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Entry version 163 (12 Aug 2020)
Sequence version 2 (21 Sep 2011)
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Protein

Matrilin-2

Gene

Matn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in matrix assembly.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrilin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Matn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109613, Matn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000765624 – 956Matrilin-2Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi242 ↔ 253By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 277By similarity
Disulfide bondi283 ↔ 294By similarity
Disulfide bondi290 ↔ 303By similarity
Disulfide bondi305 ↔ 318By similarity
Disulfide bondi324 ↔ 335By similarity
Disulfide bondi331 ↔ 344By similarity
Disulfide bondi346 ↔ 359By similarity
Disulfide bondi365 ↔ 376By similarity
Disulfide bondi372 ↔ 385By similarity
Disulfide bondi387 ↔ 400By similarity
Disulfide bondi406 ↔ 417By similarity
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi428 ↔ 441By similarity
Disulfide bondi447 ↔ 458By similarity
Disulfide bondi454 ↔ 467By similarity
Disulfide bondi469 ↔ 482By similarity
Disulfide bondi488 ↔ 499By similarity
Disulfide bondi495 ↔ 508By similarity
Disulfide bondi510 ↔ 523By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi536 ↔ 549By similarity
Disulfide bondi551 ↔ 564By similarity
Disulfide bondi570 ↔ 581By similarity
Disulfide bondi577 ↔ 590By similarity
Disulfide bondi592 ↔ 605By similarity
Disulfide bondi611 ↔ 622By similarity
Disulfide bondi618 ↔ 631By similarity
Disulfide bondi633 ↔ 646By similarity
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O08746

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O08746

PeptideAtlas

More...
PeptideAtlasi
O08746

PRoteomics IDEntifications database

More...
PRIDEi
O08746

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O08746, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O08746

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O08746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in a variety of organs, including calvaria, uterus, heart and brain, as well as fibroblast and osteoblast cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022324, Expressed in female gonad and 300 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O08746, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O08746, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201321, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4467, Matrilin-2 complex

Protein interaction database and analysis system

More...
IntActi
O08746, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000128202

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O08746, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O08746

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 232VWFA 1PROSITE-ProRule annotationAdd BLAST176
Domaini238 – 278EGF-like 1Add BLAST41
Domaini279 – 319EGF-like 2Add BLAST41
Domaini320 – 360EGF-like 3Add BLAST41
Domaini361 – 401EGF-like 4Add BLAST41
Domaini402 – 442EGF-like 5Add BLAST41
Domaini443 – 483EGF-like 6Add BLAST41
Domaini484 – 524EGF-like 7Add BLAST41
Domaini525 – 565EGF-like 8Add BLAST41
Domaini566 – 606EGF-like 9Add BLAST41
Domaini607 – 647EGF-like 10Add BLAST41
Domaini655 – 830VWFA 2PROSITE-ProRule annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili917 – 955Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008905_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O08746

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECVNADN

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.30, 1 hit
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR030747, Matrilin-2
IPR036337, Matrilin_cc_sf
IPR019466, Matrilin_coiled-coil_trimer
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24020:SF35, PTHR24020:SF35, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 5 hits
PF10393, Matrilin_ccoil, 1 hit
PF00092, VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 10 hits
SM00179, EGF_CA, 10 hits
SM01279, Matrilin_ccoil, 1 hit
SM00327, VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 2 hits
SSF57184, SSF57184, 3 hits
SSF58002, SSF58002, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 7 hits
PS01186, EGF_2, 9 hits
PS50234, VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O08746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKMLVGCLL MLGQLFLVLP VDGRERPQAR FPSRGRHVRM YPQTALLESS
60 70 80 90 100
CENKRADLVF IIDSSRSVNT YDYAKVKEFI LDILQFLDIG PDVTRVGLLQ
110 120 130 140 150
YGSTVKNEFS LKTFKRKSEV ERAVKRMRHL STGTMTGLAI QYALNIAFSE
160 170 180 190 200
AEGARPLREN VPRIIMIVTD GRPQDSVAEV AAKARNTGIL IFAIGVGQVD
210 220 230 240 250
LNTLKAIGSE PHKDHVFLVA NFSQIESLTS VFQNKLCTVH MCSVLEHNCA
260 270 280 290 300
HFCLNTPGSY ICKCKQGYIL STDQKTCRIQ DLCATEDHGC EQLCVNMLGS
310 320 330 340 350
FVCQCYSGYT LAEDGKRCTA VDYCASENHG CEHECVNAES SYLCRCHEGF
360 370 380 390 400
ALNSDKKTCS KIDYCASSNH GCQHECVNAQ TSALCRCLKG FMLNPDRKTC
410 420 430 440 450
RRINYCALNK PGCEHECVNT EEGHYCRCRQ GYNLDPNGKT CSRVDHCAQQ
460 470 480 490 500
DHGCEQLCLN TEESFVCQCS EGFLINDDLK TCSRADYCLL SNHGCEYSCV
510 520 530 540 550
NTDKSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC VSSEDSFVCQ
560 570 580 590 600
CFEGYILRDD GKTCRRKDVC QDVNHGCEHL CVNSGESYVC KCLEGFRLAE
610 620 630 640 650
DGKRCRRKNV CKSTQHGCEH MCVNNGNSYL CRCSEGFVLA EDGKHCKRCT
660 670 680 690 700
EGPIDLVFVI DGSKSLGEEN FETVKHFVTG IIDSLAVSPK AARVGLLQYS
710 720 730 740 750
TQVRTEFTLR GFSSAKEMKK AVTHMKYMGK GSMTGLALKH MFERSFTQVE
760 770 780 790 800
GARPPSTQVP RVAIVFTDGR AQDDVSEWAS KAKANGITMY AVGVGKAIEE
810 820 830 840 850
ELQEIASEPI DKHLFYAEDF STMGEISEKL KEGICEALED SGGRQDSAAW
860 870 880 890 900
DLPQQAHQPT EPEPVTIKIK DLLSCSNFAV QHRFLFEEDN LSRSTQKLFH
910 920 930 940 950
STKSSGNPLE ESQDQCKCEN LILFQNVANE EVRKLTQRLE EMTQRMEALE

NRLKYR
Length:956
Mass (Da):106,748
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E4A608FF92BDE55
GO
Isoform 2 (identifier: O08746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     861-879: Missing.

Show »
Length:937
Mass (Da):104,662
Checksum:i6FBBA81D1CF75B50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQM7A0A0A0MQM7_MOUSE
Matrilin-2
Matn2
957Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRF3A0A2I3BRF3_MOUSE
Matrilin-2
Matn2
810Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRV5A0A2I3BRV5_MOUSE
Matrilin-2
Matn2
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321V → M in AAC53163 (PubMed:9083061).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041771861 – 879Missing in isoform 2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U69262 mRNA Translation: AAC53163.1
AF358844 AF358843 Genomic DNA Translation: AAM11539.1
AC126028 Genomic DNA No translation available.
AC133101 Genomic DNA No translation available.
AC144632 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37056.1 [O08746-2]
CCDS88747.1 [O08746-1]

NCBI Reference Sequences

More...
RefSeqi
XP_006520086.1, XM_006520023.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022947; ENSMUSP00000022947; ENSMUSG00000022324 [O08746-2]
ENSMUST00000227759; ENSMUSP00000154040; ENSMUSG00000022324 [O08746-1]

UCSC genome browser

More...
UCSCi
uc007vln.1, mouse [O08746-1]
uc007vlo.1, mouse [O08746-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69262 mRNA Translation: AAC53163.1
AF358844 AF358843 Genomic DNA Translation: AAM11539.1
AC126028 Genomic DNA No translation available.
AC133101 Genomic DNA No translation available.
AC144632 Genomic DNA No translation available.
CCDSiCCDS37056.1 [O08746-2]
CCDS88747.1 [O08746-1]
RefSeqiXP_006520086.1, XM_006520023.2

3D structure databases

SMRiO08746
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201321, 4 interactors
ComplexPortaliCPX-4467, Matrilin-2 complex
IntActiO08746, 2 interactors
STRINGi10090.ENSMUSP00000128202

PTM databases

GlyGeniO08746, 2 sites
iPTMnetiO08746
PhosphoSitePlusiO08746

Proteomic databases

MaxQBiO08746
PaxDbiO08746
PeptideAtlasiO08746
PRIDEiO08746

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26033, 172 antibodies

Genome annotation databases

EnsembliENSMUST00000022947; ENSMUSP00000022947; ENSMUSG00000022324 [O08746-2]
ENSMUST00000227759; ENSMUSP00000154040; ENSMUSG00000022324 [O08746-1]
UCSCiuc007vln.1, mouse [O08746-1]
uc007vlo.1, mouse [O08746-2]

Organism-specific databases

MGIiMGI:109613, Matn2

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000158008
HOGENOMiCLU_008905_0_0_1
InParanoidiO08746
OMAiECVNADN
OrthoDBi1174178at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
17181, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Matn2, mouse

Protein Ontology

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PROi
PR:O08746
RNActiO08746, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000022324, Expressed in female gonad and 300 other tissues
ExpressionAtlasiO08746, baseline and differential
GenevisibleiO08746, MM

Family and domain databases

Gene3Di1.20.5.30, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR030747, Matrilin-2
IPR036337, Matrilin_cc_sf
IPR019466, Matrilin_coiled-coil_trimer
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR24020:SF35, PTHR24020:SF35, 5 hits
PfamiView protein in Pfam
PF07645, EGF_CA, 5 hits
PF10393, Matrilin_ccoil, 1 hit
PF00092, VWA, 2 hits
SMARTiView protein in SMART
SM00181, EGF, 10 hits
SM00179, EGF_CA, 10 hits
SM01279, Matrilin_ccoil, 1 hit
SM00327, VWA, 2 hits
SUPFAMiSSF53300, SSF53300, 2 hits
SSF57184, SSF57184, 3 hits
SSF58002, SSF58002, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 7 hits
PS01186, EGF_2, 9 hits
PS50234, VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMATN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O08746
Secondary accession number(s): E9QPK9, Q8R542
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 21, 2011
Last modified: August 12, 2020
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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