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Protein

DNA-directed RNA polymerase II subunit RPB11

Gene

Polr2j

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11
Short name:
RNA polymerase II subunit B11
Alternative name(s):
DNA-directed RNA polymerase II subunit J
RNA polymerase II 13.3 kDa subunit
RPB14
Gene namesi
Name:Polr2j
Synonyms:Rpo2-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109582 Polr2j

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493101 – 117DNA-directed RNA polymerase II subunit RPB11Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO08740
MaxQBiO08740
PaxDbiO08740
PRIDEiO08740

PTM databases

PhosphoSitePlusiO08740

Expressioni

Gene expression databases

CleanExiMM_POLR2J

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with AATF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO08740, 1 interactor
MINTiO08740
STRINGi10090.ENSMUSP00000038505

Structurei

3D structure databases

ProteinModelPortaliO08740
SMRiO08740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4392 Eukaryota
COG1761 LUCA
HOGENOMiHOG000179862
HOVERGENiHBG073419
InParanoidiO08740
PhylomeDBiO08740

Family and domain databases

CDDicd06926 RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685 RBP11
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O08740-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAPPAFESF LLFEGEKKIT INKDTKVPNA CLFTINKEDH TLGNIIKSQL
60 70 80 90 100
LKDPQVLFAG YKVPHPLEHK IIIRVQTTPD YSPQEAFTNA ITDLISELSL
110
LEERFRGAIK DKQEGIE
Length:117
Mass (Da):13,251
Last modified:July 1, 1997 - v1
Checksum:i6F78BE306EF8F647
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PI63Q6PI63_MOUSE
DNA-directed RNA polymerase II subu...
Polr2j mCG_1879
117Annotation score:
D3YZ20D3YZ20_MOUSE
DNA-directed RNA polymerase II subu...
Polr2j
111Annotation score:
D3YZ19D3YZ19_MOUSE
DNA-directed RNA polymerase II subu...
Polr2j
87Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85818 mRNA Translation: BAA19918.1
UniGeneiMm.4896

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85818 mRNA Translation: BAA19918.1
UniGeneiMm.4896

3D structure databases

ProteinModelPortaliO08740
SMRiO08740
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08740, 1 interactor
MINTiO08740
STRINGi10090.ENSMUSP00000038505

PTM databases

PhosphoSitePlusiO08740

Proteomic databases

EPDiO08740
MaxQBiO08740
PaxDbiO08740
PRIDEiO08740

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109582 Polr2j

Phylogenomic databases

eggNOGiKOG4392 Eukaryota
COG1761 LUCA
HOGENOMiHOG000179862
HOVERGENiHBG073419
InParanoidiO08740
PhylomeDBiO08740

Miscellaneous databases

ChiTaRSiPolr2j mouse
PROiPR:O08740
SOURCEiSearch...

Gene expression databases

CleanExiMM_POLR2J

Family and domain databases

CDDicd06926 RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685 RBP11
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPB11_MOUSE
AccessioniPrimary (citable) accession number: O08740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 10, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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