed:9110176).Curated1
Sequence conflicti613Missing in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti710 – 711NL → IS in AAB63361 (PubMed:9182527).Curated2
Sequence conflicti802Q → L in AAB63361 (PubMed:9182527).Curated1
Sequence conflicti854 – 855KE → NV in AAB63361 (PubMed:9182527).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0575631 – 21Missing in isoform 2 and isoform 3. Add BLAST21
Alternative sequenceiVSP_057564784 – 870Missing in isoform 3. Add BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U96636 mRNA Translation: AAB63361.1
U82122 mRNA Translation: AAB47756.1 Frameshift.
AK029133 mRNA Translation: BAC26314.1
AC167971 Genomic DNA No translation available.
BC131658 mRNA Translation: AAI31659.1
BC131659 mRNA Translation: AAI31660.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS39973.1 [O08759-1]
CCDS80733.1 [O08759-2]

NCBI Reference Sequences

More...RefSeqi		NP_035798.2, NM_011668.2 [O08759-1]
NP_766598.1, NM_173010.3
XP_006540862.1, XM_006540799.3 [O08759-1]
XP_011249149.1, XM_011250847.2 [O08759-2]
XP_017177614.1, XM_017322125.1 [O08759-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000107537; ENSMUSP00000103161; ENSMUSG00000025326 [O08759-2]
ENSMUST00000200758; ENSMUSP00000143859; ENSMUSG00000025326 [O08759-1]
ENSMUST00000202945; ENSMUSP00000143962; ENSMUSG00000025326 [O08759-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:22215

UCSC genome browser

More...UCSCi		uc009heg.1, mouse
uc009hei.1, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96636 mRNA Translation: AAB63361.1
U82122 mRNA Translation: AAB47756.1 Frameshift.
AK029133 mRNA Translation: BAC26314.1
AC167971 Genomic DNA No translation available.
BC131658 mRNA Translation: AAI31659.1
BC131659 mRNA Translation: AAI31660.1
CCDSiCCDS39973.1 [O08759-1]
CCDS80733.1 [O08759-2]
RefSeqiNP_035798.2, NM_011668.2 [O08759-1]
NP_766598.1, NM_173010.3
XP_006540862.1, XM_006540799.3 [O08759-1]
XP_011249149.1, XM_011250847.2 [O08759-2]
XP_017177614.1, XM_017322125.1 [O08759-1]

3D structure databases

SMRiO08759
ModBaseiSearch...

Protein-protein interaction databases

IntActiO08759, 3 interactors
MINTiO08759
STRINGi10090.ENSMUSP00000103161

PTM databases

iPTMnetiO08759
PhosphoSitePlusiO08759
SwissPalmiO08759

Proteomic databases

EPDiO08759
jPOSTiO08759
MaxQBiO08759
PaxDbiO08759
PeptideAtlasiO08759
PRIDEiO08759
ProteomicsDBi298183 [O08759-1]
298184 [O08759-2]
298185 [O08759-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9118, 391 antibodies

The DNASU plasmid repository

More...DNASUi		22215

Genome annotation databases

EnsembliENSMUST00000107537; ENSMUSP00000103161; ENSMUSG00000025326 [O08759-2]
ENSMUST00000200758; ENSMUSP00000143859; ENSMUSG00000025326 [O08759-1]
ENSMUST00000202945; ENSMUSP00000143962; ENSMUSG00000025326 [O08759-3]
GeneIDi22215
KEGGimmu:22215
UCSCiuc009heg.1, mouse
uc009hei.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7337
MGIiMGI:105098, Ube3a

Phylogenomic databases

eggNOGiKOG0941, Eukaryota
GeneTreeiENSGT00940000155050
HOGENOMiCLU_002173_5_0_1
InParanoidiO08759
OMAiFEMVTDE
OrthoDBi339404at2759
TreeFamiTF315189

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22215, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ube3a, mouse

Protein Ontology

More...PROi		PR:O08759
RNActiO08759, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025326, Expressed in vas deferens and 311 other tissues
GenevisibleiO08759, MM

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di1.10.286.60, 1 hit
InterProiView protein in InterPro
IPR032353, AZUL
IPR042556, AZUL_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR017134, UBE3A
PfamiView protein in Pfam
PF16558, AZUL, 1 hit
PF00632, HECT, 1 hit
PIRSFiPIRSF037201, Ubiquitin-protein_ligase_E6-AP, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBE3A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08759
Secondary accession number(s): E9QKT1, P97482, Q8CE29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 1, 2015
Last modified: June 2, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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