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Protein

Hepatocyte nuclear factor 6

Gene

Onecut1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi283 – 369CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi385 – 444HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • B cell differentiation Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cilium assembly Source: MGI
  • endocrine pancreas development Source: MGI
  • endoderm development Source: MGI
  • epithelial cell development Source: MGI
  • glucose metabolic process Source: MGI
  • liver development Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • Notch signaling pathway Source: MGI
  • pancreas development Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell-matrix adhesion Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • spleen development Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 6
Short name:
HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene namesi
Name:Onecut1
Synonyms:Hnf6, Hnf6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1196423 Onecut1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024031 – 465Hepatocyte nuclear factor 6Add BLAST465

Proteomic databases

MaxQBiO08755
PaxDbiO08755
PeptideAtlasiO08755
PRIDEiO08755

PTM databases

PhosphoSitePlusiO08755

Expressioni

Gene expression databases

BgeeiENSMUSG00000043013
CleanExiMM_ONECUT1
GenevisibleiO08755 MM

Interactioni

Subunit structurei

Binds DNA as a monomer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058020

Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi295 – 305Combined sources11
Helixi312 – 318Combined sources7
Beta strandi320 – 322Combined sources3
Helixi326 – 330Combined sources5
Helixi344 – 355Combined sources12
Beta strandi378 – 380Combined sources3
Helixi394 – 403Combined sources10
Helixi412 – 419Combined sources8
Beta strandi424 – 426Combined sources3
Helixi427 – 435Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S7ENMR-A291-437[»]
ProteinModelPortaliO08755
SMRiO08755
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08755

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 72Poly-His4
Compositional biasi124 – 138Poly-HisAdd BLAST15
Compositional biasi450 – 460Poly-SerAdd BLAST11

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiO08755
KOiK08026
OMAiQMEEVNT
OrthoDBiEOG091G0E7H
PhylomeDBiO08755
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVGH RGSHLPPAHP
60 70 80 90 100
RSMGMASLLD GGSGGSDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP
110 120 130 140 150
TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT
160 170 180 190 200
LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSGSGLGSI HNSQQGLPHY
210 220 230 240 250
AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH
260 270 280 290 300
HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
310 320 330 340 350
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM
360 370 380 390 400
WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL
410 420 430 440 450
HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGGS
460
NSGSSSSSSS TCTKA
Length:465
Mass (Da):50,952
Last modified:July 1, 1997 - v1
Checksum:iA770D27DD5AAC896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95945 mRNA Translation: AAB53863.1
BC024053 mRNA Translation: AAH24053.1
CCDSiCCDS23339.1
RefSeqiNP_032288.1, NM_008262.3
UniGeneiMm.303355

Genome annotation databases

EnsembliENSMUST00000056006; ENSMUSP00000058020; ENSMUSG00000043013
GeneIDi15379
KEGGimmu:15379
UCSCiuc009qrh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHNF6_MOUSE
AccessioniPrimary (citable) accession number: O08755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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